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2-(3-Chlorophenyl)Ethylamine

    • Product Name 2-(3-Chlorophenyl)Ethylamine
    • Alias m-Chlorophenylethylamine
    • Einecs 249-809-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    754281

    Iupac Name 2-(3-chlorophenyl)ethan-1-amine
    Molecular Formula C8H10ClN
    Molar Mass 155.63 g/mol
    Cas Number 3886-69-9
    Appearance Colorless to pale yellow liquid
    Melting Point -
    Boiling Point 251-253 °C
    Density 1.11 g/cm3
    Solubility In Water Slightly soluble
    Smiles C1=CC(=CC=C1CCN)Cl
    Inchi InChI=1S/C8H10ClN/c9-8-3-1-2-7(6-8)4-5-10/h1-3,6H,4-5,10H2
    Pubchem Cid 86239

    As an accredited 2-(3-Chlorophenyl)Ethylamine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The packaging for 2-(3-Chlorophenyl)ethylamine (25g) features a sealed amber glass bottle with a tamper-evident cap and hazard labeling.
    Shipping 2-(3-Chlorophenyl)ethylamine is shipped in tightly sealed, chemically compatible containers to prevent leaks or contamination. The chemical is handled under appropriate safety regulations, typically as a hazardous material. Packaging is compliant with international transport standards, and temperature-sensitive conditions are maintained if required. All shipping includes safety documentation and labeling.
    Storage 2-(3-Chlorophenyl)ethylamine should be stored in a tightly sealed container, protected from light and moisture, in a cool, dry, and well-ventilated area. Keep away from sources of ignition, strong oxidizers, acids, and incompatible materials. Store at room temperature or lower if advised, and ensure proper labeling. Only trained personnel should handle and access the chemical storage area.
    Application of 2-(3-Chlorophenyl)Ethylamine

    Applications of 2-(3-Chlorophenyl)Ethylamine in Industrial Manufacturing

    2-(3-Chlorophenyl)Ethylamine supports several advanced manufacturing disciplines as a precision intermediate essential for pharmaceutical synthesis, agrochemical development, and fine chemical production. As the original manufacturer, we emphasize its integration in the following specialized downstream sectors, where its chemical profile delivers true application value from synthesis through to final product formulation.

    1. Active Pharmaceutical Ingredient (API) Synthesis for CNS Drug Intermediates

    This intermediate plays a pivotal role in the assembly of central nervous system (CNS) active compounds, where precise substitution patterns on aromatic amines shape target pharmacological activity. During the multi-step API synthesis, our material introduces a 3-chlorophenyl ethylamine moiety at a defined step, establishing core structures for several investigational drugs. Manufacturers tune loading based on route optimization and target molecular weight, with strict adherence to global pharmaceutical quality directives and trace impurity controls necessary for regulatory approval.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice (GMP) for Active Pharmaceutical Ingredients
    • EU EudraLex Volume 4, Part II: GMP for APIs
    • US FDA 21 CFR Part 211: Current Good Manufacturing Practice in Manufacturing, Processing, Packing, or Holding of Drugs
    • Chinese Pharmacopoeia API standards (ChP)

    Typical usage ratio

    • 0.85–1.10 molar equivalents per core assembly step, adjusted for side reactions and yield optimization; proportion may shift in process scale-up following pilot campaign results

    Downstream process integration

    • Amine coupling or reductive amination sequence following halogenation or protection/deprotection steps; charging occurs post-solubilization in polar aprotic solvents under inert conditions

    Final product types

    • Psychoactive agent intermediates targeting neuroreceptor modulation
    • Serotonin and norepinephrine analog drug candidates
    • Small-molecule CNS drugs in clinical development

    2. Agrochemical Synthesis: Herbicide Intermediate

    Downstream agrochemical operations utilize this amine derivative to construct select herbicidal actives featuring halogen-substituted phenyl ethylamine backbones. The compound acts as a critical synthon for ring-functionalized agents designed to disrupt plant-specific metabolic pathways. Producers rely on precise dosing during the condensation reactions to maintain crop protection efficacy and environmental safety, complying with agricultural chemical standards globally.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • EU Regulation (EC) No. 1107/2009 for Plant Protection Products
    • US EPA 40 CFR Part 158 Data Requirements for Pesticides
    • China GB/T 16000 Quality Standard for Pesticide Technicals

    Typical usage ratio

    • 0.7–1.3 mole per target molecule depending on scale, catalyst efficiency, and substitution yield in cyclization/carbonylation steps

    Downstream process integration

    • Introduced during secondary amine formation (Mannich or alkylation reactions) post-aromatic functionalization; maintained under controlled pH to prevent by-product formation

    Final product types

    • Pre-emergent and post-emergent herbicide actives
    • Field-ready herbicide formulations for cereals and legumes
    • Selective weed control products for commercial agriculture

    3. Fine Chemicals: Photoinitiator Intermediates

    This aromatic amine intermediate enables production of functionalized photoinitiators applied in UV-cured coatings and inks. Conversion proceeds via amide or imine coupling, yielding chromophores tailored to absorb specific UV wavelengths. Fine chemical processors regulate input closely, balancing purity and reactivity to meet end-user specifications for curing speed and migration limits in UV-cured materials.

    Industry compliance standards

    • EN ISO 9001: Quality Management Systems for Chemical Processing
    • REACH Regulation (EC) No 1907/2006 for Chemical Safety
    • GMP for Fine Chemicals per EXCiPACT Certification
    • Swiss Ordinance on Materials and Articles (SR 817.023.21) for Printing Inks

    Typical usage ratio

    • 0.6–1.0 equivalent per chromophore layer depending on target absorption and polymer matrix compatibility; purity levels above 98% required for downstream polymerization stability

    Downstream process integration

    • Charged as nucleophile in amidation or imination steps under controlled reaction temperature; quick removal of unreacted amines to minimize UV absorber instability

    Final product types

    • UV-cured coating photoinitiators for electronics
    • Offset and inkjet printing ink photoinitiators
    • Adhesive formulation initiator blends

    4. Specialty Material Synthesis: Liquid Crystal Intermediate

    In the specialty materials sector, aromatic amines with halogen handles form backbones for various liquid crystal molecules, particularly in engineered displays and optical devices. Precision integration ensures transition temperatures and dielectric properties align with application-specific performance metrics. Liquid crystal manufacturers employ exact addition strategies to enhance purity, as off-stoichiometry affects phase stability and image fidelity in terminal display panels.

    Industry compliance standards

    • IEC 62899-202 Standards for Printed Electronics
    • ISO 9001:2015 for Advanced Materials Manufacturing
    • JEITA EM-3506B: Standard for Materials for Liquid Crystal Displays
    • RoHS Directive (2011/65/EU) for Restriction of Hazardous Substances

    Typical usage ratio

    • 0.9–1.05 molar equivalents per mesogenic core assembly, typically 100–120 g per kg of final precursor, based on specific nematic or smectic liquid crystal structure requirements

    Downstream process integration

    • Introduced in mesogenic unit coupling or as a reactant for end-group functionalization; staged addition in nitrogen-purged vessels to prevent oxidative contamination

    Final product types

    • High-purity nematic and smectic liquid crystal compounds
    • LCD and OLED panel fluid precursors
    • Optical phase retarders and display alignment layers
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    Certification & Compliance
    More Introduction

    Introducing Our 2-(3-Chlorophenyl)Ethylamine: A Manufacturer's Perspective

    Understanding 2-(3-Chlorophenyl)Ethylamine in Industrial Contexts

    As a producer specializing in specialty organic chemicals, our facility has spent years refining routes to create 2-(3-Chlorophenyl)Ethylamine with a high level of process reliability. This compound, recognized by chemists for its aromatic chloro substitution and flexible ethylamine side chain, supports many downstream syntheses. Researchers and manufacturers working on advanced intermediates, pharmaceutical building blocks, or novel agrochemical candidates often depend on this molecule when classic feedstocks do not provide the selectivity needed for further modifications.

    Drawing from our own batch records, we know the difference a strict manufacturing environment makes. Consistent purity, above 98% by GC, sets the foundation for reproducible results in multi-step syntheses. Uncontrolled trace byproducts can complicate scale-up or introduce unpredictable reactivity. We address these risks by integrating multi-stage distillation and chromatography into our upstream processes, and by maintaining end-to-end traceability for each lot.

    Model, Specifications, and Handling in Production Settings

    Our current production model prioritizes both output and worker safety. The crystalline or liquid form of 2-(3-Chlorophenyl)Ethylamine depends on the storage temperature and batch concentration, and our reactors and purification lines accommodate both. Every year, our technical team reassesses specification targets based on direct feedback from regular clients. We realized early on that receiving a batch with inconsistent melting point could derail an entire synthesis plan. For this reason, our published melting point range cites values from in-house validated equipment, giving researchers reliable benchmarks for their methods.

    In containerization, moisture sensitivity triggers concerns among our team. We use nitrogen blankets during storage and transfer. Customer reports from years past, where lesser-protected product picked up water from the environment, continue to guide us to improve this part of our process. Working as the actual manufacturer means each logistic improvement, whether double sealing or improved drum selection, gets implemented to avoid recurring issues.

    Application Diversity and Customer Feedback

    We interact most with companies developing either pharmacologically active compounds or pesticide candidates, who are seeking intermediates built on chlorinated phenyl structures. Some pursue new antidepressants, referencing literature where this ethylamine backbone forms a critical scaffold. Others leverage the amine portion for further N-alkylation, acylation, or cyclization, which benefits from a starting material of known reactivity and defined impurity profile. Our technical support group, staffed by experienced chemists, receives a steady stream of synthesis troubleshooting queries—usually from labs running pilot projects or scaling up batches for field trials.

    Academic collaborators sometimes request smaller aliquots for SAR (Structure-Activity Relationship) explorations. They cite the value of batch-to-batch reproducibility. In this environment, we receive candid feedback: solvents used in final purification, storage container shape, and even labeling clarity matter just as much as the analytical certificate. Years of these exchanges informed our practice. For instance, there was a period when clients experienced delays due to imprecise labeling—each incident led us to revise our process and retrain warehouse teams.

    Production Experience: Avoiding Pitfalls and Reducing Contaminants

    From our experience, subtle shifts in reagent quality or reaction times can have outsized effects on chlorinated aromatic compounds. Initially, we fought recurring issues where trace isomers complicated the chromatogram. Our laboratory teams launched a campaign to identify contamination sources, eventually tracing some to raw materials from suppliers whose own quality systems had drifted over time. We responded by narrowing down to a small group of audited suppliers and running more frequent incoming inspections.

    Our main analytical chemist remembers a learning process during one summer where elevated ambient humidity in storage bays led to marginal hydrolysis of stored product. Now, each order passes through a climate-controlled room before dispatch. Technicians record data in real-time, and unusual spikes trigger review and root cause investigation. Technical rigor at the manufacturing level stands between a successful downstream synthesis and a failed batch, and we organize our entire workflow to respect that.

    Comparison With Other Aromatic Ethylamines

    We receive regular requests to compare 2-(3-Chlorophenyl)Ethylamine with other similar compounds, such as the non-chlorinated phenylethylamines or ortho/para-chloro analogs. The meta-chloro variant we produce gives a balance of reactivity and stability not always matched by its peers. Based on our R&D pilot programs, we find that the position of the chloro group determines not only electronic distribution, but also solubility and compatibility with various catalysts. Subtle differences in reaction time or conversion are often explained by this structural variation.

    Clients who initially used the para-chloro derivative sometimes report solubility challenges or poor performance during coupling reactions, particularly under phase transfer conditions. Our QC group has run side-by-side tests, confirming superior behavior of the 3-chloro analog in solvent combinations useful to scale-up. Periodic literature reviews back up these findings, especially in syntheses where downstream functional groups either activate or deactivate the phenyl ring.

    Some customers new to using meta substitution expect reactivity patterns similar to the unsubstituted homologue. Based on factory data, we caution that this assumption often leads to lower than expected yield or byproduct formation at different stages. Chemists at our own facility adjust reaction temperature or base selection to optimize transformation, and we routinely pass on these learnings to clients working to streamline their process.

    Quality as an Ongoing Process, Not a Marketing Point

    A manufacturing mindset means product quality starts from raw materials and ends only after our client’s process performs as expected. Laboratory staff, operators, and warehouse handlers each carry experience handling 2-(3-Chlorophenyl)Ethylamine under production-scale conditions. They know that rushing through a reaction cooldown or skipping a filter change risks contamination—lessons reinforced by years of root cause analysis.

    Customers have approached us with concerns about color changes, or unexpected odor from shipments stored longer than expected in hot climates. Each legitimate concern becomes a prompt for actions—a shipment review, a process step audit, or a stability test under more aggressive conditions. Rather than rely on generic “guarantee statements”, we maintain a dialogue with regular clients about long-term storage, sample retention, and documentation standards.

    We have expanded our in-house reference library, building a record for each batch and each modification in synthetic approach. If a client ever observes a shift in performance, we can trace it backward within our internal systems. Open transparency, rather than generic compliance promises, makes the difference when troubleshooting a synthesis hiccup.

    Safety, Compliance, and Worker Perspective

    Though the chemical structure offers significant value as an intermediate, it presents hazards intrinsic to amine organics—strong odor, skin or eye irritation, and flammability under some conditions. Our operations team wears personal protective equipment specific to handling amines, not only to meet regulations, but to protect the technical crew’s long-term health. In periodic safety reviews, supervisors raise real world incidents—splash exposures, vapors during drum opening, or container pressure build-up—that collectively shape our policies.

    The regulatory landscape around aromatic amines demands diligence: our shipments include labelling designed to match current directives, and we archive all proof of compliance. Every regulation update triggers a review led by our compliance specialist, not only to satisfy client audits, but to keep our crew informed and protected. Years spent handling compounds like 2-(3-Chlorophenyl)Ethylamine bring respect for the risks and emphasize storage, handling, and response protocols.

    Sustainability in Manufacturing: Actual Practices and Challenges

    Looking at environmental impact, producing chlorinated aromatics compels scrutiny of emissions, waste management, and solvent recovery. Our factory invested in upgraded fume scrubbers and activated carbon beds based on regular atmospheric monitoring. The site environmental officer monitors discharge streams for residual chlorinated organics, issuing maintenance or improvement work orders where metrics exceed internal thresholds. During expansion projects, our team favored equipment with reduced solvent usage, and we capture feedback from staff about process bottlenecks leading to unnecessary waste.

    Everyone in the production chain benefits from clear procedures on spill response and hazardous waste. Regular training sessions, driven by real-world incidents, remind us of the impact mistakes can have: on our crew, on local surroundings, and on compliance status. Rather than papering over gaps with reassurances, we prefer to engage with corporate buyers and regulatory authorities about emissions management, offering site tours and third-party test data where appropriate.

    Technical Problem Solving: Examples from the Factory Floor

    Each batch run reveals new minor variables affecting outcome. Last winter, unexpected low humidity resulted in static build-up during final transfer, prompting our technicians to ground all filling stations and alter operator workflow. Once, a supplier altered the grade of their precursor aromatic, leading to inconsistent HPLC readings at the endpoint. Because our operators routinely sample intermediates during every pump transfer, the faulty material got flagged before contaminating the entire line.

    One tipping point came during the introduction of a continuous distillation unit. Original batch-based separations struggled to keep up with demand, and operators found it hard to maintain target purity above 99%. After several iterations, including testing packing material and varied reflux ratios, the new system reduced downtime and cut waste solvent volumes by a third. Operators take pride in not just running a process, but directly influencing product consistency through their own interventions.

    Learning from Collaboration and Client Requests

    Manufacturing agility across multiple client industries encourages us to view requests as opportunities for improvement. Early on, one pharmaceutical partner flagged unusual side product formation attributed to trace metallic impurities. We overhauled both reactor cleaning processes and expanded finished product testing, learning to spot threshold trends before they became customer complaints. Even minor variation in intermediate color or odor often sparks a root cause review.

    For pilot plants or R&D labs testing the boundaries of new molecular design, our willingness to supply detailed production notes goes beyond the “standard” Certificate of Analysis. Our laboratory team fields technical follow-ups: advice on simple transfer methods to avoid product loss, purification tweaks for unusual reactor geometries, or packaging changes to fit non-standard storage. We share these learnings internally to revise operational protocols and ensure each batch better meets real client conditions.

    Differences: In-house Production Versus Reseller Sourcing

    Sourcing directly from a chemical manufacturer means more than just lower cost—it gives access to real-time process adjustments based on unique application requirements. When handling bulk orders, our line managers can modify schedule and output based on insightful feedback from established partners. Over the years, we adjusted surfactant levels, improved drying conditions, and changed packaging design all in direct response to downstream issues reported by those using this compound as a building block. As part of our client support, we track trends in requests for smaller-scale sampling, rush orders during project launches, and the shift toward more environmentally conscious packaging. Distributors and repackagers might relay product with standard documentation, but they cannot influence upstream process parameters or guarantee insight on changes in production routine.

    Direct manufacturer relationships extend to scalability guarantees. We maintain capability to ramp up volume with minimal lead time, supported by established supply chain relationships and redundant equipment. Problems arising from one-off campaigns or unreliable suppliers get resolved through direct oversight and root-cause analysis in our own facility. Where traders may struggle with batch traceability or process transparency, owning the full workflow allows us to resolve issues before they manifest in our partners’ plants.

    Value of Manufacturer Experience in Supporting Cutting-Edge Projects

    We frequently see new methods in medicinal chemistry, materials science, and agrochemical innovation that stretch traditional synthetic boundaries. Our in-house chemists and production supervisors translate journal findings and technical bulletins into plant-level modifications—sometimes swapping catalysts, sometimes revalidating purification schemes. When customers roll out projects requiring kilograms, not grams, of 2-(3-Chlorophenyl)Ethylamine, we provide both the product and advice rooted in serial batch production, direct troubleshooting, and anticipation of common scale-up challenges.

    As scientists shift to greener, more efficient routes, we engage with innovators to understand driver projects and hurdles—be it solvent swaps, shift in reaction conditions, or low-waste objectives. Manufacturing depth means our quality team offers insight into these transitions, having seen how minor parameter shifts play out over hundreds of kilograms. This insider view allows us to spot efficiency pitfalls and work proactively with those relying on our product as a launch platform for future applications.

    Concluding Thoughts: What Sets Our 2-(3-Chlorophenyl)Ethylamine Apart

    Years of hands-on experience running large-batch, continuous, and toll-manufacturing campaigns shape the way we build and supply 2-(3-Chlorophenyl)Ethylamine. We recognize this product not simply as a chemical identifier, but as the result of choices made at each production and inspection step. Every person in our organization contributes to the journey from raw material to packaged drum, grounded in the reality of day-to-day operations, safety vigilance, and honest dialogue with end users.

    Partnership with direct manufacturers means more than standardized product; it offers continuity of supply, agility in solving real synthesis problems, and open lines for technical collaboration. Using data from our operations, coupled with client input drawn from field experience, we can address new challenges as they emerge and help others build from a reliable starting point. For anyone seeking a foundation for innovation, informed by deep production knowledge and a responsive manufacturing culture, our 2-(3-Chlorophenyl)Ethylamine stands as a proven option.