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2,4-Dichloro-3-Ethyl-6-Nitrophenol

    • Product Name 2,4-Dichloro-3-Ethyl-6-Nitrophenol
    • Alias Nitrofen
    • Einecs 221-918-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    585271

    Cas Number 2321-03-5
    Molecular Formula C8H7Cl2NO3
    Molecular Weight 236.06 g/mol
    Appearance Yellow to orange crystalline powder
    Melting Point 122-126°C
    Solubility In Water Slightly soluble
    Density 1.54 g/cm³ (approximate)
    Purity ≥98% (typical)
    Storage Temperature Store at room temperature, away from light
    Synonyms 2,4-Dichloro-6-nitro-3-ethylphenol
    Logp Approx. 3.6
    Ec Number 219-057-2

    As an accredited 2,4-Dichloro-3-Ethyl-6-Nitrophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g amber glass bottle, tightly sealed, with hazard labels and chemical name "2,4-Dichloro-3-Ethyl-6-Nitrophenol" clearly printed.
    Shipping 2,4-Dichloro-3-Ethyl-6-Nitrophenol should be shipped in tightly sealed, corrosion-resistant containers, clearly labeled with hazard warnings. Transport in accordance with local, national, and international regulations for hazardous materials, avoiding heat, moisture, and incompatible substances. Use appropriate protective measures and ensure emergency procedures are in place in case of spillage or exposure.
    Storage **2,4-Dichloro-3-Ethyl-6-Nitrophenol** should be stored in a tightly sealed container, in a cool, dry, well-ventilated area, away from direct sunlight and incompatible substances such as strong acids, bases, and oxidizing agents. Store away from heat sources and ignition points. Clearly label the container, and restrict access to authorized, trained personnel. Use appropriate secondary containment to prevent leaks or spills.
    Application of 2,4-Dichloro-3-Ethyl-6-Nitrophenol

    Applications of 2,4-Dichloro-3-Ethyl-6-Nitrophenol in Industrial Manufacturing

    2,4-Dichloro-3-Ethyl-6-Nitrophenol serves as a specialized intermediate within selective industrial sectors, supporting precise synthesis, formulation, and active compound development. Given its functional profile, most end uses concentrate in regulated downstream settings involving agrochemicals, specialty dye manufacturing, pharmaceutical intermediates, and biocidal preparations.

    1. Synthesis of Herbicide Intermediates

    Agrochemical producers utilize this compound as a core nitrophenol building block in the synthesis of pre-emergent and post-emergent herbicide actives. Its chloro and nitro-substitution supports ring modification protocols for the preparation of targeted weed control molecules, especially for cereal and legume crop applications. Controlled reactions with suitable aminating or alkylating agents allow formulation of systemically active phenoxy-based herbicides, with careful process monitoring to meet regulatory residue and toxicity requirements.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • US EPA 40 CFR Part 180 - Tolerances and exemptions for pesticide chemicals in food
    • EU Regulation (EC) No 1107/2009 concerning the placing of plant protection products on the market
    • ISO 17025 accredited internal QC protocols

    Typical usage ratio

    • 5–15% w/w in multi-step herbicide synthesis pipeline; ratio subject to final molecule design and activity profile

    Downstream process integration

    • Charged in the initial aromatic nitration and subsequent ring substitution stages before coupling or alkylation steps in the main synthesis reactor

    Final product types

    • Phenoxy acid herbicides (e.g. derivatives of 2,4-D)
    • Chloro-nitro herbicide active concentrates
    • Cereal pre-emergent granules
    • Selective broadleaf weed control formulations

    2. Precursors in Specialty Dye Manufacturing

    Advanced dye and pigment manufacturers use this nitrophenol derivative to introduce electron-withdrawing groups for the controlled synthesis of high-performance azo and anthraquinone dyes. It acts as a functionalized aromatic precursor, supporting diazotization and coupling processes for stable, lightfast colorants used in textile, inkjet, and plastics applications. Strict batch consistency and impurity control remains mandatory to achieve required color indices and product safety for regulated end uses.

    Industry compliance standards

    • EN 71-3:2019 for migration of certain elements in toys (dyes for children’s products)
    • REACH Regulation (EC) No 1907/2006 for chemical safety assessment
    • Oeko-Tex Standard 100 Appendix 4 and 6 (textile dye safety)
    • ISO 9001:2015 for dye plant QC systems

    Typical usage ratio

    • 3–8% by weight in the diazo component mix or as a coupling partner, adapted based on final shade intensity and application method

    Downstream process integration

    • Dosed during diazotization or as a co-reactant in azo dye coupling stages; can be pre-dissolved or added as a suspension for homogeneous reaction kinetics

    Final product types

    • Azo textile dyes (direct, disperse, or reactive types)
    • High-stability pigment pastes for plastics
    • Inkjet digital printing inks
    • Colorant powders for industrial coatings

    3. Pharmaceutical Intermediate Manufacturing

    Our material enters multi-step active pharmaceutical ingredient synthesis as a regulated intermediate where chloro- and nitro-functionalized aromatics enable development of specific drug scaffolds. Process development teams use precise phenolic reactivity and substitution patterns to achieve target molecular properties essential for downstream clinical candidates, especially in anti-infective and anti-inflammatory drug research. Full traceability and impurity profiling are implemented at every hand-over point in accordance with global GMP systems.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • European Pharmacopoeia 11.0 (relevant monographs for synthetic intermediates)
    • US FDA 21 CFR Part 211 – GMP for finished pharmaceuticals
    • ISO 13485:2016 for pharma plant QA

    Typical usage ratio

    • 2–7% molecular input, calculated according to target route yield and transformation step; adjusted for process scale (pilot to commercial)

    Downstream process integration

    • Fed into closed-system reactors during the formation of substituted phenol intermediates; intermediate purified prior to final API assembly steps

    Final product types

    • Drug substance intermediates (select nitroaromatic and phenoxy drugs)
    • Clinical trial reference standards
    • Process research samples
    • Small molecule active pharmaceutical ingredients (APIs) following subsequent synthesis

    4. Biocidal and Antimicrobial Additive Formulation

    Producers of industrial biocidal products use this compound as a controlled-release antimicrobial precursor in formulations intended for antifouling paints, wood preservatives, and polymeric surface treatments. The dichloro-nitro structure offers durable performance against fungal regrowth and microbial colonization under extended contact conditions. Strict quality assurance enables end-use producers to meet product safety documentation and residue margin specifications for regulated consumer and industrial applications.

    Industry compliance standards

    • EU Biocidal Products Regulation (EU BPR, Regulation (EU) No 528/2012)
    • US EPA FIFRA regulations for antimicrobial pesticides
    • JIS K 1571:2019 for antifungal testing of industrial products
    • Global Product Stewardship guidelines for biocidal ingredients

    Typical usage ratio

    • 0.5–2.5% in formulated coatings or treated substrates; adjusted upward for high-load antifouling paints or heavy-duty wood treatments

    Downstream process integration

    • Dispersed as a micronized powder or pre-mixed liquid concentrate in compounding stages immediately before final packaging or coating application

    Final product types

    • Marine antifouling coatings for ship hulls and submerged structures
    • Decorative and protective wood preservatives
    • Polymeric antimicrobial sheets
    • Industrial and architectural paints with built-in biocidal performance
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    Certification & Compliance
    More Introduction

    Introducing 2,4-Dichloro-3-Ethyl-6-Nitrophenol: Product Insight from an Experienced Chemical Manufacturer

    Understanding the Backbone of Specialty Chemical Synthesis

    As a manufacturer who spends each day surrounded by the sights, sounds, and challenges of chemical production, there’s a unique satisfaction that comes from introducing a compound as versatile and powerful as 2,4-Dichloro-3-Ethyl-6-Nitrophenol. Our process runs on years of practical refinement, real-world feedback, and constant reexamination of every step: from selection and sourcing of raw materials to the moment the finished product meets our rigid release testing. 2,4-Dichloro-3-Ethyl-6-Nitrophenol, a refined nitrophenolic derivative, stands out because chemists looking for both reactivity and precise substituent placement find real value in its profile.

    Model and Specifications Reflecting Real-World Demands

    We manufacture 2,4-Dichloro-3-Ethyl-6-Nitrophenol under the label model 246ENP-95, referencing a minimum content of 95%. This isn’t just a bold number typed into a certificate of analysis; in practice, every kilogram undergoes HPLC and melting point analysis to validate its identity and purity. Our product’s fine yellow crystalline form signals effective purification. All batches pass heavy metal screening and residual solvent checks. Moisture content, monitored at several points along the drying line, makes a difference in product stability and keeps storage headaches to a minimum.

    We use true batch records and traceability, not only because regulators demand it, but because unwanted by-products can introduce inconsistencies in downstream application. The small things stack up in synthesis chemistry, so our technicians log deviations, temperature profiles, and time-in-reflux for every run. Our team values this transparency—a missed parameter can show up months later as yield loss for someone reformulating a crop protection product or pharmaceutical intermediate.

    Typical Usage Grounded in Daily Practice

    This compound carries weight in the synthesis of specialty agrochemicals and advanced chemical intermediates. The nitro and chloro substituents are not added as afterthoughts. In practice, nitro groups act as activating gates for further substitution, while chloro substituents direct reactivity and anchor the structure against untimely hydrolysis. We have worked with clients who use 2,4-Dichloro-3-Ethyl-6-Nitrophenol to build up selective herbicides where both quick knockdown and soil persistence matter.

    Another use involves colorant and pigment industries. A well-placed ethyl group shifts absorption maxima and opens doors to unique shades or stability against fading. We see research groups routinely request kilogram samples to explore new dye intermediates, leveraging the electronics of both the nitro and the chloro positions. In pharmaceutical synthesis, this molecule’s electron-deficient ring creates unique opportunity for further functionalization. Medicinal chemists benefit from reliable substitution patterns, so a consistent product allows scale-up from flask to pilot without fear of side reactions from uncontrolled impurities.

    Differences and Advantages Over Related Phenolic Compounds

    Real decisions are made in the plant floor lab. Unlike basic nitrophenols or simple dichlorophenols, our 2,4-Dichloro-3-Ethyl-6-Nitrophenol’s three substituents create a profile that stands out from generic intermediates. For one, the ethyl group boosts the molecule’s oil solubility, which translates to faster mixing during emulsion formation processes—a detail that might look minor until scale-up exposes issues with dissolution or dispersion. It’s also less prone to hydrolysis than ortho- or para-substituted analogues lacking this ethyl bridge. That reduces the risk of degraded active content during prolonged storage.

    As someone who oversees process improvement, I have seen how this compound’s purified grade reduces waste at both the factory and laboratory scale. Downstream users get less carryover of unwanted tars or colored side products that can easily plague lower purity nitrophenol grades. This is not a theoretical advantage: batch records from pigment clients show that using high-purity 2,4-Dichloro-3-Ethyl-6-Nitrophenol means they avoid long column cleanups and filter clogging, translating to lower downtime and better operational economy.

    Reliability Born from Hands-On Production

    We don’t approach chemical production as a theoretical pursuit—every process tweak is shaped in the heat and noise of an active plant. Our reactors run multi-ton batches with double containment and online spectroscopic monitoring. Each batch tells its own story, and what gets logged in those records rarely matches the simplicity of academic recipes.

    Storage also plays a big role. With nitrophenolic compounds, the tiniest moisture ingress leads to stickiness and lump formation. Our dedicated climate-controlled warehouse prevents degradation, and the push for manufacturing under dry nitrogen demonstrates a response to real-world storage demands, not just theory. Our technical team manages the entire supply chain, from raw chemical inspection to secure export packaging, focusing on keeping every container in spec until it reaches the customer.

    Supporting Comments from Downstream Partners

    Over years of supplying this product to specialty chemical formulators, agrochemical innovators, and pigment laboratories, feedback comes fast and unfiltered. One agricultural chemical firm, scaling from lab grams to tonnage, told us directly that shifting to our high-purity grade gave them better crystallization in their active formulation, shaving hours from their own process without compromising quality.

    Pigment manufacturers find that our 2,4-Dichloro-3-Ethyl-6-Nitrophenol provides robust starting points for sulfonation, halogenation, and coupling steps. Their records show consistent color from batch to batch, meaning less waste in high-value runs. We value these relationships and feed back every insight into our manufacturing and QA review cycles.

    Sustainable Practice and Worker Safety

    Chemical manufacturing carries responsibility. Nitrophenols, with their energetic profiles, demand managed processes. We have engineered vented reactors, triple filtration for waste minimization, and closed handling systems. Our team’s commitment shows not only in the finished product but also in how up-to-date training and strict exposure control keep our workers safe and our community protected.

    Our focus on waste reduction ensures that by-product levels remain low, minimizing hazardous waste disposal. Filtration systems and closed reactors cut down fugitive emissions, and ongoing investments in containment and personal protective equipment show in the accident-free operation history. We track eco-impact, drawing from real data rather than aspiration. Our constant upgrades and re-validation cycles reinforce both process reliability and environmental stewardship.

    Process-Driven Quality Assurance

    From experience, quality is never the result of paperwork alone. True quality emerges from hands-on supervision, regular calibration, and process discipline. Our written specifications guide us, but every technician and supervisor understands the expectation: if something looks or smells off, testing and corrective action happen right away. Melting point drift or deviations in TLC patterns prompt immediate review, with full documentation and batch holds until we resolve the concern.

    Feedback cycles from end-users play a direct role in shaping our testing. A pigment customer faced trace metal contamination, prompting us to tighten supplier audits and switch to more reliable processors for upstream chlorination step. This transparency and willingness to adapt help keep our finished 2,4-Dichloro-3-Ethyl-6-Nitrophenol line consistently inside spec, batch after batch.

    Traceability from Raw Material Sourcing to Final Delivery

    We maintain full traceability for every lot: reagent origin, production conditions, packing date, and delivery details are transparently logged and made available to all customers on request. This tracking isn’t only for troubleshooting; it enables rapid feedback if someone notices changes down the line in solubility or yield. Our approach rests on the belief that customers deserve more than a generic guarantee—they should get the whole history behind the chemistry they rely on.

    Storage matters as much as production. Each package of 2,4-Dichloro-3-Ethyl-6-Nitrophenol is tracked for temperature exposure; lot numbers link shipment to container to external lab verification. Our records allow a complete audit trail, and we don't take shortcuts with documentation or CIP (clean-in-place) routines.

    Technical Collaboration and Real-World Application Support

    Besides delivering bulk quantities, our technical support staff works side by side with customers testing new active deliverables or troubleshooting scaling operations. We can recount dozens of occasions where a change in granularity or drying protocol shifted color tone in client product, and time spent on process audit with actual plant operators saved both sides money and effort.

    Our R&D chemists routinely develop modified protocols for those downstream users seeking better performance in less-conventional solvents, or requiring even tighter by-product profiles for regulatory review. We listen closely to clients, especially those pushing the boundaries in formulation science, so improvements stay rooted in practical experience instead of theory.

    Market Position and Supply Challenges

    Global demand for high-purity phenolic intermediates grows each year, driven by advances in both crop protection and specialty pigments. As an established manufacturer, we recognize two facts: end-users want both steady supply and transparency. Material shortages or fluctuations in chlorine and ethyl precursors strain capacity. Our procurement contracts support reliable supply, but we also keep inventory buffers based on years of usage data—predicting needs before orders pile up.

    Price spikes tempt some to cut corners on secondary purification or to source raw materials from unverified suppliers. Our commitment, shaped in years of producing specialty chemicals, keeps us focused on quality as a constant. Deliveries meet spec not just for one season, but consistently through the cycles of demand swings and logistics hiccups.

    Why 2,4-Dichloro-3-Ethyl-6-Nitrophenol Remains Essential

    This compound has earned its standing because formulators see clear results, whether in a robust active ingredient or a pigment intermediate with less batch-to-batch drift. Its distinct substituents—chlorines for selectivity, nitro for reactivity, and ethyl for solubility—create a rare balance for advanced synthetic challenges. Many in laboratory synthesis first test generic nitrophenol or dichlorophenol sources, then come back for the high-purity, controlled specification that real-world manufacturing delivers.

    Our years of production experience translate to a product line that meets the toughest end-user requirements. Chemical plant operations have taught us that purity cannot be assumed; every production campaign involves close operator oversight, timely sample analyses, and open communication across departments. This process ensures that every shipment of 2,4-Dichloro-3-Ethyl-6-Nitrophenol represents the best of what hands-on chemical manufacturing can provide.

    Going Forward: Meeting New Challenges

    Regulatory scrutiny and novel chemical application keep the bar high. Preparing for these realities, we invest in continuous training, technical upgrades, and traceability improvements. Our customers need assurance not only in product specification, but in lineage and compliance history. Every batch of 2,4-Dichloro-3-Ethyl-6-Nitrophenol carries both our production expertise and commitment to traceable transparency.

    Feedback doesn’t stop at shipment. Our technical hotline logs each inquiry, from mixing compatibility to impurity profiles for patent filing. This dialogue closes the loop—every comment begins another round of learning, and improvement. The result? A product better fitted to the realities of end-use applications, whether high-volume herbicide active or boutique pigment intermediate.

    As chemical processes advance, our methods evolve as well. From in-plant process control to close-knit relationships with end-users, every shipment of 2,4-Dichloro-3-Ethyl-6-Nitrophenol represents the outcome of years of hard work, the drive to improve, and a belief that chemical manufacturing depends as much on relationship as on reaction.