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2,4'-Dihydroxydiphenyl Sulfone

    • Product Name 2,4'-Dihydroxydiphenyl Sulfone
    • Alias Dapsone
    • Einecs 217-426-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    285287

    Cas Number 80-09-1
    Molecular Formula C12H10O4S
    Molecular Weight 250.27 g/mol
    Synonyms Bis(2-hydroxyphenyl) sulfone, 2,4'-Dihydroxydiphenyl sulphone
    Appearance White to off-white powder
    Melting Point 245-249°C
    Solubility In Water Slightly soluble
    Purity Typically ≥98%
    Density 1.43 g/cm³
    Chemical Classification Aromatic sulfone
    Storage Conditions Store at room temperature, keep container tightly closed

    As an accredited 2,4'-Dihydroxydiphenyl Sulfone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 2,4'-Dihydroxydiphenyl Sulfone is packaged in a 500g amber glass bottle with a secure, tamper-evident screw cap.
    Shipping 2,4'-Dihydroxydiphenyl Sulfone is shipped in tightly sealed, chemical-resistant containers to prevent contamination and moisture absorption. It should be handled according to standard chemical shipping regulations, including appropriate labeling and documentation. Store in a cool, dry place and protect from direct sunlight and incompatible materials during transport. Handle with suitable safety precautions.
    Storage 2,4'-Dihydroxydiphenyl Sulfone should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible materials such as strong oxidizing agents. Protect from moisture and direct sunlight. Ensure proper labeling and limit access to authorized personnel. Follow all relevant safety and environmental regulations regarding chemical storage.
    Application of 2,4'-Dihydroxydiphenyl Sulfone

    Applications of 2,4'-Dihydroxydiphenyl Sulfone in Industrial Manufacturing

    2,4'-Dihydroxydiphenyl sulfone serves as a critical raw material across several high-performance industrial sectors. As a manufacturer, we understand its impact on product formulation, process efficiency, and regulatory compliance in downstream operations. The following sections detail precise applications in real-world manufacturing, including process positioning, relevant compliance standards, dosage parameters, and types of final products.

    1. Engineering Thermoplastics: Polyethersulfone (PES) Resin Production

    This material acts as a key monomer in polyethersulfone (PES) polymerization for the plastics industry. Its dual hydroxyl groups enable nucleophilic aromatic substitution with activated difluorodiphenyl sulfone or dichlorodiphenyl sulfone, forming high-molecular-weight resins. The process requires rigorous quality monitoring and precise stoichiometric control, as material purity and functional group integrity directly affect end-use plastic performance, including thermal stability, hydrolytic resistance, and mechanical strength.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems
    • UL746C Standard for Polymer Materials – Use in Electrical Equipment Evaluations
    • ASTM D6394 Standard Specification for Polyethersulfone Resin
    • RoHS Directive 2011/65/EU (EU Restriction of Hazardous Substances)

    Typical usage ratio

    • 0.98–1.02 molar equivalents relative to dihalo monomers, optimized for target molecular weight control
    • Adjustment by viscosity and targeted melt-flow index in specific PES grades

    Downstream process integration

    • Direct charge into condensation reactors during prepolymer stage
    • Dissolution in dipolar aprotic solvents (NMP, DMAc) for solution polymerization
    • Real-time analytical verification of consumption rate via titration or HPLC
    • Extended removal of residuals in devolatilization step before extrusion

    Final product types

    • PES granules for injection molding
    • PES films and hollow-fiber membranes
    • Molded components for automotive, aerospace, electronics
    • Thermally stable electric insulation parts

    2. Epoxy Resin Curing Agent Manufacturing

    In specialty epoxy systems, 2,4'-dihydroxydiphenyl sulfone functions as a crosslinking agent or modifier, imparting high glass transition temperatures and improved chemical resistance. In two-component formulations, it reacts with epoxy prepolymers containing glycidyl moieties under controlled thermal curing profiles. Its incorporation increases matrix rigidity and dimensional stability demanded in high-reliability electrical laminates and composite parts.

    Industry compliance standards

    • IEC 61249-2-7 Base Materials for Printed Circuit Boards
    • UL94 Flammability Standard
    • JIS K 6911 Standards for Epoxy Resins
    • REACH Regulation (EC) No 1907/2006

    Typical usage ratio

    • 5–15% by weight of total resin formulation in laminates
    • Adjusted per target Tg enhancement and flow properties

    Downstream process integration

    • Pre-blending with bisphenol A or F epoxies and filler matrix
    • Addition during melt or solvent blending prior to lamination
    • Participates in thermal crosslinking reactions (150–200°C)
    • Post-cure properties fine-tuned via resin stoichiometry

    Final product types

    • High-Tg copper-clad laminates for PCBs
    • Advanced composite circuit substrates
    • Coatings with solvent and alkaline resistance
    • Electrical insulation varnishes and adhesives

    3. Pharmaceutical Intermediate for Sulfonyl-Containing APIs

    This compound provides a structural motif for the synthesis of several sulfone-based active pharmaceutical ingredients, primarily in anti-infective and anti-inflammatory categories. Used in active ingredient synthesis, it introduces the diphenyl sulfone core via aromatic substitution or coupling routes. Material purity, trace metal content, and residual solvent levels are tightly monitored to align with pharmacopeial monograph requirements.

    Industry compliance standards

    • USP-NF (United States Pharmacopeia and National Formulary) guidelines
    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) monographs
    • 21 CFR Part 211 (US cGMP regulations)

    Typical usage ratio

    • Stoichiometric equivalent or slight excess depending on coupling yield requirements
    • Ranges from 0.9 to 1.2 molar equivalents per reaction step

    Downstream process integration

    • Direct incorporation in core sulfonylation or diazotization reactions
    • Purification via crystallization and controlled drying prior to downstream API assembly
    • In-process checks for trace-level impurities as per ICH Q3A, Q3C
    • Documentation for full traceability from raw, intermediate to final API

    Final product types

    • Sulfone-class antibacterial drugs (e.g., Dapsone derivatives)
    • Anti-inflammatory intermediates
    • Specialty building blocks for custom synthesis
    • Research and pilot-scale pharmaceutical reference compounds

    4. Organic Pigment and Dye Production

    The bisphenol sulfone structure enables its use as an intermediate in azo and anthraquinone dye synthesis. Its chemical rigidity imparts lightfastness, improved wash resistance, and acid stability to finished pigments. It enters as a building block for complex chromophores, where electron-withdrawing sulfone groups tune optical properties desired in automotive, textile, and plastic masterbatch sectors.

    Industry compliance standards

    • OEKO-TEX Standard 100 (for textiles and leather)
    • EN 71-3 Migration of Certain Elements (toys, children’s products)
    • ISO 105-A02:2010 for colorfastness
    • REACH Annex XVII (restrictions on hazardous dyes and pigments)

    Typical usage ratio

    • 0.6–1.0 molar equivalents per dyestuff backbone, adjusted for target chromophore strength
    • Fine-tuning based on absorption spectra and final pigment loading

    Downstream process integration

    • Charged during condensation or coupling phases in amine/azo dye synthesis
    • Participates in controlled sulfonation or esterification
    • Material filtration and grinding prior to pigment dispersal
    • Final blending with application-specific additives for optimal dispersion

    Final product types

    • Disperse and acid dyes for fibers
    • High-performance pigments for automotive finishes
    • Masterbatch colorants for engineering plastics
    • Printing inks for resistant graphic media

    5. Ion Exchange Membrane and Filtration Material Manufacturing

    The molecular structure supports the synthesis of specialty ion exchange resins and filtration membranes. It provides sulfone linkages and phenolic groups, resulting in enhanced hydrolytic and oxidative stability. Manufacturers leverage it in the production of membranes used for water purification and chemical processing, where durability and ionic selectivity are priorities. The degree of crosslinking and incorporation ratio directly influences permeability and lifetime.

    Industry compliance standards

    • NSF/ANSI 61 (Drinking Water System Components – Health Effects)
    • ISO 14021 Environmental labeling (for recycled water applications)
    • EU Regulation 10/2011 (Plastics intended for food contact, for process filters)
    • ASTM F2013 Standard for Membranes Used in Water Filtration

    Typical usage ratio

    • 7–15% by mass in copolymer blend matrices (varies with porosity and target retention rate)
    • Adjusted to optimize flux and mechanical strength blend as required

    Downstream process integration

    • Solution blending in co-polymer dope preparation for membrane casting
    • Reactive extrusion to achieve desired crosslink density
    • Post-formation annealing to stabilize microstructure
    • Surface chemical activation for specific ion selectivity

    Final product types

    • Ultrafiltration and nanofiltration membranes
    • Dialysis and medical filtration modules
    • Industrial water treatment cartridges
    • Process separation materials for pharmaceutical manufacturing
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    Certification & Compliance
    More Introduction

    2,4'-Dihydroxydiphenyl Sulfone: Practical Insights and Real-World Experience from the Plant Floor

    Production Experience and Consistent Quality

    In our manufacturing environment, producing 2,4'-Dihydroxydiphenyl Sulfone has taught us the value of rigorous process control. Over countless batches, a few truths stand out: purity never comes easy, and small flaws in temperature or moisture content during synthesis turn up rapidly in the finished product. Our plant team manages reaction kinetics meticulously to ensure minimal by-products and low color formation. Consistency matters. Customers rely on a product with stable melt point, minimal insolubles, and proper particle size. From initial charging of starting aromatics through sulfonation and hydroxylation, every step demands attention. Cutting corners means losing the properties that customers demand in critical applications.

    The right setup means the final compound—white to very pale crystals, free of residual odors and dark spots—arrives packaged, meeting not just specifications on paper but the expectations of engineers and chemists who have built processes around our material. Years of lab analysis and refining purification show up in the clarity and flow properties seen each time a drum opens. LC, GC, and titration data anchor our trust in each lot number leaving our site, reducing surprises for formulators. We fix trace metal content at source, recognizing how even slight iron or copper contamination disrupts downstream polymer processes or overshadows color requirements in sensitive applications.

    Understanding the Model and Specifications from a Manufacturer’s Lens

    We manufacture 2,4'-Dihydroxydiphenyl Sulfone under the model name DHDS 24P. This model name goes beyond batch code and provides a shorthand assurance of historical reliability. On our line, DHDS 24P guarantees a melting point between 213°C and 217°C, with purity above 99.5% as proven by HPLC and NMR cross-verification. We target ash content below 0.05%, knowing how higher residues have upset our partners’ extruders. Particle size distribution holds steady thanks to sieving control—no surprises in feeding or blending stages.

    Moisture content stays capped at 0.1%. Our technical staff remember well the headaches even small deviations here have created—lump formation, feeding issues, unnecessary downtime. We keep nitrogen blanketing in the final packaging zone for this reason. Customer audits have confirmed the stability of our packing, shelf-life, and quality certificates. Most queries about stability, storage life, and shipment are best answered by our lab’s open-door policy, inviting clients to inspect or test alongside us. DHDS 24P batches are now well-regarded among repeat clients for these attributes: clarity, white color, crystal morphology, and repeatability in key tests.

    Field Uses and Real-World Benefits

    2,4'-Dihydroxydiphenyl Sulfone fills a unique chemical need, and over the years we have seen its two main applications predominate—polymer chain extension and performance resin intermediates. End users, particularly in high-value polymer plants, prize DHDS 24P as a core building block for polyethersulfones. The reasons are clear in day-to-day operations: the compound enables high-temperature polymers with exceptional mechanical and chemical resistance.

    We have worked closely with clients scaling batch polymerizations. The hydroxy and sulfone groups react smoothly, allowing predictable molecular weight targeting. Deeper in the formulation chain, our product’s purity means fewer side reactions and cleaner finished resins—essential for medical-grade and electronic applications. Relying on poor-quality material, clients have come back to us after trying lower-priced imports, especially when discoloration or brittle polymer parts appeared. In frequent technical exchanges, our team troubleshoots polymer runs, addressing activation issues, catalyst residue fears, and compatibilities. Our long view—built from supply to top medical device companies and electronics manufacturers—proves that tight purity controls pay back in fewer off-grade production days for our partners.

    Labs developing flame retardants and specialty surfactants employ DHDS 24P, citing its well-matched reactivity and clean end products. Where other dihydroxy compounds yield inconsistent color or hydrolysis, ours stands the test of high-temperature operation. Battery separators, reverse osmosis membranes, electrochemical assemblies—engineers in these fields seek high-performance at molecular levels and rarely tolerate inconsistency. In our conversations, materials managers cite the unique sulfone backbone of DHDS 24P as improving membrane lifetime and chemical attack resistance. This matches what our process engineers see: end users push these boundaries, and predictability from our material allows them faster process qualification.

    Real Differences: What Sets Us Apart from Other Offerings

    Comparisons between our DHDS 24P and generic 2,4'-Dihydroxydiphenyl Sulfone abound, especially as the market faces price pressure. Practical differences show up fast on real production lines. Our customers report that less-refined material, often sourced indirectly, tends to exhibit higher organic and inorganic impurity levels, unpredictable melt points, and greater moisture variability. One global resin producer shared their experience with third-party alternatives—off-color polymer runs, poor extrusion, and costly line cleaning episodes.

    DHDS 24P, thanks to rigorous upstream raw material controls and in-process checks, ensures reproducible chemical conversion at every scale. Our routine provides traceability from delivered starting raw material to finished lot packaging—a feature heavily valued during unexpected troubleshooting events or regulatory questions. We refrain from using recycled solvents in critical stages, aware of their impact on polymer compatibility. This attention pays off when clients ramp up production or face audits from demanding end customers.

    Our technical feedback loop proves essential. Formulators routinely contact our technical team before new product launches or scale-ups, reporting better machine uptime and fewer rejected batches using our compound. They emphasize how tight bulk density and particle shape matching eliminates feeding and metering issues which, in high-speed compounding, translate directly into productivity gains.

    While the market contains less expensive options, the biggest cost for end users often comes not from per-kilogram price but from process interruptions, waste, or troubleshooting symptoms from inconsistent raw materials. Decades of hands-on partnership in the field confirm that it's product stability—day after day, ton after ton—that wins new business and locks in repeat orders. Our position as the manufacturer means we see and act on feedback rapidly, investing in incremental improvements and aggressive QC protocols.

    Commitment to Quality and Safety: In-House Best Practices

    Our safety measures extend beyond compliance. Our teams perform documented risk assessments and invest extensively in spill prevention, process containment, and operator training. Years of experience in handling sulfone chemistry have led to built-in response plans and fast communication channels with local emergency centers. Each staff member in production and quality assurance undergoes yearly handling refreshers—not just technical reviews but practical drills for rare events such as accidental release.

    We track and restrict all possible exposures for both operators and downstream users. Clients trust our analytical results, which we share in full—impurity profiles, residual solvent levels, trace metal scans—because we use internally the same data science tools as some of our largest global clients. Our plant infrastructure features closed-system transfer, double-clad storage tanks, and filtered air management limiting particulate contamination. Proactive engagement with transporters, warehouses, and packaging suppliers ensures the DHDS 24P received at our customers’ plants matches the quality certified in our laboratory. One department specializes in regulatory monitoring, tracing the evolving needs of RoHS, REACH, and new regional EHS standards, letting customers focus on downstream innovation while we maintain their risk profile compliance.

    Supporting Customers through Collaboration and Openness

    Clients approach us frequently about shifting formulations or exploring new high-performance polymer backbones. Our technical service group, made up of experienced plant chemists, sits at the table from first trial through scale-up. Our staff know these applications from years in the field and provide practical advice—on polymerization steps, filtration, blending, and testing. They visit end-user sites, troubleshoot extruder start-ups, and solve challenges with batch-to-batch matching. By opening our manufacturing records as needed, we give formulators peace of mind in traceability.

    Early communications about trial shipments, forecasts for bulk orders, or nuanced shipping requirements receive attention right away. The market expects reliability, and our responsiveness backs up our product’s historical reputation. Unlike traders or brokers, we provide root-cause analysis for rare issues, drawing on firsthand knowledge of our formulation and safe handling. Application research often flows both directions—customers’ requests challenge us to push specifications tighter, improve packaging formats, or extend shelf-life with better sealing materials. Regular customer dialogue fuels an evolving product, not a static commodity.

    End users testing extended stability, new crosslinking methods, or critical performance under elevated thermal exposure receive direct sampling support from our pilot plant, reducing development costs and shortening time-to-market for their innovations. We have built one of the industry’s deepest experience bases in sulfone chemistry, shaping not just the molecule but the entire supply experience for our partners.

    Addressing Frequently Asked Challenges

    In the global chemical supply chain, shipping reliability stands out as a day-to-day concern. Because of this, we operate several redundant packaging and logistics lines. By owning the shipment timeline from in-plant final inspection through customs release, we minimize disruptions for our customers. This method covers last-minute regulatory changes and weather-related disruptions, keeping our partners confident in their production schedules.

    We receive questions about long-term shelf-stability, caking, and resistance to environmental changes during transport. In response, we run accelerated aging tests, simulate tropical storage scenarios, and share these reports candidly. Over time, we transitioned to lined, moisture-resistant drums—a change that came directly from collaborative customer feedback following a series of transport events several years ago. Our job, as we see it, means responding not only with words but tangible design or processing shifts.

    For clients transitioning between suppliers, our technical transfer protocols offer detailed comparison data and full disclosure about process windows—parameters under which our DHDS 24P operates optimally. Some clients worry about switching cost or the need to recalibrate; we offer detailed guidance and on-site support. Feedback shows that the payoff is fewer line stoppages, more robust product yields, and less troubleshooting as a result.

    Environmental Stewardship and Evolution of Practices

    Sulfone chemistry, while a backbone for advanced materials, requires careful stewardship. Our plant integrates closed-loop water systems and solvent recovery, reflecting years of effort in minimizing waste. Staff track every kilogram of input and output, turning plant data into emissions reductions. Third-party audits confirm that our operations run consistently below permitted release limits for all key species. We regularly invest in cleaner process chemistry—updates to catalysts, less hazardous reagents, and more robust filtration systems—transforming traditional challenges into continuous improvement stories.

    Regulatory trends, especially demands from international firms on lifecycle assessments and sustainable sourcing, match our own goals. Evidence from audits and customer questionnaires shows that our long-term partnerships stem in part from this environmental transparency. We believe this accountability extends from the raw material buyer to the floor operator to the executive signing off on management plans. One recent switch to a greener sulfonation route grew directly out of joint workshops with clients focused on their environmental footprint goals.

    The Experience and Perspective Only Direct Production Brings

    Decades producing 2,4'-Dihydroxydiphenyl Sulfone shape our experience. We see trends shift, alternatives come and go, and new technical standards emerge. Through all this, our direct hand in the process means deep understanding of what makes a material succeed on the floor—not just on a spec sheet, but in the day-to-day struggles and victories of engineers and plant workers. Relationships built on this shared experience lead our field teams to tackle unique product variations, technical challenges, or downstream modifications head-on. It is in these relationships that improvements emerge, unforeseen savings appear, and new applications develop.

    Our journey with DHDS 24P grows out of a single-minded focus: make life easier for the people who count on consistent, high-performing chemical building blocks. Honest feedback, technical transparency, and a commitment to flexible manufacturing make our product more than just a molecule—it’s a partnership, tested daily in the world’s most demanding applications.

    Looking Forward: Evolving with Customers and Industry Needs

    As demand grows for more advanced polymers, higher-performance electronic components, and medical materials, the role of consistency in specialty chemicals like 2,4'-Dihydroxydiphenyl Sulfone intensifies. We continually re-invest in plant automation, analytical instrumentation, and R&D, improving both throughput and control. Our staff participate in industry conferences, customer working groups, and technical consortia, exchanging practical lessons with peers. Such involvement means not just proposing changes but understanding how tweaks to process variables, packaging, or logistics ripple through to every plant floor using our material.

    Clients increasingly require traceability, documentation, and rapid technical support—demands that only a manufacturer, fully in control of its operations, can satisfy reliably. The more complex the end-use application—medical implants, aerospace electronics, specialty filtration—the greater the need for direct lines of communication, fast change implementation, and ongoing feedback loops. Trials with new cross-linkers, blends, or polymerization aids often reveal unanticipated interactions; we learn and adapt rapidly because the product is ours from start to finish.

    We do not see our compound as a static commodity. We see it as a vital component that adapts in real time to new performance needs, regulatory environments, and market pressures. Our customers challenge us constantly—demanding faster lead times, higher specification guarantees, or custom batch modifications. From these requests, tomorrow’s quality standards are shaped, and our product continues evolving in pace with the industries that trust it.