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2,3,4-Trichloroaniline

    • Product Name 2,3,4-Trichloroaniline
    • Alias CACL3AN
    • Einecs 219-461-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    964872

    Cas Number 634-93-5
    Molecular Formula C6H4Cl3N
    Molecular Weight 196.46 g/mol
    Appearance Light brown to beige solid
    Melting Point 63-67°C
    Boiling Point 306°C
    Density 1.54 g/cm³
    Solubility In Water Slightly soluble
    Flash Point 153°C
    Purity Typically ≥98%
    Synonyms 2,3,4-Trichloro-1-aminobenzene
    Odor Aromatic
    Storage Temperature Store at room temperature, tightly closed

    As an accredited 2,3,4-Trichloroaniline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 100g amber glass bottle with a tightly sealed cap, labeled "2,3,4-Trichloroaniline, CAS 634-93-5, for laboratory use only."
    Shipping 2,3,4-Trichloroaniline should be shipped in tightly sealed containers, clearly labeled, and protected from physical damage. It must be transported as a hazardous material according to local, national, and international regulations. Handle with care to avoid spills, and keep away from incompatible substances, heat, and sources of ignition during transit.
    Storage 2,3,4-Trichloroaniline should be stored in a cool, dry, and well-ventilated area away from sources of ignition and incompatible substances such as strong oxidizers and acids. Store in tightly sealed, clearly labeled containers, protected from moisture and direct sunlight. Ensure storage area has appropriate spill containment and is secured to prevent unauthorized access. Personal protective equipment should be available nearby.
    Application of 2,3,4-Trichloroaniline

    Applications of 2,3,4-Trichloroaniline in Industrial Manufacturing

    2,3,4-Trichloroaniline plays a significant role in several industrial manufacturing chains, serving as a key intermediate or functional component. The following sections outline specific downstream applications, technical requirements, and integration practices based on actual process knowledge from manufacturing operations.

    1. Synthesis of Agrochemical Active Ingredients

    Many agrochemical producers use 2,3,4-trichloroaniline as a building block for manufacturing selective herbicide and pesticide actives, particularly within the chloroaniline derivative class. Downstream process engineers incorporate it into multi-step syntheses, including nucleophilic substitution and condensation reactions to yield target molecules such as dichlobenil and related benzamide herbicides. Material traceability and consistency in impurity profiles remain critical during each stage, from raw material pre-treatment to final reaction. Quality assurance monitors specifically for regulated intermediates and byproduct formation at each batch step to remain within compliance guidance and customer specifications.

    Industry compliance standards

    • European REACH Directive on Substances (EC 1907/2006)
    • US EPA Pesticide Registration (40 CFR 152)
    • Chinese GB 38502-2020 Agrochemical Manufacturing Standard
    • FAO/WHO Technical Specifications for Pesticides

    Typical usage ratio

    • Varies from 0.8 to 1.3 molar equivalents per target molecule, depending on desired compound and side reaction minimization

    Downstream process integration

    • Added in the initial condensation or amidation reaction step as the primary amine source
    • Dosed directly after solvent charge, typically under controlled temperature for selective reactivity
    • Tracked for conversion via in-process HPLC or GC assay
    • Washed and isolated with product after completion of synthesis

    Final product types

    • Pre-emergence and post-emergence herbicides (e.g., dichlobenil, phenoxy herbicides)
    • Soil-applied pesticides with trichloroaniline moieties
    • Specialty crop protection agents
    • Benzamide-class weed control agents

    2. Dye and Pigment Intermediate Production

    Producers of specialty dyes and pigments use 2,3,4-trichloroaniline to introduce specific chlorine substituents on aromatic rings, enabling targeted chromophore development. Process engineers in colorant manufacturing incorporate the raw material into diazotization and coupling steps for azo, anthraquinone, and phthalocyanine dyes. The compound’s halogenation pattern imparts defined color stability and fastness, commonly required by automotive, textile, and plastics customers. Incoming quality control focuses on chlorination uniformity, amine content, and trace metal levels since these parameters affect downstream batch-to-batch consistency and regulatory release.

    Industry compliance standards

    • EN 71-3 European Toy Safety Standard (Colorants, extractables)
    • Oeko-Tex Standard 100 (Textile Safety; Class I-IV)
    • ISO 9001:2015 for Pigment Manufacturing
    • REACH Annex XVII for Aromatic Amines in Colorants

    Typical usage ratio

    • 1.0 equivalent per azo dye chromophore unit; up to 1.5 equivalents for complex pigment scaffolds

    Downstream process integration

    • Serves as the primary amine precursor during aqueous or alcoholic diazotization reactions
    • Coupled with coupling components via controlled temperature and pH protocols
    • Monitored in real-time for Free Amine and monochlorinated byproduct formation
    • Colorant purification follows with repeated washing and crystallization cycles

    Final product types

    • Disperse dyes for synthetic fibers
    • Automotive grade pigments
    • High-stability textile colorants
    • Inorganic-organic pigment preparations for plastics and coatings

    3. Pharmaceutical Intermediate Synthesis

    Within cGMP-regulated pharmaceutical facilities, chemists utilize 2,3,4-trichloroaniline in the synthesis of API scaffolds that require multi-chlorinated aromatic rings. This intermediate enters stepwise synthesis protocols for select anti-infective and anti-inflammatory drug candidates. Raw material supply adheres to strict traceability and documentation standards, with detailed impurity assessment and validated cleaning verification at each transfer point. Process validation ensures that amine purity and heavy metal limits stay within pharmacopeial thresholds to guarantee patient safety and facilitate timely regulatory submission.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP/NF (United States Pharmacopeia/National Formulary) Monographs
    • EU EudraLex Volume 4 – GMP for Pharmaceuticals
    • China Pharmacopoeia ChP General Chapters (for Intermediates)

    Typical usage ratio

    • 0.95 to 1.1 equivalents per target scaffold; ratio adjusted to minimize excessive halogen introduction and manage downstream purification loads

    Downstream process integration

    • Introduced during aromatic amination or acylation under inert atmosphere
    • Monitored in process development for impurity carryover and reaction endpoint
    • Part of fully validated batch records with lifecycle traceability
    • Subject to process analytical technology (PAT) for routine QC

    Final product types

    • Chlorinated aniline pharmaceutical building blocks
    • Finished APIs with polychlorinated aromatic motifs
    • Drug substance precursors for anti-infective actives
    • Key intermediates for contract manufacturing outsourcing (CMO/CDMO supply chains)

    4. Polymer Additive and Cross-linking Agent Manufacturing

    Manufacturers of specialty polymers and modified resins employ 2,3,4-trichloroaniline as a performance additive or cross-linker, imparting unique thermal and chemical resistance characteristics. Applications focus on engineered plastics, epoxies, and vinyl resins where the presence of multi-chlorinated aromatic units increases durability, flame retardancy, and mechanical properties. Formulators adjust dosing based on molecular weight targets and specific polymerization kinetics, with QA laboratories routinely checking for unreacted amine and extractables to ensure compliance with end-use regulations, especially in electronic and automotive substrates.

    Industry compliance standards

    • UL 94 Flammability Standard (Polymeric Materials)
    • RoHS 2011/65/EU (Heavy Metal and Restricted Substances)
    • ASTM D638 (Plastics Tensile Properties)
    • EN 71-3 (Applicable to resins for children's products)

    Typical usage ratio

    • Ranges from 0.2 to 2.0 weight percent based on polymer matrix and desired cross-linking density; lower dosing for toughening, higher for retardancy

    Downstream process integration

    • Added as a reactant or functional additive during melt or bulk polymerization
    • Dispersed in monomer blend prior to initiation of thermal/catalytic polymerization
    • Analyzed post-polymerization for uniform incorporation and byproduct elimination
    • Residual trichloroaniline content controlled through extraction and curing process steps

    Final product types

    • Flame-retardant engineering plastics
    • Cross-linked epoxy and vinyl resin systems
    • Polymer additives for electronic encapsulation
    • Compounded resins for automotive under-the-hood parts
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    Certification & Compliance
    More Introduction

    2,3,4-Trichloroaniline: A Closer Look at Its Role in Modern Manufacturing

    As chemical manufacturers, we see the entire life cycle of 2,3,4-Trichloroaniline, from raw ingredients all the way up to shipments bound for plants and research facilities. Over years of practice and observation, we’ve come to appreciate the significance of this compound in advanced material science and industrial chemistry. What sets it apart in our daily work isn’t just its molecular formula. The confluence of purity requirements, technical performance, and traceable origin makes every kilogram of 2,3,4-Trichloroaniline a testament to the responsibility that rests on the factory floor.

    What 2,3,4-Trichloroaniline Means to Practical Chemistry

    2,3,4-Trichloroaniline finds use where chemists demand a precise tool for building more complex molecules. At our plant, each batch is synthesized using only verified input chemicals, handled by trained technicians who follow tight quality controls. The resulting product appears as an off-white to pale yellow crystalline solid. This isn’t an aesthetic point; even minor color variations can betray the presence of residual impurities or unreacted starting materials, which matters deeply if the end user expects consistent results in dye intermediates or pharmaceutical research.

    Our production flow focuses on minimizing traces of unwanted isomers and related compounds, so chemists starting their syntheses from our 2,3,4-Trichloroaniline model rely on predictable reaction profiles. We run gas chromatography and high-performance liquid chromatography on every run, checking not only for chemical purity but also for moisture content, since certain reactions involving this molecule can be water-sensitive. Keeping water below 0.2% and maintaining purity at or above 99% means downstream labs and blenders spend less time troubleshooting and more time focusing on their own craft.

    Why Purity and Consistency Matter: Real-World Lessons

    Sourcing mattered less years ago, at least for smaller-scale projects. Today, research institutes and factories increasingly expect documentation all the way from the day a batch leaves the reactor. In pesticide manufacturing, a deviation of 0.1% in purity can lead to differences in the final crop protection agent’s performance, its solubility, or even just its processability in subsequent steps. Troubles on the customer’s line trace back to lapses upstream, so we double down on checkpoints.

    In practice, differences between batches often trace back to synthesis method and reaction control. For 2,3,4-Trichloroaniline, those runs that manage temperature more closely and limit byproduct formation in the reduction phase consistently produce a finer, easier-to-handle product. Experienced operators know by smell and visual inspection when a batch is veering off course, and we pair that intuition with machine data to lock down reproducibility. This tends to set product made by chemical manufacturers apart from off-the-shelf alternatives, especially where volume-driven resellers cut corners or mix sources.

    Distinctive Features in Specification and Function

    Our standard 2,3,4-Trichloroaniline model comes with a tightly controlled melting point, generally between 68 and 72°C, which signals uniformity at the molecular level. Too much deviation there means dimer formation or excessive residual solvent. By calibrating every batch for precise melting characteristics, we help downstream engineers and lab staff avoid the sort of unexpected crystallization or softening that could disrupt a synthesis or a reaction run.

    Some competitors offer similar purity but slacken their focus on controlled particle sizing. Fine, uniform crystals—generated through careful cooling and filtration—dissolve more reliably and react more evenly. This difference saves time for formulation engineers, who then avoid prolonged mixing or filtration steps during additional processing. Time and again, technical buyers mention reductions in clumping and variation in reaction rates as the tangible effect of tighter particle size control.

    Manufacturers with deep experience supply technical documentation beyond basic batch certificates. For our own records, we keep detailed run logs, impurity fingerprints using advanced analytic methods, and maintain samples for two years after production. This provides traceability for clients who must comply with regulatory inspections, not just on paper but in real operation. With environmental scrutiny on the rise, this record-keeping translates directly into peace of mind for our partners.

    Comparing 2,3,4-Trichloroaniline to Similar Compounds

    We often get asked about the difference between 2,3,4-Trichloroaniline and its close relatives like 2,4,6-Trichloroaniline or monochlorinated anilines. Each variant reacts differently under laboratory and industrial conditions. For example, the placement of chlorine atoms on the aromatic ring of 2,3,4-Trichloroaniline controls both reactivity and solubility. Chemists seeking specific intermediates for diazo compounds or pigments find that minor changes in substitution patterns lead to large shifts in the color, fastness, or toxicity of the downstream product.

    Among our clients, pharmaceutical and dye specialists choose 2,3,4-Trichloroaniline because its particular chlorine arrangement fits into further synthesis steps without extra protection or deprotection strategies. This not only streamlines production but keeps waste streams cleaner and reduces costs related to side-product handling. In laboratory validation, certain routes to advanced active ingredients require a molecule with precisely arranged chlorine atoms; using a different trichloroaniline can lead to lower yields, unusable byproducts, or extra separation work. That’s feedback we hear directly from technicians who run analytic columns and flash chromatography every day.

    Comparing our model to high-volume commodity trichloroanilines, we see better outcomes where process design limits exposure to heat and moisture, avoiding polymeric impurities and side products that may escape routine detection. Process chemists report shorter reaction times and cleaner isolation steps when working with our product, as the exclusion of colored or tarry byproducts directly reduces their own workload in purification. Those differences surface most clearly in plants scaling up from bench to pilot to multi-ton batches, where reproducibility becomes a commercial necessity.

    Safety, Handling, and Real-World Use

    Working with 2,3,4-Trichloroaniline requires attention to details that paper specifications don’t fully capture. Even small traces of dust may irritate skin and mucous membranes, so we house the production area under strict ventilation controls and use closed-system filling for bulk shipments. This also keeps airborne contaminants away from the material, preserving product quality through final delivery.

    We send out information on proper storage—dark, cool, and dry conditions—to all users, not just because that’s what regulations say but because improper storage diminishes value quickly. For one client, changes in storage protocol led to off-odors and slight clumping, which compromised weighing and dosing steps. We shared our protocols, improved the climate control in their stores, and saw the issue resolved over a single production run.

    Over years in operation, we’ve seen every manner of mishandling—from overfilling drums to ignoring trace moisture indicators in critical glassware. We invest in rugged packaging (fiber drums with inner liners or HDPE containers, depending on destination) because breakages not only cause economic loss, but may also expose staff to unnecessary risk. Close coordination with shippers and warehouse managers minimizes incident reports and has become routine at our facility.

    Fueling Progress in Research and Application

    The most innovative customers aren’t always restricted to high-tech labs; many breakthroughs come from humble facilities that value reliable building blocks. We take pride when researchers send us feedback describing successful synthesis of a new pigment or agrochemical intermediate based on our 2,3,4-Trichloroaniline. The pathway from raw material to bright new dye or pharmaceutical lead hinges on each intermediate step conforming to rigorous standards.

    Notable advances in organic synthesis arose when chemists explored new reactions using unique starting materials. By offering a product with guaranteed purity and full analytical backup, we make it easier for scientists to unlock novel routes. For example, recent developments in cross-coupling chemistry depend on having clean, well-characterized aniline derivatives. Where reaction conditions are harsh, as in C-N bond formations, the wrong impurity could deactivate catalysts or generate unusable byproducts. We contribute to progress by supplying material that won’t stall out trial runs or set back a research timeline by weeks.

    As environmental and regulatory frameworks change, requirements for 2,3,4-Trichloroaniline shift too. We constantly update our procedures in line with evolving best practices for waste reduction, energy use, and emissions management. In cases where a downstream user seeks specific certifications, we collaborate directly with third-party laboratories to generate requested reports, be it for residual solvent testing or compliance with newer hazardous substance directives.

    Addressing Ongoing Challenges

    We face continual pressure to reduce the environmental footprint of our production processes. Multi-step chemical reactions generate both desired product and byproducts, some hazardous if not managed correctly. Over time, we’ve upgraded reactor liners, installed multi-stage scrubbers for gas emissions, and improved liquid waste separation. Our plant steadily reduced releases into the atmosphere and improved recovery of usable solvents.

    Another ongoing concern is the stability of supply chains, particularly when precursors to 2,3,4-Trichloroaniline face market volatility. By securing multiple sources for core starting materials and building safety stock, we minimize interruptions for clients running critical synthesis lines. Clear, open communication with buyers has become part of our support system, ensuring nobody gets caught off-guard by delays or changes in product characteristics.

    We also invest in staff training, both for production technicians and quality analysts. The turnover of skilled workers poses real risk to continuity, but long-term employees carry invaluable practical skill—recognizing production anomalies before instrumentation picks up the problem. We support ongoing education so every hand in the plant works to the same standard of safety and care.

    Looking Forward: Adaptation in Global Markets

    Demand patterns for 2,3,4-Trichloroaniline evolve rapidly due to new regulations and shifting industrial practices. Textile dye manufacturing cycles change year by year, while agrochemical formulations must quickly adapt to new pest pressures and climate conditions. We track these changes through a mix of trade reports, direct client feedback, and industry forums, adjusting our production schedules and R&D focus accordingly.

    Emerging markets present both challenges and opportunity. Companies from diverse regions now request documentation, custom grades, or alternate container types. Our flexibility in packaging and shipping—from tanker to small bottles for research scale—reflects an understanding that manufacturers must do more than refine just the product itself; adaptability in everything from logistics to file formats for certificates adds visible value.

    Digitization has influenced our daily operation, too. We moved from paper logs to integrated digital systems that connect production output, inventory management, and quality records. This transition lets us resolve client questions about batch history or reactivity in minutes, not days, connecting every drum or bottle to its origin in the plant. It’s a far cry from the early years, when handwritten records required painstaking effort to reconcile during audits or customer claims investigations.

    Practical Collaboration: Beyond Transactional Relationships

    Our strongest relationships with users of 2,3,4-Trichloroaniline come from collaboration, not just transactions. Technical managers often reach out with questions about changing requirements or suggestions to optimize performance for a new application. We answer with more than paperwork: conversations include sharing best practices around dosing, mixing, and storage, helping users avoid problems we’ve already solved at scale.

    Site visits to customer factories or research departments provide valuable insight. By seeing firsthand how the compound interacts with other inputs and processes, we adjust production calibrations or suggest alternate grades to suit a new process. In several cases, collaborating on sample trials led to optimized particle sizes or moisture contents that improved their own product quality. Mutual trust leaves less room for miscommunication, and these partnerships often lead to long-term supply agreements built on shared goals.

    Emphasizing Safety and Responsibility

    Handling and transporting 2,3,4-Trichloroaniline can only be as safe as the diligence at every stage, from sourcing through use. We continually revise handling procedures, invest in spill protection, and enforce strict labeling and tracking of every container. This culture of accountability—shared by all staff—means fewer accidents and a record of near-miss tracking that we use to refine our operations.

    As part of the broader chemical sector, we work under intense scrutiny, and use every audit and client inspection as a learning opportunity. A single incident erodes trust built over decades, so staff training, clear documentation, and quick correction of errors keep our reputation strong and invite repeat business.

    Ongoing Evolution: Meeting Higher Expectations

    Expectations for specialty chemicals rise each year, not only in chemical performance but in supply chain transparency and safety. As manufacturers, we respond by combining proven production techniques with an openness to new technology, more responsive support, and constant improvement of analytics. The technical benchmarks for 2,3,4-Trichloroaniline become more demanding with every generation of innovation in dyes, pharmaceuticals, and agrochemicals.

    Clients often approach us with specific project needs—lower impurity levels, better documentation, faster turnaround. Our experience on the manufacturing floor gives us confidence in offering these enhancements, knowing firsthand what it means to meet specifications not just in the lab but at full industrial scale. Reliable feedback, repeat testing, and practical know-how all contribute to the secure feeling our partners report after working with us.

    Conclusion: Experience as the Basis for Value

    Looking back, the expertise that supports success with 2,3,4-Trichloroaniline does not come only from compliance documents or lists of specifications. Years of running every stage of the process, collaborating directly with end users, and adjusting to changing conditions build up a body of experience that you just cannot shortcut. Reliable processing, real-world attention to detail, and a willingness to solve clients’ problems ground our work every single day. In a fast-changing chemical industry, those factors remain our best guarantee of quality and partnership.