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2-(4-Amino-2-Nitroanilino)-Ethanol

    • Product Name 2-(4-Amino-2-Nitroanilino)-Ethanol
    • Alias Meclofenoxate
    • Einecs 259-356-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    436180

    Cas Number 19853-12-2
    Molecular Formula C8H10N4O3
    Molecular Weight 210.19 g/mol
    Appearance Solid (exact color may vary)
    Solubility Soluble in water
    Synonyms 2-(4-Amino-2-nitrophenylamino)ethanol
    Purity Typically ≥97%
    Structural Formula C6H3(NH2)(NO2)NHCH2CH2OH
    Smiles C1=CC(=C(C=C1N)NCCO)[N+](=O)[O-]
    Inchi Key ZMPKRAYJNJCBTB-UHFFFAOYSA-N

    As an accredited 2-(4-Amino-2-Nitroanilino)-Ethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The packaging contains 25 grams of 2-(4-Amino-2-Nitroanilino)-Ethanol in a tightly sealed amber glass bottle with hazard labeling.
    Shipping 2-(4-Amino-2-Nitroanilino)-Ethanol is shipped in tightly sealed containers, protected from light and moisture. The chemical is transported in compliance with hazardous materials regulations, including proper labeling, documentation, and the use of secondary containment. Temperature and handling instructions are strictly followed to maintain product stability and ensure safe delivery.
    Storage Store 2-(4-Amino-2-Nitroanilino)-Ethanol in a tightly sealed container, protected from light and moisture, in a cool, dry, and well-ventilated area. Keep away from incompatible substances such as strong oxidizing and reducing agents. Use secondary containment if possible, and clearly label all containers. Follow all standard laboratory safety and chemical hygiene protocols when handling.
    Application of 2-(4-Amino-2-Nitroanilino)-Ethanol

    Applications of 2-(4-Amino-2-Nitroanilino)-Ethanol in Industrial Manufacturing

    2-(4-Amino-2-Nitroanilino)-Ethanol serves as an essential functional intermediate across several chemical industries. Our facility produces this raw material specifically for downstream manufacturers requiring advanced performance in specialized formulations. Below, we detail major industrial application areas, process integration points, compliance guidelines, mixing ratios, and finished products manufactured by end-users.

    1. Reactive Dye Intermediate for Textile Industry

    This chemical finds dedicated use in dye synthesis. Textile pigment manufacturers utilize it as a key intermediate in the preparation of reactive dyes, especially for cotton and viscose fibers. It participates in condensation and coupling reactions, directly impacting color fastness and wash resistance in bulk textile applications.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (class I-IV for textile dye applicability)
    • ZDHC Manufacturing Restricted Substances List
    • REACH Regulation (EC) No 1907/2006 Annex XVII for aromatic amine content
    • ISO 9001:2015 Quality Management for dye intermediates

    Typical usage ratio

    • 0.8% – 2% by weight in the crucial dye coupling stage
    • Ratio adjusted for dye color depth or required reactivity
    • Fine-tuned based on substrate (cotton, viscose blends) and process temperature profile
    • Laboratory verification before scaling up batch size

    Downstream process integration

    • Charging at the pre-condensation reaction vessel before diazotization
    • Bleach neutralization carried out prior to amine introduction
    • Included in batch records for full traceability through color development stages
    • GMP documentation during impurity control in pigment mass production

    Final product types

    • Reactive dyes for printing and cold-pad batch dyeing
    • Low-salt, high-fixation textile dyes for high-speed machines
    • Reactive dye powders and concentrated liquid dye pastes
    • Custom-developed color solutions for premium apparel fabrics

    2. Synthons for Pharmaceutical Active Ingredient Development

    The compound serves as a starting synthon in several complex pharmaceutical synthesis routes. R&D and API producers employ it to introduce nitro and amino groups in preclinical compound libraries and as a scaffold in antineoplastic agent development.

    Industry compliance standards

    • Good Manufacturing Practice (EU GMP Part II; ICH Q7)
    • Regulatory documentation per FDA 21 CFR 210/211 for intermediates
    • Ph. Eur. monographs for related chemical intermediates
    • Change control according to ISO 13485 for medical chemistry applications

    Typical usage ratio

    • 0.5 – 1.5 molar equivalents depending on target molecule synthesis
    • Adjusted per reaction pathway (e.g., Suzuki coupling, reductive amination)
    • Pilot synthesis scales from 10 grams to 12 kilograms per campaign
    • QC-controlled addition at critical reagent introduction step

    Downstream process integration

    • Added after initial substrate activation by halogenation or acylation
    • Participates in formation of intermediates for kinase inhibitors and imaging agents
    • Full batch tracking from procurement to waste management per GMP documentation
    • Purity analysis performed via HPLC before transfer to next synthetic stage

    Final product types

    • Advanced pharmaceutical intermediates for oncology targets
    • Exploratory compound libraries for drug discovery screening
    • Bulk APIs for regulatory submission batches
    • Reference standards for process validation studies

    3. Intermediate for High-Performance Specialty Polymer Additives

    Several specialty polymer compounders utilize this molecule as a chain-modifying intermediate in engineered plastic additives. It introduces amino/nitro-based functional groups, enhancing compatibility with epoxy resins and polyamide systems in high-durability industrial goods.

    Industry compliance standards

    • ASTM D638 for mechanical property validation of final plastics
    • UL 94 V-0 and HB flame retardancy performance for polymer systems
    • RoHS Directive 2011/65/EU for hazardous substance restriction
    • EN ISO 4892 for weathering resistance testing in outdoor plastics

    Typical usage ratio

    • 0.2% – 1.0% by resin weight for modification additive masterbatches
    • Ratio varies based on molecular weight of carrier resin
    • Line trials determine compatibility and mechanical effect
    • Scaling done in increments of 500 g–2 kg per extrusion batch

    Downstream process integration

    • Direct metering into twin-screw extruders with polymer and co-additives
    • Incorporated during high-shear mixing ahead of compounding step
    • Sampling for spectroscopic confirmation of chemical incorporation
    • Integrated QC validation on finished pellets before downstream injection molding

    Final product types

    • Polymer masterbatches for automotive and E&E applications
    • UV-stabilized plastics for architectural and transport parts
    • High-impact-resistant housing for industrial electronics
    • Custom-tint engineering plastics for packaging and appliance sectors

    4. Analytical Reagent for Environmental and Food Testing

    Laboratories and test kit producers employ 2-(4-Amino-2-Nitroanilino)-Ethanol as a chromogenic reagent in trace analysis protocols. It allows precise colorimetric detection of contaminants such as heavy metals and nitrites in water and food matrices.

    Industry compliance standards

    • EPA Method 200.9 and 353.2 for trace metal/nitrite detection
    • ISO 17025 accreditation for analytical measurement laboratories
    • AOAC Official Methods for food safety screening reagents
    • EN 12457 standard protocols for leachate and soil analysis

    Typical usage ratio

    • 10 – 50 mg/L in test solution depending on analyte and sensitivity
    • Concentration adapted to calibration curve and LOD/LOQ specifications
    • Kit manufacturers standardize aliquot for batch-to-batch reproducibility
    • Technical support for protocol optimization in end-user labs

    Downstream process integration

    • Pre-dissolved to working concentration in aqueous solution or buffer
    • Supplied lyophilized or in solution for test kit assembly lines
    • Gravimetric and spectrophotometric QC prior to packaging
    • Documentation and COA provided with every analytical lot

    Final product types

    • Ready-to-use environmental water testing kits
    • Analytical grade reference solutions for food labs
    • Portable test strips for rapid field detection
    • Colorimetric assay reagents for public health laboratories
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    Certification & Compliance
    More Introduction

    2-(4-Amino-2-Nitroanilino)-Ethanol: Experience Shaped by Daily Production

    Practical Insight from the Manufacturer’s Bench

    Each day in our reactors, 2-(4-Amino-2-Nitroanilino)-Ethanol moves through its careful synthesis. We know this compound better than any catalog entry or brief sales description could ever capture. Handling it means watching color shifts, listening to reaction rates, double-checking pH drift after every batch. We’ve learned the characteristic odor of a clean run, and we know what to look for in the finished crystal structure under the microscope. Our technicians love getting involved in the finer details, and this hands-on knowledge guides everything we do.

    Bringing Real-World Consistency to a Critical Intermediate

    In our experience, the best results with 2-(4-Amino-2-Nitroanilino)-Ethanol come from taking consistency seriously. Subtle changes in input chemicals or temperature tweaks show up right away in the final product. You can’t fake purity when planning downstream applications, especially for customers in dyes, pharmaceuticals, or specialty resins. Each batch gets thorough internal review. We make sure both the physical appearance and chemical composition match the specs confirmed through our in-house analytical instruments—high-performance liquid chromatography, UV-Vis spectroscopy, and FTIR. Customers insist on reliable melting point and consistent assay values, and we know even a small deviation can throw off whole production cycles further down the chain.

    Understanding the Chemical: Structure, Behavior, and Nuances

    2-(4-Amino-2-Nitroanilino)-Ethanol stands out in a crowded landscape of related anilines and substituted ethanols. Structurally, it features an amino group and a nitro group placed on the aromatic ring, playing against the hydroxylated ethanol tail. Everything about its behavior—in water, in solvents, in reaction vessels—reflects these groups: amphiphilicity, selective reactivity, and modest polarity are all shaped by the core structure. We’ve watched how its solubility can shift with even minor impurities, so regular monitoring is part of our daily operations. Compared with simple anilines, this compound brings both nucleophilic and electrophilic activity, which helps in condensation and coupling reactions. The nitro and amino functionalities serve as two reactive points, making the molecule valuable for synthetic routes looking to create more complex aromatic systems or for forming stable linkages in polymer matrices.

    Model and Specifications We’ve Learned Work Best

    In our workshop, the most reliable grade of 2-(4-Amino-2-Nitroanilino)-Ethanol measures above 98% purity as established through repeated batches. Achieving this needs careful attention during both the nitro reduction and the ethanol functionalization stages. Moisture control makes a clear difference—if water content sneaks into the final product, storage life drops fast, and physical properties like flowability and appearance shift. We work with fine orange-red crystals, often collected on vacuum filtration and dried over low temperature to preserve structure. For customers, that crystalline habit signals low levels of residual solvent, while our COA confirms impurity profiles below 1%, including limits for heavy metals and related aromatic compounds. Melting point, color, and active component content matter most for clients, much more than supplier certifications or batch branding.

    Value Comes from Performance, Not Just Paper Specifications

    Purchasers look at price per kilogram, but anyone who has ever run a pilot-scale synthesis using 2-(4-Amino-2-Nitroanilino)-Ethanol will say yield and purity matter a lot more. If there’s any issue—off-color, slower than normal dissolution, or out-of-range impurity peaks—downstream synthesis can grind to a halt. That creates cost overruns and headaches for everyone involved. We take pride knowing our material passes the test in actual application: repeatable color development for dye houses; stable intermediate formation in pharma synthesis. Engineers and chemists in the field regularly check our product under their own SOPs, and we collect feedback constantly. This has taught us where small improvements in isolation and drying conditions can make large impacts at scale.

    What Sets It Apart from Lookalikes

    Shop around for aromatic chemicals, and you’ll find several relatives to 2-(4-Amino-2-Nitroanilino)-Ethanol, many using the same root names. Yet, our customers come back to this molecule for its dual-reactivity and unique balance between water solubility and aromatic stability. The ethanol group brings a level of miscibility and functional compatibility that simple nitroanilines lack. We’ve compared the downstream success rates with other compounds—a substitute without the ethanol tail can bottleneck during further amido or etherification steps, dropping both conversion and selectivity. This isn’t just theory: we’ve sat with technical teams helping them troubleshoot why a competing batch failed to yield the desired dye or pharmaceutical compound, tracing the problem back to minute structural differences. Molecular structure here really does drive application performance, and our product’s purity profile means fewer headaches for anyone aiming to push yields close to quantitative values.

    Where It Fits: Real-World Uses

    Across our customer base, 2-(4-Amino-2-Nitroanilino)-Ethanol sees use mainly in dye manufacturing, specialty pigment synthesis, and as a linking or starting unit in pharma and agrochemical routes. Dye houses come to us because our crystals dissolve predictably, supporting precise timing in colorant development. Pharmaceutical techs value the reliable reactivity between the amino and nitro sites, allowing targeted substitution and reduction under controlled conditions. Polymer firms, chasing new material performance levels, depend on the dual functional groups to support crosslinking or build-in modifiable side chains. We have seen these uses shift with customer innovation: as research teams publish new protocols, demand can shift rapidly, but reliability in foundational intermediates like ours keeps R&D moving forward.

    How Genuine Manufacturing Oversight Helps

    Being the manufacturer, we see every variable. If the reactor jacket fails and leads to a slow temperature ramp, purity suffers. If input lots from raw suppliers vary in moisture or trace contaminants, HPLC tells us right away. That’s why we run parallel testing on both input and output materials. No distributor or reseller knows the process better than the person who actually makes the product from scratch. We’ve tweaked solvent choices for better selectivity or easier filtration, experimented with changing reducer agents for the nitro group, and learned which steps are most sensitive to equipment cleanliness. This practical background shows up in the confidence customers have with our product over unfamiliar or “on-spec” imports.

    Building Quality Through Process Control

    Instead of batchwise correction, we focus upstream—controlling syntheses from the very beginning. By integrating in-process analytics, we see issues before intermediates ever hit the dryer. Our reactors have in-line sensors for temperature, pH, and viscosity. Data gets reviewed with every shift change. We teach operators what deviations mean at a chemical level, not just how to fill out paperwork. Fine-tuning steps like filtration, washing, and drying make a noticeable impact. Forces like vacuum level, surface area of filter cake, and temperature profile during drying factor deeply into final properties. We stay away from shortcuts. Over time, that discipline has become a core strength, proven through QC logs and customer audits. The difference shows up batch after batch: clean burnout curves, low ash, almost no trace solvent.

    Direct Manufacturer Relationships Save Time and Trouble

    Many buyers, especially those sourcing from overseas, hunt for the best price or the fastest ship time. Yet, as we’ve seen first-hand, troubleshooting later can cost far more than getting a batch right the first time. By working directly with us—the actual producer—customers gain fast response to any issues, flexible scheduling for urgent lots, and real technical support rooted in hands-on experience. If something feels off, we can walk through the process and pull up actual production logs within hours. That level of control creates repeat customers who value continuity, especially in regulated or high-volume markets. We also own the responsibility for traceability. From raw input records to final batch releases, every step remains within our oversight, which customers find reassuring when facing compliance or registration questions.

    Market Changes and Responsive Production

    Chemical markets change swiftly—supply chain crunches, feedstock shortages, or rising regulatory standards all demand adaptation on the shop floor. Over the years, we’ve adapted by keeping safety stocks of key raw materials, strengthening our relationships with trusted suppliers, and qualifying back-up process pathways. If a ligand’s legal status changes or new impurity limits appear in a pharma monograph, we get to work updating both process chemistry and analytical methods. Being manufacturers, not just traders, means we can actually drive these changes instead of waiting for someone else to lead. Our R&D teams collaborate with customers to trial new runs or produce pilot lots on short notice. We’ve succeeded by embracing flexibility—allocating reactor time for urgent custom specs, running after-hours to hit tight delivery dates, and staying transparent through process changes.

    Responsible Production and Environmental Concerns

    Innovation in specialty chemicals means stricter environmental standards every year. As the team responsible for the actual byproducts and waste from each lot of 2-(4-Amino-2-Nitroanilino)-Ethanol, our strategy focuses on genuine improvements, not just box-checking. Closed-loop recycling for solvents, careful neutralization of acidic and basic washes, and real-time emission tracking have become standard practice. Over time, we’ve invested heavily in waste minimization, reducing everything from off-gas volatiles to liquid effluent. Maintaining this discipline takes work: staff training, regular process reviews, and a commitment to honesty about where improvement is possible. Regulatory pressure does shape some choices, but for us, the goal is long-term process safety and lower life-cycle impact. Customers see the benefit in smoother delivery, less regulatory delay, and a reduced environmental footprint attached to every lot.

    Solving Problems from the Bottom Up

    Whenever issues or new requirements appear—be it tightening specifications, new downstream process needs, or unique customer requests—we handle these from within our facility. The ability to run trial syntheses and adjust purification protocols gives us an edge. Many customers have brought us unexpected hurdles: changes in their end product color, altered solvent compatibility, or sudden demand for higher-purity “pharma grade” lots. As manufacturers, we respond by adjusting protocols, testing additional purification cycles, or redesigning process steps. The solution process involves hands-on troubleshooting, not just swapping to another supplier’s catalog. Over years of facing and solving real technical challenges, we’ve built a team that thrives on problem-solving and agile, customer-centric chemistry.

    Looking Beyond Specs: Real Value from Trusted Production

    On paper, many products look alike—especially intermediates with complex names—yet practical results tell another story. The true value in 2-(4-Amino-2-Nitroanilino)-Ethanol comes down to who makes it, how carefully, and with what foundation of experience. Anyone can quote a purity spec or certificate of analysis. It’s how the product lines up to real-world use, fits within complicated synthetic routes, and responds to production realities that matters. As the team behind the process, we stand ready to back our product, batch by batch, and bring confidence to chemists and engineers demanding more than just a line on a purchase order. Our experience lives in every shipment, backed not just by data on a page, but by a culture of diligence, transparency, and genuine chemical understanding. As manufacturing chemists, we know that’s what builds lasting relationships—and real breakthroughs in every lab and plant relying on our work.