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2,4,5-Triamino-6-Hydroxypyrimidine Sulfate

    • Product Name 2,4,5-Triamino-6-Hydroxypyrimidine Sulfate
    • Alias Minoxidil USP
    • Einecs 241-273-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    299909

    Cas Number 1608-17-9
    Molecular Formula C4H8N6O·H2SO4
    Molecular Weight 274.22 g/mol
    Appearance White to off-white powder
    Solubility In Water Soluble
    Melting Point Decomposes before melting
    Ph Value 4.0 - 6.0 (1% solution)
    Storage Temperature Room temperature, tightly sealed
    Purity Typically ≥98%
    Synonyms 2,4,5-Triamino-6-hydroxypyrimidine hemisulfate
    Ec Number 216-544-2
    Chemical Structure Pyrimidine ring with three amino groups and one hydroxyl group, sulfate salt
    Odor Odorless
    Hazard Statements May cause irritation to skin, eyes, and respiratory tract
    Shelf Life 2 years under recommended storage conditions

    As an accredited 2,4,5-Triamino-6-Hydroxypyrimidine Sulfate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White, opaque, high-density polyethylene bottle labeled “2,4,5-Triamino-6-Hydroxypyrimidine Sulfate, 100g,” featuring hazard symbols and lot number.
    Shipping 2,4,5-Triamino-6-Hydroxypyrimidine Sulfate should be shipped in tightly sealed containers, protected from moisture and light. Transport according to local, national, and international regulations for chemicals. Handle with care to prevent physical damage and avoid exposure. Ensure labeling includes hazard identification, and provide appropriate documentation for safe and compliant delivery.
    Storage 2,4,5-Triamino-6-Hydroxypyrimidine Sulfate should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from moisture and incompatible substances such as strong oxidizing agents. Protect from light and excessive heat. Proper labeling and secondary containment are recommended to prevent accidental release. Store in compliance with relevant local, state, and federal regulations.
    Application of 2,4,5-Triamino-6-Hydroxypyrimidine Sulfate

    Applications of 2,4,5-Triamino-6-Hydroxypyrimidine Sulfate in Industrial Manufacturing

    2,4,5-Triamino-6-hydroxypyrimidine sulfate serves as a key intermediate in advanced chemical synthesis. Its highly reactive aromatic structure supports several critical processes in modern industrial sectors, where downstream users integrate it for targeted performance in specialty products. Below are detailed sectors and their practical applications of this material.

    1. Pharmaceutical API Synthesis

    This raw material functions as a nucleophilic building block in multi-step syntheses of pyrimidine-based drug intermediates. Downstream pharmaceutical companies use it for constructing core heterocyclic scaffolds present in certain cytostatic and antiviral drug molecules. Operators in GMP-certified plants implement this compound at early-reactive stages for precise substitution at C2, C4, or C5 positions, allowing further functionalization into regulated active pharmaceutical ingredients. Selection and dosage depend on target molecule complexity, batch scale, and QC requirements. FDA and EMA registration dossiers often reference this intermediate as part of their impurity control strategies.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • 21 CFR Part 211 (US FDA)
    • EU GMP EudraLex Volume 4, Part II
    • USP/NF and European Pharmacopoeia monographs for related substances and intermediates

    Typical usage ratio

    • Pharmaceutical intermediate input at 0.9–1.2 molar equivalents relative to coupling partner
    • Adjustment based on compound purity and tolerance for residual byproducts

    Downstream process integration

    • Charged during heterocyclic ring assembly, condensation, or amidation reactions
    • Precursor for direct amination, chlorination, and acylation steps under controlled atmosphere

    Final product types

    • Pyrimidine-derivative antimicrobial drugs
    • Nucleoside analog antiviral agents
    • Antineoplastic compound intermediates

    2. Specialty Colorant and Dye Manufacturing

    Advanced pigment and dye manufacturers employ 2,4,5-triamino-6-hydroxypyrimidine sulfate in the synthesis of specialty pyrimidine-based chromophores. Its triamino and hydroxyl functionalities deliver selectivity during azo-coupling, diazotization, or condensation process, supporting production of water-soluble functional dyes used in medical diagnostics, inkjet printing, and fiber staining. Application engineers tune input levels for color strength, solubility, and lightfastness based on end-use testing and batch coloration standards. Colorant output requires strict traceability and control of secondary amine residues.

    Industry compliance standards

    • OEKO-TEX® Standard 100 for textile dyes
    • EN 71-3 for toy dye safety
    • REACH Annex XVII on restricted amines
    • ISO 1833 for fiber-specific coloration

    Typical usage ratio

    • Ranges from 0.5–2.5% mass fraction based on formulation and batch volume
    • Variation driven by shade depth, fiber substrate, and dispersibility requirements

    Downstream process integration

    • Enters at initial diazotization or azo-coupling stage
    • Used as a reactive core in condensation with aldehydes for vivid chromogenic systems

    Final product types

    • Medical diagnostic stains (chromogenic reagents)
    • Reactive and acid dyes for polyamide and acrylic fibers
    • Non-toxic inks for security printing

    3. High-Performance Polymer Additives

    Producers of advanced engineering plastics formulate this sulfate salt as a performance modifier in the polymer resin matrix. It provides nucleation sites and thermal stabilization effects for polyamide, polyimide, and PPS compounds used in electrical insulation or flame-retardant applications. Compounders select specific loadings to optimize crystalline distribution and decomposition onset temperatures. Real-time process adjustments depend on melt flow, extruder torque, and downstream fibre spinning or injection molding parameters. Strict inbound QA and residual solvent control protect product reliability under electrical or thermal load.

    Industry compliance standards

    • UL 94 Flammability Standard
    • RoHS Directive 2011/65/EU
    • IEC 60216 for thermal endurance of insulators
    • ISO 9001:2015 for quality management

    Typical usage ratio

    • 0.1–0.7 wt.% based on resin blend and targeted property enhancement
    • Proportion determined by compounding trial outcome and end-use certification results

    Downstream process integration

    • Integrated during masterbatch preparation or pre-polymerization
    • Dispersion achieved by twin-screw extrusion or high-shear mixing

    Final product types

    • High-temperature resistant wire coatings
    • Printed circuit board base polymer sheets
    • Fiberglass-reinforced structural components

    4. Agrochemical Active Ingredient Synthesis

    This pyrimidine derivative is a strategic intermediate for manufacturing selective pesticides and soil-protectant chemicals. Agrochemical formulators exploit its amine configuration for coupling reactions in triazine herbicidal actives and systemic fungicides. Scale-up chemists maintain controlled addition rates to minimize environmental releases during sulfonation or alkylation. Downstream blending matches local compliance on residue levels and field safety. Batches undergo multi-point QC and environmental monitoring to meet agricultural market requirements.

    Industry compliance standards

    • FAO/WHO specifications for pesticide active ingredients
    • EU Plant Protection Products Regulation (EC) No. 1107/2009
    • ISO 9001:2015 and ISO 14001:2015 for agrochemical producers
    • EPA 40 CFR Part 180 on residue tolerances

    Typical usage ratio

    • Used at 0.8–1.5 stoichiometric ratios relative to coupling partners
    • Levels fine-tuned according to crop type and active ingredient synthesis method

    Downstream process integration

    • Added at core pyrimidine ring assembly or pre-chlorination
    • Feedstock for final coupling with alkylating agents to obtain active agro components

    Final product types

    • Triazine-based pre- and post-emergence herbicides
    • Systemic seed coatings
    • Contact and systemic fungicides for cereal crops
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    Certification & Compliance
    More Introduction

    2,4,5-Triamino-6-Hydroxypyrimidine Sulfate: Our Perspective from the Lab Floor

    How Years of Manufacturing Experience Shape the Product

    Every batch of 2,4,5-Triamino-6-Hydroxypyrimidine Sulfate coming out of our reactors tells its own story. For over two decades, we've watched this compound move from obscure specialty ingredient to an essential staple for advanced formulation in several industries. From the raw material selection right down to the filtration step, our production process reflects the kind of practical, hands-on attention that few suppliers can match. We’re not just turning out an item from a catalog; we’re carrying the collective knowledge of our chemists and operators into something end-users can truly rely on.

    The Compound at a Glance

    2,4,5-Triamino-6-Hydroxypyrimidine Sulfate stands out because it offers reliable reactivity and excellent purity levels, consistently measured batch after batch. With a model based around our standard formulation, users receive a crystalline product showing a typical white to pale-yellow appearance. Solid at room temperature and relatively stable in standard storage, it integrates into processes that demand high performance and robust chemical properties.

    The Reality Behind Specifications

    We’ve built our product around actual process requirements. Laboratory data does matter, but it’s the downstream feedback that really refines our parameters. For example, customers in electronic materials and advanced pigment makers ask for finer particle size and a narrow distribution. Our equipment is set up to hit a mean particle size within the agreed range—no overstated figures, just honest, measurable results. Not every producer of this molecule can claim a loss on drying below 1% without sacrificing flowability. It's the nuances like this—from controlled crystallization through to tray drying under precise temperature monitoring—that demonstrate the value added by a dedicated manufacturing team.

    Taking Purity Beyond Industry Minimums

    Industry standards suggest a certain assay range, but our own benchmark goes higher. Reproducibility is our watchword. Sulfate content is kept strictly consistent, managed during each crystallization cycle using automated dosing and in-line conductivity checks. Amine tests and spectroscopic analysis keep trace impurities in check, avoiding color shifts or byproduct formation when customers push our product into their own aggressive synthesis protocols. This directly translates to fewer unwanted surprises on your end—fewer adjustments, greater yield predictability.

    Product Stability and Handling

    2,4,5-Triamino-6-Hydroxypyrimidine Sulfate may seem straightforward, but even the best batch can disappoint if storage and handling are afterthoughts. We’ve seen compounds from less attentive sources degrade in color and granule integrity after a month in transit. Years of feedback have led us to optimize not just the formulation, but also our packaging methods. Sealed, moisture-proof containers are standard—not an upsell or an optional extra. For users, this means fewer headaches in downstream screening or mixing.

    Our Insights: Why This Molecule Has Found Its Niche

    Working closely with research chemists and process engineers, we’ve come to appreciate why 2,4,5-Triamino-6-Hydroxypyrimidine Sulfate is so often the preferred choice for high-value synthesis and specialty applications. This compound’s amine positions and hydroxyl group form reactive handles that can undergo modification—a must for the stepwise creation of advanced heterocycles, dyes, or pharmaceuticals. Our own R&D labs keep in regular conversation with customers, ensuring our output matches the demands of developing processes, not just today, but years down the line.

    What Sets Our Sulfate Apart from Others

    It’s easy to find the basic chemical on the market, but experienced users spot the differences fast. Some suppliers prioritize output at the expense of exacting standards—what goes unmentioned on a generic datasheet might be the source of a month-long troubleshooting headache for a formulator. We've learned from firsthand customer audits that what matters most is not just the main assay, but also how tightly we control color, flow, and residual solvent levels. Our manufacturing protocol is built around robust, repeatable steps signed off by operators trained above the industry average. This means every delivery can confidently slot into validated recipes and internal quality systems, reducing delays and surprises for downstream R&D or production runs.

    How Usage Patterns Influence our Manufacturing Process

    Our long-standing customers work in environment-sensitive facilities, where even minor inconsistencies can impact an entire pilot campaign. We’ve attuned our production cycle to avoid batch-to-batch drift, especially for those who use this compound in catalyst design or polymer modification. Meeting target concentrations and purity is crucial when only a slight deviation can destroy months of optimization. Problems with competing products—sticky or overly dense crystals, unpredictable color, sluggish dissolution—have been related to less disciplined drying schedules or cost-driven shortcuts. Our method involves consistent monitoring and actively listening to feedback, which has shaped everything from our grinding protocols to our packaging orientation.

    Navigating the Challenges of Consistency

    Chemical manufacturing is never about simply hitting numbers on a certificate. Challenges like sulfate balance, impurity knock-on effects, and even trace metal contamination require vigilant monitoring and continuous process tweaking. Operators on our factory floor flag issues directly to the technical team, making room for rapid troubleshooting. Emergency interventions don’t get buried in paperwork; they result in swift changes to filtration screen sizes, extra analytical crosschecks, or raw material source revisions. The result is a product where consistency is not just a promise but an expectation, sharply reducing the risk for those counting on us.

    The Importance of End-Use Compatibility

    Every customer’s application has its own quirks—from UV-curable inks to advanced resin systems or even intermediates for pharmaceuticals. Because we handle every ton ourselves, we anticipate compatibility issues well before they reach your line. We avoid making broad claims without evidence. Instead, we lean on customer feedback and our own test results to tailor our production cycles. In more demanding fields, such as the creation of active pharmaceutical ingredients or optoelectronic materials, simple mistakes in residual moisture content or filter fines spell disaster. Because we are the ones behind the reactors, filters, and packaging lines, we have the freedom to make nuanced, hands-on changes—adjusting washing sequences, tuning drying temperatures, or swapping packing materials—without long delays or communication breakdowns.

    Industry Evolution and How It Shaped Our Understanding

    The industrial demand for 2,4,5-Triamino-6-Hydroxypyrimidine Sulfate has shifted over the years. Early on, users accepted some inconsistency if the price was low. Now, expectations run higher, especially with the growth of tightly regulated end uses. This shift forced us to invest in new analytical instruments—routinely running HPLC, ICP-MS, and UV-Vis checks. On the production side, flexible batch reactors and semi-automated control systems help us anticipate raw material variation. Every bit of process improvement is rooted in real challenges faced by our customers, reflected in the product’s reliability back at the bench or in the field.

    Environmental and Safety Considerations

    Our experience tells us that chemical management goes hand-in-hand with environmental responsibility. Unlike traders or third parties, we handle every container of raw and finished material ourselves. At every step, safe handling and minimal waste matter to our community and future customers. We actively collect and recycle processing water, manage solvent recovery, and analyze our waste streams for potential improvements. This hands-on approach means we can react quickly if new environmental standards emerge or if a customer raises a concern regarding trace metal or residual organic solvent content.

    Supporting Innovation in Customer Laboratories

    Innovators depend on reliable starting materials. Synthetic organic labs need predictable behavior when scaling up, while automated production lines call for flow properties that don’t throw off meters or feeders. Early adopters of new technologies often cross the mysterious “pilot plant” chasm with forms of our 2,4,5-Triamino-6-Hydroxypyrimidine Sulfate—sometimes packed one kilogram at a time, sometimes delivered in lined drums. At each stage, our operators and technical team keep a close eye on feedback. This symbiotic relationship accelerates the adoption of new ideas—many times, an improvement in particle handling or stability begins with a practical suggestion from a customer blending our material with something unique.

    Practical Differences: Our Approach vs. Less Attentive Suppliers

    Distributors and non-manufacturer intermediaries may shift their sourcing every month, chasing prices or running out of stock. As the actual producers, we commit to one core formulation, improved slowly as insights accumulate. Direct experience with the process means we own every step, from raw materials inspection to delivery checks. Recurrent challenges—like keeping cake porosity even during solid-liquid separation—keep us honest and accountable. Less vetted versions sometimes introduce extra sodium, unplanned coloring, or wild variations in moisture, sabotaging sensitive reactions. Our repeat clients demand predictability over flash-in-the-pan bargains, a point that direct hands-on manufacturing uniquely addresses.

    Responsiveness: The Value of Close Customer Partnerships

    We maintain strong technical partnerships with many of our users, who reach out to us directly during process upsets or new product rollouts. Instead of a faceless help desk, actual production experts respond, troubleshooting problems rooted in real manufacturing limits or equipment idiosyncrasies. If a pigment line throws a color drift, or if a new solvent system causes precipitation, our chemists can propose practical adjustments without weeks of conference calls or communication breakdowns. This direct manufacturer-to-end user relationship often results in smoother, faster process improvements—another subtle, but crucial, difference compared with buying from a middleman.

    Continuous Improvement in a Real-World Setting

    Running the plant has taught us that success depends on iteration, not just a single big innovation. Regular face-to-face meetings between plant operators, engineers, and analytical staff have eliminated gaps that used to lead to bottlenecks or off-spec product. Small but routine process changes—switching agitator speed, fine-tuning temperature ramps during crystallization, trimming filter cloth weave—often have outsized effects on downstream success. Continuous improvement is a culture, not a checklist: everyone from the operators on the night shift to the QC managers knows their work directly shapes the usability of the finished batch.

    Looking to the Future Together

    We see ourselves as long-term partners with users of 2,4,5-Triamino-6-Hydroxypyrimidine Sulfate. Regulatory requirements, environmental expectations, and technical specifications all march forward. Our plant, at the intersection of chemistry and practical reality, stays alert to these changes, preparing for new directions in next-generation materials and formulation strategies. Direct experience with the entire production process lets us proactively upgrade practices, tooling, and analytical protocols before a small inconsistency becomes an industry-wide problem. Customers can count on an open line to our technical leadership, ensuring they receive not just a product, but a resource for ongoing innovation.

    In Our Hands, From Raw Material to Final Application

    This compound has never been just an item on a spreadsheet for us. Each bag or drum reflects hundreds of choices—raw material selection, employee training, analytical method verification, equipment maintenance. Down-to-earth manufacturing delivers a product meant for those who take their own applications just as seriously. We’ve learned, batch by batch and conversation by conversation, how a strong manufacturing focus makes the difference between hope and confidence in every delivery of 2,4,5-Triamino-6-Hydroxypyrimidine Sulfate.