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2,3-Dichloroacetophenone

    • Product Name 2,3-Dichloroacetophenone
    • Alias CN_AGENT_V
    • Einecs 211-599-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    103639

    Cas Number 89-98-5
    Molecular Formula C8H6Cl2O
    Molecular Weight 189.04 g/mol
    Iupac Name 1-(2,3-dichlorophenyl)ethan-1-one
    Appearance White to pale yellow crystalline solid
    Melting Point 47-49 °C
    Boiling Point 272-274 °C
    Density 1.36 g/cm³
    Solubility In Water Slightly soluble
    Flash Point 135 °C
    Refractive Index 1.584
    Pubchem Cid 7278

    As an accredited 2,3-Dichloroacetophenone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 100g amber glass bottle with a red screw cap, labeled "2,3-Dichloroacetophenone," UN hazard warnings, and supplier details.
    Shipping 2,3-Dichloroacetophenone is shipped in tightly sealed, chemical-resistant containers to prevent leaks. It is classified as a hazardous material and must comply with local and international transport regulations, including appropriate labeling. The chemical should be kept dry, away from incompatible substances, and transported in a cool, well-ventilated environment to ensure safety.
    Storage 2,3-Dichloroacetophenone should be stored in a tightly closed container in a cool, dry, well-ventilated area, away from heat sources, ignition, and incompatible materials such as strong oxidizers. The storage area should be clearly labeled, and access should be restricted to trained personnel. Protect from moisture and direct sunlight to ensure chemical stability and minimize risks.
    Application of 2,3-Dichloroacetophenone

    Applications of 2,3-Dichloroacetophenone in Industrial Manufacturing

    2,3-Dichloroacetophenone serves as a crucial intermediate in multiple chemical production industries, with integration in advanced synthesis pathways and specialty formulations. The following sections illustrate authentic downstream application segments, specifying compliance demands, inclusion levels, integration points, and actual end products derived from industrial-scale operations.

    1. Pharmaceutical Intermediate Synthesis for Active Pharmaceutical Ingredients (APIs)

    This raw material functions as an irreplaceable building block within multi-step synthesis of benzodiazepine derivatives and related heterocyclic APIs. Facilities utilize its electrophilic properties to construct core structures under tightly regulated conditions, adhering to current Good Manufacturing Practice (cGMP) requirements and pharmacopeial specifications. Precise dosing controls enable adaptation of substitution reactions that affect product purity and pharmacological profiles.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • EU GMP Part II (APIs)
    • United States Pharmacopeia (USP) chapters relevant to API synthesis
    • Guidance for Industry: Process Validation, FDA

    Typical usage ratio

    • 0.1–0.4 molar equivalents, dependent on target molecular transformation and batch scale; adjusted based on yield optimization and reagent purity

    Downstream process integration

    • Integrated in the initial condensation or acylation phase during multi-step API routes, particularly where dichlorinated motifs enhance biological activity or alter pharmacokinetics

    Final product types

    • Benzodiazepine-based APIs (e.g., clonazepam intermediates)
    • Triazole and imidazole containing pharmaceuticals
    • Advanced pharmaceutical intermediates for further derivatization

    2. Agrochemical Synthesis: Herbicide and Fungicide Intermediate

    Manufacturers across the crop protection sector employ 2,3-dichloroacetophenone to synthesize chlorinated aromatic intermediates vital for selective herbicide and fungicide actives. This material directly enters substitution reactions to yield haloaromatic moieties required for specific field efficacy and regulatory compliance in agrochemical final products.

    Industry compliance standards

    • FAO/WHO Specification for Pesticide Products
    • ISO 9001: Quality Management Systems for agrochemical manufacturing
    • REACH Annexes VII–XI (European regulation for chemical safety in agriculture)
    • OECD Guidelines for the Testing of Chemicals

    Typical usage ratio

    • 2–10% by weight in intermediate synthesis stages, varying with target molecule structure and required chlorine substitution pattern

    Downstream process integration

    • Applied during aromatic ring chlorination or condensation reaction phases, prior to formulation of technical grade herbicides or fungicides

    Final product types

    • Chlorinated aniline and triazole herbicides
    • Phenolic fungicide actives and their technical concentrates
    • Precursor compounds for sulfonylurea and triazolinone crop protection products

    3. Specialty Dye and Pigment Intermediate

    Within synthetic colorants manufacturing, this material provides necessary dichloro-substituted aromatic backbones for dyes and pigments that require resistance to light, solvents, and heat. Formulators leverage its reactivity to introduce tailored functional groups, serving the demands of textile, ink, and plastics coloration sectors under standardized quality protocols.

    Industry compliance standards

    • Oeko-Tex Standard 100 (for restricted substances in finished textile dyes)
    • ISO 9001:2015 Quality Management for dye manufacturing
    • EN 71-3: Safety of toys – migration of certain elements (for pigment applications in consumer products)
    • REACH candidate list substance control for intermediate and finished dyes

    Typical usage ratio

    • 5–15% by weight, referenced to desired chromophore structure and dye load requirements; formulated based on targeted hue, fastness, and matrix compatibility

    Downstream process integration

    • Enters diazotization, azo-coupling, or Friedel-Crafts acylation steps to build dichloro-based chromophores prior to grinding, dispersion, or standardization stages

    Final product types

    • Anthraquinone and azo dyes for synthetic fibers
    • High-performance pigments for plastics and industrial coatings
    • Printing inks with enhanced solvent resistance

    4. Chemical Synthesis Intermediate for Perfume Ingredients

    This compound supports high-purity synthesis of aromatic intermediates used in the fragrance industry, most notably for producing musk analogs and aldehyde derivatives. Precision in its usage and handling ensures that downstream distillates meet strict sensory thresholds and IFRA-adopted safety guidelines for consumer-facing formulations.

    Industry compliance standards

    • IFRA (International Fragrance Association) Standards and Amendments
    • ISO 9235: Aromatic Natural Raw Materials for the Perfume Industry
    • Good Manufacturing Practice (GMP) for cosmetics, Regulation (EC) No 1223/2009
    • REACH compliance for aroma chemicals

    Typical usage ratio

    • 1–6% by weight, with calculation dependent on final olfactory strength and downstream conversion efficiency

    Downstream process integration

    • Used in early-stage condensation and cyclization reactions to form macrocyclic and non-cyclic musk molecules or aldehyde intermediates prior to fractionation and purification

    Final product types

    • Synthetic musk aroma chemicals
    • Aldehyde-based perfume bases
    • Complex fine fragrance compounds for personal care and home care sectors
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    Certification & Compliance
    More Introduction

    2,3-Dichloroacetophenone: Built on Experience and Purpose

    Understanding the Chemical: Value in Precision

    Consistency comes from years spent refining the synthesis of 2,3-Dichloroacetophenone. Bringing this compound off the bench and into full-scale production taught us where the real sticking points lie. Every chemist faces subtle variables—temperature drift, raw material purity, mixing regimes. Many cut corners in batch control or process monitoring. We don’t. For 2,3-Dichloroacetophenone, a product used in sensitive applications, faint shifts in isomer content or residual solvents matter more than any theoretical specification sheet admits. That’s been proven to us over hundreds of hours tracking reaction kinetics and working side-by-side with our R&D technicians in the plant.

    Sourcing and Model: From Raw Material to Reliable Delivery

    Before this chemical leaves our site, each lot passes full inspection on GC, with regular HPLC and mass spectrometry cross-checks. We don’t rely on off-the-shelf reagents with unpredictable impurity profiles. Instead, we maintain direct relationships with upstream suppliers and audit them in person—no video calls, no desk audits. The specific model designation we assign, 2,3-Dichloroacetophenone (CAS 118-97-8), reflects a product of exactly defined melting point range, strict moisture limits, and accurate assay percentages by qNMR. For research-grade requests or regulatory needs, extra purification steps get put in place as necessary, and supporting documentation isn’t an afterthought stapled to a barrel—it follows the lot from inception to shipment.

    Manufacturing Realities: Choosing the Right Chemistry

    In the past, outsourcing tempted many teams to rely on unknown reactors in distant countries, hoping for the best. We learned patience by building every critical stage of the process in-house, investing in strict environmental controls inside our chlorination units. That choice brings tighter color control, fewer trace organics, and less batch-to-batch noise—a subtlety that only frequent synthetic users will notice. This lets us guarantee a level of performance, not just compliance.

    Packing, Stability, and Lot Tracking

    Nobody wants a drum of acetophenone byproducts losing potency before it arrives. This compound may not appear fussy at first glance, but poor packaging lets light or moisture sneak past. With sealed, lined steel containers and clearly labeled batch numbers, even cold storage or longer hauls get managed without product drift. We take full accountability for every kilogram; we don’t distribute product that’s sat around longer than our internal standards allow.

    Key Uses: Why Experience Matters

    In our history, 2,3-Dichloroacetophenone mainly draws attention for specialty chemical synthesis routes and as a crucial intermediate in organic transformations. Academic groups, custom synthesis labs, and major manufacturing sites rely on it not for novelty but for backbone reliability. Diversions into impurity-laden feeds may make spreadsheets look better, but they result in lost time, failed reactions, and frustrated scale-ups. Over a decade, we’ve fielded stories from users whose work paused for weeks because they purchased an off-brand variant containing unpredictable mono- or tri-chloro contaminants. That scenario never ends well.

    Purity and Impurities: The Hidden Story

    2,3-Dichloroacetophenone seems straightforward on a certificate. The real measure sits underneath: residual monochloro isomers, stubborn corrosion byproducts, trace aldehydes. Many producers chase the next sale without learning which impurities trip up later steps in downstream reactions. In our labs, we routinely isolate byproducts and run test reactions ourselves. Sometimes this means retooling purification to chase down a persistent aromatic impurity or investing in new detector calibration. That means fewer headaches for researchers and fewer surprises for process engineers.

    Comparison: What Sets Ours Apart

    Other commercial grades tend to skate past detailed impurity tracking, relying on minimal spot checking or rapid in/out logistics. Our model stands apart: every run, every shift, data logged and scrutinized by team members who share both pride in their work and responsibility for any oversight. This tight tracking ensures consistent behavior in photochemical use, analytical standards, and as an intermediate for more complex active pharmaceutical ingredients.

    Solubility and Handling Insights

    The acetophenone backbone gives a product useful solubility in chlorinated solvents and ethers. Subtle tweaks in crystal habit can affect your weighing and mixing process—not a detail anyone puts in a standard description but one we track for our larger industrial customers. Over years of shipping, we’ve prevented supply chain snags by recognizing that minor caking or moisture uptake in the wrong packaging can change the nature of the whole process downstream.

    Lessons from the Field: Supporting End-User Safety

    We don’t approach safety as an afterthought, nor by copying regulatory text. Handling 2,3-Dichloroacetophenone takes care. Inhalation, skin exposure, accidental release—all scenarios we consider in our production training and shipping planning. We built on decades working with regulatory bodies. We’ve tracked research on toxicity, environmental breakdown, and workplace exposure to offer end-users real answers, not just legal statements. Over time, this has built trust—real, seldom-acknowledged trust between our teams and laboratories all over the world who know we won’t ignore a question about safety, waste, handling, or alternatives.

    Batch Reproducibility: Why It Matters in Real-World Synthesis

    Reproducibility in scale-up often gets underestimated, but in our direct experience, process deviations pile up fast with subpar raw materials. Some buyers see chemicals as interchangeable commodities—they find out only after major losses in yield and wasted weeks that this is not the case. For this acetophenone derivative, our approach keeps every batch aligned within tight assay limits, reducing those dreaded chemist-to-engineer headaches before they arise. Chemists and plant operators look for reliable color, melting point, and reactivity. Meeting those needs has been part of our company culture long before supply chain transparency became a buzzword.

    Real Solutions: Supporting Custom Syntheses

    Sometimes we face requests for specialized modifications or unique specifications driven by new project needs. Adjusting synthesis or purification protocols for a given client means direct conversation between our technical staff and the end-user. No guesswork, no sales office runaround. Solving obscure solubility issues, helping troubleshoot downstream conversion problems, or running custom characterization is not an exception in our operation—it’s routine.

    Building Trust with Transparent Data

    Labs and production plants want to see real supporting data, not just supplier claims. We bring in outside analytical verification regularly on our dichloroacetophenone batches. This helps us improve technique and proves to customers there’s substance behind our certificates. The supply chain has seen too many instances where forged numbers undermined long-term partnerships. We run toward auditing and traceability; our reputation grew around admitting problems when they turn up—and solving them, fast.

    Global Perspective: Meeting Regional Demands

    Markets in North America and Europe come with strict expectations for documentation, compliance, and product stewardship. Our operations answer those calls. Local customers often value speed and flexibility, while export clients want assurance over long-haul transport. Either way, our manufacturing choices consider not only the final product but also what happens after the drum gets unloaded at the user site. That’s why we invest in logistics and continuous review cycles with freight handlers and customs professionals.

    Impact of Regulations: More Than a Checklist

    Regulatory landscapes keep shifting for specialty chemicals. Our technical team tracks relevant changes, not just as a legal requirement but because our customers depend on staying ahead of the curve. When you’re developing a new agricultural compound or working on an advanced materials project, the last thing you want is to hit a regulatory roadblock from upstream non-compliance. We contribute perspective and proactive planning in major consortia focused on safe, responsible chemical manufacturing.

    Tackling Industry Challenges: Resource Sustainability

    Raw material volatility caused headaches industry-wide during recent supply chain crises. We built redundancy into our raw material procurement, contracting with multiple pre-approved partners, and maintaining on-site reserves. As demand for specialty intermediates fluctuates, we monitor shifts and keep dialogue open with customers to avoid surprise shortages. There are no magic solutions, but years spent nurturing honest relationships with both suppliers and end-users minimize shocks and keep manufacturing schedules on course.

    Supporting Emerging Applications

    Innovation rarely follows predictable timelines. In several cases, our acetophenone derivatives played roles in pilot projects for new materials or next-gen pesticides. Success in these roles didn’t come from a generic approach but from a willingness to adjust product characteristics, improve purification, or even take on new analytical challenges to help push a project past its barriers. Customization, built on stable production foundations, drives both our growth and the technical confidence our clients tell us they value.

    Why Choose Direct Manufacturing Over Third-Party Procurement

    Over the decades, companies that rely only on resellers often experience lags or surprises—stockouts, incomplete certifications, missed opportunities for technical dialogue. Being both manufacturer and technical point-of-contact, we bring facts and solutions directly to the customer. No chain of unclear responsibility and no ambiguous answers on performance or impurity profile.

    Future Outlook: Leveraging Feedback for Continuous Improvement

    Every dissatisfied customer or failed project we’ve witnessed left its mark on our internal systems. Reviewing those cases, we invested in improved monitoring and digital traceability. Product improvement isn’t just about adding new documentation or compliance files, but learning from real-life customer challenges and outcomes. New technology and evolving standards push us to test boundaries, reduce waste, and keep an open line with users who care about result-driven supply.

    Collaborative Development: Partnering for Better Results

    We welcome feedback from the lab bench and the process line. By working side-by-side with innovators who demand not just reliability but real technical understanding, we cement sturdy partnerships and accelerate discovery. Our history with 2,3-Dichloroacetophenone production underscores the value of transparent manufacturing—from starting material to final lot, from specification sheets to outcome in the user’s experiment or new process launch. This kind of collaboration drives improvement not just in our facility, but for the entire value chain relying on dependable sourcing.