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2-(2-Chloroethoxy)Ethanol

    • Product Name 2-(2-Chloroethoxy)Ethanol
    • Alias Ethylene glycol monochloroethyl ether
    • Einecs 219-376-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    467863

    Cas Number 629-14-1
    Molecular Formula C4H9ClO2
    Molecular Weight 124.57 g/mol
    Iupac Name 2-(2-chloroethoxy)ethanol
    Appearance Colorless to pale yellow liquid
    Boiling Point 197-199 °C
    Melting Point -62 °C
    Density 1.153 g/cm3 at 25 °C
    Solubility In Water Miscible
    Refractive Index 1.438-1.442
    Flash Point 87 °C
    Purity Typically ≥98%
    Synonyms 2-Chloroethyl cellosolve, Chloroethoxyethanol

    As an accredited 2-(2-Chloroethoxy)Ethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 500 mL of 2-(2-Chloroethoxy)ethanol, tightly sealed with a screw cap and clear hazard labeling.
    Shipping **Shipping Description:** 2-(2-Chloroethoxy)ethanol should be shipped in tightly sealed, chemical-resistant containers. It must be accompanied by a Safety Data Sheet (SDS), comply with relevant hazardous material regulations (e.g., DOT, IATA), and be clearly labeled. Protect from heat and physical damage. Appropriate cushioning and secondary containment are recommended during transportation.
    Storage 2-(2-Chloroethoxy)ethanol should be stored in a tightly closed container in a cool, dry, well-ventilated area away from heat, sparks, open flames, and incompatible materials such as strong oxidizers. Protect it from moisture and direct sunlight. Ensure appropriate chemical-resistant labeling, and store it in secondary containment to prevent leaks or spills. Use only with proper personal protective equipment.
    Application of 2-(2-Chloroethoxy)Ethanol

    Applications of 2-(2-Chloroethoxy)Ethanol in Industrial Manufacturing

    2-(2-Chloroethoxy)Ethanol serves as a critical intermediate in several industrial manufacturing streams, contributing unique chemical functions that downstream processors leverage for consistent performance and regulatory adherence. As a production-established material, it supports synthesis, formulation, and finishing steps in tightly regulated industrial environments. Below, we present application scenarios that reflect our experience as a primary manufacturer, including compliance pathways, integration methods, and typical end products.

    1. Synthesis of Pharmaceutical Intermediates

    This material is widely adopted by active pharmaceutical ingredient (API) manufacturers for building ether- and ester-linked intermediates, primarily in the synthesis of APIs for antihypertensive and antiviral drugs. Its molecular structure introduces reactive chloroethyl and ethoxy groups, streamlining nucleophilic substitution reactions and supporting efficient linker formation during step-growth synthesis. Manufacturers apply this raw material under strict regulatory environments, with continual verification of chemical traceability and purity throughout production.

    Industry compliance standards

    • Current Good Manufacturing Practices (cGMP) – ICH Q7
    • USP/NF Monographs – Relevant API-specific guidelines
    • EMA Guideline on the Manufacture of the Finished Dosage Form (EMA/CHMP/QWP/245074/2015)
    • 21 CFR Part 211 (US FDA regulations for finished pharmaceuticals)

    Typical usage ratio

    • 0.8%–2.5% molar ratio relative to target precursor; adjusted by reaction pathway and scale

    Downstream process integration

    • Used during the controlled etherification or alkylation stage for intermediate synthesis, often under microbatch or semi-batch reaction conditions

    Final product types

    • API intermediates for antihypertensive agents (e.g., certain sartans)
    • Nucleoside analogues for antiviral therapies

    2. Surfactant Manufacturing for Industrial Cleaners

    In the specialty surfactant sector, downstream producers select this chloroethoxy alcohol to construct nonionic surfactant chains. Its dual functionality as a chain extender and hydrophilic group source enables the derivatization of alcohol ethoxylates with targeted solubility and surface activity profiles. Stringent safety and biodegradability compliance frameworks govern its use, especially in products formulated for large-scale institutional and industrial cleaning.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006 (Europe)
    • U.S. EPA Safer Choice – Surfactant Ingredient Criteria
    • OECD Guidelines for Testing of Chemicals – Section 3 (Biodegradability)
    • ISO 9001:2015 Quality Management Systems

    Typical usage ratio

    • 1–5% by weight in surfactant synthesis reaction mixtures; tuned for target hydrophile-lipophile balance

    Downstream process integration

    • Introduced into the main alkoxylation reactor as a primary alcohol component, reacted under controlled pH and temperature, followed by neutralization and purification

    Final product types

    • High-performance nonionic surfactants for industrial floor cleaner concentrates
    • Emulsifiers for degreasing applications in automotive maintenance

    3. Agrochemical Intermediate Synthesis

    Producers in the crop protection industry rely on this molecule as an intermediate for generating selective herbicide and fungicide actives, where its chloro and ethoxy moieties drive the construction of specific ether-linked heterocycles. The agricultural sector demands robust traceability and environmental safety controls, enforced by global residue limits and technical grade material regulations.

    Industry compliance standards

    • FAO/WHO Codex Alimentarius – Guidelines for Pesticide Residues
    • EPA Registration Requirements for Pesticide Chemicals (40 CFR Part 158)
    • OECD Good Laboratory Practice (GLP) Principles
    • EU Regulation (EC) No 1107/2009 concerning plant protection products

    Typical usage ratio

    • 2–6% molar ratio relative to main active substance backbone; dependent on crop-specific efficacy and regulatory residue allowances

    Downstream process integration

    • Added during the heterocyclization or side-chain functionalization phases, followed by neutralization and distillation for intermediate isolation

    Final product types

    • Technical-grade active ingredients for selective post-emergent herbicides
    • Intermediate building blocks for systemic fungicides

    4. Epoxy Resin Modifier Production

    Epoxy resin system manufacturers select this chemical as a reactive diluent or functional chain modifier, taking advantage of its balance of hydrophilicity and alkyl reactivity. The incorporation modifies viscosity profiles and enhances substrate adhesion properties, which is essential in specialty coatings and electronic-grade potting compounds. Material entry demands adherence to downstream electronic, mechanical, and finished chemical quality protocols.

    Industry compliance standards

    • UL 94 Flammability Standards (applicable for electronic encapsulants)
    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances)
    • ISO 14001:2015 (Environmental Management for resin processing)
    • ASTM D1763 (Epoxy Resin Standards)

    Typical usage ratio

    • 3–10% by resin weight, titrated against target viscosity and cure profile requirements

    Downstream process integration

    • Blended directly into the resin prepolymer batch prior to catalyst addition; subsequently processed under controlled exotherm for uniform functional group integration

    Final product types

    • Potting and encapsulation resins for electronic assemblies
    • Industrial protective coatings for metal and composite substrates

    5. Textile Chemical Synthesis

    This compound is routinely utilized by textile auxiliary manufacturers for creating surface-active agents and dye-leveling compounds with controlled molecular weights. Its inclusion enables custom etherification and promotes dye affinity in aqueous and solvent-based finishing baths. Compliance with textile safety and performance standards governs its integration from synthesis to textile finishing.

    Industry compliance standards

    • Oeko-Tex Standard 100 (Textile Chemical Safety)
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals Manufacturing Restricted Substances List)
    • REACH Annex XVII (Regulation on Substances in Textile Wet Processing)
    • ISO 14024 Type I Environmental Labeling (Eco-labeling schemes)

    Typical usage ratio

    • 0.5–2.0% weight of bath formulation in surfactant and leveling agent preparations; range defined via textile substrate type and processing route

    Downstream process integration

    • Incorporated during aqueous finishing, immediately prior to fixation or padding in the wet finishing line

    Final product types

    • Dyeing auxiliaries for synthetic and cellulose fibers
    • Leveling agents and wetting agents for textile pre-treatment
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    Certification & Compliance
    More Introduction

    2-(2-Chloroethoxy)Ethanol: Real-World Know-How from Our Production Line

    Working with 2-(2-Chloroethoxy)Ethanol: Chemist’s Perspective

    Spending years on the floor of a chemical plant shapes how you think about a product like 2-(2-Chloroethoxy)Ethanol. It’s not just a compound from a catalog. This is a versatile building block, and its performance starts from the moment the raw materials land in our tanks. Each batch tells its own story: the humidity in the air, the minor lot-to-lot tweaks that skilled operators make, every bit of it shapes what finally gets delivered. On our line, the process for producing 2-(2-Chloroethoxy)Ethanol draws on continuous monitoring and old-school hands-on experience. Each pump bolt, each percentage change in feed rate, can affect reaction yields and impurity levels.

    In our work, understanding these subtleties means knowing what the end users expect. Our chemists don’t simply push buttons—they step out onto the line when trouble brews and pitch in if a run starts looking peculiar. When we make a batch, we monitor for reaction byproducts like ethylene glycol or 1,2-dichloroethane, which can cause problems downstream. Every lot comes with data from gas chromatography and water content tests instead of vague promises. Our goal remains consistent: batch after batch, we aim to produce a transparent, nearly colorless liquid that meets expectations for purity and reactivity.

    Why 2-(2-Chloroethoxy)Ethanol Keeps Earning Its Place

    Talk to anyone using this compound in their synthesis and they’ll mention its ability to act as a handy intermediate. You see it in the pharma sector, fine chemistry, or even specialty lubricants. Since it delivers a reactive chloro group anchored to an ethoxy ethanol structure, it serves as a reliable bridge in many syntheses, enabling downstream modifications that just aren’t as straightforward when using shorter or bulkier alkoxy analogs.

    We have clients who drop it straight into etherification steps or use it as a precursor to prepare bis-alkylated architectures. Frankly put, there’s more flexibility in the synthetic protocol than with simple chloroethanols or short-chain ethylene oxide derivatives. That longer spacer, while not enormous, does adjust physical and reactive behavior in significant ways. Switch to a simple 2-chloroethanol and you’ll get faster reactions, but you run into more volatility and risks with handling. Replace with a bulkier or less reactive analog, and overall yields usually drop, or side-reactions crop up more often than with this product.

    From Experience: Handling, Packing, and Shipping Insights

    No product leaves our plant until we’ve had our own team handle it in standard containers. You get a sense of how a liquid will behave in transit by physically pumping, draining, and loading it into drums or IBCs. Spillage, vapor pressure, and solubility dictate every part of our logistics. 2-(2-Chloroethoxy)Ethanol, compared with shorter-chain monochlorinated ethanols, keeps vapor pressure down. That pays off in fewer losses during shipment and less odor when unloading.

    Our warehouse team deserves credit for flagging drum compatibility issues early on. After two seasons of trial and error, we found specific HDPE drums handle 2-(2-Chloroethoxy)Ethanol without leaching or seeping over months in warehouse temperatures. Steel drums introduced rust after extended storage, so we shifted back toward plastic-lined options. Every time a problem appeared in the warehouse, we brought the feedback straight into our process meetings. That aggressive feedback loop led to improvements in drum drying, improved sealing, and investment in validated cleaning protocols after each use.

    Model and Specification: What Actually Matters

    You’ll hear stories from customers who tried different suppliers and got wildly different experiences. Some brands sell a marginally cheaper version “for technical applications” with significantly greater residual water and higher levels of 1,2-dichloroethane. Our product stands out for its tight water content controls—errors like sloshing excess water or traces of corrosive byproducts can lead to equipment damage in downstream reactions. Customers told us that a seemingly minor difference in water content, from 0.5% to just 0.1%, can drive major changes in throughput for their own lines. Keeping the glassware and reactors cleaner, slashing maintenance downtime, it matters more than you’d expect, especially at industrial scale.

    Specifications for GC purity are more than paperwork—they reflect years of tightening process parameters at our plant. By minimizing unwanted byproducts like 2-chloroacetaldehyde or residual starting material, we help customers avoid headaches with side-reactions. When you’re up at midnight troubleshooting a batch, those slight spec differences show up clearly in reaction profiles and product cleanups. That’s why our main model, produced in batch reactors with a continuous monitoring system, typically lands a GC purity above 99%, with water controlled below 0.1%.

    Comparisons that Matter: How Is This Different?

    Most traditional glycol ethers offer a mix of properties: good solvent characteristics, gentle evaporation, predictable performance in coatings, inks, and cleaning blends. 2-(2-Chloroethoxy)Ethanol, on the other hand, isn’t about bulk blending—it delivers a reactive chloro group perfectly positioned for substitution, alkylation, or condensation chemistry. The difference isn’t academic; it changes how you plan your synthetic route and what precautions you put in place for each step.

    Some customers ask if they can swap in mono- or dichloroethanols. Theoretically, yes, but it leads to process headaches. Monochloroethanols give higher volatility and often demand more containment in reactors. Dichlorinated products start introducing environmental and safety burdens. Over time, the sweet spot for utility, cost, and safety keeps coming back to 2-(2-Chloroethoxy)Ethanol. Several customers have run comparative trials, confirming lower side-product formation and improved downstream yields versus both longer and shorter analogs.

    Wider Use Cases: Stories from the Field

    We’ve watched 2-(2-Chloroethoxy)Ethanol find its way into a growing list of sectors. Pharmaceutical synthesis leads the way, with R&D teams using it as an O-alkylating agent for the preparation of advanced intermediates that feed into several active pharmaceutical ingredients. There’s a reason big pharma dependencies often center on this product—it checks all the boxes for reactivity, selectivity, and ease of purification.

    Fine chemical companies, especially those running pilot plants and scale-up lots, regularly touch base with our tech service team. Their feedback remains clear: success hinges on tight purity and a repeatable process. Coatings formulators and custom blend operators also look to us for advice on how to incorporate the product into protocols that demand minimal levels of free chloride or aldehyde.

    One memorable feedback loop came from a client in Japan who pushed our team to come up with a more detailed impurity profile after experiencing minor issues in downstream hydrogenations. We worked together, sharing data, debugging sampling lines, and ended up adjusting our own purification step to shave residual aldehyde levels by 30%. The client’s next round of runs improved, and both sides learned something valuable from the process. These partnerships move the whole field forward.

    Environmental and Safety Realities: The Practical Side

    Every operator who stands by a reactor knows that chloroalkyl compounds carry risks. We don’t downplay those issues—rather, our crew gets regular hands-on safety refresher days, always with a real-world slant. 2-(2-Chloroethoxy)Ethanol keeps toxicity and volatility in check, compared to some more hazardous analogs, but personal protective equipment, contained handling, and fume scrubbing remain non-negotiable. Our ventilation and containment systems see routine upgrades. The safety crew runs simulations on spill scenarios with the same product we ship out—no laboratory surrogates or diluted samples.

    Waste treatment protocols reflect the lessons we’ve learned from real accidental releases and past regulatory audits. By investing in on-site containment, rapid separation, and neutralization systems, we’ve trimmed both actual and potential environmental footprints. From first alert to final neutralization, every incident becomes a lesson for the next production cycle. Partners in waste management check our procedures every quarter, making sure the paperwork matches the practical, on-the-floor expectations.

    Improving Our Production: Lessons in Optimization

    Standing on the factory floor, many improvements arise from spotting the unexpected: a filter plug in a cold snap, a new grade of catalyst outlasting its previous best by dozens of cycles, or operators at the filling station noticing a slight haze that points to hidden moisture ingress. Each process modification gets stress-tested in small runs before any changes land in the main reactor. Old mistakes—pushing a process too hard, skipping a temperature hold, assuming a new pump wouldn’t shed elastomer fragments—echo through our training sessions. We talk about them freely when onboarding new technicians.

    One ongoing project involves further tightening GC spec windows and upgrading our fractional distillation column. Investment in higher-resolution sensors and real-time temperature monitors helps catch the rare early fractions with off-spec components. Improving column purification cut rework rates and keeps the product’s color and odor fresh. Small, everyday upgrades—new seals, better insulation, or updated software—translate into fewer customer returns and steadier lot-to-lot consistency.

    Regulations and Compliance: Walking the Talk

    Chemical production revolves around more than permits and certificates. Teams learn to anticipate regulatory changes, adjusting documentation and process controls before inspections require it. During training, we review current local and international materials restrictions, always double-checking labels and manifests. Auditors see the same quality and batch records as our internal staff. These open records encourage accountability; teams share responsibility for each shipment and every bit of waste generated.

    We engage with regulators not just on paper but in person. Participating in industry safety roundtables and contributing to regional best-practices committees keeps us sharp. We believe in knowledge-sharing, especially on product stewardship topics—why scrubbing systems matter, how to manage tank ventilation, and how proper drum stacking helps avoid product exposure. Keeping colleagues in the loop and sharing technical details pays dividends in long-term safety and compliance metrics.

    Sustainability Challenges and Pathways Forward

    Every chemical plant contends with the push for greener production. We recognize the need to minimize energy consumption, cut solvent and reagent wastage, and capture every bit of recoverable material from each process cycle. Modifying the reaction workflow—whether by recycling internal wash streams or experimenting with emerging non-chlorinated feedstocks—offers occasional gains, but real breakthroughs come from incremental improvements built on direct production feedback.

    Over the past two years, we piloted a recovery loop that turns overhead vapors into usable feedstock, reducing overall solvent purchases and shrinking emissions per batch. Our engineering group installed in-line monitors to flag leaks before they reach regulatory thresholds. Every win, big or small, owes a debt to line workers—ideas bubble up from the shop floor, from those who know the quirks of each valve and drum fill port.

    We also stay tuned to the evolving conversation about sustainable logistics—shifting to returnable drum fleets, engaging in local supplier networks to trim transportation emissions, and cooperating with downstream partners on responsible disposal. Sustainability targets look ambitious from the outside, but they start with ordinary, everyday choices. Using less wash solvent, designing equipment for easier draining, and investing in leak-proof storage all boil down to practical, hands-on stewardship.

    Final Thoughts: Why Our Approach Matters

    Experience on our side of the fence teaches us that products like 2-(2-Chloroethoxy)Ethanol deliver value beyond a simple chemical specification. Unpredictable situations, customer feedback, supply chain bumps, and process upsets all affect what’s really delivered. The feedback loop runs both ways—production techs offer suggestions, our QA team fine-tunes protocols, and we welcome honest, tough questions from our customers.

    Keeping our word isn’t about slogans; it’s about learning from each delivery, listening to the market, and digging into the details. Every time we batch, fill, and deliver 2-(2-Chloroethoxy)Ethanol, it’s the product of an ongoing conversation: between plant teams, customers, regulators, and the communities we serve. We move forward by valuing practical knowledge, open communication, and a plainspoken commitment to quality—one shipment at a time.