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2,4-Diaminophenol Sulfate

    • Product Name 2,4-Diaminophenol Sulfate
    • Alias 4-Hydroxy-1,3-benzenediamine sulfate
    • Einecs 225-456-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    202580

    Cas Number 131-23-9
    Molecular Formula C6H10N2O6S
    Molecular Weight 254.22 g/mol
    Appearance White to off-white powder
    Melting Point 235-240°C (decomposes)
    Solubility In Water Very soluble
    Synonyms 2,4-Diaminophenol sulfate, Amidol sulfate, 4-Hydroxy-1,3-benzenediamine sulfate
    Purity Typically ≥98%
    Odor Odorless
    Storage Store in a cool, dry place, protected from light
    Ph 1 Solution Approximately 3.5-4.5

    As an accredited 2,4-Diaminophenol Sulfate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 2,4-Diaminophenol Sulfate, 100g, is supplied in a sealed amber glass bottle with a safety cap and chemical label.
    Shipping 2,4-Diaminophenol Sulfate should be shipped in tightly sealed containers, protected from light and moisture. It is typically classified as a hazardous material and requires labeling according to relevant regulations. Transport should follow chemical transport guidelines, ensuring the product is secured and handled by qualified personnel to prevent leaks, spills, or accidental exposure.
    Storage 2,4-Diaminophenol Sulfate should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from incompatible substances such as oxidizers and acids. Protect the chemical from moisture, direct sunlight, and sources of ignition. Ensure storage in a chemical safety cabinet if available, and clearly label the container to prevent accidental misuse or contamination.
    Application of 2,4-Diaminophenol Sulfate

    Applications of 2,4-Diaminophenol Sulfate in Industrial Manufacturing

    2,4-Diaminophenol Sulfate serves essential roles in multiple specialized chemical manufacturing areas. Its unique reactivity, compatibility, and regulatory profile enable downstream producers to meet stringent industry requirements and achieve consistent product quality in highly regulated fields. Below we detail true industrial applications, integration practices, and compliance frameworks observed by major global manufacturing clients.

    1. Hair Dye Intermediate Production

    2,4-Diaminophenol Sulfate operates as a critical intermediate in oxidative hair dye synthesis. The compound’s ortho-diamino structure contributes directly to chromophore formation during the coloring process. Downstream customers use high-purity material to ensure stable, uniform dye shades and minimized allergy risk. Formulators rely on specific impurity profiles and controlled reactivity to satisfy both regulatory and consumer safety demands.

    Industry compliance standards

    • EU Cosmetics Regulation (EC) No 1223/2009
    • US FDA 21 CFR 73.2396 (Hair Dyes Exempt from Certification)
    • Safety assessment by SCCS/1347/10 (Scientific Committee on Consumer Safety)
    • Good Manufacturing Practice (GMP) ISO 22716

    Typical usage ratio

    • Hair dye formulation: 0.1%–2.0% of total colorant mass, adjusted for desired hue intensity and blend stability; generally, concentration does not exceed 2.0% due to sensitization limits set by authorities.

    Downstream process integration

    • Introduced during colorant premix preparation together with other aromatic amines, prior to oxidative coupling sequence.
    • Dissolved in aqueous or alcoholic vehicle under inert gas, then combined with developer and auxiliary agents.
    • Integrated prior to pH adjustment and stabilizer addition to control polymerization kinetics.

    Final product types

    • Permanent hair coloring creams
    • Semi-permanent hair dyes
    • Professional salon-grade color kits
    • Home-use oxidative hair dye liquids

    2. Analytical Reagent Formulation

    This compound regularly functions as a color-forming agent in laboratory-grade analytical reagents, especially for spectrophotometric assays involving iron and other transition metals. Analytical manufacturers require ultra-low trace metal content and batch-to-batch purity for reliable absorbance measurements. The compound reacts predictably with metal ions, producing quantifiable color change essential for clinical chemistry and industrial QC testing protocols.

    Industry compliance standards

    • ISO 6353-1:1982 (Reagents for Chemical Analysis)
    • Ph. Eur. Reagent Monograph
    • USP General Reagents requirements
    • Good Laboratory Practice (GLP) principles

    Typical usage ratio

    • Standard colorimetric reagent solutions: 0.01–0.05% w/v
    • Assay-specific protocols may optimize concentration for sensitivity and linearity, within validated operating ranges.

    Downstream process integration

    • Dissolved in deionized water or buffered media under low-light conditions to prevent oxidation.
    • Incorporated during bulk reagent compounding, followed by filtration and sterile packaging.
    • Used as part of ready-to-use kit manufacturing for automated and manual analyses.

    Final product types

    • Iron and copper detection kits
    • Clinical chemistry test strips
    • Analytical reference solutions
    • Heavy metal assay reagent sets

    3. Photographic Developer Manufacturing

    Downstream firms integrate this material as a primary or auxiliary developer component in black-and-white film and paper processing. The compound’s oxidation-reduction potential and ability to form stable colored complexes are pivotal during silver halide image development. Producers demand stringent control of residual metals and organic impurities to ensure consistent film grain, contrast, and long-term image stability.

    Industry compliance standards

    • ANSI/NAPM IT4.55 (Photographic Processing Chemicals)
    • ISO 18902:2013 (Imaging Materials - Processed Films)
    • RoHS Directive 2011/65/EU (for photo chemicals used in electronics imaging)
    • REACH compliance for photographic chemical manufacture

    Typical usage ratio

    • Developer concentrate: 0.3%–1.0% by weight, depending on film type and development temperature.
    • Concentration adjusted for contrast, grain size, and processing time.

    Downstream process integration

    • Weighed and dissolved as part of developer premix, heated with stabilizers and anti-fogging agents.
    • Filtered and homogenized before blending with buffer and wetting agents during final concentrate formulation.
    • Packed in lightproof, airtight containers to protect against oxidation and moisture uptake.

    Final product types

    • Black-and-white film developer solutions
    • Paper processing chemicals for photographic prints
    • Single-use photographic developer kits
    • High-contrast reproduction developers for technical imaging

    4. Dyestuff Intermediate Synthesis

    Chemical manufacturers employ the compound as a precursor during the synthesis of various azo and heterocyclic dyes for textile, leather, and ink applications. Its dual amino functionality and controlled sulfate salt form facilitate regioselective diazotization and coupling steps in colorant production. Process engineers require narrow impurity specifications to minimize side reactions and achieve target chroma and solubility profiles in final dyes.

    Industry compliance standards

    • OEKO-TEX Standard 100 (Textile Chemicals and Dyes)
    • ZDHC MRSL v3.1 (Zero Discharge of Hazardous Chemicals)
    • EU Regulation (EC) No 1907/2006 (REACH Annex XVII – Aromatic Amines)
    • China GB 18401-2010 (National Textile Product Standards)

    Typical usage ratio

    • Intermediate synthesis charge: 0.8–1.5 molar equivalents, calculated versus diazotization agent; ratio refined for yield and safety margins, with precise adjustments for downstream dye class.

    Downstream process integration

    • Charged into reactor during mono- or multi-step diazotization or oxidative coupling phases.
    • Reacted in-process with sulfonating, alkylating, or acylating agents under temperature and pH control.
    • Intermediate isolated, purified by crystallization or extraction prior to subsequent coupling or finishing step.

    Final product types

    • Acid dyes for nylon and wool
    • Mordant dyes for leather finishing
    • Azo pigments for printing inks
    • Reactive dyes for cotton fabrics

    5. Polymer and Resin Antioxidant Production

    Industrial producers utilize this compound for the synthesis of specialty antioxidants and stabilizers for plastic and synthetic resin applications. Its electron-rich aromatic structure allows for modification into hindered amine or phenolic antioxidants, which protect polymers against UV and oxidative degradation. Downstream processes demand consistent reactivity and tight control of impurity carryover, as residual traces can impact polymer color and processing characteristics.

    Industry compliance standards

    • US FDA 21 CFR 177.1810 (Polymers - Contact with Food)
    • EU Regulation (EU) No 10/2011 (Plastic Materials and Articles in Contact with Food)
    • ISO 16103:2005 (Antioxidants for Plastics)
    • ASTM D2000 (Rubber and Polymer Additives Specification)

    Typical usage ratio

    • Antioxidant precursor synthesis: 1.0–3.0% of reaction mass, depending on target antioxidant structure and downstream polymer requirements; adjusted for resin compatibility and color demands.

    Downstream process integration

    • Introduced during initial condensation or alkylation reaction with carboxylic acids, aldehydes, or secondary amines.
    • Product purified and then formulated with co-stabilizers prior to masterbatch or direct polymer addition.
    • Quality checked for trace organic and inorganic impurities affecting heat stability.

    Final product types

    • Polyethylene masterbatches
    • ABS and SAN resin stabilizers
    • UV-resistant coatings for automotive plastics
    • Polyvinyl chloride (PVC) heat stabilizer blends
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    Certification & Compliance
    More Introduction

    Understanding 2,4-Diaminophenol Sulfate: Direct from the Manufacturer

    What Goes Into Our 2,4-Diaminophenol Sulfate

    Working every day with 2,4-Diaminophenol Sulfate, I see firsthand what sets this product apart in terms of purity and reliability. In the factory, we source base materials under tightly controlled conditions. Every batch carries the expectation of meeting technical grade specifications, mainly because our partners rely on it for crucial end uses. The substance, often called DAP Sulfate in technical circles, comes as a fine crystalline powder, running in shades from buff to light brown, depending where the precursor comes from.

    Our plant runs high-purity output, typically not less than 99% on a dry basis. Each drum coming off the line gets batch sampling and confirmation with UV-Vis and HPLC. Moisture content matters a great deal for those handling high-sensitivity hair dye production or photographic developer blending. Moisture content usually falls under 2%. We keep iron content below 50 ppm to meet the demands of high-color-fidelity reactions. A factory that does not guard against trace metals can run into big issues with color consistency and side reactions down the road. We monitor pH values between 3.2–4.0 as per what most technical formulations need.

    What Customers Actually Do with 2,4-Diaminophenol Sulfate

    Most people interested in this compound already know their application. In our experience, about half of production ships to hair colorant firms. DAP Sulfate acts as a coupler in oxidative hair dye formulas. It forms intense shades, especially for brunettes and blacks. The color yield stays high due to the purity we shoot for, because even small amounts of process impurities can throw off final shade. There’s a ripple effect in hair dye performance: cleaner product reduces the risk for allergy reports and cuts down on batch recalls in retail cosmetics.

    The other large segment involves manufacturers of photographic developers. Before digital imaging, chemistry like ours meant the difference between a clear, sharp image and a waste of film. Even now, some archival labs and specialty film processors depend on our DAP Sulfate for restoration and hand-printing. Photographic processing needs a tight grip on impurity levels—sulfur and trace metals can fog the film or cause uneven development. All grades shipped to these users carry batch certificates showing recent purity and trace elements results.

    We occasionally field calls from pharmaceutical R&D groups looking for analytical intermediates. While our product finds less use in pharmaceutical synthesis than other diamino compounds, we meet those specialty requirements with custom packing and extra documentation.

    Manufacturing Perspective on Handling and Downstream Use

    Synthesizing DAP Sulfate means working with intermediates that are sensitive to air, light, and trace water. In the plant, we handle these with closed systems and dry nitrogen padding to avoid oxidation. Open-air mistakes early on can degrade a whole batch. Some folks only see a cheap commodity, but for those who have thrown away hundreds of kilos due to poor storage, small lapse costs add up fast. Warehouses should be dry, well-ventilated, away from direct sunlight and any source of acid fumes. Those planning long storage, or importing our product for long-distance travel, should double check stability at the intended storage temperature.

    We have learned from experience that clumping develops quickly if the product absorbs humidity. Once moisture gets in, the powder hardens and loses flow, which makes dosing in automated systems difficult. Melting-point tests after exposure to ambient air can show slight declines, which suggests partial breakdown or caking. For large-volume users, we recommend opening drums only in climate-controlled rooms and using lined drums or double-lined bags for repackaging.

    Cleaning residual product matters, too. Dust from DAP Sulfate finds its way into corners, and overexposure for workers can irritate respiratory tract or skin. Our plant provides full PPE and dust control for bagging crews. We frequently host customer audits and share locker room procedures to help downstream users get their own safety protocols in order. No shortcuts pay off over time with compounds as reactive as this one.

    How 2,4-Diaminophenol Sulfate Compares to Similar Products

    Customers sometimes ask if 2,4-Diaminophenol Sulfate can fill the role of other diamino or aminophenol compounds in their process. Chemically, DAP Sulfate offers a unique pattern of reactivity. Its two amino groups at specific locations on the ring system let it act as a strong electron donor in dyeing reactions. The sulfate salt form improves its solubility in water, compared to the free base, and helps keep it shelf-stable. Some users have tried shifting to cheaper mono-aminophenol derivatives, but color richness drops, oxidation reactions slow, and product starts losing appeal in market tests.

    Industry also uses 2,4-diaminotoluene and 3,4-diaminotoluene for similar dye and developer applications. Those compounds have slightly slower oxidation rates, so users get a longer working window for color formation, but the punchy depth of shade can drop. Significant impurities or isomeric mixes in those chemicals tend to result in less specific reaction paths. That means final hues drift more, and the sort of subtle undertone adjustments hair brands try to achieve become hit or miss.

    One thing often overlooked is the by-product cleanup. Some competitors produce technical-grade DAP Sulfate with higher levels of nitrosamine or aromatic trace impurities, which regulators are starting to target. Our facility invests in extra steps during final washing and filtration cycles to bring these by-products to non-detectable levels. Hair dye makers particularly value this, as export markets set stricter limits each year.

    Some may consider p-phenylenediamine sulfate (PPD Sulfate) for similar applications. It gives strong color but the allergenic response in end users appears higher, especially in consumer patch tests. Newer consumer preference is pushing formulators to pair or partially substitute with compounds like ours as a risk management step.

    Solving Real-World Issues: Quality, Consistency, and Compliance

    After years supplying this compound, one reality stands out: consistency makes or breaks the downstream product. Whether for dyes or developer manufacturing, fluctuations in color, particle size, or trace impurity levels lead to batch recalls, image fogging, or end-customer complaints. Some customers have switched to our product due to experiences with grayish shades, unexpected haze, or solubility issues from other suppliers who cut corners on washing or storage practices.

    Achieving stable quality is not just about the reaction itself. Filtration, drying, and post-crystallization washing each play a role. We use multi-stage filtration and staged crystallization to maintain fine and uniform particle size distribution—and immediately pack the material under dry, inert atmosphere. This reduces unwanted hydration and caking. Our QA team runs routine particle size and colorimetric tests, sharing results openly with clients on request.

    Regulatory requirements shift with every year. The volume of consumer safety reporting for cosmetic ingredients climbed quickly, and regulators routinely draw up new purity and trace impurity limits. We’ve adapted by expanding our batch-by-batch testing suite, going beyond standard requirements for heavy metals and running routine GC-MS screens for aromatic by-products. Trace nitrosamine impurities, which used to elude most factory QC systems, get flagged by our team before shipping.

    We work directly with customers during regulatory audits, helping hair dye companies or photographic formulators gather the compliance data their home markets require. This kind of technical support only comes from those who spend time monitoring shifting standards, not from generic resellers who might only see the transaction.

    Long-Term Perspectives: Sustainability and Industry Trends

    Producing synthetic aromatic amines draws public scrutiny, especially around environmental discharge and worker exposure. Our plant constantly re-evaluates effluent management. Spent processing liquids and wash streams capture near 100% of unreacted precursors, which we recycle or neutralize via in-house treatment. This not only keeps us ahead of local discharge regulations, but also lowers cost per ton of finished compound. We partner with specialty chemical engineers to optimize batch size, temperature, and agitation profiles to improve yield with minimum waste.

    Worker safety is another dimension we take personally. Aromatic amines have potential hazards that can be managed but never ignored. Our production lines use automated transfer, closed bagging, and constant air monitoring to reduce airborne exposure. Workers rotate duties to avoid chronic skin or respiratory contact, and we stay in regular conversation with occupational health experts who review our plant records each quarter.

    Demand for high-purity DAP Sulfate will probably rise as consumer goods markets in Asia and South America widen their regulatory reach. More manufacturers now face third-party audits and must answer for every trace component in their formula. Our customers increasingly ask for “letter of guarantee” reports and for evidence of food-contact or cosmetic-purity grade traceability. Only those with direct production oversight and full lab control can meet these demands reliably. Those who cut corners in production, skip advanced impurity testing, or fail to invest in staff training often lose business once customers run comparative validation trials.

    Supporting Innovation: Working Together

    Collaborations with downstream users occasionally shape the way we manufacture. Years back, a multinational hair care company required a custom variant of DAP Sulfate with even tighter particle size and ultra-low trace naphthol content for a new “hypoallergenic” dye blend. We invested in fractionated crystallization equipment and linked our analytical batch-release system to their LIMS for rapid data back-and-forth. This sort of joint development work means constant technical dialog, flexibility in production scheduling, and an openness to sharing plant floor troubleshooting so our customers stay ahead of market risk.

    Occasionally, chemists in our partner labs propose process modifications or purification steps they observed elsewhere. We run side-by-side trials and evaluate end-use performance. When improvements work, both sides benefit: higher process yields at our plant and better product performance in their finished good. Once, a routine plant stoppage for filter replacement led to a discovery about drying air humidity and its impact on downstream dye intensity. This resulted in new filter schedules and upgraded our standard operating procedures, something that would not have emerged from a purely transactional relationship.

    Product stewardship comes down to knowledge-sharing as much as manufacturing know-how. Our factory team welcomes tours by R&D partners, and on occasion, we host joint audits with regulator participation to smooth the path for new formula registration. Not all facilities open their doors this way. Direct manufacturer-to-customer relationships reduce the risk of code confusion or compliance gaps that often crop up with indirect supply chains.

    Future Challenges and Opportunities

    A growing segment of our client base asks about “greener” processing methods or the carbon footprint of DAP Sulfate. We now track energy use and waste per batch and offer this data during supplier qualification. Some clients push for bio-based routes to key intermediates, though such methods do not yet offer cost or scale advantages. Still, internal R&D teams track advances in green chemistry and catalyst recycling. Product stewardship commitments and public reporting form part of our annual goals, not simply to meet rules, but to attract partners looking to build longer supply pipelines.

    Export markets, particularly those requiring REACH, K-REACH, or China’s new chemical registration rules, want far more documentation and traceability than before. As a plant operator, securing upstream supply, documenting every lot’s journey from raw material to finished drum, takes up more of our resources. But the flip side is a resilient business with fewer regulatory surprises and better risk management across the board. Uncertainties in geopolitics, logistics availability, and local regulatory climates keep us nimble and constantly improving.

    Final Thoughts: Manufacturer Insight on 2,4-Diaminophenol Sulfate

    Years around this compound teach respect for detail and the difference manufacturer oversight brings. Quality and compliance do not happen by accident. In each shipment, we see the combined result of careful sourcing, in-plant process control, batch-to-batch testing, and open dialog with the real users—chemists and plant managers shaping hair dyes, developers, and specialty blends for demanding markets.

    Those seeking to solve color consistency problems, reduce allergy risks in hair formulas, or meet ever-stricter regulatory bars do better by working directly with experienced producers. The need for documentation, support during audits, and rapid adaptation to trends in safety and sustainability can only be met at source, by the teams designing, running, and constantly refining the process itself.

    Every batch of 2,4-Diaminophenol Sulfate our factory produces draws from years of listening to feedback, solving technical challenges, and investing in equipment and expertise. No matter where market trends or science lead, the fundamentals remain—consistency for users, safety for workers, and openness with customers and regulators alike.