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2-(3,4-Dichlorobenzyl)-1H-Benzimidazole

    • Product Name 2-(3,4-Dichlorobenzyl)-1H-Benzimidazole
    • Alias Fenbendazole
    • Einecs 259-627-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    192662

    Chemical Name 2-(3,4-Dichlorobenzyl)-1H-Benzimidazole
    Molecular Formula C14H10Cl2N2
    Molecular Weight 277.15 g/mol
    Cas Number 32852-98-1
    Appearance White to off-white solid
    Melting Point 164-167°C
    Solubility Slightly soluble in water
    Structure Type Benzimidazole derivative
    Synonyms 3,4-Dichlorobenzyl-2-benzimidazole
    Inchi InChI=1S/C14H10Cl2N2/c15-12-5-6-13(16)11(7-12)8-10-9-17-14-4-2-1-3-11(10)18-14/h1-7,9H,8H2,(H,17,18)
    Smiles C1=CC=C2C(=C1)N=C(N2)CC3=CC(=C(C=C3)Cl)Cl
    Application Pharmaceutical intermediate, research chemical
    Storage Conditions Store in a cool, dry, well-ventilated area

    As an accredited 2-(3,4-Dichlorobenzyl)-1H-Benzimidazole factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 25 grams of 2-(3,4-Dichlorobenzyl)-1H-Benzimidazole, tightly sealed, with hazard and identification labels.
    Shipping 2-(3,4-Dichlorobenzyl)-1H-Benzimidazole is shipped in tightly sealed containers, protected from moisture, heat, and direct sunlight. It is handled as a chemical substance, complying with local and international regulations. Packaging is designed to prevent leaks and contamination, and transport is typically via ground or air by certified carriers.
    Storage Store 2-(3,4-Dichlorobenzyl)-1H-Benzimidazole in a tightly sealed container, away from light, heat, and moisture. Keep it in a cool, dry, and well-ventilated area. Ensure compatibility with other chemicals and avoid strong acids, bases, and oxidizers. Label containers clearly and follow laboratory safety procedures. Store in an area designated for hazardous organic compounds.
    Application of 2-(3,4-Dichlorobenzyl)-1H-Benzimidazole

    Applications of 2-(3,4-Dichlorobenzyl)-1H-Benzimidazole in Industrial Manufacturing

    As a primary manufacturer, we supply 2-(3,4-Dichlorobenzyl)-1H-benzimidazole to key downstream sectors. This specialty intermediate integrates into advanced chemical syntheses, contributing directly to the formulation of value-added industrial products through established and compliant processes.

    1. Systemic Fungicide Production for Crop Protection

    This benzimidazole derivative forms a core building block in the synthesis of agricultural fungicides. Companies in crop protection utilize it to formulate active ingredients targeting a range of fungal pathogens. It aligns with strict regulatory requirements for food-chain safety. During manufacturing, the compound enters as a controlled precursor in multi-step reactions that yield systemic or contact fungicidal actives, which downstream processors formulate into commercial crop treatment agents.

    Industry compliance standards

    • FAO/WHO JMPR pesticide specifications
    • EU Regulation (EC) No 1107/2009 on plant protection
    • ISO 9001:2015 for agrochemical quality management
    • US EPA registration requirements for formulated products

    Typical usage ratio

    • 5–20% by weight in synthesis of technical-grade fungicidal actives; final ratio depends on targeted potency and downstream formulation requirements

    Downstream process integration

    • Reacted in condensation or substitution steps during technical material synthesis
    • Incorporated prior to crystallization, purification, and milling
    • Actives further blended with inert carriers and adjuvants for dispersible powders and suspension concentrates
    • Full traceability required from intermediate handling to batch QC release

    Final product types

    • Systemic and contact agricultural fungicides (wettable powders, flowable concentrates, seed treatment agents)
    • Formulated broad-spectrum pesticides marketed under global trade names
    • Seed dressing compounds for cereals, fruits, and vegetables
    • Specialty antifungal coatings for horticulture

    2. Veterinary Antimicrobial Agent Synthesis

    Veterinary pharmaceutical manufacturers employ this intermediate in the synthesis of benzimidazole-based actives for oral and injectable antimicrobial agents. The compound participates in tightly controlled chemical transformations, impacting the spectrum of antimicrobial efficacy. Strict residue and product safety controls apply from raw material intake through downstream formulation and packaging for veterinary goods.

    Industry compliance standards

    • Pharmacopoeia standards: USP, EP, BP for veterinary actives
    • Good Manufacturing Practice (GMP) - VICH GL GMP
    • ISO 22716:2007 for pharmaceutical production
    • Maximum residue limits (MRLs) under EU and US FDA Veterinary Drugs CFR Title 21 Part 558

    Typical usage ratio

    • 8–15% w/w in synthesis route of antimicrobial APIs; ratio varies with structure–activity requirements and purification stages

    Downstream process integration

    • Charged at early multi-step synthesis of target benzimidazole antimicrobials
    • Monitored entry into reaction vessels under GMP traceability
    • Processed through extraction, isolation, and recrystallization
    • Downstream blending with excipients in formulation and finishing operations

    Final product types

    • Oral veterinary suspensions and tablets for small and large animals
    • Injectable benzimidazole antimicrobial solutions
    • Preventive feed additives for livestock disease management
    • Animal health combination products targeting specific pathogens

    3. Intermediate for Pharmaceutical Anthelmintic APIs

    Major pharmaceutical companies source this raw material as an essential intermediate in the synthesis of benzimidazole-type anthelmintic active pharmaceutical ingredients (APIs) used to produce anti-parasitic medications. The production process requires precise quality control and documented purity. The benzimidazole structure, after further processing, imparts selective activity against helminths in human and veterinary sectors, following stringent pharmacopoeial and cGMP frameworks.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP, ICH Q7)
    • Pharmacopoeia monographs (USP, Ph. Eur., JP) for APIs
    • FDA DMF (Drug Master File) submission protocols
    • WHO Model List of Essential Medicines (for anti-parasitics)

    Typical usage ratio

    • 10–25% as molar input in stepwise API synthesis; adapted depending on downstream yield and process scalability

    Downstream process integration

    • Entry at condensation/cyclization steps in benzimidazole API routes
    • Controlled substance handling in line with cGMP batch records
    • Subsequent involvement in purification, salt formation, and granulation
    • Documented QC analysis prior to release to API formulation lines

    Final product types

    • Human and veterinary anthelmintic tablets and capsules (e.g., albendazole, mebendazole derivatives)
    • Oral suspension formulations for international healthcare supply
    • Bulk anthelmintic ingredients for contract API manufacturers
    • Pre-formulated combination anti-parasitic drugs

    4. Synthesis of Specialty Polymer Additives

    Polymer compounders use this benzimidazole derivative as a specialty additive intermediate for engineering resins with specified anti-microbial, anti-fungal, or stabilizing functions. The substance integrates via melt compounding, acting as a functional group donor or co-monomer to impart targeted resistance properties. This application demands batch traceability, consistent purity, and full compliance with polymer additive safety guidelines.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006 for polymer additives
    • US FDA 21 CFR 177 (for food contact polymers, where required)
    • ISO 9001:2015 for chemical additive quality systems
    • RoHS Directive 2011/65/EU (for electrical/electronic polymer components)

    Typical usage ratio

    • 0.1–2% by weight in engineering polymers; selected based on target efficacy, final matrix, and regulatory limits

    Downstream process integration

    • Added during masterbatch preparation or inline extrusion compounding
    • Melt-blended with thermoplastics or thermosets before pelletizing
    • Functionality maintained through mold, film, or fiber processing
    • Comprehensive traceability from additive intake through final product release

    Final product types

    • Anti-microbial engineering plastics (PA, PBT, ABS compounds)
    • Protective coatings, films, and sheets for food processing and medical areas
    • Durable molded parts for cleanroom and high-risk environments
    • Specialty industrial fibers and membranes with built-in protection
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    Certification & Compliance
    More Introduction

    Introducing 2-(3,4-Dichlorobenzyl)-1H-Benzimidazole: Practical Insights From Our Manufacturing Floor

    Decades of Experience, One Solid Chemical

    Our journey with 2-(3,4-Dichlorobenzyl)-1H-Benzimidazole runs deep. We’ve spent years tuning our process, always working with real-world demands in mind. This isn’t just another compound lined up on a catalog page. We started off in the days when every batch required extra testing and constant heat checks. Today, our process feels more like craftsmanship than production, because we know exactly where things can go wrong and how to keep them right.

    Model and Specifications: Real-World Choices Matter

    We produce 2-(3,4-Dichlorobenzyl)-1H-Benzimidazole according to a model that reflects both purity and practicality. Most requests come in for product above 98% purity in powder form, shaped by years of direct dialogue with users across research and industry. If a partner’s process handles trace byproducts poorly, they’ve told us; if a solvent in downstream steps clashes, we’ve heard about that too. We invest in glass reactors with precise temperature control because small impurities at certain heat points can throw off entire production runs for our customers in pharmaceuticals and agrochemicals.

    Particle size isn’t a mere bullet point for us—it causes differences in reactivity and handling that our team tracks. We customize grind size on request and listen to feedback on performance in real scale-ups. By getting direct feedback from chemists working hands-on at the bench, we can make subtle but vital process tweaks. Our lab team cross-checks every lot, comparing against reference standards, and we keep careful logs from mill to drum. These details matter more than glossy labels—anyone who has handled a batch that just won’t dissolve knows how a 10-micron shift can add hours to a project timeline.

    Why This Molecule Makes a Difference

    2-(3,4-Dichlorobenzyl)-1H-Benzimidazole is not a generic intermediate you use and forget. The benzimidazole scaffold serves as a cornerstone for many biologically active molecules, and the 3,4-dichlorobenzyl substitution brings a level of specificity favored in both pharmaceutical leads and crop protection research. This precise combination of rings and halogens resists degradation, giving robust stability through storage and in tough synthesis routes. We’ve run extended trials on shelf life, storing the compound under a range of temperature cycles and humidity to cover everything from heated warehouses to cool transit containers. The results speak plainly—the material keeps true to purity and form, with no unexpected breakdown.

    Stability in storage often means fewer recalls, fewer batch reworks, and a smoother flow down the production line. Our own logistics team prefers materials that do not demand climate-controlled trucks for every mile. By producing a compound that ships and stores without fuss, we help partners cut real-world costs far outside the lab.

    Usage Grounded in Industry Needs

    We’ve listened to those using our material on the ground. Laboratories often turn to 2-(3,4-Dichlorobenzyl)-1H-Benzimidazole as a starting material for antimicrobial agents, as the dichloro substitution supports a range of synthetic modifications. We hear from both large-synthesis teams and small pilot-line operators: few products balance chemical stability with synthetic flexibility as well as this one. In block synthesis for pharmaceutical screening compounds, it offers a balance—reactive enough for derivatization, stable enough to store on the shelf without headaches.

    In the agrochemical sector, teams use this compound as a building block for fungicides and growth modulators. Local field trials in humid environments revealed few degradation issues compared with other benzimidazoles carrying less robust substitutions. Feedback from users farming in unpredictable climates pushed us to double-check water-uptake behavior. Real data showed resilience, a trait that saves headaches in storage and shipment through rainy months.

    Learning From the Lab: The Difference Purity Makes

    On the manufacturer side, we have learned that not all 2-(3,4-Dichlorobenzyl)-1H-Benzimidazole behaves the same. Small-content impurities can make or break a pilot run. Sulfonated analogs, trace halogenated byproducts, and incomplete benzylation all look similar at a glance but wreak havoc downstream. We keep chromatography panels from every run to keep tight control, recording shifts batch to batch and tracking the tiniest odd signatures.

    Customers in medicinal chemistry report that scrapping a week’s worth of reactions comes down to a missed peak in the incoming material. These insights drive our investment in analytical equipment and our focus on hands-on quality checks. By holding our material above the typical minimum threshold, we avoid common complaints like inconsistent crystallization and poor solubility in mixed solvents. Staff on our floor know that precision upstream keeps headaches out of downstream operations.

    The Handling Perspective: Process Safety and Scalability

    We pay close attention to worker feedback in our own plant. Material safety isn’t theory to us—it grounds every shift. The dichloro-benzyl group introduces volatility risks if temperatures spike above determined thresholds. We keep production under close thermal surveillance, not just for regulatory compliance but to keep our own staff safe. Records from our team have led to practical adjustments: improved ventilation and batch scheduling to avoid peak summer heat, for example. We run regular drills for spills and require refresher training on handling, because real people, not just protocols, touch every drum and every flask.

    Scale-up teams outside our plant sometimes hit snags moving from gram to kilo scale. We share guidance on temperature ramps, mixing rates, and order of addition because these small process details can cut batch rejections. Drying this compound without clumping takes know-how: we switched to vacuum dryers with rotating paddles after fielding a series of clumping complaints early in our operation. Some companies try to solve that with flow agents; we approached it by adjusting moisture controls throughout the cooling phase instead. Direct customer conversations sharpen our process, and we rarely see repeats of old problems.

    Comparison: Standing Out From the Crowd

    Competitors often market similar benzimidazole derivatives. The distinction often comes down to how consistently the compound behaves through an entire toolbox of reactions. We field reviews from users switching from other suppliers after running into recurrent byproduct contamination, oxidation issues, and headaches from unstable blends. Our approach keeps the focus on chlorine placement, avoiding common pitfalls with isomeric byproducts that slip past lax controls.

    Some vendors supply with a broad purity range, but we keep the tolerance tight. That choice doesn’t just reflect pride in our process; it reflects feedback from users who run crude intermediates only to discover batch-to-batch surprises. Anyone who has sludged out a reactor chasing down invisible polar contaminants sees the value in stricter specifications. We use a dual-approach of in-line checks and final batch vetting, because single-step spot testing lets too much slip past. Over the years, the extra checks have reduced customer complaints and improved repeat orders.

    Cost, Value, and Real Outcomes

    Instead of racing to the bottom on pricing, we anchor value in repeatability and predictability. Partners judge cost on rework time, not just invoice. Persistent byproduct traces from cheaper material can wipe out savings through batch failures or extra purification. By supplying a reliable product, we help labs focus on innovation, not troubleshooting. We came to this strategy from seeing too many emergency calls about failed lots sourced at rock-bottom prices. This perspective doesn’t just build our brand, it builds trust that carries through supply chain hiccups and market swings.

    Schedulers in purchasing teams have a tough job lining up inventory when unpredictability hovers around raw material supply. Our steady quality standards, batch documentation, and rapid support give those teams breathing room. This translates to fewer fire drills, rush shipments, and late-night phone calls. We keep timelines honest by tracking every production step, logging every deviation, and keeping lines of communication open in plain language.

    Environmental Responsibility: Shaping Our Operations

    We run a manufacturing plant rooted in regulatory compliance but influenced more by the daily realities of waste management and efficiency. 2-(3,4-Dichlorobenzyl)-1H-Benzimidazole synthesis gives off halogenated byproducts. We invest in closed-loop scrubbing and neutralization, not out of obligation, but to keep our footprint as small as practical for the next generation. Staff participate in energy-saving contests, and we tweak batch size and reaction parameters to reduce waste at source.

    Wastewater treatment never takes a back seat. Team members from the shop floor to our environmental office review effluent reports and troubleshoot for unusual spikes. We carry out real-world emission tracking instead of just paperwork compliance. Our operators see firsthand how small leaks or disposal shortcuts create real problems for public health. Accountability rests on everyone here, not just the environmental manager, because we all live in the same community that surrounds our plant.

    Long-Term Relationships: Learning From Our Customers

    From university research labs through to major pharmaceutical firms, our connections flow both ways. Users teach us as much as we provide to their projects. We’ve adjusted drying cycles to prevent batch caking and worked out new packaging options following user requests for safer, more ergonomic containers. We created sample-sized packs for academic partners running small screens, and scaled-up pallet shipments for industrial plants working at multi-ton quantities.

    Real partnerships go beyond technical sheets. We routinely bring customer questions back to our R&D team, running small trial batches to dial in requested adjustments. Spare users the wait for slow process improvements: that principle drives our after-sales support. Teams value working with a manufacturer whose doors stay open. We exchange stories, not just data, and the insights flow both directions.

    Continuous Improvement: Responding to Market Forces

    Markets never stop changing. Deeper regulatory review of pesticide intermediates and new approval hurdles in pharmaceutical research both shape our work. Product traceability now ranks as high as purity for our largest clients. Our internal barcoding and blockchain-tracked lot histories allow thorough recall or audit, giving end-users confidence in their supply chain documentation. These systems grew out of real questions raised by buyers—pain points turned into new digital workflows.

    Rising labor costs and tightening energy markets mean constant innovation in our plant. Teams meet monthly to pore over cost breakdowns and improvement projects, taking ideas from anyone, from R&D to custodians. We test pilot projects in live runs, track outcomes, and improve. The best solutions come not from outside consultants, but from those working hands-on with each piece of the process.

    Beyond Compliance: A Focus on Practical Safety

    Safety rules alone can’t cover every curveball in chemical manufacturing. We follow the law, but our approach takes lessons from daily practice. Operators receive routine input on updated safety procedures drawn from near-misses. We use real mishap reports, not just hypothetical case studies, to keep risk fresh in mind. Chemical handling always presents risk, but involving the team in solutions leads to practical safeguards that stick.

    Everyone in our plant, from the chief chemist to new hires, receives training on material-specific hazards tied to 2-(3,4-Dichlorobenzyl)-1H-Benzimidazole. Staff mentor each other across departments, and open-door policies ensure no risk goes unreported. By turning safety into a daily routine rather than an annual seminar, we build habits that keep our workforce healthy and our product consistently available.

    Feedback, Transparency, and Future Directions

    We collect feedback as part of our workflow. Any concern flagged by a customer—clumping, off color, low dissolution—triggers a deep dive. We run joint testing, share outcomes, and update our processes to close out issues. Keeping upgrades transparent makes all parties stronger actors in the chemical supply chain.

    Emerging needs shape our roadmap. Our product development group tracks new regulatory standards on trace contaminants and explores greener synthesis routes. Flexibility—both in batch size and packaging—lets us serve the latest requirements in real time, never locking users into rigid terms.

    Looking Ahead: The Manufacturer’s Commitment

    Our product, 2-(3,4-Dichlorobenzyl)-1H-Benzimidazole, isn’t just a lot number to us. It’s the product of hundreds of hands-on improvements layered over years of direct experience. We never take for granted the trust customers place in our supply, and we maintain rigorous standards to keep that trust. Real-world quality, safety, transparency, and sustainability shape every step we take, and we remain open to evolving with our partners’ needs.

    As a team rooted in daily, practical chemical manufacturing, we take pride in making every kilogram count—not only for science but also for the people and processes downstream. When you work with us, you get more than a compound; you get a team invested in every outcome, every project, and every success our material helps achieve.