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2,3-Dihydro-1,4-Benzodioxin-6-Ylmethylamine

    • Product Name 2,3-Dihydro-1,4-Benzodioxin-6-Ylmethylamine
    • Alias 6-(Aminomethyl)-1,4-benzodioxane
    • Einecs 629-911-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    959458

    Cas Number 4386-55-6
    Molecular Formula C9H11NO2
    Molecular Weight 165.19 g/mol
    Iupac Name 2,3-dihydro-1,4-benzodioxin-6-ylmethanamine
    Smiles NCC1=CC2=C(C=C1)OCCO2
    Appearance Solid
    Melting Point 46-50 °C
    Purity Typically >98%
    Storage Temperature 2-8°C
    Synonyms 6-(Aminomethyl)-2,3-dihydro-1,4-benzodioxin
    Chemical Class Benzodioxane derivative

    As an accredited 2,3-Dihydro-1,4-Benzodioxin-6-Ylmethylamine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White, opaque screw-cap bottle labeled “2,3-Dihydro-1,4-Benzodioxin-6-Ylmethylamine, 25g” with hazard symbols and lot number printed.
    Shipping 2,3-Dihydro-1,4-Benzodioxin-6-ylmethylamine is shipped in tightly sealed, chemical-resistant containers, protected from light and moisture. It is transported according to relevant local, national, and international regulations for laboratory chemicals, with clear labeling and documentation. Standard shipping precautions for amines and aromatic compounds are observed to ensure safe delivery.
    Storage 2,3-Dihydro-1,4-Benzodioxin-6-ylmethylamine should be stored in a tightly sealed container in a cool, dry, and well-ventilated area, away from direct sunlight and incompatible substances such as strong oxidizing agents. Store at room temperature, protected from moisture. Handle with care, using appropriate personal protective equipment, and follow all relevant safety guidelines to prevent contamination or accidental release.
    Application of 2,3-Dihydro-1,4-Benzodioxin-6-Ylmethylamine

    Applications of 2,3-Dihydro-1,4-Benzodioxin-6-Ylmethylamine in Industrial Manufacturing

    As a dedicated producer of 2,3-Dihydro-1,4-Benzodioxin-6-ylmethylamine, we support a defined range of advanced sectors with this specialty chemical. Its application is based on strict compliance, quality standards, and close integration into downstream production workflows, leading to specific end-use products in pharmaceuticals, agrochemicals, fine chemical synthesis, and advanced polymer intermediates.

    1. Pharmaceutical Intermediate for CNS Agent Synthesis

    Our material serves as a key intermediate in the multi-step synthesis of central nervous system (CNS) active compounds, particularly targeting substituted benzodioxin scaffolds used in antidepressant and anxiolytic drug production. Pharmaceutical companies utilize it at early and mid-stages under GMP conditions to precisely control active pharmaceutical ingredient development and yield high-purity bases for final formulation.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice (GMP) for Active Pharmaceutical Ingredients
    • EU EudraLex Volume 4 – Pharma GMP
    • US FDA 21 CFR Part 210/211
    • Relevant monographs in European Pharmacopoeia (Ph. Eur.) for intermediates

    Typical usage ratio

    • Applied at 0.9–1.2 molar equivalents relative to the target core; proportion is fine-tuned according to route specificity and impurity control needs

    Downstream process integration

    • Charged during nucleophilic substitution or reductive amination steps to build substituted amine motifs before final functionalization and purification

    Final product types

    • Bulk API intermediates for CNS therapeutics
    • Final Active Pharmaceutical Ingredients for generic and innovative drugs

    2. Agrochemical Active Compound Precursor

    Researchers and commercial agrochemical plants use this compound as a selective amine source to retrofit new-generation crop protection molecules, particularly in the synthesis of fungicidal and insecticidal actives based on benzodioxin-core scaffolds. Its high purity boosts predictable reactivity and downstream stability of final molecules in formulated crop protection agents.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • OECD Principles of Good Laboratory Practice (GLP) for agrochemical research
    • REACH Registration for downstream manufacturing in the European Union
    • ISO 9001:2015 (where required for traceability and batch control)

    Typical usage ratio

    • Ranges from 0.8–1.15 equivalents per batch, depending on the specific synthetic pathway and co-reactant efficiency; adjustments based on target molecule structure

    Downstream process integration

    • Introduced pre-formulation, typically in the amination or alkylation stage to assemble active ingredient cores ahead of crystallization or further derivatization

    Final product types

    • Fungicide technical concentrates
    • Advanced insecticidal actives
    • Ready-to-use pesticide formulations

    3. Specialty Fine Chemical Building Block

    Producers of fine and performance chemicals rely on this compound for introducing benzodioxin-linked amine functionalities into photoinitiators, UV absorbers, and specialty reactive dyes. Its stable and clean reactivity lends high batch-to-batch reproducibility essential for small-volume, value-added synthesis in precision chemical lines.

    Industry compliance standards

    • ISO 9001:2015 for QMS in fine chemical production
    • REACH pre-registration or full registration for EU-bound batches
    • Internal QC protocols conforming to customer-specific purity benchmarks

    Typical usage ratio

    • Usually 0.7–1.0 equivalents, scaled precisely based on the reactivity profile of downstream coupling partners and targeted molecular architecture

    Downstream process integration

    • Used in condensation, cyclization or functional group exchange reactions, mainly at the step where amine groups are required for molecular assembly

    Final product types

    • Photoinitiators (for specialty inks and coatings)
    • UV-stabilizing agents
    • Reactive dyes for technical textile finishing

    4. Advanced Polymer Modification Agent

    Manufacturers engineer this intermediate into the main chain or as a pendant group in advanced functional polymers, such as conductive polymers for electronics or membrane materials used in separation technologies. Its amine functionality permits selective grafting and post-polymerization modification, granting tailored physical and chemical properties to the final polymer system.

    Industry compliance standards

    • ASTM D7209/D7255 for specialty polymer performance
    • IEC 60754 for polymeric materials in electronic components (where applicable)
    • ISO 14001 for environmental management in polymer production
    • Chemical Substance Control Law (CSCL) for Japan-bound shipments

    Typical usage ratio

    • Blended at 2–7 wt% as a post-polymerization grafting agent or chain extender; dosage optimized according to target polymer architecture and property requirements

    Downstream process integration

    • Reacted in melt or solution-phase polymerization steps, typically after main chain formation or as a post-functionalization reagent for surface or chain-end modification

    Final product types

    • Conductive polymer films
    • Functional separation membranes
    • Specialty copolymer blends for electronics applications
    Free Quote

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    Certification & Compliance
    More Introduction

    Unveiling 2,3-Dihydro-1,4-Benzodioxin-6-Ylmethylamine: Application-Driven, Experience-Built Innovation

    Direct Insights From The Manufacturer’s Bench

    For years, the push in fine chemicals and pharmaceutical intermediates has called for deeper technical know-how and relentless quality monitoring. 2,3-Dihydro-1,4-Benzodioxin-6-ylmethylamine is a prime example of how this mentality shapes real-world production. This compound stands out for both its structural reliability and its versatility. Our plant teams have worked long shifts perfecting every step from raw ingredient purification to final packaging, because we know sharp attention to detail separates dependable batches from troubled ones.

    Understanding the Molecular Advantage

    The chemical structure of 2,3-Dihydro-1,4-Benzodioxin-6-ylmethylamine delivers consistent performance where precision matters. Its core, shaped by the fused benzodioxin and methylamine groups, helps chemists build more complex analogs, making it valuable during the design of targeted therapies or specialty materials. In our operations, consistency doesn’t begin at filling drums — it starts with upstream selecting of reagents and calibrating reactors. Small adjustments in temperature or solvent quality show up in lab results more than paperwork ever will.

    Industry Uses: From Bench to Batch

    Our customers usually walk in with targeted projects. Over the past years, most demand for this amine variant comes from pharmaceutical research divisions and material science labs. Researchers choose this molecule as a practical intermediate when building scaffolds that mimic natural products or in prototyping candidates for neurological or oncological applications. We’ve personally followed up with project teams down the chain, hearing firsthand how downstream reactions benefit from the molecule’s reactivity profile. No off-odors, fewer side impurities: the actual outcomes speak louder than specification sheets.

    Why Model Consistency Drives Project Success

    Every kilogram shipped carries its history. Most sites making this product worldwide stop after basic purification. Our process pushes further, monitoring for trace aldehyde and chloride impurities, and cross-checking chiral purity when required. Many clients tell us their reactions run smoother, and yields go up when switching over. They aren’t just looking for pure material by the numbers—they want predictability. Project timelines shrink as a result.

    Comparing Performance: Beyond Generic Amines

    Chemically, 2,3-Dihydro-1,4-Benzodioxin-6-ylmethylamine sets itself apart from similar amines with its unique fused ring. Competitors sometimes substitute basic benzylic amines, but those alternatives often produce more decomposition under standard lab stresses. In head-to-head testing, our own process chemists have seen improved catalyst compatibility with this compound compared to basic phenethylamines or simple methylamines. From synthesis of advanced building blocks to late-stage functionalization, reaction pathways tolerate harsher conditions without derailing.

    Handling and Formulating With Confidence

    We see questions come up from clients scaling up reactions for the first time. Handling bulk amine batches brings challenges—stability upon storage, reactivity to moisture, and long-term performance drift. After multiple years tracking batch outcomes, our team responds with practical guidelines for solvent choice, container material, and best handling practices. Absent these steps, competitors often report product browning or loss of activity, creating roadblocks for pilot and manufacturing scale-up.

    Quality Control: More Than Procedures

    Quality routines at the production site run more than just box-ticking. Our technicians run both routine and random sampling: every drum passes through NMR, GC-MS, water content analysis, and optical rotation checks (if used for chiral synthesis). Trace by-products, such as minor ring-opened species or unreacted amines, get flagged right away. This vigilance comes from long experience. We've had years when slight changes in reactor temperature as low as 2 degrees made the difference between a flawless batch and wasted work—a fact learned not from manuals, but from costly reruns and customer calls.

    Scalability: Lessons From Experience

    One of our earliest challenges: scaling from a 2-liter Schlenk flask to 500-liter reactors. Many production hiccups only reveal themselves at scale; heat transfer, reagent metering, and agitation become far less forgiving. In the early days, we saw critical batches risk runaway exothermic reactions, or unpredicted by-product formation from subtle contaminant residues. Now, every time we increase production volumes, troubleshooting protocols run in parallel with synthesis, not after. The hard lessons carry forward into every lot.

    Safety: Real-World Risks and Mitigation

    Safety earns its place front and center in every shift briefing. 2,3-Dihydro-1,4-Benzodioxin-6-ylmethylamine, like many amines, reacts with acids, oxidizers, and must be kept dry. A cavalier approach guarantees lab incidents—so the protocols in place reflect real-life scenarios from our own plant: spills, vapor containment, and staff exposure. Routine onsite training, real mock drills, and periodic review of procedures anchor our safety record. Customers trust a material more when the supplier’s own teams are protected by that same material handling philosophy.

    Environmental Impact and Sustainability Commitment

    Regulatory and environmental standards aren’t just external targets. Every molecule leaving our gate represents a choice about solvent use, waste stream minimization, and resource conservation. Over the past five years, we overhauled our amine production to lower solvent emissions, recycle water, and reduce the weight of packaging without undermining product safety. Our aim: fewer hazardous residues, lower disposal costs for our clients, and a smaller carbon footprint per kilogram delivered.

    Feedback-Driven Continuous Improvement

    We don’t operate in a vacuum. Customers return again and again with questions, concerns, and stories about their own downstream hiccups. These reports shape our QC routines—they don’t just fade into post-sale silence. One of the biggest shifts in our practice happened after a pharmaceutical customer pointed out marginally inconsistent melting points, leading us to revisit an overlooked filtration step. Iterative problem-solving lies at the heart of reliable fine chemical production.

    Specification Focus: What Actually Makes the Difference

    Lab-to-lab variation shows up in the details: water content, trace ion presence, and color stability. Too much residual solvent, a slight tinge of yellow instead of bright white—these small factors can stop a downstream reaction in its tracks. Our plant has invested heavily in in-process controls, such as real-time spectrometric checks and automated dosing regimes, to lock down these factors before a misstep can propagate through several tons of inventory. Years of feedback honed these methods, shaving down batch failures and keeping performance at the level our clients expect.

    Regulatory Alignment: Proven Track Record

    Compliance matters in every global market, but navigating ever-changing documentation and third-party audits takes more than copying paperwork templates. We put full-time resources into maintaining up-to-date protocols, and senior staff participate in reviews of international standards. Having ready data packages and clear, verifiable traceability means our customers move through their own regulatory submissions more smoothly—and if a rarely asked question crops up, we can answer it from experience, not guesswork or deflection.

    Customer Engagement: Problems, Not Prescriptions

    Buying 2,3-Dihydro-1,4-Benzodioxin-6-ylmethylamine from a manufacturer should bring access to real technical support. Our engagement doesn’t stop at shipping; we troubleshoot with clients hands-on, dissecting failed syntheses, tweaking storage protocols, and sharing knowledge about specialized applications. Face-to-face on-site visits, video walk-throughs of lab setups, and open access to experienced production chemists form the backbone of our after-sales support. Projects progress faster when obstacles get cleared through dialogue, not canned advice.

    Comparing Batches: Data Not Hype

    Some suppliers tout ultra-high specifications, but we learned long ago that measured results from actual reactions matter more than paperwork promises. Our team occasionally runs competitive comparisons in model pharmaceutical reactions, publishing the findings and discussing how real-world factors like foaming, solubility, and catalyst compatibility play out. These transparency efforts let customers trust their decisions: they see actual traceability, not just claims.

    Product Development: Collaboration Over Competition

    Requests from partners and academic labs often set the agenda for future product refinements. Periodic investments in process chemistry allow us to develop new variants, adjust crystal morphology, or tailor particle size for special needs. This hands-on collaboration with researchers means more than just another checkbox in a product portfolio—it brings fresh challenges and fresh solutions, spurring us to innovate in sample dispatch, documentation, and batch reproducibility.

    Why Direct Relationships Matter For Science

    Building chemicals to spec and shipping them out doesn't capture the full picture. Direct relationships with end users—be they academic groups pushing drug discovery forward, or technical teams improving material properties—create feedback loops that elevate the standard for quality. Dry technical specs rarely flag the real stumbling blocks: our open communication culture shortens the distance between plant floor and bench scientist, making every batch better than the last.

    The Long View: Data-Driven, Result-Driven

    Quality and innovation in fine chemicals stem from hard-earned experience, an unblinking focus on measurement, and a willingness to adapt. The daily grind of plant operation—analyzing samples, running pilot batches, collaborating with end users—keeps our understanding honest. We rely on facts, not jargon, and stay anchored to straightforward principles that have fueled our progress in manufacturing 2,3-Dihydro-1,4-Benzodioxin-6-ylmethylamine. As new applications emerge, our close collaboration with scientists and manufacturers worldwide keeps the improvements flowing—not through abstract pronouncements, but through the proof measured in every delivered batch.