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2,4-Diaminophenetole Sulfate

    • Product Name 2,4-Diaminophenetole Sulfate
    • Alias 2,4-Diamino-1-phenetole sulfate
    • Einecs 215-634-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    124715

    Productname 2,4-Diaminophenetole Sulfate
    Casnumber 87-56-9
    Molecularformula C8H12N2O·H2SO4
    Molecularweight 252.28 g/mol
    Appearance White to off-white powder
    Solubility Soluble in water
    Meltingpoint 220-230°C (decomposes)
    Odor Odorless
    Storageconditions Store at room temperature, in a dry, well-ventilated place
    Synonyms 2,4-Diamino-1-ethoxybenzene sulfate
    Stability Stable under recommended storage conditions
    Color White to off-white

    As an accredited 2,4-Diaminophenetole Sulfate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 2,4-Diaminophenetole Sulfate (25g) is packaged in a sealed amber glass bottle with a secure, tamper-evident cap.
    Shipping 2,4-Diaminophenetole Sulfate should be shipped in tightly sealed containers, protected from moisture and light. It must comply with relevant hazardous material regulations. Handle with gloves and protective eyewear. Transport should occur at ambient temperature with proper labeling and safety documentation. Avoid contact with incompatible substances during shipping.
    Storage 2,4-Diaminophenetole Sulfate should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers and acids. Keep away from moisture and direct sunlight to prevent decomposition. Ensure proper labeling and limit exposure to air. Store at room temperature and restrict access to trained personnel only.
    Application of 2,4-Diaminophenetole Sulfate

    Applications of 2,4-Diaminophenetole Sulfate in Industrial Manufacturing

    2,4-Diaminophenetole Sulfate supports multiple specialized segments of the chemical and manufacturing supply chain, playing a critical role in downstream formulations where aromatic amine intermediates are required. As a direct manufacturer, our production addresses industry-driven demand for precise molecular attributes and regulatory compliance in each target application, ensuring consistent integration from lab scale to commercial batch synthesis.

    1. Pharmaceutical API Synthesis

    This raw material is a key intermediate in the multi-step synthesis of certain active pharmaceutical ingredients, especially within the class of aromatic amine-containing drugs such as local anesthetics and anti-tuberculars. Process chemists leverage its nucleophilic properties to construct benzene-based scaffolds under strictly controlled reaction parameters. Large-scale pharmaceutical plants utilize it in hydrochloride or sulfate salt forms, enhancing solubility and improving downstream feedstock purity for GMP-compliant API finishing lines. Integration occurs in both batch and continuous production environments, providing reliable input for high-purity synthesis and subsequent conversion to therapeutic agents.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP, 21 CFR Part 210/211, US FDA)
    • ICH Q7 Guidelines for API manufacturing
    • European Pharmacopoeia (Ph. Eur.) reference standards
    • USP-NF monograph requirements for starting materials

    Typical usage ratio

    • Ranges from 0.8:1 to 1.2:1 molar ratio to corresponding acylating agents, adjusted by stoichiometric control based on batch size and desired yield

    Downstream process integration

    • Charged during early-stage amide or sulfonamide coupling reactions
    • Feeds directly into catalytic hydrogenation or acetylation steps
    • Purification by filtration and recrystallization post-reaction

    Final product types

    • Active pharmaceutical ingredients (APIs) for anti-infective agents
    • Local anesthetic drug compounds
    • Further intermediates for heterocyclic drug synthesis

    2. Hair Dye Formulation (Professional & Industrial Grades)

    Cosmetic pigment manufacturers utilize 2,4-Diaminophenetole Sulfate as a primary coupler in oxidation hair dye systems, where its chemical reactivity enables formation of stable, vivid colorants. High-volume producers blend it with hydrogen peroxide and precursor dyestuffs, regulated by EU Cosmetic Regulation and industry-specific purity requirements. Precision in dosing and purity directly affects shade stability, allergenic potential, and wash-fastness of retail and salon-grade products. Production lines employ controlled addition and in-line mixing to guarantee uniform performance and consistent hue development in various color systems, including permanent and semi-permanent dye offerings.

    Industry compliance standards

    • EU Regulation (EC) No 1223/2009 on Cosmetic Products
    • Personal Care Product Council INCI ingredient standardization
    • ISO 22716:2007 Cosmetics — Good Manufacturing Practices
    • Japanese Standards of Quasi-drug Ingredients (for import/export)

    Typical usage ratio

    • Employed at 0.02–0.20% w/w in final dye formulations, adjusted according to shade profile, reactive partner concentration, and regional legal limits

    Downstream process integration

    • Introduced in the primary oxidative dye mixing vessel
    • Combined with peroxide developer at fixed pH for coupling reaction onset
    • Homogenization and stability testing prior to bottling

    Final product types

    • Permanent oxidative hair dye kits for retail and salon markets
    • Semi-permanent hair coloring creams
    • Color-depositing shampoos and conditioners

    3. Specialty Dye Intermediates (Textile & Leather Sectors)

    Producers of specialty organic dyes for textiles and leather finishing rely on this raw material to construct specific azo and anthraquinone dyestuffs. Its amine function participates in diazotization, coupling, and reduction processes, forming chromophores tailored for resistance to light, water, and mechanical wear. Leading textile chemical groups control batch quality with precision chromatographic analysis to meet robust ISO standards in industrial dyehouses. The chemical enters the process during initial color base formation, where reactivity and purity establish final product durability and reproducibility across large-scale runs of fabrics and hides.

    Industry compliance standards

    • OEKO-TEX Standard 100 Restricted Substances List
    • ISO 9001:2015 Quality Management for textile chemicals
    • REACH Annex XVII restrictions on aromatic amines (EU)
    • ZDHC MRSL v3.1 (Zero Discharge of Hazardous Chemicals Manufacturing Restricted Substances List)

    Typical usage ratio

    • Ranges from 1–5% molar ratio relative to other amine or phenol color precursors, tailored by final color shade and substrate requirements

    Downstream process integration

    • Added at the color base synthesis stage in dye manufacturing reactors
    • Undergoes controlled diazotization at defined pH and temperature
    • Subsequent work-up yields concentrated dye cakes or solutions

    Final product types

    • Azo and anthraquinone dyes for synthetic and natural fibers
    • Fastness-enhanced dyes for leather finishing compounds
    • Concentrated liquid dye intermediates for further formulation

    4. Analytical Reagent Manufacturing

    Producers of high-grade analytical reagents integrate this compound as a reagent or derivatizing agent in colorimetric detection kits. Laboratories require its selectivity for aromatic amine-based visualization, applied in trace metal ion or nitrite ion detection in regulated water analysis workflows. Only manufacturers with advanced purification protocols and robust analytical validation supply the pure, low-impurity grades suited for calibrated analytical workflows, ensuring repeatable, interference-free detection in certified contexts.

    Industry compliance standards

    • ISO 17034:2016 General requirements for reference material producers
    • ISO/IEC 17025:2017 Laboratory quality management
    • ASTM D3867 standard test methods for nitrite in water
    • EPA 40 CFR Part 136, US water quality monitoring requirements

    Typical usage ratio

    • Formulation at 0.005–0.02% w/v as per test kit design; adjusted based on sensitivity and sample matrix

    Downstream process integration

    • Dosed during batch compounding of detection reagents
    • Subjected to quality control testing for absence of interfering backgrounds
    • Packaged in sealed, UV-stable containers for laboratory delivery

    Final product types

    • Analytical grade reagents for colorimetric assays
    • Ready-to-use laboratory testing kits for nitrite and metal ions
    • Certified standard solutions for regulated environmental analysis
    Free Quote

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    Certification & Compliance
    More Introduction

    Introducing 2,4-Diaminophenetole Sulfate: The Difference Begins with Quality Control

    Our Commitment to Purity and Consistency

    Every batch of 2,4-Diaminophenetole Sulfate rolling out from our production lines must meet a set of standards we developed over years of working hands-on in our chemical plant. In our own labs, we run purification processes that go beyond industry minimums, keeping close tabs on parameters like sulfate content, ash, and moisture. The result can be seen right away—products that offer much more consistency than generic materials bounced around between traders and wholesalers. We maintain full traceability for our batches, all the way from raw input material down to the final product, so anyone using our 2,4-Diaminophenetole Sulfate can trace each kilogram back through the process. This habit comes from experience: a few ppm difference here or a deviation in particle size there may not seem like much, but down the line, these details determine the success of a formulation.

    Model and Specification by the Numbers

    We produce 2,4-Diaminophenetole Sulfate in the commercial grade our long-term clients use in their most demanding synthesis. The chemical comes out as a crystalline solid, off-white in appearance, showing good flow in jars and sacks, with a specification for purity above 99% as determined by HPLC. Moisture, often an afterthought, remains below 0.5%. Ash content stays below 0.1%. Sulfate ions, those all-important counterions, get checked batch by batch to avoid any drift that could cause solubility or reactivity changes for downstream manufacturers.

    We don’t only check by instrument—every few shifts, our QC staff pull samples for tactile testing. You wouldn’t find this policy described in a regulatory guideline. Decades making this material taught us that hands-on checks often catch issues before the instrument does. Fine material feels different than coarser, unblended material. The appearance—whether bright or showing a tinge—gives away process or storage slips. Only experienced staff, those who genuinely know the smell and feel of the chemical, can make that quick call.

    How 2,4-Diaminophenetole Sulfate Serves Industry

    Our product finds its home in oxidative dye production, as an intermediate for specialty chemicals, and in select pharmaceutical syntheses where reliability cannot be a luxury. These customers have little margin for error, especially those making colorants and high-purity intermediates where batch-to-batch drift leads directly to wasted raw materials and production delays. In many operations, even a trace impurity causes mismatched colors, clogged reactors, or thrown-away batches. This drives us to refine not just the chemical, but how we deliver it—packaged only in lined containers, nitrogen-sealed, and always with the most recent QC report included.

    A number of clients have told us they stopped troubleshooting recurring problems once they switched to our 2,4-Diaminophenetole Sulfate. This chemical’s behavior in solution gives away any process shortcut: excess sulfate, high moisture, or metallic traces all lead to unexpected reactivity. We spent years making small adjustments in our reactors, the timing of our crystallization, and in drying routines to squeeze out the last bit of variability. Our truckloads never show that sporadic caking or uneven coloration you sometimes find in low-volume, brokered lots. The difference comes from attention—supervised, batch-wise, and with constant feedback between our plant teams and QC labs.

    Distinctive Features Versus Other Sourcing Paths

    Choosing between manufacturers carries real weight. Chemically, the structure of 2,4-Diaminophenetole Sulfate doesn’t change between suppliers, but how it gets produced, handled, and certified does. We avoid off-the-shelf precursors if their documentation falls below our standards; each lot comes from vetted sources, so compositional drift doesn’t undermine critical syntheses later on. Unlike secondary market resellers, we never mix leftover lots or rebrand old inventory. Everything we ship gets freshly produced for the order at hand or cycled through strict shelf-life controls.

    One crucial point that often escapes notice lies in the method of sulfate introduction. Inexpensive routes introduce higher unreacted acid or sodium salts, which start simple but cause headaches for compounders. Our approach, refined through years of customer feedback, reduces salt by-products and foreign ions. So, our product dissolves clean, without forming haze or sediment, even in concentrated reactions.

    There’s another distinction. Many third-hand suppliers pay scant attention to packaging and transit climate. Chemical stability goes beyond the dry solid alone—humidity, sunlight, and repeated container rehandling degrade quality fast. We always use lined drums, desiccant pouches, and shrink wrap on pallets to keep internal moisture at bay. Receiving departments who once spent time scraping out caked powder now unload our shipments with zero worry about blockages or leaks.

    Technical Insights: Beyond the Typical Data Sheet

    Working with this molecule, one quickly notices that minor impurities multiply effects during actual use, especially in colorant manufacture and medicinal chemistry. Acidic micro-impurities cause color shift; ferrocyanide traces, often invisible by standard checks, ruin reactivity during key coupling steps. Our plant eliminated typical culprit ions by revamping filtration lines and equipment cleaning back in 2016, after a string of customer complaints about competing products. The investment returned more than just customer trust: it gave our own technicians a window into the sources of performance drift.

    Purification remains an ongoing process at our shop. Whenever instruments read out a new unexpected spike, it triggers a full-scale audit by our process engineers and chemists. One time, our team traced a persistent sulfurous odor in part of a run to a single drum of cleaning agent from a new vendor. We learned, and we never rely on outside suppliers’ claims without verifying in-house. It slows down procurement, but this habit shields partners from unpleasant surprises in production.

    Batch Homogeneity and Scale—Practical Lessons From Real Orders

    Most chemicals at this grade arrive in small lots, blended quickly. We take a different approach, running orders in dedicated vessels and sizing batches large enough to guarantee no customer ever receives a “corner” of a run. Once, a client reported patchy dissolving and visible foreign fibers in material sourced from a non-manufacturer. This kind of contamination doesn’t happen with segregated plant lines and dedicated filler rooms. By keeping upstream and downstream segregated, we keep metal, lint, and other physical intrusions away from the finished goods.

    Clients with continuous processes demand that every drum they pop open behaves exactly as the last. We test for this directly by sampling not only at the tank output but also during drum filling. That kind of hands-on verification, rarely part of standard practice in lower-cost plants, delivers material that never surprises its end users.

    Sustainability in Production Without Cutting Corners

    Our site adopted a closed-loop water handling system ahead of industry mandates, catching all solvent and aqueous waste for in-house processing. This goes hand in hand with our efforts to minimize excess sulfate discharge. Regular audits ensure our emissions sit below published guidelines, but that’s only one piece. We also selected production inputs based on reliability and minimization of heavy-metal contaminants. Teams at our plant trained to handle mishaps, respond to spills, and operate with safety in mind for both personnel and neighbors living around the facility.

    Every so often, we’ve met customers who voice concern about the industry’s record on chemical leaks and waste handling. We don’t offer slogans—we invite them to inspect our facilities and follow the product chain start to finish. This approach helped us cement trust in industries—particularly pharma and dye manufacturing—where brand reputation and regulatory scrutiny both hinge on supplier transparency.

    Knowledge for Buyers: Making the Switch Pays Off

    Plenty of operators spend years balancing inconsistency with cost, but persistence with unreliable material eventually cuts into profits and causes headaches for technical teams. Setting up consistent supply works out in the long run, with improved yields, reduced rework, and better employee satisfaction in the lab and plant. Not every buyer gets a seat at the reactor to see how even a slight shift in sulfate to amine ratio can throw off a synthesis, but we offer full analytical support, troubleshooting, and, if needed, process recommendations.

    Clients new to the molecule often reach out with questions on storage or solution preparation. We advise simple practices, like storing the product cool and dry, keeping containers closed between uses, and using clean scoops to avoid cross-contamination. We also share what other chemists found: for some colorant and pharmaceutical syntheses, running a pre-solution stability test cuts risks by showing right away if the formulation needs adjustment.

    Working With End Users and Technical Teams

    Our engineers and chemists stay connected with end-users, answering questions that rarely show up on paper. For example, one customer struggled with shelf life. After a few direct consultations and changes to their storage area, the problem vanished. Another user complained about residue in their mixing tanks. We checked back to our own filtering logs and found that tightening up sieve change frequency made a measurable difference. Little things—often missed by bulk traders—end up mattering far more in real-world operation than a price-per-kilo line on a spreadsheet.

    By treating each customer’s process as unique, our technical support team can offer hands-on help—not vague, canned responses. The insights from operating a full chemical plant, not just a sales office, mean that we don’t guess when recommending usage parameters or troubleshooting help. The majority of our clients use our recommendations directly, whether it’s for dissolution order, pH range, or dosing sequence.

    Staying Ahead of Evolving Industry Demands

    Chemistry as a field keeps shifting, with new regulations, technologies, and processes landing on the scene every few years. Our plant keeps up by investing in new instrumentation and staff education. We put experienced hands in those positions where judgment overrides protocol, since knowledge passed down holds weight during scale-up or customer emergencies.

    Customers have asked us about biobased production, alternate counterions, or stricter heavy metal limits. Each time, we evaluate the scientific and business case, running test batches and comparing the results with long-term sample retention. We do this not because a marketing department told us to, but because our partners want real evidence before making their own process changes—a principle that comes from years of trial, feedback, and honest communication.

    Conclusion: Experience Informs Every Batch

    Every drum of 2,4-Diaminophenetole Sulfate we ship carries our years of process knowledge, quality improvement, and direct end-user feedback. It’s not just about meeting specs—it’s about eliminating those little surprises and working with buyers to fit the product straight into their systems with no excuses needed. Our doors stay open, our labs keep improving, and we stand behind every batch, knowing our work helps others build reliable, safe, and innovative products themselves.