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1-O-Benzyl-Rac-Glycerol

    • Product Name 1-O-Benzyl-Rac-Glycerol
    • Alias rac-1-O-Benzylglycerol
    • Einecs 241-419-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    501601

    Product Name 1-O-Benzyl-Rac-Glycerol
    Chemical Formula C10H14O3
    Molecular Weight 182.22 g/mol
    Cas Number 937-48-2
    Appearance Colorless to pale yellow liquid
    Purity Typically ≥98%
    Boiling Point 163-165 °C at 0.2 mmHg
    Density 1.125 g/cm³ at 25°C
    Solubility Soluble in organic solvents (e.g., ethanol, ether); insoluble in water
    Storage Temperature 2-8°C (Refrigerated)
    Refractive Index n20/D 1.521
    Smiles C1=CC=C(C=C1)COCC(O)CO
    Synonyms Benzyl glyceryl ether; Rac-1-O-benzylglycerol

    As an accredited 1-O-Benzyl-Rac-Glycerol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 1-O-Benzyl-Rac-Glycerol is supplied in a 25g amber glass bottle with a secure screw cap, labeled for chemical use.
    Shipping 1-O-Benzyl-Rac-Glycerol is shipped in tightly sealed containers to prevent contamination and moisture absorption. Packaging complies with chemical safety standards. The container is clearly labeled, and the shipment includes a safety data sheet (SDS). Handling typically requires ambient temperatures, and transport follows all relevant regulations for non-hazardous laboratory chemicals.
    Storage **1-O-Benzyl-Rac-Glycerol** should be stored in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible materials such as strong oxidizers. Keep the container tightly closed when not in use and protect it from moisture and direct sunlight. Store at room temperature or as indicated by the manufacturer’s recommendations, and always follow standard laboratory chemical storage guidelines.
    Application of 1-O-Benzyl-Rac-Glycerol

    Applications of 1-O-Benzyl-Rac-Glycerol in Industrial Manufacturing

    1-O-Benzyl-Rac-Glycerol serves as a key intermediate in several specialized industrial processes across fine chemicals, pharmaceuticals, and polymer manufacturing. The applications outlined below represent verified downstream markets utilizing this raw material at scale. Each segment details unique compliance criteria, formulation guidance, integration steps, and resulting end products.

    1. Pharmaceutical Intermediate for Antiviral and CNS Drug Synthesis

    Pharmaceutical manufacturers employ 1-O-Benzyl-Rac-Glycerol as a building block in the multi-step synthesis of nucleoside analogues, particularly for antiviral and central nervous system (CNS) active drugs. The material’s benzyl-protected glycerol backbone allows for selective substitution and protection strategies essential for nucleoside construction, ensuring precise connectivity in the final active pharmaceutical ingredient (API). Strict adherence to global Good Manufacturing Practices remains mandatory, with in-process controls targeting trace impurity and residual solvent levels.

    Industry compliance standards

    • ICH Q7 GMP guidelines for Active Pharmaceutical Ingredients
    • USP/Ph. Eur. residual solvent limits
    • 21 CFR Part 211 (US FDA CGMP for Finished Pharmaceuticals)
    • Auditable supply chain documentation and change control

    Typical usage ratio

    • 0.8 to 1.4 molar equivalents relative to the nucleobase; the exact ratio adjusted based on coupling efficiency and batch yield targets.

    Downstream process integration

    • Introduced during glycosylation and protection/deprotection reaction sequences.
    • Requires pre-activation or derivatization under anhydrous conditions prior to coupling.
    • Purified through crystallization or preparative chromatography, ensuring contaminant levels comply with international pharmacopoeia monographs.
    • Incorporated into API production lines with validated cleaning and traceability protocols.

    Final product types

    • Nucleoside-based antivirals (e.g., lamivudine intermediates)
    • CNS-active prodrug intermediates
    • Modified nucleotides and pharmaceutical fine chemicals
    • Contract manufactured APIs for clinical and commercial supply

    2. Intermediate in Chiral Synthesis for Agrochemical Actives

    Chemical plants use 1-O-Benzyl-Rac-Glycerol as a protected glycerol source in the asymmetric synthesis of agrochemical intermediates. Its benzyl ether group safeguards the primary alcohol while enabling sequential chiral center introduction, which is critical in the synthesis of advanced herbicide and pesticide active ingredients. All production follows regional chemical regulatory frameworks, with attention given to maintenance of stereochemical purity and trace contaminant control throughout scale-up.

    Industry compliance standards

    • REACH registration (EC 1907/2006)
    • ISO 9001:2015 certified QC systems
    • Directive 91/414/EEC for plant protection product intermediates
    • Compliance with national environmental impact and handling regulations

    Typical usage ratio

    • 1.0 to 1.5 equivalents per desired chiral synthon; ratio modified for batch scale or catalyst selectivity.

    Downstream process integration

    • Added at the protection step before chiral induction to safeguard reactive centers.
    • Deprotected post-asymmetric synthesis to yield the final molecular scaffold.
    • Subjected to HPLC purity and chiral chromatography monitoring.
    • Feeds directly into further functional group transformation or final coupling reactions.

    Final product types

    • Herbicide and insecticide actives (e.g., glyphosate derivatives)
    • Pyridine and pyrimidine-based pesticides
    • Precursor intermediates for crop protection synthesis
    • Fine chemical building blocks for agrochemical formulation

    3. Protected Glycerol Component in Specialty Polymer Synthesis

    Polymer compounders rely on 1-O-Benzyl-Rac-Glycerol for its benzyl-protected glycerol structure, which allows for selective functionalization in the production of advanced materials, such as dendritic polymers and specialty polyols. This raw material supports precision backbone modification, yielding polymers with controlled hydrophilicity, branching, or surface reactivity. Strict adherence to polymer safety, impurity control, and end-use performance testing governs every batch’s release.

    Industry compliance standards

    • ISO 9001/14001 management and traceability systems
    • EN 71-3 for polymers in toys and consumer goods (where applicable)
    • FDA 21 CFR 177 for indirect food contact polymers (if required)
    • Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) compliance

    Typical usage ratio

    • 0.2 to 0.6 mole fraction of total polyol content, tuned to achieve targeted branch density and reactivity in polymer network formation.

    Downstream process integration

    • Incorporated during initial polycondensation or dendrimer assembly steps as a core or branch extender.
    • Benzyl group remains intact through early process, then removed under catalytic hydrogenation for exposed glycerol functionality in late-stage processing.
    • Process runs under inert atmosphere to prevent premature side reactions.
    • Final product passed through size exclusion chromatography for molecular weight control.

    Final product types

    • Dendritic polymers for specialty coatings
    • Functionalized polyols for high-end foams
    • Polyglycerol-based resins for adhesives and sealants
    • Medical-grade hydrogels and modified biopolymers

    4. Building Block for Fine Chemical and Cosmetic Ingredient Synthesis

    Specialty chemical manufacturers leverage 1-O-Benzyl-Rac-Glycerol as a controlled-release precursor for high-purity, functionally substituted glycerol derivatives. In formulations for fine chemicals and cosmetics, this raw material provides defined introduction points for further esterification, etherification, and amination reactions. Compliance focuses on food-grade, cosmetics, or personal care regulations, with trace analytics ensuring absence of benzyl residues in finished batches intended for regulatory markets.

    Industry compliance standards

    • IFRA guidelines for cosmetic ingredients
    • EU Regulation (EC) No 1223/2009 for finished cosmetic products
    • Japanese Standards of Quasi-Drug Ingredients (JSQI) for relevant markets
    • ISO 22716:2007 GMP for cosmetic manufacturing

    Typical usage ratio

    • 5–25% by weight in targeted fine chemical reactions; dosage based on desired chain length and degree of substitution in the cosmetic active or excipient.

    Downstream process integration

    • Material enters after initial purification as a starter component in multi-step synthesis for specialty esters or surfactants.
    • Processed through controlled esterification, alkoxylation, or amination, ensuring temperature stability and protection group retention.
    • Final benzyl deprotection via catalytic means prior to formulation or packaging.
    • Below-threshold benzyl content confirmed via GC and LC-MS before release.

    Final product types

    • Nonionic surfactants for cosmetic emulsions and cleansers
    • Glycerol-based esters for moisturizing creams
    • High-purity polyglycerols for personal care formulations
    • Glycerol ethers for fragrance and solubilizer applications
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    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

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    Certification & Compliance
    More Introduction

    Introducing 1-O-Benzyl-Rac-Glycerol: A Practical Perspective on Advanced Polyol Solutions

    Insights from the Factory Floor

    Each day in the plant, we handle raw glycerol streams, distinct reaction vessels, and the ceaseless pulse of batch records that chart the highs and lows in polyol manufacturing. 1-O-Benzyl-Rac-Glycerol represents one of those modified polyols that quietly unlock contrasts and refinements for industrial chemistry. Our experience making this molecule informs us that there is nothing generic about tweaking a simple glycerol backbone. When a benzyl group joins at the primary oxygen, the product shifts from commodity status into a specialty role, ready to address challenges that standard glycerol cannot touch.

    The Model We Stand By

    Our process targets consistency batch after batch. The structure of 1-O-Benzyl-Rac-Glycerol comes down to a glycerol molecule with a benzyl group attached to the primary position, ensured through targeted synthesis steps. This model, whether requested in technical or high-purity grades, gives chemists a differentiated building block. We focus on racemic mixtures unless a chiral specification is stipulated. Our average product retains low water content, with careful control of free benzyl alcohol and unreacted glycerol – not just for compliance, but because downstream reliability matters.

    What 1-O-Benzyl-Rac-Glycerol Brings to Daily Chemistry

    You can run the numbers, but nothing compares to watching barrels move through customer lines. Pharmaceutical labs reach for this ingredient during prodrug synthesis, where its ether linkage imparts unique reactivity and tunable solubility. Resin technicians mix it into specialty coatings that call for precise modularity between hydrophobic and hydrophilic segments. Surfactant developers point to its low-foaming properties and find the balance they need in liquid formulations. This product’s benzyl group delivers functional leverage, giving a reactive handle without losing the essence of a glycerol base.

    Comparing Against Standard Glycerol and Benzylated Alternatives

    Standard glycerol, with its triol backbone, offers bulk functionality but limited selectivity. Introducing a benzyl group at the primary position – not just tacking it onto any oxygen – shapes reactivity, slows unwanted polymerization, and expands stability under demanding conditions. Mono-benzylated, racemic structure contributes both to broadened application profiles and tailored reaction kinetics. Unlike pure benzyl alcohol, which can volatilize rapidly or interfere with sensitive catalysts, benzyl-glycerol brings a slower, steadier influence on reactivity. Our technical staff gets regular requests asking, “Can you substitute this for a pure polyol or for a simpler benzyl ether?” The answer lies in the dependency on site-specific activity and downstream compatibility; neither standard glycerol nor bulk benzyl ethers give the unique blend of mild hydrophobic protection and reactivity evident here.

    On Purity, Manufacturing Practice, and Downstream Value

    Trace impurities and isomeric content separate high-functioning benzyl-glycerol from inconsistent batches. Our best results come from controlling the molar ratios and temperatures at every synthesis step, drawing experience from cycles where excursions in water content have led to sticky, troublesome residues for downstream teams. This diligence in purification not only boosts yield but also helps formulators avoid off-odors, uneven batch behavior, or “ghost” side-reaction products. We’ve learned that reputable benzyl-glycerol never escapes the detection of a seasoned process chemist: the right color, viscosity, and clarity tell the story before a single HPLC trace is run.

    Experience with Storage, Shelf Life, and Handling

    Manufacturing brings insight that goes beyond the page. In humid climates, free water triggers slow breakdown, sometimes causing phase separation or color drift over time. Our facility invests in drum liners, nitrogen blankets, and warehouse climate monitoring not just out of obligation, but after costly lessons from the field. Effective storage keeps the integrity of the benzyl ether, ensuring users receive a reliable product every time. If a client mentions cloudy product after months in storage, technicians know to check ambient moisture exposure; we share real solutions, because we’ve confronted these scenarios firsthand.

    Real-World Challenges Solved

    Late at night, a customer calls – their batch of specialty acrylate resins isn’t setting as expected. Their old supplier sent a polyol out of spec, with unpredictable water and an undetected excess of benzyl alcohol. Our in-house analysis picks these differences apart and guides both production and technical support. Day-to-day, we ship samples to surface chemists tackling dispersant formulations for pigments where minor changes in hydrophobicity shift overall viscosity and end-use stability. By understanding not just the chemical, but its behavior in actual manufacturing runs, we turn each data point into process reliability for customers across pharmaceuticals, polymers, and specialty surfactants.

    From the Plant Floor to the Laboratory Bench

    Chemists need certainty when developing new molecules or scaling processes that rely on differentiated polyols. Our own experience proves that not every 1-O-Benzyl-Rac-Glycerol equals the next. The nuances in how we control trace benzyl alcohol content, manage heat load in reactors, and dry final product set the quality apart. Research-scale orders feed into kilogram and ton runs, with customers expecting the same product profile at any scale.

    Applications Across Industries: From Pharmaceuticals to Polymers

    Pharmaceutical intermediates draw on the specificity of 1-O-Benzyl-Rac-Glycerol’s structure. Its use as a protected glycerol scaffold enables stepwise modifications while permitting removal of the benzyl group under milder conditions than many alternative protecting groups. In coatings and resins, formulating with this product modifies polymer backbones without excessively increasing viscosity or lowering film integrity. In surfactant applications, the tuneable balance between hydrophilicity and hydrophobicity – thanks to the selective benzylation – gives manufacturers a means to adjust wetting, cleaning, or dispersant effects without disruptive foaming or incompatibility with other actives. These advantages, confirmed batch after batch, reflect years spent refining process controls and learning from feedback direct from customer lines.

    Environmental and Process Safety Considerations

    From a manufacturing standpoint, maintaining clean reaction vessels, safe benzylation conditions, and responsible waste handling are non-negotiable. We treat benzyl chloride handling and the neutralization of aqueous layers with the same seriousness as final product testing, knowing that lapses cascade into batch failures or environmental incidents. Our operators receive regular training on responsible chemical handling and incident response because process safety is learned through hard-won experience. We collaborate with clients who need detailed breakdowns of production auxiliary substances or trace contaminant migration, informed not just by data sheets, but by direct line-side analysis.

    Differentiating Real Quality through Data and Support

    Industry buyers increasingly look for more than price and basic COA compliance. They expect insights if a product drifts in reactivity, color, or storage performance. Our approach weighs each monitored parameter – density, color, purity, moisture – against extensive data banks. A sharp eye catches trends early, limiting non-conformities before they pass through outbound QC. We do not rely on third-party narratives or generic claims: our entire process, from raw material supplier auditing to each batch’s journey through the plant, stands behind every shipped drum.

    Responding to Market Demands and Regulatory Shifts

    Markets and regulations move quickly. From sudden trace allergen restrictions to shifts favoring environmentally benign solvents, 1-O-Benzyl-Rac-Glycerol must adhere not just to the original design intent, but to evolving standards. Our technical teams remain in dialogue with buyers and authorities, offering fresh samples, rapid documentation turnarounds, and practical feedback on alternative logistics. When new standards call for reduced free benzyl alcohol or lower metal residues, adjustments occur deep in our manufacturing controls, verified by the same core analytical gear our customers employ.

    Lessons Learned from Decades in Chemical Manufacturing

    It takes ongoing vigilance to keep product integrity at the level pharmaceutical and advanced material markets demand. Years of hands-on work show that shortcuts in distillation or purification quickly reveal themselves downstream. The difference between a product that “just meets” an assay and one that supports reproducible scale-up becomes clear through in-process monitoring and rigorous batch records. Sometimes it takes walking down the production line, inspecting a drum, or checking the temperature profile of a distillation unit to catch subtle clues that separate routine production from true manufacturing mastery.

    Working Directly with the User: Dialogue Over Distance

    Shipping tonnage worldwide, we keep channels open for immediate technical support and problem-solving. One cosmetics formulator may require ultra-low color in high-transparency applications; an arm’s length approach cannot substitute for real discussion about what’s driving batch rejections. Whether the goal is consistency in detergent blends or high-purity intermediates in fine chemicals, we’re used to tweaking production at the source based on actual user parameters – verified by our own analytical and application labs before any change leaves the plant floor. Reporting only what is measured, not abstract claims, forms the basis of trustworthy collaboration.

    From Customer Requests to In-house Innovation

    Frequent questions from users spark our internal projects. Some customers drive demand for even narrower specifications (lower chloride content, minimized chiral cross-contamination); others want scalable options for pilot projects. Our workflow incorporates feedback from end users facing bottlenecks, such as excess foam in continuous agitation systems or off-odors in specialty elastomers. We back up every change with run data, field-tested protocols, and hands-on evidence rather than empty marketing pitches.

    The Future for Specialty Polyols in Advanced Manufacturing

    Manufacturing specialty polyols rewards incremental innovation, not shortcuts. Whether in pharmaceuticals, advanced coatings, or surfactant science, demands center on predictability, purity, and functional leverage. In our line, 1-O-Benzyl-Rac-Glycerol demonstrates how retooling a simple triol to carry a benzyl group answers the modern challenge for more selective, more reliable, and cleaner-reacting raw materials. Decades of practical focus have shown that the best manufacturing approaches never rest on standard operating language. Actual performance, batch after batch, tells the real story.

    Commitment to Evolving Needs

    Chemical manufacturing cannot freeze at a single benchmark. As techniques for analysis sharpen, new processes come to market, and customer needs diversify, our team keeps its focus on flexible, responsive production. The trust placed in us each time a customer launches a new formulation or qualifies a process relies on more than certificates; it’s built on knowing the product coming off the latest line matches what came through a year ago – or better. For us, the evolution of 1-O-Benzyl-Rac-Glycerol means constant dialogue, careful control of all raw inputs, and respecting the subtleties that only years immersed in manufacturing can teach.

    Real-World Stories: From Batch Records to End Results

    A paper coater in Europe asks for feedback on curing inconsistencies. Analysis traces these back to subtle variances in the mono-benzyl-glycerol lot; our technical group replicates the formulation, tests for trace byproducts, and refines the washing stage. Later, a South American polymer blender pushes for higher throughput and reduced downtime. We dig into agitation profiles, streamline filtration, and deliver a batch with adjusted viscosity that holds up throughout their cycle. These stories land in our records, fueling improvements and providing confidence for the next request.

    Voices from Every Level: Operators, Chemists, and End-Users

    The story of every batch lies not just in technical sheets, but in shared experience. Operators who spot a trace haze know how a filter swap changes outcomes. Chemists who face challenging purifications recognize when product quality passes the test, or when an iterative step must return to the mixer. End-users looking for “off-the-shelf” reliability find that the story extends all the way back to raw material selection and early process design. Focused manufacturing, built on dialogue rather than automated response, ensures the highest quality product arrives at each facility.

    Conclusion: Specialty Production without Compromise

    Making and supplying 1-O-Benzyl-Rac-Glycerol as a trusted specialty polyol requires rigor at every stage, sharp attention to downstream effects, and respect for the difference experience brings to industrial chemistry. We stand ready not just with a product, but with a working partnership informed by a real-world grasp of what differentiates a batch that simply passes a spec from one that consistently empowers the front edge of discovery and production.