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2,2-Dimethylbutyric Acid

    • Product Name 2,2-Dimethylbutyric Acid
    • Alias Isovaleric acid
    • Einecs 219-662-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    770136

    Name 2,2-Dimethylbutyric Acid
    Molecular Formula C6H12O2
    Molecular Weight 116.16 g/mol
    Cas Number 595-37-9
    Appearance Colorless liquid
    Boiling Point 167-168 °C
    Melting Point -6 °C
    Density 0.918 g/mL at 25 °C
    Solubility In Water Slightly soluble
    Smiles CCC(C)(C)C(=O)O
    Inchi InChI=1S/C6H12O2/c1-4-6(2,3)5(7)8/h4H2,1-3H3,(H,7,8)
    Pka 4.80
    Synonyms 2,2-Dimethylbutanoic acid
    Refractive Index 1.410

    As an accredited 2,2-Dimethylbutyric Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 2,2-Dimethylbutyric Acid is supplied in a 100g amber glass bottle with a secure screw cap, labeled with safety information.
    Shipping 2,2-Dimethylbutyric acid is shipped in tightly sealed, chemical-resistant containers to prevent leaks and contamination. It should be stored and transported in a cool, well-ventilated area, away from incompatible substances. Proper labeling and documentation are required, and all relevant safety and regulatory guidelines for hazardous chemicals must be followed during shipping.
    Storage 2,2-Dimethylbutyric acid should be stored in a tightly sealed container, away from sources of ignition, heat, and incompatible materials such as strong oxidizers. Keep it in a cool, dry, and well-ventilated area. Avoid exposure to moisture. Properly label the container and follow all relevant safety protocols and regulations for storage of organic acids.
    Application of 2,2-Dimethylbutyric Acid

    Applications of 2,2-Dimethylbutyric Acid in Industrial Manufacturing

    2,2-Dimethylbutyric acid serves as a functional intermediate within several industrial production chains, providing unique structural properties for synthesis and formulation. Its adoption remains concentrated in select specialty downstream segments, where it fulfills narrowly defined chemistry and compliance mandates. Below, we detail four established industry-specific applications supported by regulatory context, usage guidelines, process positions, and associated finished goods.

    1. Pharmaceutical Intermediate Synthesis for Anticonvulsant APIs

    Pharmaceutical manufacturers integrate 2,2-dimethylbutyric acid into multi-step synthesis of anticonvulsant active pharmaceutical ingredients, specifically where a branched-chain acid facilitates regioselective esterification and side-chain construction. QC teams perform identity and purity assays at each stage to meet regulatory filings, supporting API submissions for solid oral dosage forms.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP, 21 CFR Parts 210/211, US FDA)
    • ICH Q7: GMP for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) format structure documentation
    • Drug Master File (DMF) and certificate of suitability (CEP) for raw material traceability

    Typical usage ratio

    • Employed at 0.6–1.5 molar equivalents per target API molecule; the precise usage depends on stoichiometry of intermediate coupling; adjusted for impurity profile control and yield optimization.

    Downstream process integration

    • Introduced after initial aryl or alkyl core assembly, entering as a nucleophilic reagent for side-chain elongation or amidation during stepwise API synthesis under inert atmosphere with solvent control.

    Final product types

    • Anticonvulsant tablets and capsules containing relevant APIs (e.g., valproate analogues)
    • Bulk active pharmaceutical ingredients for pharmaceutical compounding

    2. Fine Chemical Intermediate for Fragrance Ester Manufacturing

    Specialty fragrance compounders employ 2,2-dimethylbutyric acid to synthesize branched esters used for persistent, creamy top notes in formulated fragrances for personal care and detergents. The acid’s molecular weight and volatility profile align with IFRA-specified safety evaluations, impacting both olfactory retention and skin safety.

    Industry compliance standards

    • International Fragrance Association (IFRA) Standards and Guidelines
    • EU Cosmetics Regulation (EC) No. 1223/2009
    • ISO 9235: Natural and synthetic aromatic raw materials for perfumery–Definition
    • Cosmetic Ingredients Review (CIR) for safety assessment

    Typical usage ratio

    • Converted to fragrance ester at 5–12% w/w in concentrated intermediates; final addition to end-product fragrance compositions at 0.05–0.25% w/w depending on the intensity and target consumer safety margin.

    Downstream process integration

    • Fed to esterification reactors with specific alcohols (e.g., hexanol, benzyl alcohol); acid-catalyzed batch or continuous esterification, followed by vacuum distillation and GC purity check before fragrance compound blending.

    Final product types

    • Fine fragrance oil blends for perfumes and eau de toilette
    • Functional scents for liquid detergents, fabric softeners, and surface cleaners

    3. Organic Synthesis Building Block in Agrochemical Actives

    Producers of crop protection compounds use 2,2-dimethylbutyric acid as a carboxylic acid moiety source for assembling selective herbicide molecules. Its ability to impart metabolic stability and soil mobility characteristics benefits analogues requiring branched acid fragments, meeting certificate-of-analysis benchmarks for regulatory dossiers.

    Industry compliance standards

    • FAO/WHO Specification and Evaluation for Agricultural Pesticides
    • ISO 9001:2015 (Quality Management Systems for chemical production)
    • OECD Good Laboratory Practice (GLP) for test substance preparation
    • EU Regulation (EC) No. 1107/2009 on Plant Protection Products

    Typical usage ratio

    • Used in 0.4–2.2 molar equivalents relative to aromatic or heterocyclic core substrates; ratio adjusted to manipulate side-chain length and optimize herbicidal selectivity and biodegradation profile.

    Downstream process integration

    • Dosed post-halogenation or amidation to facilitate coupling reactions, with real-time chromatographic monitoring. Upstream calibration ensures compatibility with existing catalyst and solvent recovery systems.

    Final product types

    • Formulated selective herbicides for cereals and broadleaf crops
    • Bulk actives supplied to downstream formulation sites

    4. Specialty Plasticizer Precursor in Modified Polyester Systems

    Manufacturers of industrial polymer additives rely on 2,2-dimethylbutyric acid to introduce steric bulk and migration resistance in modified polyesters for specialty plasticizer production. Its symmetrical branching enhances cold flexibility and aging characteristics in high-performance PVC and elastomer blends, underpinned by rigorous analytical control of acid value and residuals.

    Industry compliance standards

    • REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals, EU)
    • US EPA TSCA Inventory Listing for industrial plasticizers
    • DIN EN ISO 527 and 11357 for plastic mechanical/thermal properties
    • RoHS Directive 2011/65/EU for electrical and electronic applications containing modified PVC

    Typical usage ratio

    • Introduced at 3–11% w/w of total polyester formulation prior to esterification, with adjustments made for hardness rating, chain migration risk, and anticipated process temperature windows.

    Downstream process integration

    • Reacted in melt polycondensation with primary diols and phthalic or adipic anhydrides; dosing controlled based on molecular weight targets; final product tested for compatibility and permanence in PVC/plastic blend evaluations.

    Final product types

    • Plasticizer-modified flexible PVC sheets, wire and cable insulation compounds
    • Elastomer blends for roofing membranes and gaskets
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    Certification & Compliance
    More Introduction

    2,2-Dimethylbutyric Acid: Practical Insights from the Manufacturer

    Unique Traits from the Production Floor

    At our plant, we prepare 2,2-Dimethylbutyric Acid using a process designed to minimize byproduct formation. Each batch comes with a consistent purity level above 99%, and we deliver it either as a colorless oil or a clear crystalline substance, depending on the cooling and storage phase. This attention to purity helps control off-odors and maintains reliable product performance in downstream applications.

    The substance boasts a molecular formula of C6H12O2, CAS number 595-37-9, and a molecular weight close to 116.16 g/mol. In routine handling, it shows good shelf stability, provided drums or containers get stored away from moisture and excessive sunlight. Most of our batches ship in sealed HDPE drums to lock out air and airborne contaminants—crucial where trace impurities affect yield or odor in sensitive chemistry.

    Why We Rely on 2,2-Dimethylbutyric Acid

    Over years of operation, we’ve learned that straightforward carboxylic acids often fall short in producing the branched frameworks certain synthesis paths demand. 2,2-Dimethylbutyric Acid, with two methyl groups at the second position, sidesteps this. It feeds directly into making quaternary center intermediates, which becomes essential for specialty applications—especially those that require more than basic terminal acids.

    Ask anyone working on specialty chemicals or pharmaceutical intermediates: off-the-shelf butyric acid gets thrown out quickly for advanced needs. That extra branching on 2,2-Dimethylbutyric Acid increases steric bulk, preventing unwanted side reactions. It offers a cleaner reaction profile during Friedel–Crafts acylation or esterification, for instance. As a result, customers focused on synthesis scale-up see fewer surprises in process yields, and downstream purification steps usually run shorter.

    Our operators recognized that not every carboxylic acid can offer this balance of reactivity and selectivity. It explains why manufacturers looking for alternatives to 3,3-Dimethylbutyric Acid or straight-chain hexanoic acids often settle on this specific isomer. While some competitors hint at generic performance, we noticed clear differences in both acid strength and volatility profiles in practice. Reactors respond best to the branched option in controlled heating cycles, and solid product doesn’t cake as fast as similar acids.

    From Synthesis to Specialty Polymers: Where 2,2-Dimethylbutyric Acid Excels

    Every week, we see repeated orders for processes that push other acids to their limits. Several customers request 2,2-Dimethylbutyric Acid for use as a component in esters, which later go into flavor, fragrance, and plasticizer manufacturing. In esterification, this acid produces branched esters with lower volatility. These esters help stabilize fragrances, lock in base notes, and withstand both heat and light exposure in polymers and personal care products.

    Pharmaceutical sectors turn to our product when synthesizing building blocks that require tertiary or quaternary carbon centers. Some pain management and neurological compounds use frameworks that call for precision branching, and our acid reproduces this consistently. Formulators working on new prodrugs or analogs get measurable benefits from the purity and known reactivity. Our process route, based on careful distillation and contaminant monitoring, guarantees minimal odd-chain byproducts so end-syntheses are less likely to be contaminated with hard-to-remove isomers.

    Sometimes, formulators use our acid in lubricant and corrosion inhibitor research. The high steric hindrance of 2,2-dimethylbutyric structures prevents tight packing, which can provide better cold flow performance or reduced gumming in lubricating greases. One recent case involved a client developing biodegradable metalworking fluids; they needed an acid component that resisted oxidation and kept viscosity stable after repeated thermal cycling. Our monitoring enabled us to tweak the drying and filtration steps to raise oxidation stability further, helping the client pass both in-house and external corrosion tests.

    For those exploring advanced polymers, the branching in 2,2-Dimethylbutyric Acid serves as a useful tool to disrupt linear crystallinity. When incorporated into a polymer backbone, it offers more flexibility and softness. Our material’s reactivity opens new doors in copolymer compositions, where precise melting points and mechanical performances take priority over cost savings alone.

    Standing Apart: Real-World Contrasts with Similar Products

    It’s not uncommon for specifiers to ask whether 2,2-Dimethylbutyric Acid could be swapped with cheaper acids like isovaleric acid, tert-butylacetic acid, or plain butyric acid. Based on customer feedback and our trials, the answer often ends up as no. Straight-chain acids tend to run off faster, volatilize unexpectedly under heat, or create more unwanted olfactory notes. Esters from regular butyric acid regularly emit unwanted cheese-like or rancid notes—something rarely encountered when using our product.

    Branching makes a difference in synthesis. Compared to 3,3-dimethylbutyric acid, 2,2-dimethylbutyric’s geometric arrangement delivers fewer off-pathways in alkylation or amidation reactions. It resists over-alkylation and can reduce unwanted coupling byproducts. Customers in advanced materials and flavors confirm that this small difference in carbon branching delivers far more control. Some projects we’ve supported for over a decade still use the same raw acid, simply because switching means longer cleanups, higher losses, and unpredictable side-product profiles.

    Handling also plays a part. Our 2,2-Dimethylbutyric Acid doesn’t present the same stubborn residues in tanks and tubing as heavier-branched or aromatic acids. This saves time on shutdowns and equipment cleaning, translating to more productive run cycles. The lower volatility compared to some competitors’ acids means operators face fewer odors and less vapor in production bays, creating a safer working environment. Our quality testing teams look for any signs of acid degradation; keeping an eye on the faintest off-note has become second nature here.

    How We Meet High Purity and Performance Demands

    Delivering a consistent product takes more than specifying a purity number. It means keeping water content low, controlling for residual solvents, and ensuring every drum lines up with documented specifications. Our production team runs routine gas chromatography to track purity, alongside Karl Fischer titrations to check moisture. Old hands know that even a fraction of a percent shift in moisture can change a synthesis outcome drastically—sometimes leading to failed crystallization or separation later on.

    We invest in process improvements each year, experimenting with updated reactors, improved distillation columns, and tighter filtration steps. Years back, we discovered that winter humidity could sneak into storage, so we adopted new climate controls. Tracking contamination isn’t a job left to the lab: operators at each storage stage scan batches, and only those meeting our internal threshold for contaminants move on to shipping.

    Our technical support works with end users to troubleshoot reactions that stall or produce unexpected outputs. We’ve received catalysts back from overseas users, along with their acid-solvent mixtures for root cause checks. In one ongoing case, a series of failed biotransformations turned out to hinge not on the enzyme, but on differences in trace aldehyde impurities in the raw acid. Once identified, we adjusted upstream purification—bringing the process back on track and restoring expected yields for the client.

    We keep records of traceable product lots going back a decade, and regularly pull archived samples to compare shifts in quality or to support customers tracking down historical process failures. As competitors struggle to keep batch-to-batch consistency due to fluctuating demand or outsourced processing, we notice more technical calls for troubleshooting. Direct manufacture, rather than brokering, makes it possible for us to hold tighter control over every run.

    Practical Aspects: Storage, Shipping, and Worker Experience

    On the shop floor, workers know how easy it becomes to distinguish 2,2-Dimethylbutyric Acid from the clutter of other acids in the warehouse. The mild, fruity scent hints at its nature but rarely overwhelms. Our filling crews spend less time dealing with acid vapor controls than with other volatile acids. Still, safety stays front and center—our plant follows closed-system filling in a ventilated bay to capture any fugitive vapors, and we review PPE practices with regular in-house training every season.

    Shipping 2,2-Dimethylbutyric Acid means watching temperature and humidity. Colder climates pose little risk, but hot or coastal destinations prompt us to double-check container seals on each outgoing order. We learned to reinforce pallet film and sometimes add secondary drums for the tropics, since small leaks or condensation could trigger an expensive recall or product rejection at a foreign port. As a manufacturer, we never see these challenges as minor annoyances—one broken drum in a shipment of twenty still brings the line to a halt and ties up resources.

    Within our circle of operators, minor skin irritation sometimes pops up with extended unprotected exposure, but it’s no worse than contact with many branched acids. Routine staff info sessions cover washdown, decontamination, and reminder signage in the tank farm. Visitors notice our “clean as you go” culture and the open communication about safety practice; we bring that same discipline to every outgoing drum and intermediate batch, aiming to stay ahead of any regulatory surprises.

    Regulatory Perspective and Market Shifts

    Regulations governing carboxylic acid shipping and handling shift every few years. We keep in close touch with hazardous chemical guidance in every region where our drums travel. Since 2,2-Dimethylbutyric Acid isn’t as volatile or flammable as some shorter-chain counterparts, operators often believe it poses fewer shipping headaches. Our team still completes all labeling and documentation to reduce customs hold-ups or on-site storage mix-ups.

    Growing market concern about minor impurities, trace solvents, or process residues drives our in-house push for cleaner processing. The movement toward food-contact compliance, pharmaceutical registrations, and environmental impact assessments weighs heavier each year. Agencies ask for tighter documentation and proof of non-detectable levels of regulated substances. We comply with these requests proactively, keeping MSDS and batch records ready to share, and harmonizing our internal controls with customer and authority demands in every region.

    Clients developing new applications push us to adapt. One group recently approached us with a request for an ultra-low moisture, high-purity variant for electronics applications. Current process setups allowed us to tweak one dehydration and two filtration steps. Fast feedback—something much easier for manufacturers to provide than traders—meant we delivered trial batches inside three weeks. Other requests flow in for custom packing sizes. Instead of sticking with a standard liter or drum size, we cut down or scale up packaging by working with in-house molding gear and flexible filling lines. Keeping all handling and packing in-house lets us avoid delays and cut pilferage along the shipping chain.

    Future Thoughts: Staying Ahead in 2,2-Dimethylbutyric Acid Manufacturing

    Each year brings new uses and technical demands for 2,2-Dimethylbutyric Acid. As manufacturers, we watch R&D teams move from established flavor and fragrance applications toward more advanced composites, custom surfactant systems, and polymer engineering. It’s not hype—feedback shows that customers prefer calling direct to the plant for advice, samples, or troubleshooting, instead of cycling through traders who know only the surface of the product.

    Our ongoing investment in technical staffing, process analytics, and direct customer support builds resilience against off-grade batches and end-user downtime. When the market pushes for still-higher specifications or tailored variants, in-house expertise in drying, purification, and packing steps lets us meet requirements head-on. We don’t have the luxury—or the frustration—of passing quality challenges back through a supply chain. The best lessons come by producing batch after batch, not relying purely on spec sheets or theoretical models.

    Decades of production experience teach that nothing replaces hands-on monitoring and feedback-driven process adjustment. As more customers look for trustworthy, consistent sources for critical acids, we stay committed to putting plant-level insights and practical solutions ahead of templated promises. The future for 2,2-Dimethylbutyric Acid won’t be built on buzzwords or generic claims—it will belong to those who know both the technical challenges and the everyday realities shaping the market for real chemical manufacturers.