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2,4,6-Trimethylphenol

    • Product Name 2,4,6-Trimethylphenol
    • Alias Mesitol
    • Einecs 202-208-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    445253

    Cas Number 527-60-6
    Molecular Formula C9H12O
    Molecular Weight 136.19 g/mol
    Appearance White to pale yellow solid
    Melting Point 46-50°C
    Boiling Point 224-226°C
    Density 1.01 g/cm³
    Solubility In Water Slightly soluble
    Flash Point 104°C
    Structure A benzene ring substituted with three methyl groups at positions 2, 4, and 6 and one hydroxyl group at position 1
    Iupac Name 2,4,6-Trimethylphenol
    Synonyms Hemimellitol, 2,4,6-Trimethylhydroxybenzene

    As an accredited 2,4,6-Trimethylphenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, 100g quantity, tightly sealed cap, hazard label, product name and CAS number printed clearly, for laboratory use.
    Shipping 2,4,6-Trimethylphenol should be shipped in tightly sealed containers, away from heat, sparks, and open flames. It must be clearly labeled as a hazardous material and transported according to local, national, and international regulations. Ensure compatibility with other chemicals and provide appropriate documentation, such as a Safety Data Sheet (SDS).
    Storage 2,4,6-Trimethylphenol should be stored in a cool, dry, well-ventilated area away from sources of ignition and incompatible substances such as strong oxidizers. The container must be tightly closed and clearly labeled. Protect from moisture, direct sunlight, and heat. Use corrosion-resistant shelving and equipment, and avoid contact with acids. Store under inert atmosphere if necessary to prevent oxidation.
    Application of 2,4,6-Trimethylphenol

    Applications of 2,4,6-Trimethylphenol in Industrial Manufacturing

    2,4,6-Trimethylphenol serves as a key intermediate in several specialized chemical industries. As an established producer, we supply this material to manufacturers strictly within sectors proven by industrial adoption and regulatory listing. The following scenarios detail major downstream routes, each with precise technical context regarding compliance, formulation, processing steps, and terminal applications.

    1. Vitamin E Synthesis for Nutraceutical and Pharmaceutical Manufacturing

    Major tocopherol (Vitamin E) producers rely on 2,4,6-trimethylphenol as a primary building block, engaging it in condensation reactions within multi-step synthesis. Active pharmaceutical ingredient (API) manufacturers blend this intermediate under precisely monitored conditions, adjusting process parameters to maximize purity and yield in accordance with food and pharma safety requirements. The material enters the production regime ahead of methylation and cyclization stages, determining the character of final bioactive forms that reach dietary supplement and medicinal markets.

    Industry compliance standards

    • USP/NF (United States Pharmacopeia/National Formulary) for Vitamin E APIs
    • Ph.Eur. (European Pharmacopoeia) Monograph 1250
    • 21 CFR 182.8890 (US FDA) for GRAS status in supplements
    • GMP: ICH Q7, WHO-GMP for nutraceutical API production

    Typical usage ratio

    • 75–85 mole% of total phenol input; ratio varies with target tocopherol isomer and process yield control strategies

    Downstream process integration

    • Added at the initial condensate phase with isophytol, before cyclization and methylation; batch and continuous reactor loading at 110–135°C

    Final product types

    • D-alpha-tocopherol (natural vitamin E)
    • DL-alpha-tocopherol (synthetic vitamin E)
    • Tocopherol acetate and tocopherol succinate derivatives for encapsulation

    2. Industrial Antioxidant Manufacture for High-Performance Polymers

    Specialty antioxidant producers incorporate this compound in the synthesis of sterically hindered phenolic antioxidants for engineering plastics, including polyolefins and styrenics. Its methyl substitution pattern delivers the necessary thermal resistance and polymer compatibility required in advanced formulations. Technical operations control the additive ratio in the masterbatch phase, downstream from monomer processing, to ensure stabilizer dispersion and long-term oxidative stability in the molded or extruded final goods.

    Industry compliance standards

    • EN ISO 9001:2015 for quality management in additive production
    • REACH Regulation (EC) No 1907/2006 registration for polymer additives
    • ASTM D6280-98 for antioxidant efficacy in polyolefin applications
    • FDA 21 CFR 178.2010 for indirect food contact (where applicable in packaging)

    Typical usage ratio

    • 0.1–0.5 wt% relative to total polymer mass in additive masterbatch; specific ratio tailored for resin type and thermal stress profile

    Downstream process integration

    • Incorporated during the compounding stage prior to extrusion or molding, utilizing twin-screw extruders for homogenous additive dispersion in resin pellets

    Final product types

    • Polypropylene and polyethylene pipes
    • ABS and SAN housings
    • Food-grade packaging films
    • Automotive interior and exterior polymer parts

    3. Fine Chemical Intermediate in Agrochemical Active Ingredient Synthesis

    Key crop protection manufacturers use 2,4,6-trimethylphenol in the synthesis of highly specific phenolic intermediates required for constructing certain herbicides and fungicides. Technical chemistries utilize its unique substitution for targeted reactivity in etherification and coupling reactions. Process engineers monitor purity prior to reaction quenching, ensuring that the compound enters the batch as a limiting reactant to maintain consistency in agroactive structure and field performance.

    Industry compliance standards

    • ISO 9001 and ISO 14001 for agricultural chemical manufacturing
    • FAO/WHO specification for pesticide active ingredient quality
    • EPA Registration Requirements (US FIFRA) for formulated products
    • EC Directive 91/414/EEC for approved active substance registration

    Typical usage ratio

    • 50–90 mole% of total phenolic precursor charge, dictated by the desired substitution level in target agricultural compounds

    Downstream process integration

    • Introduced post-hydrolysis in the condensation stage with alkylating agents, prior to purification and formulation of technical material

    Final product types

    • Herbicide actives with phenolic ether structure
    • Fungicide intermediates for further functionalization
    • Agrochemical technical concentrates

    4. Functional Dyestuff Intermediate for High-Performance Pigment Industries

    Advanced dyestuff and pigment manufacturers employ this trimethyl derivative as a critical intermediate for synthesizing certain azo and anthraquinone dye molecules. The compound imparts steric hindrance, supporting colorfastness and solubility improvements in specialty pigment production. Operators introduce the raw material into diazotization or coupling reactions post-initial charge of primary amines, controlling for batchwise purity and reactivity under closed system conditions. This precise introduction supports consistent tint strength across multiple industrial dye formulations.

    Industry compliance standards

    • Oeko-Tex® Standard 100 for textile dye safety
    • Ecological and Toxicological Association of Dyes and Organic Pigments Manufacturers (ETAD) Code of Practice
    • EN 71-3 Safety of Toys (where pigments are used for toys and children’s articles)
    • ISO 9001:2015 certified quality management in pigment synthesis

    Typical usage ratio

    • 0.5–2.5 parts by weight per 10 parts total aromatic input, with precise value determined by desired chromaticity and molecular weight of the pigment system

    Downstream process integration

    • Added during the coupling stage in azo dye production, or during the Friedel–Crafts acylation/methylation cycle in anthraquinone systems, prior to pigment filtration and drying

    Final product types

    • High-performance azo dyes for plastics compounding
    • Solvent-stable pigments for inks and coatings
    • Fiber-reactive dyes for synthetic textiles
    • Specialty pigments for printing toners
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    Certification & Compliance
    More Introduction

    Introducing 2,4,6-Trimethylphenol: Crafting a Reliable Solution from Raw Materials

    Our Story in Production

    Years in chemical manufacturing bring a certain respect for products that stand up under pressure, maintain consistency, and deliver. 2,4,6-Trimethylphenol, which our team crafts in dedicated production lines, reflects qualities we know matter: purity, reliability, and adaptability. Our crews don’t just follow recipes—they analyze each batch, keep their eyes on precise boiling and melting points, and ensure that every delivery meets real-world demands. We have worked steadily to minimize impurities, fine-tune our stripping and recovery systems, and verify each shipment before it hits the bulk tanks or packaging line.

    This molecule gets its character from three methyl groups on a phenol ring, a structure that influences not only reactivity but also makes handling and downstream processing less troublesome. Whether you’re running a continuous process or scaling up from the lab, a dependable feedstock sets the foundation for everything else.

    Technical Properties Backed by Experience

    Technical details matter in the lab and on the plant floor, so we put our experience to work controlling the parameters that count. Our usual lot specification ensures a product with high GC purity, low water content, and minimal metal contamination. Batch records track more than just finished product; intermediate steps see close scrutiny as well, from solvent selection to final filtration. Operators know the difference high-grade trimethylphenol makes in oxidation steps, condensation reactions, and resin manufacturing. 

    Our product most often appears as a white or off-white crystalline solid. We pack and ship it in moisture-tight containers since the phenolic hydroxyl can pick up moisture and trace atmospheric acids, shifting product stability. Our chemists follow up on feedback from customers using the product in resins, antioxidants, and custom intermediates, so we rarely see issues with yellowing, caking, or unexpected residues. 

    Pathways to Application

    Talk to process developers in resin or plastics manufacturing, and the need for consistent feedstock quality comes up often. 2,4,6-Trimethylphenol serves as a key intermediate in synthesizing antioxidants, polymers, and specialty monomers. High performance resin systems, especially those requiring thermal stability or UV resistance, draw on this phenolic core. Our own plant routes product straight from finished reactors to filling, cutting down transit time and keeping contamination low.

    We’ve supplied batches for customers developing stabilizers for lubricants, while others have trailed novel fungicides or electrical insulation systems using our material. We see firsthand how minor variances in purity or trace contamination can affect downstream yields—a fact that hasn’t changed in decades. Our on-site testing facility uses HPLC and Karl Fischer titration to confirm quality before release.

    Some of our customers run continuous production with automated metering; others maintain older batch reactors or pilot lines. Over time, we’ve customized packing and shipment for both high-volume plants and research teams needing smaller lots. Our team’s flexibility doesn’t come from a template; it’s based on years of experience working with technical support, logistics, and regulatory compliance officers. If material needs to reach Asia, North America, or Europe on short notice, we rely on our own storage and distribution infrastructure to get it done.

    Why 2,4,6-Trimethylphenol Stands Apart

    Comparing trimethylphenols, not every isomer behaves the same. The 2,4,6 isomer, in our hands, offers better melting range and less tendency to form colored impurities than either 2,3,6- or 2,3,5- variants. Colleagues in manufacturing and customers report smoother polymerization and higher conversion rates when purity stays above 99%. Natural odor, low volatility at standard conditions, and manageable dust risks make our crystalline form manageable for bulk handling yet easy to dissolve in common solvents for downstream use.

    In our process, starting phenol and methylating agents undergo strict quality control, which minimizes variable in final cut composition and keeps color ratings low. We do not blend multiple isomer sources into a lot marked as 2,4,6-Trimethylphenol; buyers can expect a true analytical fingerprint from each drum or IBC shipped from our plant. That reliability matters when specifications call for fine-tuned performance in advanced coatings, insulation foams, or specialty chemical intermediates.

    Our experience shows that high-purity 2,4,6-Trimethylphenol works well in oxidative coupling, delivering cleaner reactions compared to lower-purity, mixed-isomer streams. Some users have reported that lesser quality or impure sources bring headaches—equipment fouling, resin defects, and even customer complaints downstream. We receive these stories regularly and continue to refine our systems to avoid these pitfalls. 

    Working Within Regulatory and Environmental Demands

    Manufacturing always faces scrutiny, and chemical plants must continuously adapt. Our site operates under strict environmental and safety standards, keeping emissions and waste outputs within government guidelines. Spent solvents from our methylation lines undergo recovery and are reused or treated, reducing overall environmental footprint. Process water recycling minimizes fresh draw from municipal supplies. Waste and by-product streams move through registered handlers for recycling or safe disposal.

    Chemicals like 2,4,6-Trimethylphenol transition through diverse applications, which means we document all required material safety and regulatory information. For global customers, we comply with reach, TSCA, and other jurisdictional pre-registrations and notifications. Buyers in regulated sectors rely on complete lot records and regulatory dossiers proving supply chain compliance, and our QC team ensures these go out with every order.

    We work openly with customers during audits or product stewardship reviews. Traceability remains a top concern, with digital lot management and barcoding systems in place for both raw inputs and end product. This helps eliminate risks associated with unknown or poorly tracked supply sources and allows end users to maintain their own due diligence for downstream products.

    Day-to-Day Realities in Chemical Production

    Running a chemical plant means facing practical challenges—raw material fluctuations, energy costs, developer requests for quicker lead times, regulatory paperwork, logistical headaches, and the endless drive toward zero-defect production. 2,4,6-Trimethylphenol may seem like a simple commodity on paper, but significant work ensures it arrives with the right performance profile and consistency.

    Operators adjust reactor parameters daily to keep conversion rates up. Laboratory analysts confirm color, melting point, purity, and residual solvents on every manufactured batch, not just at the end, but through intermediate steps. Finished goods sometimes undergo additional drying or re-crystallization, depending on customer requirements, and any batch outside spec is diverted for reprocessing, not relabeling or blending.

    We regularly upgrade plant components to reduce downtime or improve energy efficiency, focusing not only on the process but on the safety and wellbeing of our crews. On busy weeks, our customer support staff maintains direct lines to dispatch, shipping, and technical service, since production delays or transit issues require rapid response and honest communication.

    All this attention to the day-to-day operation builds a product—and a reputation—that supports global manufacturing partners. We have found that consistency encourages customers to return for repeat orders, recommend our material to a new program, or even expand their use cases into completely new technical areas.

    Understanding Customer Challenges, Offering Real-World Solutions

    Let’s be honest; no production environment runs trouble-free. We have worked through shipping interruptions, shifting energy prices, and even international trade disruptions. What keeps our customers coming back is our willingness to provide documentation, quality details, and quick responses to specification requests. We field questions about alternative solvents, alternative feedstock origins, and shelf-life studies, since many innovators use our 2,4,6-Trimethylphenol as a foundation for new synthesis pathways.

    Some partners have asked for custom cuts on crystal size or bulk density; our facility supports tailored sieving or flake options when scaling into new plant designs. Environmental responsibility also means taking every opportunity to minimize byproducts and maximize use of recovered materials. We keep up with new trends in downstream chemistry, sourcing, analytical methods, and regulatory updates by maintaining open lines with technical experts and regulatory agencies.

    More than just handling complaints, we proactively review customer feedback. Years ago, after several reports of minor color drift during extended storage, our team sourced new lined drums and altered storage protocols, eliminating most discoloration issues reported since. Our outlook favors real problem-solving and improvement instead of just meeting the minimum requirements.

    Moving the Industry Forward with Technical Integrity

    Chemical manufacturing builds on decades of scientific and technical progress; a product like 2,4,6-Trimethylphenol illustrates this well. Our method draws on industry best practices and a deep pool of hands-on knowledge, not simply textbook procedures. Plant engineers modify transfer lines to reduce risk of cross-contamination, chemists design process controls that flag anomalies, and everyone from shift supervisors to R&D staff participates in ongoing training for safety and procedural excellence. 

    It pays to remember that every kilo shipped supports not just a technical process, but a trusted partnership. Our emphasis on precise, reproducible manufacturing translates to fewer disruptions in customer pipelines, shorter qualification timelines for new applications, and greater trust in supply chain stability. 

    Fulfilling production contracts means keeping the customer’s end use in mind at all times. In the field, 2,4,6-Trimethylphenol serves performance plastics, polymer intermediates, coatings technology, and antioxidant developers—applications where trace impurities can damage credibility. Reliable supply, predictable performance, and ongoing product stewardship build productive collaborations that stretch far beyond a packing slip or certificate of analysis.

    We have also worked on several projects with sustainability in focus. Using renewable feedstocks, investing in energy recovery heat exchangers, and researching process intensification for greener throughput are more than trends—they represent the future for responsible manufacturers. Keeping customers in the loop about these changes, and inviting feedback, fosters a culture of transparency in an industry that hasn’t always been known for openness.

    Beyond the Product: A Team-Based Approach

    No chemical plant succeeds on machines alone. Our team—from operators and engineers to laboratory analysts and logistics planners—shares the credit for maintaining the consistent quality of every batch of 2,4,6-Trimethylphenol shipped from our facility. Open process meetings, training on new analytical equipment, and a practical troubleshooting culture encourage spotting and solving problems before they reach the customer’s door.

    On-the-ground expertise matters most when something goes off-script; unplanned events require immediate, trained responses. Years of collaborative work with emergency services and participation in industry safety networks have taught us how to respond quickly, safely, and with respect for our neighbors and supply partners. 

    Keeping everyone informed, sharing near miss lessons, and maintaining a culture of safety and pride add up to a stronger product and a fleet-footed customer support team. It’s not about avoiding mistakes entirely, but about owning up to them and taking genuine action to prevent repeats.

    What Sets Us Apart Among Trimethylphenol Producers

    Many suppliers in the market broker or relabel bulk trimethylphenol, but our focus remains on full-cycle manufacturing control. Our customers get detailed batch histories, independently confirmed test results, and material consistently matched to their requirements. By running production, packing, and shipping out of a common facility, we catch potential issues at the source rather than passing them down the supply chain.

    Direct manufacturing means we don’t rely on changing specifications from faraway plants or recycled intermediates of unclear pedigree. Longstanding relationships with trusted raw material producers—regularly audited—help keep supply risks low. Our warehouse team knows how to store, rotate, and ship product to avoid caking, spoilage, and temperature issues common to the business. These details make the difference between an average supplier and a trusted partner.

    Many end users discovered cost savings or technical improvements after switching to our 2,4,6-Trimethylphenol, especially those working in multinational resin production or specialty additive synthesis. Consistent quality allows users to optimize upstream and downstream processing, reduce failure rates in quality control, and build in additional process flexibility, knowing the starting material will not introduce unknowns.

    Supporting the Next Generation of Innovation

    As chemistry evolves, so do the requirements for starting materials like 2,4,6-Trimethylphenol. We maintain close relationship with innovation teams to understand needs and incorporate their findings into our continuous improvement process. From supporting process pilots to providing regulatory documentation, our technical staff respond quickly and candidly to new requests.

    Academic research increasingly investigates new polymer additives, biodegradable resins, and high-performance stabilizers, often starting with high-purity phenolics. We offer pilot-scale quantities for R&D while maintaining the same high standards as our main production. Collaborations with both established firms and start-ups keep us on the leading edge of application development, from electronics to next-generation coatings.

    Product stewardship remains a shared journey. We see value in knowledge sharing, supporting safe handling training, and working with both larger plant users and specialty niche customers. Ensuring a consistent, transparent, and collaborative relationship benefits all links in the value chain, from the plant floor technician to the R&D scientist leading tomorrow’s product breakthroughs.

    Conclusion: Designed for Today, Ready for Tomorrow

    2,4,6-Trimethylphenol represents more than a line in a catalog—it’s the end result of years of dedicated manufacturing, ongoing customer dialogue, and relentless quality improvement. Our plant team works to deliver each order with care that reflects not just technical competence, but authentic pride and responsibility. We listen, solve problems, and seek to advance the chemistry behind every batch we produce.

    Whether downstream use heads into plastics, coatings, antioxidants, or completely new fields, our team stands ready to help move ideas from bench to full production with reliable, high-quality 2,4,6-Trimethylphenol. That commitment drives not just our business, but the collaborations and innovations that shape tomorrow’s industry.