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2-(4-Chlorophenylthio)Benzaldehyde

    • Product Name 2-(4-Chlorophenylthio)Benzaldehyde
    • Alias 4CPSBA
    • Einecs 630-488-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    909798

    Productname 2-(4-Chlorophenylthio)Benzaldehyde
    Molecularformula C13H9ClOS
    Molecularweight 248.73 g/mol
    Casnumber 54649-58-4
    Appearance White to off-white solid
    Meltingpoint 77-80°C
    Purity Typically >98%
    Solubility Soluble in organic solvents like DMSO, chloroform
    Smiles C1=CC=C(C=C1)SC2=CC=CC=C2C=O
    Inchikey XOPRHLRJSXXUPJ-UHFFFAOYSA-N
    Storageconditions Store at 2-8°C, keep container tightly closed

    As an accredited 2-(4-Chlorophenylthio)Benzaldehyde factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 25 grams of 2-(4-Chlorophenylthio)Benzaldehyde, sealed with a screw cap and tamper-evident label.
    Shipping 2-(4-Chlorophenylthio)Benzaldehyde is shipped in tightly sealed, chemical-resistant containers to prevent leaks and contamination. It is typically transported under cool, dry conditions with clear hazard labeling, and handled according to chemical safety regulations. Shipping documentation includes safety data sheets and hazard information for regulatory compliance and safe transit.
    Storage 2-(4-Chlorophenylthio)benzaldehyde should be stored in a tightly sealed container, away from moisture, light, and incompatible substances such as strong oxidizers. Keep it in a cool, dry, and well-ventilated area. Label the container clearly and store in a designated chemical storage cabinet, preferably under inert atmosphere, to prevent degradation. Always follow local regulations and safety guidelines when handling and storing this compound.
    Application of 2-(4-Chlorophenylthio)Benzaldehyde

    Applications of 2-(4-Chlorophenylthio)Benzaldehyde in Industrial Manufacturing

    As a core specialty intermediate, 2-(4-Chlorophenylthio)Benzaldehyde supports critical synthesis steps in downstream fine chemical sectors. Manufactured to rigorous purity and consistency standards, this compound serves as a reaction-specific starting material, building block, or modifier in regulated production environments. Below, we detail four key application areas, providing operational information for B2B process engineers and development teams.

    1. Pharmaceutical Intermediate Synthesis: Thioether-Aromatic Drug Precursors

    Research-based and volume pharmaceutical manufacturers employ this material in the formation of advanced intermediates, particularly for the synthesis of thioether-bearing aromatic drug candidates. Its controlled reactivity profile accommodates stepwise conversion via Grignard additions, reductive aminations, or cyclization routes, forming scaffolds used in investigational oncology and metabolic disorder APIs. The material integrates at the transformation step where selective functional group preservation and minimization of trace-level chlorinated side products are critical for downstream regulatory acceptance.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients)
    • USP/NF and Ph. Eur. monographs (intermediate purity requirements as specified by the target API dossier)
    • FDA 21 CFR Part 211 (cGMP for finished pharmaceuticals, where intermediate traceability is required)

    Typical usage ratio

    • Usage typically ranges from 0.8 to 1.2 molar equivalents per batch, adjusted based on the API synthetic route and desired yield; process chemists optimize ratio to reduce residual sulfur and chlorinated impurities.

    Downstream process integration

    • Added during the condensed phase functionalization step, commonly after halogen exchange or as the thioether introduction before final cyclization or coupling in API synthesis lines; batch and continuous reactor compatibility confirmed in application support trials.

    Final product types

    • Oncology and CNS drug precursors, metabolic regulator advanced intermediates, and custom fine chemicals for CRO pilot campaigns.

    2. Agrochemical Synthesis: Selective Fungicide and Herbicide Intermediates

    Formulators of novel crop protection agents utilize this compound as a building block when developing sulfur-enriched aromatic scaffolds, which form the backbone of next-generation fungicides and selective herbicide molecules. Its controlled chlorophenylthio substituent profile enables direct incorporation in halogenation and oxidation stages, critical to maintain selectivity and residue management in regulated agricultural chemical synthesis workflows.

    Industry compliance standards

    • FAO/WHO/ISO agrochemical ingredient guidelines
    • REACH registration requirements for manufacturing and downstream use in the European Union
    • China GB2763 (Maximum Residue Limits for Pesticides in Food)

    Typical usage ratio

    • Generally incorporated between 1.0–1.5 molar equivalents per transformation, with adjustments calibrated during process validation based on conversion rates and downstream cleaning constraints.

    Downstream process integration

    • Introduced during aromatic coupling or ring-extension synthesis, feeding into subsequent chlorination, nitration, or hydrolysis stages under solvent-controlled and temperature-monitored agitation protocols.

    Final product types

    • Triazole-based fungicides, heterocyclic thioether herbicide actives, sulfone-sulfoxide crop protection intermediates.

    3. Specialty Dye Intermediate Manufacturing: Azo and Anthraquinone Dyes

    Producers of high-purity specialty dyes adopt this compound as an essential intermediate where electron-rich thioether links are required to achieve specific chromophore resonance and UV stability. The aldehyde-functionalized aromatic ring framework supports azo coupling and anthraquinone backbone extension under controlled pH and redox conditions, directly affecting the color intensity, fastness, and application properties of end-use technical dyes.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (chemical safety for textiles)
    • EN 71-3 (Safety of Toys – migration of certain elements, relevant where technical dyes are formulated for consumer textiles)
    • US EPA TSCA regulations regarding dye ingredient notification

    Typical usage ratio

    • Standard addition levels vary by dye class, typically 0.5–1.3 equivalents per coupling sequence, with benchmarking conducted on target molar mass and desired chromatic shift.

    Downstream process integration

    • Applied at the condensation or azo-coupling step, preceding pigment dispersion or salt-based precipitation; precise feed rate and order depend on the dye’s electronic design and application grade.

    Final product types

    • High-performance azo pigments, anthraquinone reactive dyes, specialty optical marker dyes for industrial applications.

    4. Advanced Material Additive: High-Temperature Polymer Stabilizers

    Manufacturers of engineering plastics and advanced polymer blends employ this compound within stabilizer formulations, leveraging its aromatic thioether group as a free-radical scavenger for thermal-oxidative protection. The raw material enters compounding in controlled micro-dosages, supporting the long-term integrity of specialty resins used in electronics, automotive components, and industrial insulation systems exposed to harsh operational environments.

    Industry compliance standards

    • UL 94 (Flammability standards for plastic materials)
    • ISO 9001:2015 (Quality Management Systems for advanced materials)
    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances in electronics)

    Typical usage ratio

    • Used at 0.05–0.2 wt% of the total polymer formulation, finely tuned to balance stabilization efficacy with final mechanical performance and cost optimization; process engineers adjust based on polymer type and anticipated application conditions.

    Downstream process integration

    • Dispersed into masterbatch concentrates or metered during melt-compounding at the extrusion or injection molding stage, ensuring even distribution prior to pelletizing or direct-to-mold feedstock supply.

    Final product types

    • High-heat thermoplastics for electrical connectors, insulated housings, automotive engine covers, and heat-resistant cable sheathing.
    Free Quote

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    Certification & Compliance
    More Introduction

    2-(4-Chlorophenylthio)Benzaldehyde: Reliable Sourcing from the Manufacturing Floor

    Working with 2-(4-Chlorophenylthio)Benzaldehyde Every Day

    Stepping through the plant gates every morning, our team gets right to work on what we do best—synthesizing solid, high-quality chemicals for people who need more than just a label on a drum. 2-(4-Chlorophenylthio)Benzaldehyde has become an important intermediate for us. As a manufacturer, the daily hands-on work with this compound tells us more than a product sheet ever could. We see every batch come together, watch the color and texture mature during processing, smell its characteristic notes as it comes off the final stage, and make sure each lot is reliable for its next use.

    Our Focus: Purity and Consistency You Can See and Test

    Purity isn’t just a number to us—it’s the whole basis of the trust our customers place in us. Over years, we’ve learned that for anyone looking to build more complex molecules—especially in pharmaceutical and specialty synthesis—a high, repeatable purity saves headaches in downstream steps. On average, our current production keeps purity levels at 98% or higher. Anything underneath doesn’t leave the site. Our process engineers keep a close eye on each synthesis, from the first reaction vessel to the final drying and packaging station. We know there’s no shortcut here, and we put time into proper recrystallization and filtration, because even small deviations in product quality at this intermediate stage can cost dozens of wasted work hours on the customer’s end.

    Using the Right Ingredients and Real Control Over Each Batch

    Many folks who use 2-(4-Chlorophenylthio)Benzaldehyde are aiming for consistent reaction profiles in their projects. They want predictability. Our chemists mix the starting materials—4-chlorothiophenol and benzal chloride—in carefully controlled stages. Having in-house quality control over not only our final goods but the raw starting products makes a massive difference. We don’t entrust this process to outside vendors, and we keep our own teams running the critical steps. Over years, this has helped us avoid the common pitfall of batch-to-batch surprises.

    Physical Spec and Handling—A Manufacturer’s View

    Here in the factory, actual handling conditions matter as much as lab properties. 2-(4-Chlorophenylthio)Benzaldehyde comes off the line as a yellow crystalline solid. This allows fast vacuum filtration, easy sizing, and minimal dusting during packing. We pack in units ranging from 1 kg up to 25 kg drums. From a worker’s point of view, this crystal habit means less compacting in the drum, less sticking to tools, and a product that stays easy to pour out down to the last gram. Asking teams who actually fill and transport these chemicals tells a lot that books rarely cover. The melting point usually lands between 59 and 63°C with each lot checked for consistency, again driven by practical needs: if the product melts below spec, you get cross-contamination issues; above range, it won’t dissolve properly in the next production step.

    What Sets Our Material Apart

    Some buyers come to us after wrestling with inconsistent sources—odd colors, sticky residues, unexpected byproducts showing up on GC analysis. Our process narrows the yield of side products by tuning every variable in the oxidation and condensation stages, and we flush glassware or swap columns when off-odors or tints show up. We know that color isn’t just cosmetic; it signals trace materials that cause costly failures in later coupling reactions. Behind every ton shipped make up hundreds of decisions our operators and QC analysts have built from years standing on the floor, talking to colleagues, responding to every batch report, not just ticking a box.

    Why 2-(4-Chlorophenylthio)Benzaldehyde Matters

    Chemists keep finding new uses for thiobenzaldehyde derivatives like this one. In our daily conversations with researchers and process engineers, the leading uses remain in pharmaceutical intermediates, agricultural R&D, and the electronics sector. Down the synthesis pipeline, this compound often turns up in coupling reactions, often as a key step for producing arylthioethers found in anti-fungal agents, certain dyes, and even some types of OLED precursors. In practice, when our customers need a sulfur atom securely anchored on a benzaldehyde ring, they often lean on this product. They talk to us directly about scaling up for gram-to-kilogram batch sizes and rely on short lead times.

    Differences from Other Benzaldehyde Derivatives

    What does this compound do that others don’t? It’s all about that p-chlorophenylthio piece—adding both sulfur and chlorine changes the chemistry completely compared to simple benzaldehyde or para-substituted variants. With the thioether linkage, this molecule holds up better in harsh reaction conditions, especially nucleophilic substitutions where stability matters. Other materials—say, plain p-chlorobenzaldehyde—aren’t as robust in similar settings, and you’ll end up with more byproducts or degradation. In direct condensation work, 2-(4-Chlorophenylthio)Benzaldehyde stands up in cross-coupling runs that push solvents or catalysts harder. Our technical partners say this makes all the difference in yields and reliability, which justifies every step we commit to in the factory.

    Dealing with the Less Obvious Issues

    Long days here have taught us that problems don’t only start in the reactor—sometimes they come up in drum storage or shipping. Early on, customers flagged occasional clumping or slow dissolution in polar solvents. We switched to an improved drying and sieving protocol, and now, even after months of storage, the material retains a free-flowing texture. To anyone in a scale-up lab, these things matter: wasted time opening a caked tub or fiddling with silty suspensions under a hood can drag an entire shift off schedule.

    Environmental and Health Responsibility from the Shop Floor

    Some chemicals are benign. Others deserve more care. 2-(4-Chlorophenylthio)Benzaldehyde lands somewhere in the middle— handled with common-sense caution but not requiring the most extreme protocols. We take pride in knowing our own workers use double-nitrile gloves, work under local extraction, and follow spill prevention routines born from actual near-miss events. Our commitment doesn’t end once the drums leave our gates; we share real-life tips with customers for onsite handling, including neutralization routes for small spills and waste transfer best practices from operators who have seen every trick in the book. Compliance is important, but so is human safety. We keep reinforcing these lessons so no one lets down their guard over time.

    Scaling Production: Factory Engineering, Not Just Chemistry

    People outside the plant rarely see the challenges of making enough product to stock every order without overloading warehouses or pushing aging inventory into the supply chain. During the global logistics crunch, we changed several production cycles and retooled calendar schedules based on both order intake and real-time shipping news. This helped us adapt to fluctuating demand while keeping fresh batches available. Our facility runs several reactors dedicated to this line and can adjust output by 20% up or down with a lead time of about two weeks. We’ve learned from shortages before, so we keep strategic stocks of starting materials and maintain tighter process integration than most suppliers.

    Technical Collaboration and Feedback Loops

    Many of our improvements come straight from customer feedback. Once, a pharmacology lab reported trace chlorinated byproducts above acceptable levels. After checking our own records, we found a minor but recurring impurity spiking during a change in raw material supply. Our quality team dug into every stage, from filtration to the point of crystallization, and caught the exact interval where the problem crept in. These findings pushed us to enforce tighter vendor appraisal and in-house testing. Each step—no matter how time-consuming—has reduced callbacks and strengthened our reputation. Most of the process changes we’ve made in the last five years started from these pragmatic conversations, not just theoretical models.

    Comparing to Other Producers: A Direct Perspective

    We hear plenty of stories from customers burned by poor communication or unclear documentation from other suppliers. Some come to us carrying samples with unusual tints or inconsistent melting points, frustrated by losses in their processes. Working directly on the floor every day, our crew values straight talk. We provide full COAs with each shipment—these aren’t generic; they represent a true snapshot of that batch, run immediately before packing. Our documentation aligns with regulatory expectations and customer audit requirements, but more importantly, responds to concrete needs. For research and production teams alike, transparency saves hours of uncertainty and fast-tracks troubleshooting. Our open approach helps everyone move projects forward.

    Cost Considerations: Not Just About the Price Per Kilogram

    The real expense of a specialty compound like 2-(4-Chlorophenylthio)Benzaldehyde isn’t always found on the invoice. Downstream yields, ease of purification after reactions, and storage losses all add up. Clients who chase only the lowest price end up spending more on process corrections or scrapping failed batches. By keeping our quality consistent, we support them in minimizing “invisible costs”: less time re-filtrating, less solvent waste, fewer hours spent looking for the source of a contamination. This isn’t just theory—it’s feedback we hear directly from scale-up teams and pilot plant engineers who want the right result, not just the cheapest drum.

    Packing Options Learned from Real Users

    Over years of running bulk orders to local and overseas clients, we understand every industry handles goods differently. We pack most drums at 25 kg for ease of transport by both truck and pallet lift. Sometimes, pharmaceutical users want smaller, 1 kg packs for high-value, low-throughput steps. Our line operators have tweaked the drum liners and sealing methods to prevent microleaks, and we switched inner bags to anti-static types after feedback from electronics customers. The difference isn’t in flashy packaging, it’s in listening to the actual users working with each container in often less-than-ideal real-world spaces.

    Production Traceability Everyone Can Follow

    We believe in keeping things traceable from start to finish. Each batch gets its own identifier, linking the incoming raw material lot to the final packed drum. Every QC result, staff sign-off, and shipment movement ties back to this unique tag, allowing total transparency. If an issue pops up downstream, we pull up our digital records and collaborate with customer teams—resolving hazy paperwork before it becomes a real-world problem. For some, that level of traceability is new. For our crew, it’s a point of pride and daily practice. It keeps everyone honest and every process accountable.

    Addressing Greener Chemistry and Waste Management

    The chemical world keeps moving towards cleaner syntheses and lower-impact processes. We’ve experimented in-house with alternative oxidants and greener solvents but only stick with changes that meet both yield and safety standards. Spent reagents and wash solvents flow directly to recovery, not landfill. By monitoring emissions and using closed systems, we limit both waste and exposure. Our team continues pushing process improvements to satisfy both regulatory demands and the real-world need for safer, more sustainable production. These changes may appear incremental from the outside, but over many tons, the impact builds.

    Listening to the Next Generation of Users

    Every year brings new faces into research labs and factories—graduates eager to solve things differently. We welcome questions, doubts, and ideas from young chemists probing the boundaries of what 2-(4-Chlorophenylthio)Benzaldehyde can do. Sometimes they spot small issues that older hands miss. Our doors stay open to student inquiries, whether on the nuances of handling, solvent compatibility, or new transformational chemistry. Their feedback keeps us grounded and drives us to keep updating our internal guides with fresh real-world insights. We see our role not as distant suppliers but as long-term technical partners in changing chemical research.

    Global Reach, Local Roots

    Exports have grown, but we still think like a plant-floor manufacturer rather than an anonymous global trader. Shipping chemicals across borders means not just filling documents, but knowing what customs, safety authorities, and freight handlers actually need in each country. Supply chain headaches are real, but we’ve got a logistics team built on decades of shipping hazardous and sensitive goods. Our warehousing teams pack with preservation in mind, coordinating closely with air, sea, or road transporters to minimize transit times. This practical, hands-on experience shows in fewer rejected lots and more satisfied feedback from customers worldwide.

    Looking Ahead in the Market

    By keeping operations lean, we’re able to respond quickly to custom requests—whether it’s a different pack size, modified purity spec, or third-party analytical verification. Our flexibility isn’t just about equipment; it’s a mindset based on day-to-day learning from everyone who touches this product, whether in production, QA, or shipment. The field keeps shifting—regulations, supply chains, research trends all evolve. We know that winning tomorrow’s business means keeping one foot in today’s reality and an eye out for smarter, safer ways to keep delivering value.

    Summary of What Sets Our 2-(4-Chlorophenylthio)Benzaldehyde Apart

    For those who count on each kilogram to show up on time and match its certificate every single run, full process control and skilled operators make the difference. Other suppliers talk about paperwork and specs. We stand by every lot because we see each one made, tested, and packed. That hands-on, plant-floor experience—plus hundreds of informal conversations with chemists at every skill level—keeps us focused on what actually matters: real results, predictable outcomes, less hassle for every user down the line. If you care about these things, so do we. That commitment keeps us showing up each day, turning raw materials into something you can rely on, batch after batch.