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2,2,2',4'-Tetrachloroacetophenone

    • Product Name 2,2,2',4'-Tetrachloroacetophenone
    • Alias CN
    • Einecs 211-516-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    570455

    Chemical Name 2,2,2',4'-Tetrachloroacetophenone
    Molecular Formula C8H4Cl4O
    Molecular Weight 258.93 g/mol
    Appearance White to off-white solid
    Melting Point 95-98 °C
    Cas Number 4658-46-6
    Synonyms 1-(2,2,2-Trichloro-1-(4-chlorophenyl)ethyl)ethanone
    Solubility Slightly soluble in water; soluble in organic solvents
    Smiles CC(=O)C(Cl)(Cl)c1ccc(Cl)cc1
    Inchi InChI=1S/C8H4Cl4O/c1-4(13)8(11,12)6-2-3-7(10)5-6/h2-5H,1H3

    As an accredited 2,2,2',4'-Tetrachloroacetophenone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 100 grams of 2,2,2',4'-Tetrachloroacetophenone, sealed with a screw cap, labeled with hazard warnings.
    Shipping 2,2,2',4'-Tetrachloroacetophenone should be shipped in tightly sealed containers, away from incompatible materials and moisture. Transport must comply with relevant local, national, and international chemical regulations. Use appropriate hazard labeling and documentation. Handle with caution—protect from physical damage and avoid exposure to heat or direct sunlight during transit.
    Storage 2,2,2',4'-Tetrachloroacetophenone should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizing agents. Protect from moisture and direct sunlight. Store in a designated chemical storage cabinet, preferably designed for hazardous or corrosive materials. Clearly label the container and restrict access to authorized personnel only.
    Application of 2,2,2',4'-Tetrachloroacetophenone

    Applications of 2,2,2',4'-Tetrachloroacetophenone in Industrial Manufacturing

    As the direct manufacturer of 2,2,2',4'-Tetrachloroacetophenone, we supply global industrial clients with material tailored to the stringent needs of downstream applications. Below, we outline key industrial uses, each with detailed technical insights on regulatory compliance, dosage, process integration and finished product types.

    1. Tear Gas and Riot Control Agent Formulation

    Security product manufacturers further process 2,2,2',4'-Tetrachloroacetophenone as the primary irritant in tear gas and riot control chemical blends. Rigorous regulatory scrutiny shapes every phase from raw material qualification to the engineering of delivery devices. The active content requires close control to fulfill international safety mandates and minimize collateral exposure risks. Downstream users dissolve, mill, or emulsify the substance into propellant or carrier matrices, with strict environmental and personnel protection compliance in finished munitions.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006 (European Union)
    • US EPA TSCA Title VI (United States)
    • UN Recommendations on the Transport of Dangerous Goods
    • OSHA 29 CFR 1910.1200 (Hazard communication requirements)

    Typical usage ratio

    • 1–5% by weight in smoke or aerosol devices (adjusted for desired emission strength and device capacity)
    • Formulators may reduce content for non-military civilian applications; military standards may require higher maximum concentration

    Downstream process integration

    • Direct addition to granulated charge compositions or oil-based dispersants
    • Incorporation during propellant mixing, or post-production filling into munitions and canisters
    • Final blending under controlled ventilation to minimize occupational exposure
    • Quality control using chromatographic purity assessments

    Final product types

    • Tear gas cartridges and canisters
    • Hand-held aerosol riot control sprays
    • Law enforcement crowd dispersal grenades
    • Field training simulation devices

    2. Intermediate for Pharmaceutical Precursors

    Pharmaceutical enterprises utilize 2,2,2',4'-Tetrachloroacetophenone as a critical halogenated building block when synthesizing select intermediates. Its controlled introduction enables fine-tuning of chemical frameworks in the preparation of specific amides, esters, and ketone derivatives, ensuring the required selectivity and yield during advanced synthesis stages. The process requires strict tracking of material purity, trace contaminants and batch consistency, guided by global pharmacopoeia protocols and GMP site controls.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP, ICH Q7)
    • US Pharmacopoeia (USP)
    • European Pharmacopoeia (Ph. Eur.)
    • FDA 21 CFR Part 211 (Finished pharmaceuticals)

    Typical usage ratio

    • 0.5–3.0 molar equivalents in coupling, Friedel–Crafts acylation or halogenation stages
    • Actual charge determined by targeted yield and downstream conversion efficiency

    Downstream process integration

    • Charging at the intermediate step in multi-stage synthesis (e.g., as an acylating agent)
    • Monitoring purity by HPLC or GC to meet drug intermediate specifications
    • Subsequent purification/derivatization prior to the final API production
    • Integration with continuous flow or batch reactors equipped for halogenated compounds

    Final product types

    • Halogenated pharmaceutical intermediates
    • Advanced amide precursors for API synthesis
    • Research-use reference substances
    • Specialty fine chemicals for drug discovery

    3. Synthesis of Agrochemical Active Ingredients

    2,2,2',4'-Tetrachloroacetophenone contributes structurally to advanced pesticide and fungicide manufacturing, most notably for agrochemicals requiring tailored halogenated acetophenone motifs. The chemical enters multi-step production chains that demand strict input control and reproducible output performance. Downstream compounders integrate the raw material via controlled acylation, producing proprietary actives evaluated under national and international agrochemical residue regulations.

    Industry compliance standards

    • FAO/WHO Codex Alimentarius for agricultural chemical residues
    • EU Plant Protection Products Regulation (EC) No 1107/2009
    • US EPA Pesticide Registration (FIFRA standards)
    • ISO 9001:2015 (for agrochemical manufacturing sites)

    Typical usage ratio

    • 2–10% by weight as a functionalized intermediate in the core synthesis
    • Adjusted as required to optimize biocidal/plant protection efficacy versus cost/scalability

    Downstream process integration

    • Direct charge to reaction vessels for acylation or chlorination during active ingredient assembly
    • Incorporation monitored by reaction endpoint analytics (e.g. GC-MS)
    • Follow-up refinement through crystallization or solvent extraction
    • Residue testing prior to formulation in downstream crop protection blends

    Final product types

    • Active ingredients for fungicides
    • Pesticide intermediate compounds
    • Insecticidal formulation intermediates
    • Formulated agrochemicals for crop protection

    4. Polymer and Specialty Resin Modification

    Manufacturers of specialty polymers and engineered resins add 2,2,2',4'-Tetrachloroacetophenone as a functionalized monomer or crosslinker to impart targeted chemical resistance or flame retardancy. The process depends on precise stoichiometric dosing and thermal cycling in bulk or solution polymerization lines. Modifications with this raw material consistently alter end-use properties of downstream resin grades, subject to oversight under global chemical content and performance standards for plastics.

    Industry compliance standards

    • REACH Registration and Authorization (EU)
    • UL 94 (Plastic flammability standards)
    • RoHS 2011/65/EU (for electronics-related plastics)
    • ISO 9001:2015 (polymer plant QMS)

    Typical usage ratio

    • 1–8% by total monomer feed in resin matrix formulation
    • Adjusted according to desired halogen load and resulting flame resistance

    Downstream process integration

    • Introduction to pre-polymer mixture during resin synthesis or copolymerization
    • Heat/UV curing with in-process monitoring of conversion efficiency
    • Homogenization for specialty film, coating or bulk plastic grades
    • Final off-gassing or post-curing to minimize residual monomer content

    Final product types

    • Flame-retardant polymers
    • Specialty engineering resins
    • Protective plastic films and sheeting
    • Extruded or molded high-performance plastic components
    Free Quote

    Competitive 2,2,2',4'-Tetrachloroacetophenone prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing 2,2,2',4'-Tetrachloroacetophenone: Real-World Insights from Chemical Manufacturing

    Understanding the Value of 2,2,2',4'-Tetrachloroacetophenone in Daily Production

    At the core of our production lines, 2,2,2',4'-Tetrachloroacetophenone—sometimes known to chemists by its CAS number—brings efficiency and reliability to workflows where both performance and purity matter. Over the years, our teams have personally handled drum after drum of this compound. It's a solid, crystalline material, off-white to very slightly yellow in color, reflecting both high purity and stable composition. Our instruments regularly confirm the melting point in a narrow, reliable range, and we insist on clarity when dissolved—details that make a difference at filling stations, not just under a lab microscope.

    Every Batch, A Promise

    Consistency isn't a marketing claim—it's a hard-won reality that takes shape in our reactors, filtration units, and drying rooms. We calibrate every part of the process so specifications aren't just lines on a certificate. Typical purity reaches above 99%, but we run checks to catch anything below our target, no matter the batch size. It's much more than a guarantee—it keeps us on our toes and ready to answer direct questions from customers who rely on results rather than advertising gloss.

    Why This Molecule?

    In practice, the structure and chlorination of this acetophenone provide unique advantages in downstream chemistry. Laboratories and manufacturers value the specific placement of its chlorine atoms; it's not just about loading up on halogens but about how they influence both reactivity and stability. Over the years, project chemists visiting our facility have asked about substitutions. We explain why 4'-chlorination makes a functional difference in some syntheses—providing both reactivity under milder conditions and often cleaner extractions or purifications.

    Applications That Make a Difference

    Among our regular conversations with clients, one recurring topic centers around the applications of 2,2,2',4'-Tetrachloroacetophenone. Its principal use shows up in specialty chemical syntheses: it serves as an important intermediate, helping to create compounds used in colorants, pharmaceutical precursors, agrochemical work, and even certain polymer-modification pathways. In some areas, the molecule steps in where single-chlorine acetophenones struggle, particularly when a higher electron-withdrawing profile is needed to control reaction rates or yields.

    The People Behind the Product

    Every drum or bag comes out of our own plants—not from anonymous sources—so the crew knows exactly which batch is on the road and which shift produced it. The people who oversee our charging and mixing lines recognize the unmistakable scent and flakes of pure tetrachloroacetophenone. Our quality teams stay close to the process, not just to fulfill standards but to build a reputation based on facts. We know not just the chemistry but the mechanics of getting a product from specification, through purification, to the final packaging step.

    In-Plant Handling Observations

    We have learned through long practice that this compound keeps best when stored dry and away from sunlight. Full barrels retain their solid form for months under the right conditions. Workers who have spent years around chlorinated acetophenones know not to cut corners. We make sure venting and temperature control keep the product from clumping or degrading, even over extended storage.

    Differences That Matter: Our Tetrachloroacetophenone Versus Others

    Not every supplier delivers on both purity and logistical reliability. Some batches offered on the open market may come with excessive moisture, off-colors, or contamination from related chlorinated compounds. Production shortcuts elsewhere can leave excessive acids, sometimes at levels detectable by smell or color. Over the years, we have fielded samples from buyers switching from other sources, seeking a cleaner, more predictable feedstock. Our customers consistently point to fewer side-reactions when running our material, translating to smoother scale-up and fewer headaches at the separation stage.

    Environmental and Regulatory Observations

    Legal frameworks around chlorinated intermediates continue to evolve. Over the last decade, our compliance team has kept up close dialogue with regulatory advisers. We build our documentation on measured values, not estimates, because inspectors sometimes ask for more than just a printed certificate. We keep dioxin and furan levels monitored below stringent cutoffs. Each container traces back to a complete process log, so customers can respond confidently to inquiries on origin and impurity control. These are not abstract requirements—they keep shipment moving and projects on schedule at every checkpoint.

    Traceability and Authenticity

    Authenticity has become more valuable than ever in the specialty chemical business. In our own experience, even established buyers request detailed batch records. Each shipment leaves our plant with a coded label that matches back to original weigh tickets and operator records. This system supports not just our own audits, but the increasingly precise questions from international buyers. The few times there have been discrepancies, we have addressed them with point-by-point, data-backed explanations, saving projects for customers who can’t afford downtime.

    Customer-Driven Refinements

    As manufacturing demands increase, we hear calls for customized solutions. Some customers request particle size refinements or stricter moisture caps. Our plant adapts—grinding, screening, and drying on request. On occasion, specialty end-users have needed solvent-rinsed material for ultra-clean syntheses, and we have adjusted our downstream purification to suit. Longtime partners have even helped us spot subtle patterns in stability across different storage conditions, leading us to revise our recommendations for best in-plant handling practices. These incremental changes flow directly from feedback, not theoretical “improvements” detached from everyday use.

    Lessons from Market and Production Volatility

    Every year brings news of raw material disruptions or shifts in demand from end-users. Our raw material buyers have had to scramble during force majeures at monochlorinated benzene factories, or during regulations affecting chlorination capacity. We maintain robust local supplier relationships and strict entry specs for our own inputs. We don't rely on third-party brokers for this compound, because being able to trace every lot back is not just about paperwork—it makes a difference when something unusual turns up in the column or extraction vessel.

    Worker Health and Safety at the Source

    We never lose sight of worker safety: daily routines include respiratory protection, glove checks, and continuous airflow in the flaking areas. It’s not just about meeting checklists. Our operators give constant feedback on how well personal protective equipment holds up after shifts spent near the product. Annual training incorporates lessons from both near-miss events and day-to-day routines, building a foundation where safety is integrated, not tacked on after the fact.

    Practical Advice for End-Users

    End-users who depend on smooth downstream reactions often ask for practical steps to keep the product in optimal condition. We have seen that using dedicated tools for measuring and transferring, keeping storage out of humid areas, and unsealing containers only when needed improves result predictability. Over multiple years, storage at moderate temperatures shows little change in texture or reactivity. We advise against transferring small quantities to secondary containers, since fragments of old product left behind can take up atmospheric moisture—practical details that save time and reduce scrap at scale.

    Collaborative Problem-Solving with Clients

    Sometimes unexpected challenges in downstream applications draw us into joint troubleshooting. For instance, one partner encountered an unanticipated by-product after scaling up a reaction that ran flawlessly on the bench. After on-site visits and analysis, we traced the culprit to temperature spikes during the melt. Adjustments to both our drying protocol and the customer’s reaction setup fixed the yield issue. These experiences sharpen our eye for process improvements and deepen the trust with technical teams relying on every kilogram shipped.

    Observations on Waste Minimization

    A molecule like 2,2,2',4'-Tetrachloroacetophenone doesn’t only carry its own footprint; the way it’s made determines downstream burdens. We engineer our process streams for closed-loop solvent handling and minimize off-spec production. Scraps and fines from final sieving either get recycled into new batches or undergo approved neutralization. Our plant team reviews waste metrics monthly, looking for practical tweaks to save both money and environmental impact. Buyers downstream appreciate knowing the supply chain is engineered for measurable reductions in waste and emissions, not just marketing claims.

    In-the-Field Experiences with Alternative Molecules

    Buyers sometimes consider more common di- or monochloroacetophenones, hoping to cut costs or simplify supply chains. Yet feedback often comes back to specificity. At scale, mismatched reactivity introduces risk—side-products or plant upsets that cost far more than initial savings. We work with R&D teams to review actual reaction outcomes, not just theoretical substitutions. With certain pharmaceutical intermediates, for example, only the 2,2,2',4'-tetrachloro structure can guarantee isolation of the desired acetophenone derivative in high yield. These field notes become part of our living documentation, guiding future clients toward evidence-based choices.

    Supplying Global and Local Markets

    Our shipments do not just fill trucks headed for familiar clients in our home region. Every year, containers bearing our product reach users from North America to Europe and Asia. Meeting a diverse set of requirements has driven us to tighten our internal logistics and documentation. Direct customer conversations reveal the different pain points faced in various regulatory environments; for example, we have seen how requirements for purity documentation differ between the U.S. and Europe, and we adjust our paperwork accordingly. Every exported drum carries the reputation of our production floor—long walks around the plant floor and late-night calls with logistics partners are all part of moving a product rooted in consistent effort.

    Relying on Fact, Not Hype

    Chemical manufacturing always leaves room for exaggerated marketing or vague claims. We have seen buyers disappointed by promises of “advanced” or “new” processes that did not deliver real-world improvements. In every document we send, the measurements come from calibrated, recent runs. New process improvements only become part of standard operations after repeated confirmation—pilot batch by pilot batch—not on the strength of a vendor’s slideshow. This approach has helped us build trust with plant engineers and buyers alike, who need more than just convincing words to keep projects running.

    Looking to the Future – Innovation Rooted in Experience

    Markets shift, and customer expectations never remain static. We respond by investing not just in new technology, but in day-by-day observation and iteration. Our technical team frequently revisits old batch records, looking for patterns in yield or impurity trends that can point the way to marginal gains. When suppliers change a raw material’s spec or a customer reports a shift in downstream conversion rates, we run parallel tests using archived product samples. Adjustments do not happen overnight, but draw on decades of logged data and lived experience—keeping each new improvement grounded in repeatable success, not just optimism.

    No Shortcuts, No Substitute for Direct Communication

    Over the years, our team learned that no amount of automated reporting or AI-driven analysis can replace direct conversations between people who actually use the product. Whether it’s a new technical director or a longtime operator reaching out, immediate explanations about grade, handling, and performance yield stronger, more enduring partnerships. We remain accessible for questions, sample requests, and site visits, because shared understanding beats abstract claims every time.

    Product Availability and Responsible Practice

    With multiple years of reliably producing and supplying 2,2,2',4'-Tetrachloroacetophenone, we stay focused both on the molecule’s day-to-day performance and our role as stewards of quality. Demand can fluctuate, but the fundamentals do not change: regular calibration, open lines of feedback, and a commitment to authentic data push us to maintain both product and professional standards. Every outgoing shipment represents not just a chemical, but the sum of hard-earned expertise and dedication on the manufacturing floor.

    Final Thoughts from the Factory Floor

    For people on the purchasing or technical sides of chemical manufacturing plants, there are daily pressures—deadlines, audits, tweaks to process recipes. Our role in supplying 2,2,2',4'-Tetrachloroacetophenone involves more than ticking off a specification sheet. It’s about building day-in, day-out trust, based on proof that stands up under pressure. The differences between products show up in finished reactions, operational smoothness, and successful audits. That’s the measure we hold ourselves to—because those are the standards our customers use when deciding who they trust with critical materials.