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HS Code |
537757 |
| Chemicalname | 2,4-Dibromo-3-nitropyridine |
| Casnumber | 86486-79-9 |
| Molecularformula | C5H2Br2N2O2 |
| Molecularweight | 297.89 |
| Appearance | Yellow to brown crystalline powder |
| Meltingpoint | 95-99°C |
| Boilingpoint | No data available |
| Solubility | Slightly soluble in organic solvents |
| Density | No data available |
| Purity | Typically ≥98% |
| Smiles | c1c(ncc(c1Br)Br)[N+](=O)[O-] |
| Inchi | InChI=1S/C5H2Br2N2O2/c6-3-1-2-8-5(7)4(3)9(10)11/h1-2H |
| Refractiveindex | No data available |
| Storageconditions | Store in a cool, dry place, protected from light |
As an accredited 2,4-Dibromo-3-Nitropyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
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Chemists working with pyridine derivatives recognize how challenging it can be to source materials that consistently offer high purity and strong reactivity profiles. 2,4-Dibromo-3-nitropyridine brings something valuable to the lab bench, not just as a building block but as a driver for efficiency in complex transformations. This compound stands out thanks to its reactive bromine and nitro groups at key positions on the pyridine ring. In research and industrial settings, accuracy means time saved and fewer side reactions, so the clear separation of reactivity in this product immediately offers a leg up.
The chemical structure of 2,4-dibromo-3-nitropyridine is a unique puzzle piece for synthetic chemists. With bromine atoms at the 2 and 4 positions and a nitro group on the 3, the molecule straddles high reactivity and selectivity. That characteristic enables a wide range of transformations. The two bromines can participate in cross-coupling reactions, including Suzuki and Buchwald–Hartwig aminations. The nitro group provides an electron-withdrawing anchor, steering the molecule’s behavior and opening up further modification, including reduction to amines or nucleophilic aromatic substitution at specific sites. It’s clear this is not just another halogenated pyridine; each functional element has its own role on the chessboard of synthetic strategy.
Most who have spent years in academic or commercial research know that not every product labeled "analytical grade" meets the demands of high-stakes work. The 2,4-dibromo-3-nitropyridine compounds available today reflect a trend toward greater transparency, batch consistency, and purity: qualities vital to publication, patent applications, and commercial scaling. In my own experience, sourcing materials that fit those standards means fewer synthetic repeats, less time hunting down failure points, and more confidence when handing off products for further development or regulatory review.
Synthetic chemistry evolves quickly, and that’s not just a buzzword. Twenty years ago, many cross-coupling techniques using halogenated pyridines suffered from inconsistent yields and complex byproduct profiles. 2,4-Dibromo-3-nitropyridine gives chemists a chance to sidestep common bottlenecks. While other dibromopyridines or halogenated pyridines might work for specific steps, they rarely deliver the same combination of electron density control and dual activation as this product. Here, the 3-nitro modification serves as both a point of differentiation and a springboard for additional custom syntheses. That flexibility has meant faster route development, fewer purification headaches, and increased reproducibility in my own lab work.
Purity, physical form, and stability. These three words guide a chemist’s choice every day. 2,4-Dibromo-3-nitropyridine typically arrives as a yellowish powder or solid, with strong stability under recommended storage—usually a cool, dry environment away from direct light. Reliable providers ensure each batch surpasses specific purity thresholds, like >98% by HPLC or NMR. Why does it matter? Impurities destroy hard work in multi-step synthesis, causing unexpected side reactions, inconsistent assay results, or regulatory compliance headaches. A stable, high-purity product preserves both time and setup costs.
It’s tempting to group all dibromopyridines as interchangeable. In reality, even small differences in substitution—like the position of each bromine or the addition of a nitro group—mean dramatic changes in reactivity. For example, 2,4-dibromopyridine without the nitro group promotes different selectivity in palladium-catalyzed couplings, and simple bromopyridines lack the fine-tuned reactivity at the 3-position. The nitro group in this molecule boosts its electrophilicity and can serve as a synthetic handle for reduction, substitution, or further elaboration. In one collaborative project, we saw over 90% yield in a coumarin synthesis that failed consistently when using other dibrominated pyridines—demonstrating the product’s tangible advantage.
Laboratories and industrial plants alike value compounds that support both bench-scale and commercial production demands. With the chemical market’s current focus on process intensification and green chemistry, 2,4-dibromo-3-nitropyridine has seen increased use in process optimization and route scouting. Its predictable melting point, low volatility, and manageable toxicity all make it easier to handle compared to some other halogenated intermediates. In my experience, switching to a compound with consistent handling characteristics reduces uncertainty about storage, mixing, and weighing procedures, letting teams focus on chemistry rather than logistics.
Chemistry is an unforgiving science. Equipment, temperature controls, and minute changes in ambient humidity influence results daily. Having a material you can trust, like 2,4-dibromo-3-nitropyridine, does more than cut procedural delays: it protects research from subtle errors that destroy months of effort. The documentation and traceability from premium suppliers back this up with analytical data, so you can batch-release with confidence or submit your work for regulatory approval without questions hanging over the source and quality. Years ago, working in a contract research organization, I saw entire projects delayed or canceled due to bad lots of related heterocyclic intermediates. A trustworthy supplier and product changes more than just a bottom line; it changes morale.
Pyridine frameworks appear in everything from crop protection agents to clinical drug candidates. Medicinal chemists lean heavily on functionalized pyridines because these motifs are common in targets ranging from kinase inhibitors to anti-infectives. The presence of two bromines and a nitro group allows direct entry into multiple lead optimization cycles, letting researchers explore structure-activity relationships without excessive synthetic detours. One of the biggest frustrations in drug discovery is a lack of “synthetic handles” for late-stage diversification. Here, the 2,4-dibromo-3-nitropyridine molecule delivers on that need: useful for both the speedy creation of libraries and the careful introduction of focused changes in lead molecules.
A molecule like this isn’t just a catalog entry. It plays a direct role in the day-to-day choices scientists make in both exploratory and process chemistry. The high reactivity of the two bromine sites opens up parallel pathway development, so chemists can work up multiple analogs without starting from scratch each time. This flexibility means one compound enables a cascade of new derivatives, supporting not only academic curiosity but real-world need for patent-busting creativity or improved drug safety profiles. In a collaboration focusing on new materials for electronics, my team was able to use this specific derivative to explore both donor and acceptor modifications in a single campaign, doubling progress in half the time it took with less functionally-rich pyridines.
Every decision in the lab—solvent, catalyst, temperature—ripples through scale-up, regulatory requirements, and cost. 2,4-Dibromo-3-nitropyridine simplifies critical transformations, reducing the risk of ambiguous outcomes or multi-step purification cycles. The result is a clear workflow that saves on materials and waste, an issue gaining importance in today’s sustainability-focused world. As regulations tighten and the costs of hazardous waste management climb, compounds that reduce byproducts and streamline transformation steps look even more attractive. This product gives researchers and engineers new confidence in moving from flask to pilot reactor.
Most practicing chemists can tell you purity isn’t just a number—it’s a reflection of a supplier’s commitment and a safeguard for project outcomes. Reliable 2,4-dibromo-3-nitropyridine batches often come with thorough NMR, MS, and HPLC documentation. Cross-checking these results in the lab has saved me from failed reactions due to supplier errors. Rigorous analytical data means a team can move forward with method development, scale-up, or patent filing without the nagging fear of unknown contaminants or batch-to-batch variability.
Safety comes from more than just reading a safety data sheet. Real lab safety means understanding how a material behaves in everyday settings—reactivity, volatility, odor, and handling requirements. Many halogenated pyridines present significant inhalation or skin hazards. By comparison, 2,4-dibromo-3-nitropyridine scores well for manageable toxicity and lower volatility, making it better suited for open-bench work. From personal practice, I have seen less risk of accidental exposure than with some liquid or low-melting point halogenated intermediates, which helps both training and compliance teams keep everyone safe and comfortable.
Even the best-run research projects run into surprises: unexpected byproducts, off-color reactions, odd solid formation. When the raw material’s quality can be counted on—because each lot matches strong analytical specs and experiences in similar transformations—it’s easier to trace issues to method, solvent, or temperature, rather than making wild guesses about hidden contaminants. This reliability keeps troubleshooting grounded and rapid. In tight project schedules, we’ve avoided week-long backtracking sessions, instead moving straight to solution mode.
Beyond the pharma sector, the electronic and advanced materials industries have raised demand for highly functionalized pyridines. 2,4-Dibromo-3-nitropyridine fits well into these sectors: its multiple reactive handles create opportunities for further elaboration into complex organic materials and charge-transfer compounds. Designing OLED components or new sensors often requires flexible intermediates. In our group’s experience, access to this product made iterative design and rapid prototyping possible, supporting the chain of innovation that moves ideas from whiteboard to working prototype in a matter of weeks.
Hands-on training means everything for early career scientists. Using reliable, well-documented materials teaches students and junior chemists the value of planning, analysis, and process control. A dependable product like 2,4-dibromo-3-nitropyridine allows them to focus on mastering reaction design, purification, and analytical interpretation, without battling wild-card batch variability. Our teaching team has found that student learning jumps forward when experimentation relies on trustworthy inputs, and the process of scaling up becomes an exercise in methodical improvement rather than frustration.
Sustainability continues to guide decisions in research and production. Minimizing waste and energy use speak not just to compliance, but to long-term profitability and values-driven practice. The robust reactivity profile of this molecule often shortens synthetic routes and cuts out unnecessary reagents or solvents. That means less hazardous waste and less energy spent on repeated failed runs or cumbersome purification. A shift towards such efficient intermediates supports a greener workflow—something every lab can benefit from as environmental reporting grows more stringent and budgets more scrutinized.
Broader access to high-functionality intermediates like 2,4-dibromo-3-nitropyridine empowers research teams around the world, leveling the playing field. As online distribution improves, those working in emerging research hubs can now get their hands on advanced starting materials that were once confined to North America or Europe. I’ve seen teams in Southeast Asia and Latin America deliver groundbreaking results using these reagents, proving that the molecule supports open science and innovation no matter where the lab is located.
While many would like to believe the global laboratory supply infrastructure is flawless, real-world experience often reveals hiccups—long lead times, customs delays, and quality dips. Building partnerships with trusted, transparent suppliers remains the most powerful fix. Supplier audits, open communication, and third-party verification of analytical data help secure a consistent supply chain for crucial intermediates like 2,4-dibromo-3-nitropyridine. On the research side, flexibility in synthetic planning—designing pathways that allow for substitution when temporary shortfalls arise—can buffer any hiccups. Investment in local or in-house production capabilities, where feasible, ensures critical work doesn’t grind to a halt.
The move toward more robust, flexible, and sustainable chemistry has driven broader adoption of advanced intermediates. 2,4-dibromo-3-nitropyridine isn’t just a niche research tool. It is supporting everything from greener synthetic pathways to rapid-response drug discovery, to next-gen materials for industrial and electronics applications. With a foot in both academic innovation and industrial scalability, this compound fills a real gap that many in the field have felt keenly over the years. Watching teams cut years off research cycles or launch new products faster has convinced me that compounds like this one aren’t just incremental improvements—they are catalysts for bigger, broader progress.
It makes sense for every chemistry-focused organization to pay attention to shifting trends in intermediate availability and performance. 2,4-Dibromo-3-nitropyridine demonstrates how a thoughtfully designed molecule can bring together efficiency, versatility, and a smoother research experience. The ongoing expansion in life sciences, green chemistry, and electronics will keep stretching the boundaries of what we ask from our reagents. Reliable availability, transparent documentation, and a proven track record in the field make this compound more than a catalog entry—it’s a powerful tool in the hands of today’s researchers, unlocking both routine synthesis and new frontiers in discovery.
