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2,3,5,6-Tetrabromo-4-Methylphenol

    • Product Name 2,3,5,6-Tetrabromo-4-Methylphenol
    • Alias Bromophenol Blue
    • Einecs 242-150-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    505584

    Productname 2,3,5,6-Tetrabromo-4-Methylphenol
    Casnumber 118-79-6
    Molecularformula C7H4Br4O
    Molecularweight 468.73 g/mol
    Appearance White to off-white crystalline powder
    Meltingpoint 189-192 °C
    Density 2.69 g/cm³
    Solubility Slightly soluble in water
    Purity Typically ≥98%
    Synonyms Bromomesitol, Bromkmethylphenol
    Ecnumber 204-276-4
    Storagetemperature Room temperature, dry conditions
    Smiles Cc1c(c(c(c(c1Br)O)Br)Br)Br

    As an accredited 2,3,5,6-Tetrabromo-4-Methylphenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, 25 grams, tightly sealed with a screw cap, hazard labeling, product name and chemical formula displayed on label.
    Shipping 2,3,5,6-Tetrabromo-4-Methylphenol is shipped in tightly sealed containers, protected from moisture and light. It should be transported as a hazardous material according to local and international regulations. Ensure proper labeling and use appropriate packaging to prevent leaks or contamination. Handle with care and store in a cool, dry, well-ventilated area during shipping.
    Storage 2,3,5,6-Tetrabromo-4-methylphenol should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from sources of ignition, heat, and direct sunlight. Keep the chemical away from strong oxidizing agents and incompatible materials. Use appropriate chemical-resistant storage equipment, and ensure proper labeling to prevent accidental exposure or misuse. Store following all relevant safety guidelines.
    Application of 2,3,5,6-Tetrabromo-4-Methylphenol

    Applications of 2,3,5,6-Tetrabromo-4-Methylphenol in Industrial Manufacturing

    2,3,5,6-Tetrabromo-4-Methylphenol is a precision halogenated phenolic compound widely recognized in specialty chemical manufacturing. Our production process guarantees purity and batch-to-batch consistency, supporting specialized downstream applications requiring strict compliance and advanced process controls. Below, we outline verified industrial applications and technical guidance for integration within key sectors.

    1. Flame Retardant Synthesis for Engineering Plastics

    As a functional intermediate, this material is integral in producing high-performance brominated flame retardant additives for engineering polymers. Downstream processors incorporate it as a reactive intermediate in synthesizing polybrominated compounds, enhancing fire resistance properties in polyamides, polyesters, and thermoplastic blends. Manufacturers must control precursor reactivity and residuals to meet international safety standards for plastics employed in electronics and transportation sectors.

    Industry compliance standards

    • UL 94 Flammability Standard
    • IEC 60695-11-10 Fire Hazard Testing
    • REACH Annex XVII Restriction on Halogenated Substances
    • RoHS Directive for Electrical/Electronic Equipment

    Typical usage ratio

    • Typically 3–15% by weight in masterbatch formulations; adjust according to polymer resin type and required flame retardancy grade.

    Downstream process integration

    • Introduce during the pre-polymer melt blending or at masterbatch production phase. Control blending temperature and residence time to ensure full reaction and dispersion in base polymer.

    Final product types

    • Flame retardant engineering resins (PA, PBT, PET)
    • Cable insulation compounds
    • E&E housing plastics
    • Automotive components subject to heat and combustion

    2. Building Blocks for Specialty Reactive Dyes

    This brominated phenol serves as a key aromatic building block for the synthesis of reactive dye intermediates, valued for their stability and affinity to synthetic and cellulosic fabrics. Dye manufacturers apply it to introduce bromine substituents, which enable downstream coupling and fixation chemistry required for high-color-fastness dyes used in technical textiles and automotive interiors. Processors focus on maintaining product purity and minimizing OPPs to meet textile eco-label requirements.

    Industry compliance standards

    • OEKO-TEX Standard 100
    • ZDHC MRSL (Manufacturing Restricted Substances List)
    • ISO 9001:2015, ISO 14001:2015
    • GB/T 17592-2011 Textiles—Determination of Azo Dyes

    Typical usage ratio

    • In dye intermediate synthesis: 5–12% by mass relative to total reactant charge, adjusted by target chromophore structure.

    Downstream process integration

    • Incorporate during the aromatic substitution and coupling reaction step. Strict temperature and pH control required to prevent undesired by-product formation and to achieve uniform bromination.

    Final product types

    • Reactive and disperse dyes for synthetic fabrics
    • Technical textile colorants for automotive/upholstery use
    • High-performance printing inks
    • Dye intermediates for specialty coatings

    3. Intermediate in Pharmaceutical Active Ingredient Synthesis

    Pharmaceutical manufacturers utilize this halogenated phenol as an advanced intermediate for specific APIs and bulk drugs requiring brominated aromatic motifs. Its inclusion supports bromination steps where exact structural control may influence final bioactivity and pharmacokinetic profiles. Quality routines require rigorous residual solvent and heavy metal checks to comply with global cGMP and pharmacopoeia demands during downstream active compound synthesis.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for APIs
    • USP-NF Monograph Guidance
    • EMEA/CHMP GMP Guidelines
    • API Manufacturer's Quality System ISO 17025

    Typical usage ratio

    • Applied at 0.3–2.5 molar equivalents depending on target pathway and bromine substituent requirements of final API structure.

    Downstream process integration

    • Enter after substrate functionalization during step-wise syntheses. Employ careful temperature control and validated purification sequences to isolate and purify intermediates for onward processing to API stage.

    Final product types

    • Brominated phenolic drug intermediates
    • Specific antimicrobial or thyroid pharmaceuticals
    • Precursor compounds for radiolabeled diagnostic agents
    • Custom bulk actives for generic drug development

    4. Additive for Epoxy Resin Formulations in Electrical Laminates

    Within the advanced composites industry, processors add this material as a brominated additive to enhance flame retardancy and thermal performance of epoxy-based laminates. Its role as a co-reactive agent in cured resin systems improves char yield and circuit board rating in multilayer PCB production, helping manufacturers comply with stringent electrical fire safety regulations. Critical factors include controlled incorporation into resin blends and QC for halogen balance and curing behavior.

    Industry compliance standards

    • IPC 4101 Specification for Base Materials for Printed Boards
    • UL 796 Standard for Printed Wiring Boards
    • RoHS Directive for Halogen Use
    • IEC 61249-2-21 for Halogen-Free Base Material

    Typical usage ratio

    • Generally 6–15% (w/w) in total epoxy blend; final content adjusted based on target fire resistance (V-0, V-1 ratings) and mechanical properties of laminate.

    Downstream process integration

    • Blend into epoxy resin pre-polymer stage, prior to addition of hardener/curing agent. Optimize shear mixing, and monitor viscosity to ensure uniform dispersion and complete cure profile in press molding.

    Final product types

    • FR4-type printed wiring board laminates
    • Epoxy prepregs for multilayer PCBs
    • Thermoset molded circuit substrates
    • Electrical insulation boards for consumer and industrial electronics
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    Certification & Compliance
    More Introduction

    Introducing 2,3,5,6-Tetrabromo-4-Methylphenol

    Our Experience with 2,3,5,6-Tetrabromo-4-Methylphenol in Manufacturing

    For over twenty years, our facility has specialized in the synthesis of specialty halogenated phenols. 2,3,5,6-Tetrabromo-4-methylphenol has evolved as a keystone product in our line. Its unique arrangement—four bromine atoms tightly anchored to a methylphenol backbone—locks in chemical stability and gives it a combination of heat resistance, insolubility in water, and rare reactivity. During the early years, R&D teams inside our plant kept searching for a phenolic compound with flame-retardant behavior that could hold up during polymerization in the presence of both heat and reactive catalysts. Traditional bromophenols did not last; most would decompose, discolor, or overreact. Adding a methyl group at the fourth position, as our chemists learned, shielded the molecule, anchoring the structure and stabilizing performance during compounding and end use. We have seen demand grow steadily not only due to our high process quality but also the difficulty that comes up when other bromophenols fall short in exacting formulations.

    Detailed Model and Specifications

    Our batches of 2,3,5,6-Tetrabromo-4-methylphenol come to market as off-white to tan crystalline solid, with a molecular formula of C7H3Br4O. Each lot undergoes rigorous halogen analysis and GC-HPLC characterization; purity routinely surpasses 98%, loss on drying stays below 0.5%, and traces of related bromophenols are monitored by in-house NMR. Product consistency has been a strict priority since we first began full-scale runs. Our reactors and purification lines are set up to minimize contamination by neighboring halophenols—one of the nagging problems seen in small lab-scale syntheses. Years of troubleshooting chemical plant bugs have taught us that high product quality means fewer complaints about handling, dust, solubility variance, or yield loss during application.

    Physically, the material does not cake or form aggressive static charge due to a carefully developed drying and milling protocol. We package exclusively in lined fiber drums to guard against moisture or partial hydrolysis. Material safety and lot conformance are confirmed by our on-site QA group, which reports directly to technical sales. With every release, we issue a full certificate of analysis based on in-plant measurements. Inspection by several of our long-time OEM partners found that our batches can be dispersed or melt-compounded into target matrices without inducing unwanted tint, blooming, or filter clogging. This traceability down to individual batch numbers, not just “purity,” reinforces confidence for formulators who build critical specifications for plastics and resins.

    Product Uses and Field Performance

    Polymer and electronics industries have long chased reliable flame retardants that do not degrade under high heat. 2,3,5,6-Tetrabromo-4-methylphenol sees its principal use as an intermediate and additive in advanced polymer compositions meant for electrical housings, circuit laminates, and insulation materials that demand robust resistance to both ignition and thermal stress. Our feedback from the field points to unparalleled performance in high glass transition polymers and specialty engineered thermoplastics. Materials scientists in advanced circuit board facilities, particularly those looking for alternatives to banned or restricted flame retardants, routinely consult us for this molecule. Several larger compounders conducted in-house burn tests and sent us their data: at only 5-7% loading, final compounds could pass UL-94 V-0 criteria without waxy exudation or the drop in mechanical strength so common with alternate additives.

    In antimicrobial coatings—another demanding segment—our material offers synergistic action with silver or copper ions, proving its value for specialized paints, sealants, and plastics in public health applications. Here, the tight control over organic impurities pays off; competitors sometimes report odor, side-color formation, or reactivity with metallic components. We removed this barrier by pulling in a dedicated vacuum step after synthesis, based on direct feedback from antimicrobial formulators who struggled with prior supplies.

    We have tracked regulatory and market trends as governments placed restrictions on persistent organic pollutants. Since 2010, regulatory agencies in Europe, North America, and several Asian countries increased scrutiny on legacy flame retardants due to concerns over environmental and human health. 2,3,5,6-Tetrabromo-4-methylphenol stands apart due to controlled synthesis routes that ensure very low dioxin/furan formation. Our lab reports, shared openly with all customers, show results well below international migration standards, with each lot produced in alignment with the latest responsibilities under REACH guidelines. This is not just a technical detail; for midsize and larger users, batch-to-batch compliance avoids disruptions that can halt entire production runs if a contaminant is flagged at the customs dock or during final product certification.

    How Our Product Differs from Other Bromophenols

    We have synthesized and analyzed just about every commercial and literature bromophenol over the years. Standard 2,4,6-tribromophenol and octabromodiphenyl ether showed some flame retardant effect but introduced migration problems, polymer compatibility issues, and increasing regulatory risk. Many of our direct users previously relied on these or on brominated compounds meant for textiles or coatings. In contrast, the extra bromine substitution at the 3- and 5- positions in the methylphenol structure generates stronger electron delocalization, which improves thermal decomposition profiles during polymer processing. In one detailed customer trial, several hundreds of kilograms of lesser-substituted bromophenols left brownish streaks and encouraged resin degradation; our product maintained clarity and finished strength, freeing the quality engineers from late-stage rework.

    The methyl group at the 4-position seems like a small modification, but real-world plant runs confirm its importance. In formulations exposed to high UV or high shear, small changes in the side-group structure can spell the difference between stable performance and unwanted byproducts. Customers experimenting with analogous compounds pointed out higher volatility, less retention in finished polymers, and measurable migration leading to failure in heat aging tests. In all of our tracked application reports, 2,3,5,6-tetrabromo-4-methylphenol delivered lower volatility, greater permanence, and minimal impact on melt viscosity compared to old-guard alternatives. Large-scale batch records show not only technical advantage but also increased reliability in meeting safety and certification standards.

    Market feedback also highlights handling differences. Some older brominated phenols irritate skin or give off potent odors, deterring production staff or requiring costly air handling upgrades. Our controlled purification routes, backed by real-world exposure monitoring on our own site, keep airborne exposure well below published occupational limits. Partners testing legacy versions found more dust, stickiness, or uncontrolled particle sizes. We invested in modern mills and air-classifiers after learning from the headaches our earlier shipments caused in customers’ plants. End users no longer see shutdowns for pre-melt screening or cleaning of sticky product residue.

    Potential Challenges and our Approach to Solutions

    Making high-purity 2,3,5,6-tetrabromo-4-methylphenol consistently is demanding. Batch reactors for bromination produce a byproduct soup, especially if temperature, stirring, or feed rates drift even a little. Early process runs highlighted phase separation and runoff impurities that could sneak past basic crystallization. Our people invested months in in-process controls—carefully tracking feed behaviors, adding staged reagent addition, and slowing down quench cycles. Years of tweaking reactor baffle designs have finally paid off, cutting secondary reactions and boosting yields. We found that even small differences in solvent quality show up later as off-spec material, so we audit suppliers for every solvent and test everything that goes into the reaction pot.

    Another issue is powder handling: moisture pickup means not just caked drums, but chemical change and lost performance. Staff in our packaging section lobbied for improved closed-transfer filling and continuous nitrogen blanketing, building a system robust enough for extended transport or warehouse storage. Adopting better materials handling does not just reduce spoilage; it keeps our technical team out of emergency troubleshooting and lets users plan longer campaigns with less risk. When large-scale compounders in humid regions complained about caking, our team initiated tailored QA protocols and adjusted both storage and logistics workflows to keep every shipment fully functional upon delivery. Other facilities sometimes try to cut corners here; the result is troublesome variation down the production chain.

    Industry-wide, there is a move towards safer and more sustainable flame retardants. We speak directly with downstream processors, who now face markets with growing expectations for environmental safety, reduced toxicity, and confirmed non-persistence. High-bromine aromatic phenols attract their share of scrutiny due to brominated dioxins and potential persistence in the environment. Through advanced purification and third-party monitoring, our process heads off most persistent organic pollutant risks. We continually invest in process R&D to keep byproduct levels—specifically brominated dibenzodioxins and dibenzofurans—well under published international guidance. Results are included with every batch we ship, and our process has been adapted several times to stay ahead of both impending regulations and high-profile end-market audits.

    Many customers require secure, traceable supply, especially for product formulations under tight regulatory review. We blend just-in-time scheduling with extra buffer inventory so disruptions in the base chemicals market do not knock our factory out of sync. This strategy pulled its weight during the COVID disruptions and during spikes in halogen demand. Upcoming regulatory changes—such as those aimed at restricting additional classes of persistent brominated substances—are always part of our planning discussions. We have already invested in developing lower-bromine and mixed-halogen analogues, ready to adapt if product needs shift under new legislation or customer requests. Our direct communications with users—engineers, process managers, chemists—keep us grounded in the reality of production line challenges rather than just positive-sounding marketing commitments.

    Why Quality, Compliance, and Service Matter for Tetrabromo-4-Methylphenol

    In the crowded field of flame retardant intermediates, quality assurance and technical support still set manufacturers apart. A missed impurity in 2,3,5,6-tetrabromo-4-methylphenol does more than spoil cosmetics; it may ruin an end formula, drive up reworking costs, or even cause regulatory failure. Over the years, we have served users who shifted away from us for lower-cost material, only to return after fighting poor flow, inconsistent polymer performance, or shipment rejections based on trace contaminants. One multinational returned to our factory in need of higher quality after disqualifying two years’ worth of subpar content—highlighting that up-front scrutiny actually pays off when end-use stakes run high.

    We keep technical support lines open not just to field questions, but to help adapt material handling, dosing, and even process adjustments to specific compounder or polymerizer needs. This pays off both in customer loyalty and in the learning cycle that drives our continual improvements. Industry partners have relied not only on product quality but on our guidance—whether that means optimizing melt dispersion or offering direct solutions to process hiccups rarely addressed by generic technical data sheets. Multiple users have sent formula residues, polymer failures, or plant scrap our way for troubleshooting. We provide honest input, even if it means adapting blend ratios, adjusting shipment schedules, or collaborating on supply chain resilience strategies. End-to-end transparency, with clear lab data and lot traceability, helps users face their own internal and regulatory reviews with confidence.

    “E-E-A-T” Principles at the Heart of Production

    Our operations have always focused on trust. We employ chemists, plant operators, and QA staff with decades of direct halophenol production experience. Our operators know the consequences firsthand if raw material quality, plant hygiene, or process control slips. In the chemical industry, a company cannot keep customers on wishful thinking or vague claims; the stakes are too high in sectors like flame retardants, circuit board manufacturing, and advanced composites.

    We offer full transparency in process, from origin of key precursors through purification to final QC checks. All data, from batch certificates to environmental discharge results, is prepared by career industry professionals and submitted for third-party audits where required. Engineers and technical buyers welcome site visits or direct conference with our team to better understand our control and analytical protocols. We draw on not only our internal records but also direct customer feedback. Every product improvement comes from experience and real-world challenges, not abstract corporate goals. For years, this philosophy has steered us through changing markets, ensuring that we keep both new and long-term users equipped with detailed information and candid advice on integrating this compound into their applications.

    Continuous Improvement: Listening to the Market and the Science

    Change in the chemicals sector is constant. Regulations shift, end applications grow more demanding, and supply chains stretch ever longer. Our team routinely participates in technical workgroups and standards development, aiming for continuous improvement rather than simply defending legacy processes. Feedback loops matter—a lesson learned through cycles of growth, setback, and recovery. We prioritize the reporting of analytical data, technique upgrades, and real-time process modifications based on global standards and emerging compliance guidance. Each operator, manager, and chemist brings personal commitment to safe, consistent, and honest manufacture; this ethos draws both from past experience and a shared investment in our broader technical community.

    2,3,5,6-tetrabromo-4-methylphenol today stands as the product of thousands of lab hours, hundreds of customer conversations, and years of process adaptation. Ours is a story of learning by doing—meeting polymerization demands, responding to regulatory change, and upholding stewardship in every step of production. For users who value more than just a name on a barrel, our knowledge, accountability, and product performance bring real advantages to technical partnerships in high-stakes markets.