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1-Octylpiperazine

    • Product Name 1-Octylpiperazine
    • Alias N-Octylpiperazine
    • Einecs 253-981-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    367148

    Chemical Name 1-Octylpiperazine
    Cas Number 5445-85-0
    Molecular Formula C12H26N2
    Molecular Weight 198.35 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 266-268°C
    Density 0.871 g/cm³ at 25°C
    Melting Point -24°C
    Solubility Slightly soluble in water, soluble in organic solvents
    Refractive Index 1.453
    Flash Point 126°C
    Purity Typically ≥98%
    Structural Formula C8H17-N(C4H10N)
    Smiles CCCCCCCCN1CCNCC1
    Storage Conditions Store in a cool, dry, well-ventilated area away from incompatible substances

    As an accredited 1-Octylpiperazine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 1-Octylpiperazine is supplied in a sealed 100g amber glass bottle with a tamper-evident cap and safety labeling for laboratory use.
    Shipping 1-Octylpiperazine is shipped in securely sealed containers, compliant with chemical safety regulations. Packaging ensures protection from moisture, light, and physical damage. The product is labeled with appropriate hazard symbols and shipped with a Safety Data Sheet (SDS). Transport follows local and international guidelines for handling and shipping specialty chemicals.
    Storage 1-Octylpiperazine should be stored in a tightly sealed container, away from direct sunlight, heat, and sources of ignition. Keep it in a cool, dry, and well-ventilated area, separate from incompatible substances such as strong oxidizing agents. Proper labeling and access control are recommended to ensure safety and prevent accidental exposure.
    Application of 1-Octylpiperazine

    Applications of 1-Octylpiperazine in Industrial Manufacturing

    As an established producer of 1-Octylpiperazine, we supply material that meets the specifications required for high-value sectors where chemical consistency and regulatory alignment are critical. See below for well-documented industrial use cases, including key formulation ratios, regulatory benchmarks, process integration points, and the resulting finished product grades observed by leading downstream manufacturers.

    1. Active Pharmaceutical Intermediate for Antihypertensive APIs

    Downstream pharmaceutical manufacturers employ our material as a key intermediate in the multi-step synthesis of select antihypertensive drug actives, leveraging its strong nucleophilicity and chain length to optimize medicinal chemistry outcomes under well-defined process protocols. The compound features in N-alkylation or derivatization steps, where strict feedstock quality and traceability are monitored under process validation and cleaning verification regimes, ensuring compliance with pharmacopoeial and regulatory guidelines for APIs.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice (GMP) for APIs
    • United States Pharmacopeia (USP) and European Pharmacopoeia (Ph. Eur.) for intermediates
    • FDA 21 CFR Part 211 (Finished Pharmaceuticals)
    • China Drug Master File (DMF) technical requirements

    Typical usage ratio

    • Active loading of 1-Octylpiperazine typically falls between 0.05 to 0.16 molar equivalents, calculated against the limiting reagent in synthetic batch runs. Process chemists adjust the precise input based on stepwise conversion efficiency and impurity profile monitoring.

    Downstream process integration

    • Material enters mid-stage reaction vessels for N-alkylation, followed by chromatographic purification; batch records and in-process controls document traceability from raw handling to API crystallization.

    Final product types

    • Pharmaceutical API for antihypertensive medications (e.g., certain sartan derivatives)
    • Regulatory-submitted Drug Substance for further downstream tableting or encapsulation

    2. Specialty Corrosion Inhibitor Component for Oilfield Chemicals

    Our material integrates with oilfield chemical formulations as a chain-extended amine, where downstream blenders incorporate it to enhance pipeline and vessel corrosion protection in upstream crude processing. Field operators choose 1-Octylpiperazine because its structural attributes favor film persistence under high chloride and CO₂ partial pressures, and ensure compatibility with demulsifier packages and scale inhibitors. Blenders track technical compliance to widely adopted industry standards, validating batch-to-batch consistency in offshore or refinery-grade applications.

    Industry compliance standards

    • API RP 14J: Recommended Practice for Chemical Injection Systems
    • NACE MR0175/ISO 15156: Petroleum and natural gas industries — Materials for use in H₂S-containing environments
    • REACH Registration for supply chain transparency (EU)
    • ISO 9001 Quality Management for chemical blending

    Typical usage ratio

    • Formulators dose 1-Octylpiperazine in corrosion inhibitor concentrates at 3.5–8.0% w/w of the total amine blend, with field adjustments made based on brine composition and corrosion loop trial feedback.

    Downstream process integration

    • The material enters during the final blending stage together with carrier solvents and surfactants; it is then filtered and drummed for field transfer. Application occurs via continuous injection systems or batch treatment in pipelines and separation vessels.

    Final product types

    • Oilfield corrosion inhibitor packages (for pipelines, well casings, and separators)
    • Multipurpose treatment fluid concentrates for upstream production facilities

    3. Surfactant Precursor for Industrial Cleaning and Metalworking Fluids

    Industrial formulators utilize our material as a hydrophobic amine block in the synthesis of surfactant intermediates, where the resulting tailored amphiphilicity improves wetting, cleaning, and rinsing behavior for demanding applications in automotive components and precision metal finishing. Structure-activity studies support its use in surfactants governing low-foam, fast-acting detergency, essential for wash cycles in food equipment, aerospace parts, and high-purity manufacturing environments where residue audits are routine.

    Industry compliance standards

    • REACH Compliant (Europe, surfactant registration and SVHC status)
    • FDA 21 CFR 178.3400 (U.S.: Surfactants—incidental food contact status)
    • SAE AMS 1526 for commercial aircraft cleaning products
    • ISO 14001 (Environmental Management in surfactant production)

    Typical usage ratio

    • As a precursor, 1-Octylpiperazine is reacted at 1.0–1.3 mol ratio per equivalent of hydrophilic head group, with possible excess (up to 10%) to drive conversion in alkylation or quaternization steps.

    Downstream process integration

    • Added in the amine block input stage of surfactant synthesis reactors; downstream neutralization, post-reaction distillation, and blending with chelators or corrosion inhibitors prior to packaging.

    Final product types

    • Industrial cleaning surfactant concentrates
    • Low-residue metalworking fluid additives for water-based coolants and rinses
    • Specialty detergents for food and beverage production lines (with incidental contact)

    4. Antistatic Agent for Engineering Plastics Compounds

    Compounders in the polymer sector incorporate 1-Octylpiperazine as an antistatic amine modifier for polyolefins, styrenics, and engineering resins, where its molecular structure promotes migration to polymer surfaces, imparting conductivity and reducing dust attraction or powder caking. Masterbatch producers and processors verify additive dispersion and long-term migration rates through rigorous QC tests matched to regulatory and end-use requirements (e.g., food packaging, electronics housings, or automotive interiors).

    Industry compliance standards

    • EU Plastics Regulation (EU) No 10/2011 for food contact compliance
    • UL 94 Flammability Standard (for end-use item evaluation)
    • RoHS 2011/65/EU for electronics safety
    • ISO 11469 plastics identification and labeling

    Typical usage ratio

    • Compounders add antistatic content at 0.08–0.35% w/w in masterbatch granules; processing temperature and resin type guide precise level to maintain transparency and mechanical strength.

    Downstream process integration

    • Blended with polymer pellets or powder before extrusion, compounding, or injection molding; downstream dry blending or melt mixing ensures even distribution and migration profile.

    Final product types

    • Antistatic polypropylene or polystyrene compounds
    • Films and sheets for food and medical packaging
    • Plastic parts for computer, TV, and automotive assemblies

    5. Intermediate for Agrochemical Synthesis (Herbicide and Fungicide Actives)

    Producers of agrochemical intermediates select our compound for cyclization or side-chain functionalization stages in active ingredient synthesis, emphasizing its role in tailoring lipophilicity or optimizing crop safety margins of the final formulation. Integration trials under validated SOPs confirm impurity control at every synthesis juncture, in accordance with global pesticide regulatory schemes governing raw material sourcing, trace residue, and on-site safety documentation.

    Industry compliance standards

    • FAO/WHO International Code of Conduct on Pesticide Management
    • OECD Principles of Good Laboratory Practice (GLP)
    • EU Regulation (EC) No 1107/2009 (Plant Protection Products)
    • China GB 2763 (Maximum Residue Limits for Pesticides)

    Typical usage ratio

    • Usage varies from 0.06–0.21 molar equivalents, based on the reactivity of the targeted backbone modification or cyclization. Process development teams assess the ratio via pilot-plant trials, factoring in conversion yield and cost profile.

    Downstream process integration

    • Charge addition in dedicated reaction modules before heterocycle closure or amidation; monitoring includes real-time HPLC for conversion control, and post-reaction quenching or solvent swapping for intermediate isolation.

    Final product types

    • Active intermediates for systemic herbicides
    • Precursor blocks for fungicide active formulation
    • Bulk technical concentrate grades for further downpacking or granulation
    Free Quote

    Competitive 1-Octylpiperazine prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing 1-Octylpiperazine: A Reliable Choice from a Trusted Producer

    Our Experience with 1-Octylpiperazine

    At our facility, we have been producing 1-Octylpiperazine for years—long enough to know the ins and outs of what makes this compound valuable and how best to manage its introduction into different chemical processes. As the jack-of-all-trades among substituted piperazines, this product has proven its worth both as a building block in organic synthesis and in specialty pharmaceutical research. Our commitment stretches from sourcing the right base materials to refining each batch for consistency. We have seen the market needs and quality standards evolve, and our team has adapted our production line to keep up, without sacrificing the practical know-how gained on the factory floor.

    Why Our 1-Octylpiperazine Stands Out

    We understand that users care about more than just a chemical’s basic profile. Our customers run demanding labs, maintain precise records, and expect no surprises in purity or performance. Our 1-Octylpiperazine—CAS number 5451-15-4—shows up ready to work, delivered as a clear, colorless liquid with high purity. Each batch is checked for consistency, and every shipment can be traced back through our records. This lets chemists and engineers rely on the same chemical behavior every time. Over the years, we’ve learned to fine-tune key product specifications—like the concentration of water, the boiling and melting points, and impurity control—so our clients face fewer headaches down the line.

    Getting the Model Right: Practical Choices for End Users

    When we began scaling production, we saw early on that different research and manufacturing groups prefer specific characteristics. Some need a higher purity for pharmaceutical synthesis, others seek moderate purity for use in agrochemicals or dye intermediates. Our main model offers a purity above 98%, and we certify it using chromatographic methods. We also make sure trace impurities fall well below thresholds that could interfere in downstream reactions. Packing options can go from kilogram flasks to industrial drums, and our team handles each order according to shipping regulations. We’ve streamlined labeling and documentation, so when the containers arrive at your loading dock, there’s no confusion about what’s inside.

    Over time, we have received detailed feedback from industrial-scale customers. Some faced issues with residual solvents or byproducts in earlier purchases from other sources. By adjusting our purification steps and focusing on raw material quality controls, we've lowered main contaminants like n-octylamine or unreacted piperazine. That improvement isn’t a marketing line—it’s the result of listening to technical staff at real production plants and working with them through troubleshooting. Chemical manufacturing leaves little room for error, and a single off-spec batch can halt a process or cause expensive rework. We take that responsibility seriously and design our internal testing routines accordingly.

    Applications Based On Real-World Needs

    Talking to our buyers—especially from the pharmaceutical, agrochemical, and intermediate industries—has shaped our view of the market for 1-Octylpiperazine. Laboratory teams count on our product when synthesizing patented drug candidates or screening new ligands. A reliable intermediate accelerates test cycles and keeps R&D chemists focused on breakthrough results, not cleaning up starting material problems. In large-scale production, customers leverage the unique alkyl chain of octylpiperazine to improve solubility properties in their end compounds, especially when formulating molecules that need balanced hydrophobic and hydrophilic features.

    This specific substituted piperazine has gained interest for pilot-scale pharmaceutical research, where researchers explore new antipsychotic or anti-infective agents. Our product delivers a clean backbone for further modification. Agrochemical producers, meanwhile, use it to build custom fungicide or herbicide molecules, making sure the seasonal supply arrives in step with planting schedules. Custom synthesis teams choose our 1-Octylpiperazine because it blends easily in reaction setups, thanks to its solvent characteristics. They tell us our packaging simplifies setup in flow chemistry or batch systems, helping them meet tight development timelines.

    How Does Our 1-Octylpiperazine Differ From Other Offerings?

    We hear from customers who previously sourced through traders or low-volume resellers and faced recurring challenges: uneven purity, unpredictable supply times, and little support for technical questions. Our difference rests on our position as a direct manufacturer, not a go-between. Every liter of 1-Octylpiperazine leaves our facility after thorough in-house quality checks. When a researcher or plant manager contacts us about a technical detail, our production chemists can pull up batch records or recommend handling protocols based on actual experience, not just a spec sheet. That shortens the feedback loop and reduces wasted time.

    Other suppliers sometimes rely on generic bulk intermediates or cut corners with less-controlled reaction setups. We oversee every major step—from raw ingredient selection to closed-system reactions that cut air-sensitive incidents and reduce exposure to external contaminants. We developed our batch standardization protocols in response to customer input, especially after learning how minor impurities could have outsized effects in sensitive synthesis or pilot plants. By sharing test data and adjustment logs with end users, we help engineers tweak their SOPs or clean-up processes.

    Specifications That Make an Impact on Your Process

    Our 1-Octylpiperazine comes with specifications tailored to core industry needs. Most batches exhibit a GC purity above 98%, with water content controlled below 0.5% on entry. We routinely check for the presence of common by-products and guarantee that traces of unreacted starting material or piperazine moieties fall below set thresholds. This hands-on approach makes a noticeable difference when your downstream reactions need reproducibility with minimal side-product formation.

    Customers working with strict process validations have commented on our consistent lot-to-lot quality. They report fewer failed runs, more reliable yields, and no surprise deviations in critical parameters. We support this by providing COAs for each delivery, including impurity profiles and stability history when requested. By locking in core quality markers, we help technical teams focus on scaling their core chemistry, not chasing hidden issues in the starting material.

    Supporting Your Team in Handling and Usage

    Handling 1-Octylpiperazine isn’t just a matter of opening a drum and tipping out a measured amount. Over the years, we’ve fielded questions from plant operators dealing with batch prep, solvent recovery, or vessel rinsing. This practical know-how has taught us a few lessons: keeping the storage area free of excess moisture makes for smoother dispensing, and controlling the delivery hose temperature offers better metering for larger batches. Many teams follow our recommendations to use lined containers for long-term storage, especially in humid climates.

    Our on-site engineers also review customer SOPs and can provide clear suggestions on dosing and mixing. This helps integrate our product into continuous flow or batch setups. Some teams have asked about reusable drums, and we’re equipped to help reclaim and clean containers for those aiming to reduce waste. We see real progress when this kind of open collaboration builds up over time. From small research labs up to industrial-scale reactors, our crews understand that 1-Octylpiperazine isn’t just a line item in an inventory; it’s an integral contributor to your productivity. We stay responsive to the practical obstacles you face, learning from your process tweaks and adjustments.

    Feedback from the Field: Lessons Learned Across Sectors

    Compared to other piperazine derivatives, 1-Octylpiperazine bridges a practical gap. Some researchers tell us that classic unbranched, unsubstituted piperazines lack the balance of solvent power and chemical stability that their syntheses demand. Meanwhile, bulkier or multi-substituted piperazines often run into solubility snags or introduce headaches in downstream purification. Our product’s octyl group provides a handy middle ground for many reaction schemes. Medicinal chemists highlight the balance of lipophilic and hydrophilic behaviors, which serves their molecular design requirements. Chemical engineers notice that octylpiperazine maintains predictable flow characteristics in continuous production lines.

    Our agricultural clients, working under tough timeframes and shifting crop regulations, comment on the value of trustworthy supply. They plug our product into seasonal cycle plans, banking on fresh delivery windows. Strong technical support from our team keeps their operations running when calibration or purity checks throw an unexpected flag.

    We have seen more start-ups and university departments tackle cutting-edge research calling for alkylated piperazines. Our flexibility in filling smaller volume orders or helping with special-use documentation lets these teams work at full pace without wrangling with oversupply or long lead times. Behind these custom orders stands a lab team ready to answer questions about batch behavior, unintended side reactions, or integration into unusual reaction systems.

    Safety, Regulatory Awareness, and Environmental Impact

    Health and safety concerns have evolved over the decades, especially for chemicals that see both lab-scale and industrial applications. Standing behind the drum, our production leads oversee safe manufacture and packaging, minimizing exposure through closed handling. We have invested in routine exposure monitoring and protective procedures in the plant. Every employee understands safe-handling standards—training involves not just policy sheets but hands-on walkthroughs and troubleshooting for tricky cleanup scenarios.

    On the regulatory side, we keep current with shifting international standards. Market demands change; new environmental rules arise with little warning. We monitor chemical inventories and registrations on relevant databases, working alongside downstream users to provide necessary documentation through the full supply chain. We respond to audits and provide compliance paperwork on short notice, helping customers navigate country-by-country regulations without delay.

    As for environmental impact, we have tweaked our plant operations to capture and recycle solvent streams and reduce volatile organic emissions during production. Used containers don’t leave our site until they’re clear of residues, and we coordinate with licensed waste handlers on responsible disposal. With the rise in calls for sustainable production, we now support clients moving toward green chemistry initiatives. Our customers see that shift reflected in our operations—from minimized water consumption down to improved process waste tracking, giving them peace of mind about their supply chain’s footprint.

    Troubleshooting and Continuous Improvement: Insights from Manufacturing

    Problems don’t disappear once 1-Octylpiperazine leaves our gate. Sometimes clients call with a failed reaction or outlier data from an analytical run, seeking advice. Our technical team has real-world experience, not just textbook knowledge. If a customer’s HPLC trace shows a strange impurity, we can dig back through batch samples and re-test to isolate the cause. Sometimes, it’s root contaminants from their own system, not the starting material. Other times, it’s an issue with a recent lot, and we quickly spot it and get replacement stock moving before bottlenecks build up.

    We run small pilot batches whenever our clients want to tweak incoming material characteristics, such as custom concentrations or alternative solvent handling. Our team has learned that a collaborative approach delivers reliable results. We don't just send a sample and leave the rest up to chance. If your process faces new constraints—perhaps a temperature bump or solvent change—we can run side-by-side tests or suggest tweaks based on years of hands-on manufacturing experience.

    Plans for the Future, Driven by User Feedback

    We are not done learning. Each year, we collect real feedback from people using 1-Octylpiperazine in daily applications—from academic labs to multinational manufacturing lines. That input shapes our investment choices: newer purification technologies, better containment systems, improved training for frontline staff. As users ask for lower residual solvents, greener process metrics, or custom blends that fit their specifications, we look for ways to deliver actual progress. A strong feedback loop means that every iteration pushes us all forward.

    Our journey with 1-Octylpiperazine reflects a production mindset that values close partnerships, clear communication, and relentless reliability. We welcome new challenges from our customers and adapt our processes to fit your unique situations. Whether your team’s next milestone is a scientific breakthrough or simply another day running a safe and predictable plant, we know how important every batch can be. Our door remains open for questions, feedback, or a fresh look at your sourcing needs—because a good product grows out of shared effort and long-term commitment.

    Final Thoughts

    One lesson stands out above all: chemicals like 1-Octylpiperazine are not just formulae on a page—they underpin real work, drive innovation, and keep countless processes moving. We see our role as something more than just supplying drums; we share your problems, celebrate your successes, and keep pushing for better solutions. Each day, we take pride in the reliability of our production, the openness of our team, and the trust our customers place in us. As the landscape of chemical manufacturing shifts with every new regulation or market demand, we’ll be here—working alongside you, batch after batch.