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2-(3,4-Dichlorophenyl)-2-Oxoethylamine Hydrochloride

    • Product Name 2-(3,4-Dichlorophenyl)-2-Oxoethylamine Hydrochloride
    • Alias DCPI-HCl
    • Einecs 'EINECS 695-975-1'
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    325542

    Productname 2-(3,4-Dichlorophenyl)-2-Oxoethylamine Hydrochloride
    Casnumber 152444-53-8
    Molecularformula C8H8Cl2NO•HCl
    Molecularweight 240.54 g/mol
    Appearance White to off-white solid
    Purity Typically ≥98%
    Solubility Soluble in water
    Storagetemperature 2-8°C (Refrigerated)
    Synonyms 2-Oxo-2-(3,4-dichlorophenyl)ethylamine hydrochloride
    Chemicalclass Aromatic amine hydrochloride
    Inchikey WMGPICJEWWQVKV-UHFFFAOYSA-N
    Smiles C1=CC(=C(C=C1Cl)Cl)C(=O)CN.Cl

    As an accredited 2-(3,4-Dichlorophenyl)-2-Oxoethylamine Hydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The chemical is packaged in a sealed, amber glass bottle containing 25 grams, labeled with product details, safety, and hazard information.
    Shipping 2-(3,4-Dichlorophenyl)-2-Oxoethylamine Hydrochloride is shipped in tightly sealed containers, protected from moisture and light. It is packed according to regulations for hazardous chemicals, with appropriate labeling and documentation. Temperature control may be applied as required, and all handling follows safety and transportation guidelines to prevent spillage or decomposition during transit.
    Storage 2-(3,4-Dichlorophenyl)-2-Oxoethylamine Hydrochloride should be stored in a tightly sealed container, protected from light and moisture. Keep it in a cool, dry, and well-ventilated area, ideally at room temperature or lower (2–8°C). Avoid exposure to incompatible materials, acids, and oxidizing agents. Ensure storage is secure and access is limited to trained personnel.
    Application of 2-(3,4-Dichlorophenyl)-2-Oxoethylamine Hydrochloride

    Applications of 2-(3,4-Dichlorophenyl)-2-Oxoethylamine Hydrochloride in Industrial Manufacturing

    As the original manufacturer, we supply 2-(3,4-Dichlorophenyl)-2-Oxoethylamine Hydrochloride to specialized industrial sectors where consistent quality and compliance with stringent regulatory requirements are fundamental to downstream production. The following application scenarios demonstrate established use cases with precise integration points, dosage guidelines, industry benchmarks, and real-world product outputs.

    1. Pharmaceutical Intermediate for CNS Active Ingredient Synthesis

    Pharmaceutical manufacturers use this compound as a key intermediate in the synthesis of central nervous system (CNS) active pharmaceutical ingredients, such as certain antipsychotics and anticonvulsants. In these settings, maintaining consistent purity and traceability throughout the batch process is critical. Integration occurs at the advanced stage of API assembly, where this raw material enters a targeted acylation or condensation reaction within a controlled reactor environment.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.), United States Pharmacopoeia (USP)
    • ISO 9001:2015 Quality Management System for API supply chain
    • FDA 21 CFR Part 210/211 Current Good Manufacturing Practice

    Typical usage ratio

    • Ranges from 0.5% to 2.8% w/w relative to the total mass of finished API, depending on target molecule and conversion yield; precise proportion set according to validated synthetic route and molar stoichiometry.

    Downstream process integration

    • Batchwise or continuous reaction as a nucleophilic building block in multi-step synthesis of CNS pharmaceuticals
    • Integration after initial halogen exchange or deprotection phases
    • Incorporation within reaction vessels equipped for strict temperature and atmosphere control
    • Subsequent purification by crystallization or liquid-liquid extraction

    Final product types

    • Antipsychotic drug APIs (e.g., derivatives for atypical antipsychotics)
    • Anticonvulsant APIs
    • CNS disorder research molecules
    • Reference standards for pharmaceutical development

    2. Agrochemical Synthesis Intermediate (Herbicide Prodrugs)

    Agricultural chemistry formulators employ this substance as a synthesis intermediate for producing herbicide prodrugs with selective action. Precision in the input ratio and purity impacts the overall efficacy and environmental profile of the finished agrochemical. This compound typically enters the formylation or amide coupling stage to generate advanced precursors for crop protection solutions.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • ISO 9001:2015 for chemical manufacturing
    • REACH Regulation (EC) No 1907/2006 for European markets
    • China GB2763 - Maximum Residue Limits for Pesticides

    Typical usage ratio

    • Utilized at 1.0–4.0% w/w of precursor material, based on the desired yield and conversion efficiency in target molecule synthesis; adjusted to optimize downstream purification requirements.

    Downstream process integration

    • Reacted in a sealed reactor with subsequent in-situ modifications, such as carbamate or urea linkage formation
    • Enter at the intermediate coupling phase after halogenated aromatic core assembly
    • Product isolation via solvent extraction and purification by preparative chromatography
    • Analytical QC by HPLC/GC prior to bulk formulation

    Final product types

    • Pre-emergence herbicide prodrugs
    • Post-emergence selective herbicide actives
    • Herbicide formulation standards for regulatory testing
    • Agrochemical R&D reference materials

    3. Fine Chemicals: Custom Synthesis Building Block

    Manufacturers of fine chemicals integrate this chlorinated amine as an advanced building block for contract synthesis projects, including specialty molecules for material science research and diagnostics. Customers specify usage based on precise functional group requirements in heterocyclic and aromatic frameworks. It generally joins reactions during amidation, reductive amination, or Michael addition in gram-to-multikilogram scale synthesis.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for specialty chemical production
    • Responsible Care® management systems
    • Global Harmonized System (GHS) labeling for all supply stages
    • Specific customer quality agreements and analytical protocols

    Typical usage ratio

    • Ranges from 0.2% to 5.0% w/w depending on molecular design, scale, and yield targets; ratio set by route optimization during custom project development.

    Downstream process integration

    • Added as a functionalized amine in closed reactor set-ups for controlled coupling
    • Mid-stage insertion in multi-step organic synthesis
    • Subjected to continuous or batchwise QC, including NMR and LC-MS analysis
    • Final downstream purification by column chromatography or recrystallization

    Final product types

    • Fluorescent probe precursors for diagnostics
    • Heterocyclic specialty intermediates
    • Reference compounds for analytical standards
    • Functionalized monomers for polymer research

    4. API Impurity Marker and Analytical Reference Compound

    Quality control laboratories in the pharmaceutical industry use this compound to synthesize regulatory-specified API impurity markers and set analytical calibration standards. These uses require exceptional traceability to original manufacturing lots, along with certified purity documentation, as they form the benchmark for regulatory submission and internal release testing.

    Industry compliance standards

    • Good Laboratory Practice (GLP) as per OECD Guidelines
    • USP <1086> Impurities in Drug Substances and Drug Products
    • ICH Q3A/B Impurities Guidelines
    • ISO/IEC 17025 Laboratory Accreditation for reference material standards

    Typical usage ratio

    • Introduced at ≤0.1% w/w for analytical spiking based on validated calibration protocols; concentration adjusted to reflect detection limits of regulatory methods.

    Downstream process integration

    • Synthesis of certified impurity standards for HPLC, LC-MS, or GC-MS calibration curves
    • Preparation of spiking solutions in QC laboratories
    • Direct dissolution and filtration under controlled atmosphere
    • Documentation accompanying each batch for audit traceability

    Final product types

    • Certified impurity reference standards
    • Regulatory analytical kits for API batch release
    • Calibration blends for validated testing methods
    • Stability study marker compounds for finished dosage forms
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    Certification & Compliance
    More Introduction

    2-(3,4-Dichlorophenyl)-2-Oxoethylamine Hydrochloride: A Manufacturer’s Perspective

    Introduction to Our Product

    As a chemical manufacturer focused on high-specification intermediates, we produce 2-(3,4-Dichlorophenyl)-2-Oxoethylamine Hydrochloride under rigorous quality protocols. This compound, recognized for its role in specialty synthesis, presents a reliable choice for research firms and firms developing next-generation pharmaceuticals. Over the years, we have fine-tuned processes to balance purity, consistency, and yield, aiming to meet growing demand for dependable supply chains. Through our hands-on experience scaling this molecule, we have gathered substantial insight on both its technical profile and its practical value in the laboratory and production environment.

    Our Model and Specifications

    Every batch of 2-(3,4-Dichlorophenyl)-2-Oxoethylamine Hydrochloride is produced in-house, using refined solvent extraction and recrystallization steps to ensure clarity and steep purity margins. We've analyzed and verified each lot using advanced chromatography and NMR, regularly achieving assay values above 99%. Impurities common in less controlled syntheses—such as oligomeric byproducts or unreacted chlorinated benzene derivatives—are held well below 0.25%. Our finished product appears as a stable, white to off-white crystalline powder, free from agglomerates, with measured water content under 0.3%. Every kilo leaves our floor after passing thorough checks for melting range, bulk density, and residual solvent, all tailored to deliver a substance both reliably reactive and manageable for end-users.

    Manufacturing Process and Compositional Reliability

    The truckloads of reagents we receive do not become valuable intermediate materials by accident. We've invested in both people and automation to catch fluctuations at every step. Our continuous monitoring has taught us that temperature control—right down to the degree—determines side reactions. Water quality and airflow during crystallization also affect the ease of handling in downstream processes. Staff receive regular hands-on training on these points, as subtle missteps cascade into scale losses or product deviation. We regularly recalibrate instruments, replace filter cartridges, and validate material traceability. Such attention often makes the difference between a clean batch and a problematic one, especially on a commercial scale where tiny variations multiply. Customers share feedback that the consistent handling properties from batch to batch translate into smoother integration on their production lines.

    Practical Use-Cases and Working Insights

    Feedback from our clients points to reliable results using our 2-(3,4-Dichlorophenyl)-2-Oxoethylamine Hydrochloride as a versatile intermediate. Many synthesis pathways that require this component rely on its high reactivity and purity profile. Our chemists have observed smoother downstream reactions when this product forms the starting amine segment or goes through N-alkylation. Yields stay high, with fewer side-reactions compared to others on the market.

    Applications are mainly research-based, often in novel pharmaceutical lead compounds, but we’ve seen uptake from agrochemical and specialty material firms. Customers using micro-gram to multi-kilogram quantities report fewer filterability issues or undesired discoloration, even in moisture-sensitive or high-temperature transformations. In direct practice, time lost from recurrence of impurities can mean project delays and operational headaches—something we work to minimize by holding close control of particle size and chemical integrity.

    Technical Differentiators and Advantages Over Other Offerings

    We have often received samples from clients who reached out frustrated by unreliable batches from other sources. In our quality-control lab, we see a clear difference in lot-to-lot reproducibility. Many generic suppliers do not invest in frequent process reviews, and the effect shows as unexpected melting point shifts, off-odors, or the presence of tars and resinous residues. These issues can require repeated re-work or, worse, stall ongoing synthesis.

    By optimizing our workflow—for example, through the use of multi-stage filtration and calibrated crystallization—we hold down trace amines, colored impurities, and insoluble particulate contamination that would otherwise snarl precision applications. Our fully validated process enables us to supply at a higher scale without widening confidence intervals or compromising specifications. What this means for end users is less time spent correcting for inconsistent input, and a greater freedom to focus on exploratory or production chemistry.

    Quality Control and Documentation

    Consistent product performance begins with transparent documentation. Every drum carries a tested certificate, backed by a web of retained samples and batch history. Our clients value being able to audit every aspect: starting materials, processing conditions, and storage parameters. We've seen that clear, prompt responses to quality queries build longstanding partnerships. The facility receives regular internal reviews, plus audits from long-term client teams. Lab data comes directly from and is signed off by our team leads, avoiding the “black box” effect that often complicates troubleshooting by the end-user.

    Experience tells us that specification drift often starts creeping in long before it shows up in product appearance. In our company, we regularly test for both targeted analytes and unsought-for contaminants, using both classical titration and advanced spectrophotometry. Material stays quarantined until all required parameters pass review—no skipping steps or releasing batches on schedule pressure alone. Our goal is to eliminate rework, avoid customer complaints, and reduce waste, in a way that keeps everyone’s downstream work less stressful.

    Handling and Integration Feedback

    Some intermediates are notorious for clumping, excessive dust, or unpredictable static properties. Through careful choice of drying conditions and packaging, our teams have minimized handling annoyances. The product pours without sticking during dispensing, avoiding material loss and waste. Bulk lots also pack consistently in lined containers, limiting airborne particle escape—a point raised by partners concerned with both worker safety and weighing accuracy in high-precision transformations.

    Handling feedback from repeat users continues to drive our batch-to-batch adjustment philosophy. Internal observation and open channels for customer input have allowed us to catch possible weak points before they become process interruptions. As a result, users mention faster integration into production lines and less need for on-site reprocessing steps. In a few published collaborations, project leads noted that faster initial dissolution and lack of foreign particles helped speed up pilot-scale experiment cycles.

    Comparison with Market Alternatives

    Competing offerings often fail to meet strict impurity or moisture thresholds or offer spotty documentation or inconsistent supply. Clients switching from other producers find stark differences in reproducibility over multiple lots. Peers may cut corners by relaxing washing or drying standards, which translates into brown tints, inter-batch lumps, or the need for in-house polishing. Low-cost batches from unregulated vendors sometimes carry questionable solvent residues or incomplete analytical profiles.

    We maintain a stable, locally sourced supply of starting materials which prevents the kind of sudden shortages or substitutions that can creep into third-party or trading house models. Our direct manufacturing ties reduce lead time and enhance responsiveness to design changes. Firms working under validated environments tell us that our clear batch-release process helps them tie their input chemicals to regulatory compliance filings—something less accessible via middlemen or dealers.

    Having longstanding experience with regulatory documentation has helped navigate changes in demand and compliance standards. Our process transparency supports rapid qualification in both research and wider markets. We do not rely on off-the-shelf methods alone—instead, our internal R&D continually investigates process improvement, adjusting to both scientific progress and practical customer feedback.

    Supporting Continuous Innovation

    Working with drug research firms and specialty material developers highlights the central role stable intermediates play in cycle times. We recently partnered with an innovation-driven group seeking to optimize a step using our 2-(3,4-Dichlorophenyl)-2-Oxoethylamine Hydrochloride. Their previous suppliers delivered lots with shifted reactivity, torpedoing monthly throughput targets. With us, they observed greater predictability, which translated into more laboratory flexibility. Our perspective from the factory floor is that a chemical is more than the sum of its purity figures or assay sheet—a manageable, reliable product accelerates broader program goals and helps creative teams push boundaries.

    Over years, we have observed that root cause analysis on failed syntheses often traces back to mediocre starting materials. Sometimes, barely-visible shifts in color, powder texture, or moisture quietly disrupt major downstream steps. We treat every technical inquiry as a chance to learn and adapt, supporting not just individual sales, but better chemistry outcomes and programs that might one day deliver real advances in medicine or technology.

    Process Safety and Environmental Management

    Direct oversight lets us address both worker safety and environmental management proactively. By refining temperature controls and exhaust systems, we've limited exposure to fugitive emissions and batch runoffs. Our waste stream is monitored at several points, with spent solvents reclaimed and solid byproducts tracked for secure disposal. In our experience, good environmental practice is not just about compliance, but preventing extra process steps or corrective actions that ultimately slow down production and increase resource use.

    Several clients have visited our facilities as part of their own due diligence. Walkthroughs often highlight controlled material flow, PPE standards, and batch documentation. These open-door audits provide reassurance—for both our clients and our own staff—that the route from raw material to finished compound is being managed thoughtfully. We continually update protocols as new environmental regulations evolve, and take satisfaction from running operations that match both technical and societal expectations.

    Supply Chain Continuity and Technical Partnership

    Experience tells us that reliability in bulk intermediates depends not just on good technical methods, but on managing sources, forecasting, and communication. We develop redundancies for critical starting materials, both chemically and logistically. Advance communication with client procurement departments helps avoid delivery gaps, even at higher frequency schedules. Key partners have asked for direct integration into their ERP and forecasting systems—an accommodation we've supported—to ensure forward planning on both sides.

    As production scales up or custom derivatives gain traction, requirements often shift. Direct manufacturer-to-client exchange has shortened turnaround times for documentation, regulatory support, and minor order modifications. Many of our long-term clients initially approached with single-use orders, later developing broader technical partnerships as they discovered how much easier side-by-side process troubleshooting becomes with open technical access. Such relationships thrive on the shared understanding that delays—even minor ones—carry financial and project risks that outstrip any savings from lower-quality alternatives.

    Training and Support for End Users

    Our team frequently assists firms onboarding new technical staff or transitioning to larger scale. Workshops, both remote and in-person, give practical tips for handling and integrating the compound. On several occasions, our QC experts have joined client teams in diagnosing unexpected outcomes—blending operational experience with technical expertise. Access to our in-house analytical resources means technical support extends beyond simple product replacement or returns.

    We find that these training opportunities become two-way streets. Field experiences, from sluggish reactions to outlier batch behaviors, guide feedback loops. We have translated several external troubleshooting lessons into tighter process controls or updated specifications. The boundary between supplier and technical partner blurs as knowledge is shared, leading to more effective solutions for all parties.

    Looking Ahead: Commitment to Quality and Innovation

    Markets, regulations, and application fields do not stay fixed, and neither do we. Our operations team meets regularly to review both near-miss events and process improvement ideas, sourced from shop floor to customer interface. The growing complexity of specialty chemical and pharmaceutical synthesis places even greater weight on reliable, predictable building blocks. Every insight gained—whether during production, customer support, or technical troubleshooting—feeds back into our operating manual.

    There are no shortcuts to building the reputation we've earned for this intermediate. Years of continuous production, rigorous documentation, and attention to client needs drives both our current capabilities and vision for ongoing growth. We see ourselves not merely as suppliers, but as supporters of research, innovation, and the genuine advancement of science and technology. Every drum leaving our facility carries this commitment.

    Conclusion

    Producing 2-(3,4-Dichlorophenyl)-2-Oxoethylamine Hydrochloride is more than an exercise in meeting a spec sheet—it means attention to every upstream and downstream point where care and expertise can improve outcomes. Manufacturing at scale reveals both opportunities and pitfalls; our approach aims to learn and adapt without sacrificing integrity or responsiveness. Those working on the next generation of pharmaceutical, materials, or agricultural products benefit from intermediates whose value arises from solid, attentive practice at every stage. In an industry where detail determines outcome, we stand by a product—and a process—shaped by experience, technical rigor, and honest feedback from those who build on what we deliver.