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2,2-Dimethyl-3-Hexanone

    • Product Name 2,2-Dimethyl-3-Hexanone
    • Alias Methyl neohexyl ketone
    • Einecs 211-990-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    791280

    Compound Name 2,2-Dimethyl-3-Hexanone
    Molecular Formula C8H16O
    Molecular Weight 128.21 g/mol
    Cas Number 637-42-7
    Appearance Colorless liquid
    Boiling Point 146-148°C
    Melting Point -66°C
    Density 0.79 g/cm³
    Refractive Index 1.409
    Flash Point 34°C (93°F)
    Solubility In Water Insoluble
    Odor Ketonic, sweet
    Pubchem Cid 11934
    Un Number UN 1159
    Flammability Flammable liquid

    As an accredited 2,2-Dimethyl-3-Hexanone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, 100 mL, with tamper-evident cap, chemical label displaying "2,2-Dimethyl-3-Hexanone" and hazard warnings.
    Shipping 2,2-Dimethyl-3-Hexanone should be shipped in secure, sealed containers compliant with chemical transport regulations. It must be protected from physical damage, moisture, and incompatible materials. Clearly label the package with hazard information and use secondary containment if necessary. Follow all pertinent local, national, and international shipping guidelines for flammable liquids.
    Storage 2,2-Dimethyl-3-hexanone should be stored in a tightly closed container in a cool, dry, well-ventilated area, away from sources of ignition and oxidizing agents. Keep it away from direct sunlight, heat, and incompatible substances. Ensure containers are clearly labeled and check for leaks regularly. Store at room temperature, and use appropriate grounding and bonding during transfer to prevent static discharge.
    Application of 2,2-Dimethyl-3-Hexanone

    Applications of 2,2-Dimethyl-3-Hexanone in Industrial Manufacturing

    As a dedicated manufacturer of chemical intermediates, we supply high-purity 2,2-Dimethyl-3-Hexanone for advanced formulations across several established sectors. Our extensive application support relies on proven industry use and integration into customer value chains. Below, we outline the primary industrial domains utilizing this ketone, specifying compliance, blend parameters, actual process roles, and finished goods derived from its implementation.

    1. Pharmaceutical Intermediate Synthesis

    Producers of active pharmaceutical ingredients (APIs) incorporate this ketone as a carbon skeleton builder in key side-chain elaborations, particularly within small-molecule drug synthesis. Its functionalization profile aids in selectivity during Grignard reactions or reductive amination workflows, ensuring efficiency and yield in constructing target molecules for medicinal chemistry, notably for certain analgesics and antimicrobials. Production protocols hinge on regulatory traceability and impurity control, which necessitate understanding specifications relevant to the life sciences sector.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice (GMP) for Active Pharmaceutical Ingredients
    • US FDA 21 CFR Part 210/211 requirements for pharmaceutical manufacturing
    • European Pharmacopoeia (Ph. Eur.) monographs where applicable to API class
    • Standard analytical protocols for residual solvents (USP <467>)

    Typical usage ratio

    • Ranges between 0.5–5.0 mol% relative to the target API intermediate, with dosing optimized according to substrate reactivity and process yield requirements.

    Downstream process integration

    • Introduced at the heterocycle assembly or chain extension stage as a direct reactant, often followed by asymmetric reduction or functional group modification.

    Final product types

    • Non-steroidal anti-inflammatory drugs (NSAIDs)
    • Cephalosporin antibiotic side-chain intermediates
    • Antiparasitic drug scaffolds
    • Specialty intermediates for custom API manufacture

    2. Agrochemical Synthesis (Herbicides and Insecticides)

    Leading agrochemical companies utilize this ketone as a core raw material for synthesizing selective herbicide and insecticide compounds. The molecule’s structure enables controlled alkylation and condensation steps essential to preparing complex crop protection actives. Compliance with purity and process safety is central, given strict regulation on agrochemical precursors and trace contaminant content for field and export approval.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • ISO 9001:2015 Quality Management System for agrochemical production
    • REACH regulation (EC 1907/2006) for supply in Europe
    • Guidelines for maximum residue limits (MRLs) by Codex Alimentarius

    Typical usage ratio

    • Generally added at 1–8% on a molar basis within the synthetic step, with dosage based on the desired alkyl moiety incorporation and crop protection effect target.

    Downstream process integration

    • Charged in either nitration or condensation schemes, serving as a starter material in syntheses of dialkyl amino derivatives or aryl ketone-based pesticide actives.

    Final product types

    • Pyridyl-type herbicides (e.g., triclopyr intermediates)
    • Novel organophosphate insecticides
    • Selective pre-emergence crop protectants
    • Value-added intermediate packages for licensed agrochemical brands

    3. High-Performance Coating and Resin Modifiers

    Producers of specialty resins, coatings, and adhesives select this ketone for its ability to introduce desired branched alkyl character and modulate resin plasticity and gloss in demanding applications. The precise structure influences the cross-linking degree in UV- and solvent-cured coatings. Production compliance targets batch consistency, low VOC thresholds, and integration into technology platforms for automotive, aerospace, and industrial finishes.

    Industry compliance standards

    • ISO 9001 and 14001 Certification for resin and coatings plants
    • US EPA National Volatile Organic Compound Emission Standards for Architectural Coatings (40 CFR Part 59)
    • GHS labeling and SDS requirements per OSHA 29 CFR 1910.1200
    • European Union CLP Regulation (EC) No 1272/2008 on classification and safe use

    Typical usage ratio

    • Incorporated within 0.2–1.5% by total resin mass, adjusted based on required final viscosity, gloss level, and substrate adhesion characteristics.

    Downstream process integration

    • Added after initial polymer prepolymerization in the blending stage to tailor flow, gloss, and mechanical strength, then cured via thermal or radiation-induced processes.

    Final product types

    • Automotive OEM and refinish clear coats
    • Industrial machinery enamels
    • Protective marine and pipeline coatings
    • Flexible polyurethane-based adhesive resins

    4. Fragrance and Flavor Ingredient Production

    Manufacturers in the aroma chemicals sector rely on 2,2-Dimethyl-3-Hexanone for its unique branched structure, which facilitates selective transformation into key intermediates for high-impact fruity and floral notes. Its suitability for further reductive amination or catalytic hydrogenation enables diverse profile development for use in compound flavors and fine fragrance bulk synthesis, always under tight food and perfume industry standards.

    Industry compliance standards

    • IFRA (International Fragrance Association) Code of Practice
    • FEMA GRAS (Flavor and Extract Manufacturers Association Generally Recognized As Safe) Flavor Ingredient List
    • EC Regulation No 1334/2008 on flavorings and certain food ingredients
    • ISO 9001-certified quality and batch traceability protocols

    Typical usage ratio

    • Usage typically ranges from 0.1–0.7% of the total mass in the perfumery or flavor intermediate batch, determined by desired strength and volatility profile; lower limits apply for food-grade products.

    Downstream process integration

    • Processed via reductive transformations (e.g., formation of corresponding alcohols or amines) or as a precursor in aldol condensations, typically in flavor molecule synthesis or bulk aroma feed preparation.

    Final product types

    • Fruity-floral fragrance bases (e.g., apple, pear, or melon notes)
    • Flavoring intermediates for beverage and confectionery applications
    • Fine fragrance concentrates for toiletry and household blending
    • Custom aroma chemical ingredients for multinational F&F brands

    5. Specialty Solvent for Polymer Processing

    Chemical processors employ 2,2-Dimethyl-3-Hexanone as a specialty solvent component, particularly for dissolving engineering polymers and facilitating controlled film casting and extrusion in high-temperature operations. Its volatility curve and solvency allow use where traditional ketones may not deliver needed compatibility or surface performance standards. Selection in this area focuses on batch purity, process reproducibility, and end-use worker safety protocols.

    Industry compliance standards

    • OSHA Process Safety Management (29 CFR 1910.119) for solvent handling
    • ISO 14692-3:2017 for polymer matrix composite material manufacture
    • RoHS (Restriction of Hazardous Substances Directive) for electronics-related applications
    • TSCA (Toxic Substances Control Act) listed for industrial use and compliance

    Typical usage ratio

    • Employed at 2–10% weight of total solvent blend, refined by polymer type, film thickness target, and production line temperature; higher rates for tougher engineering plastics.

    Downstream process integration

    • Charged post-polymer dissolution or pre-extrusion, where it facilitates uniform mixing and transfer of polymer melt, supporting consistent film or fiber output.

    Final product types

    • Polyester and polyamide specialty films
    • High-durability electronic insulating tapes
    • Membranes and filter media for technical applications
    • Precision extrusion-grade polymer pellets
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    Certification & Compliance
    More Introduction

    Introducing 2,2-Dimethyl-3-Hexanone: Reliability in Chemical Manufacturing

    An Experienced Manufacturer’s Perspective

    Across decades of chemical production, certain compounds have proven indispensable through their sheer versatility and consistently reliable performance. Among these, 2,2-Dimethyl-3-Hexanone deserves more attention for what it actually brings to customers who rely on purity, stable sourcing, and functional adaptability every time they order. Drawing on years behind reactors, careful analytical methods, and the daily discipline of chemical processing, our team sees 2,2-Dimethyl-3-Hexanone as more than a formula. It’s a backbone ketone for both legacy and evolving applications, balancing classic strength with practical adaptability.

    Model and Specifications Brought Down to the Bench

    On the shop floor, controlling impurities and batch consistency means everything. 2,2-Dimethyl-3-Hexanone appears in our catalog with the CAS number 625-55-8 and molecular formula C8H16O, but the work goes deeper than a label. Industrial customers see the difference when a product repeatedly meets the expected boiling point, refractive index, and GC analysis purity—above 99% always, with water and non-volatile residues kept to stricter than typical industry allowances. Each batch is triple-checked on instruments that have gotten to know the expected fingerprint of this material. There’s a commitment underpinning every kilogram shipped, because any shortfall means downstream headaches for our partners in formulation and scale-up.

    Inside the Plant: How We Approach Quality

    Margins for error tighten every year. With 2,2-Dimethyl-3-Hexanone, even minor contaminants translate to major headaches: whether making fine chemicals, specialty coatings, or unique fragrances, performance comes down to trace-level assurance. Every reaction kettle and storage drum under our roof has handled ketones before, but we don’t allow shortcuts or faded certificates. Experienced operators test, collect, and review every parameter directly—odor, clarity, absolute content, mass spec results. Only clear, sharply-defined product survives batching, filtration, and final QA checkpoints. That confidence lets us sign off on each outgoing shipment, knowing we are sending more than a commodity: we’re providing a promise.

    Tracking Changes in Usage and Customer Demand

    Several core sectors regularly request 2,2-Dimethyl-3-Hexanone, often because earlier alternatives simply don’t blend as cleanly or react with as much predictability. Organic synthesis research teams trust its stability for Grignard reactions, nucleophilic additions, and selective reductions. Paint and solvent formulators have made the switch after less hindered ketones led to vaporization, off-odors, or slow dry times in earlier systems. Fragrance blenders find it brings valuable balance between volatility and smoothness, especially in compositions where “green” or “fresh” profiles matter. Traditional ketones struggle when off-notes or instability creep in, but with careful lot tracking and close customer feedback, refinements in our process have kept our version at the top of many order sheets.

    Recently, smaller specialty buyers—biotech startups, academic research teams—have pulled the compound into targeted synthesis workflows. They report high selectivity and yield, crediting the steric arrangement of the molecule’s two methyl groups near the carbonyl. Our scale allows us to provide both pilot-scale lots and full tanker loads, with little difference in quality metrics. We’ve even supported custom blends on special request, collaborating with long-standing friends in the custom synthesis community to troubleshoot purification and minimize losses.

    Differentiating 2,2-Dimethyl-3-Hexanone from Other Ketones

    Many chemical markets default to Methyl Ethyl Ketone (MEK) or Acetone for short-chain ketone needs. These materials bring speed and economy, but they drop short in selectivity, odor neutrality, and sometimes solubility with contemporary polymer technologies. 2,2-Dimethyl-3-Hexanone’s stronger steric hindrance means it brings higher resistance to unwanted side reactions and a slower evaporation profile, which has become a sought-after trait for formulators aiming at regulatory compliance and worker comfort. The minimal water affinity limits hydrolysis issues, a relief for anyone weathering the humidity shifts in aging storage tanks or global transport routes.

    Compared to branched alternatives like Diisobutyl Ketone, 2,2-Dimethyl-3-Hexanone sits at an ideal midpoint. Its flashpoint and vapor pressure support safer blending in crowded production lines, and its physical behavior ensures smoother handover from chemistry lab to factory scale. Whether customers operate in North America, East Asia, or the Middle East, our lab has gathered feedback on performance in all climates and batch sizes. Field notes regularly confirm that this ketone’s purity reduces the need for on-site reprocessing, letting end-users focus on their own formulas rather than chemical workup headaches.

    Meeting Real-World Performance Standards

    It’s one thing to supply a specification sheet that ticks the analytical boxes. Real credibility comes when customers report back after trying a batch in production. Over the years, our most demanding partners—coatings manufacturers, resin developers, specialty aroma houses—have held us to ever-higher expectations. When they dial in a new recipe or adjust a reactor for greater yield, the ketone’s role becomes clear. They want product that behaves identically each time—no darkening, no unpredictable volatility, no “side” odor that creeps into sensitive blends. We maintain close communication with these clients, sharing lab data, sample vials, and even on-site visits when necessary.

    Weather events and supply chain shocks can disrupt even the most robust operation. Our customers, especially those running continuous processes, trust that shipments from our plant won’t introduce surprises. During the global logistics turbulence of recent years, feedback from major buyers highlighted our flexibility: guaranteed lead times, honest updates, and technical support when they needed to adjust dosing or blend ratios. Those partnerships didn’t survive on price alone. They thrived because our technical managers, production foremen, and shipping coordinators worked as a true team—everyone invested in the integrity of what leaves our loading docks.

    Safe Handling and Transportation: Producer Insight

    Routine on our end means discipline. Each outbound drum, tote, or tanker gets handled with procedures proven day after day: nitrogen blanket, strict temperature controls, and documentation reviewed by experienced eyes—not just rubber-stamped. Our own transport managers run safety audits with haulers quarterly. We learned a long time ago that a minor slip during loading can undermine the best product. We work with trained logistics partners who understand what’s at stake if seals break or containers shift during transit. Our own audits flagged risks in cap seal tightness and tamper-evidence years before regulators did. No corner of production or shipment escapes detailed QA checks.

    Supporting Sustainability and Industry Responsibility

    For years, we have watched the shift toward sustainability in chemical enterprises speed up. 2,2-Dimethyl-3-Hexanone offers opportunities to support those goals. Increased process yields, lower byproduct formation, and opportunities for solvent recovery factor into our production approach. By maximizing every raw input and optimizing recycling streams around our reactor trains, our plant minimizes waste and energy use. Customers with their own targets for responsible sourcing see this chemical as an ally, not a challenge. We support those conversations by opening up our own environmental performance data and sharing transparent lifecycle analyses upon request.

    Customer requests for greener transportation and circular chemistry mirror changes we started in-house years ago. By working on catalyst selection and energy recovery during distillation, we stepped ahead of traditional high-emission practices. The result: the same high-purity 2,2-Dimethyl-3-Hexanone with real reductions in total resource consumption. Large buyers see value not only in the product itself, but also in the partnership that respects both business and environmental priorities. Frequent feedback from these partners has helped us refine our operations and supported meaningful progress on shared sustainability goals.

    Practical Solutions to Unavoidable Industry Challenges

    No raw material market is without risk. Feedstock swings, energy volatility, changing global demand—all of it feeds into what we do as producers. Over decades, we’ve learned to plan further ahead and invest in ready-to-scale backup production lines, not just speculative storage. Continual investment in employee skills and in automation means we can adjust batch sizes almost overnight. When a buyer faced a sudden bump in volumes after a competitor’s failed delivery, we reconfigured our schedule to close that gap within a week. Repeat buyers know that we treat emergencies as teamwide priorities, not just contract obligations.

    As regulations evolve—whether around air emissions, solvent residues, or worker safety—our production stays ahead through frequent training, equipment upgrades, and close attention to local and international rules. Instead of reacting to enforcement, we invite third-party certification bodies to review our site and safety setup. Input from real-world auditors sometimes stings, but every insight helps us fix overlooked hazards or procedural bottlenecks. Our goal remains simple: stable, compliant product at every transfer point, with a level of supplier engagement that matches our customers’ rising expectations.

    Transparency: A Daily Discipline

    Years of feedback have taught us that “mystery” in supply chains serves no one. Every customer, from the global multi-national to the first-time startup buyer, gets access to technical bulletins, purity certificates, and responsive Q&A before and after purchase. It doesn’t matter if the batch is a full container or a single drum to troubleshoot an R&D challenge—our technical staff treats each request with focus, answering questions about potential side reactions, storage requirements, or regulatory traceability. We share full analytical profiles, provide samples on request, and remain available after delivery. If an issue arises in downstream processing, we work with you until the root cause is clear—whether it’s with our chemical or something else on your line.

    Many end users have strict regulatory audits themselves. Our operations teams prepare detailed documentation and assign dedicated account managers who know how to track down a problem. When issues come up, we don’t hide. We show our records, explain corrective actions, and stand by our process improvements. That way our partners move forward confident that every step from raw input to finished product is accounted for—fully traceable and ready for rigorous third-party inspection.

    Harnessing Laboratory Capabilities and Collaborative Development

    Many breakthroughs in 2,2-Dimethyl-3-Hexanone applications start in our own labs. Well-equipped with GC, LC-MS, and IR, we run day-to-day analytical checks and support customer R&D with tailored testing. Consistent reproducibility lets customers switch between small pilot samples and full-scale orders without worries. For specialty requests, our chemists help design purification tweaks or recommend stabilizers to match unique downstream environments. Our long connection with academic and industry researchers keeps technical development moving: shared case studies, joint problem-solving, and rapid feedback loops let us and our partners solve formulation or process challenges before they grow into commercial risk.

    Patents and innovative end-use recipes regularly pass through our review lab. Researchers who work with us often send back practical feedback: chromatograms, observed reactivity, even odor panel results when specialty olfactory performance counts. As upstream suppliers, our first aim is to translate bench-scale innovation into full-volume reliability. Closely-knit collaboration lets breakthroughs reach the market faster—whether in next-generation coatings, advanced intermediates, or scent blends.

    Shaping What Comes Next

    The role of a manufacturer reaches far beyond meeting quoted minimums. 2,2-Dimethyl-3-Hexanone demonstrates the return of deep-rooted industry knowledge, regular reinvestment in process and people, and the result of decades spent learning what drives customers’ success. As markets for resins, fine chemicals, and specialty organics shift, we plan for what’s ahead by building flexibility—not only in capacity but in the technical expertise behind the material. Our goal is to help customers thrive through ever sharper quality, more rapid support, and open channels for joint development.

    Across disciplines, from basic synthetic chemistry through application engineering, the real value of 2,2-Dimethyl-3-Hexanone comes from the people, practices, and shared commitment built over years of real-world production. At the heart of every container and every analytical report is the cumulative experience that only a manufacturer—never just a trader or reseller—can genuinely bring. We welcome each conversation as an opportunity to refine our process and partner in future-facing chemical manufacturing, rooted in reliability and continuous improvement.