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1-Naphthol-4-Sulfonic Acid

    • Product Name 1-Naphthol-4-Sulfonic Acid
    • Alias Schaeffer’s Acid
    • Einecs 202-080-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    641572

    Cas Number 80-13-7
    Molecular Formula C10H8O4S
    Molecular Weight 224.23 g/mol
    Appearance White to off-white powder
    Melting Point 210-215°C (decomposes)
    Solubility In Water Soluble
    Synonyms Sultone, Schaeffer’s acid, 1-Naphthol-4-sulphonic acid
    Ph Acidic (aqueous solution)
    Storage Temperature Store at room temperature, keep container tightly closed

    As an accredited 1-Naphthol-4-Sulfonic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 100g package features a tightly sealed amber glass bottle, labeled “1-Naphthol-4-Sulfonic Acid,” with safety and handling instructions.
    Shipping 1-Naphthol-4-Sulfonic Acid is shipped in tightly sealed containers to prevent moisture absorption and contamination. Packages comply with chemical shipping regulations, including hazard labeling if required. The chemical should be stored and transported in a cool, dry place, away from incompatible substances, with adequate protection against physical damage and environmental exposure.
    Storage 1-Naphthol-4-Sulfonic Acid should be stored in a tightly closed container, in a cool, dry, and well-ventilated area. Keep away from incompatible substances such as strong oxidizers and bases. Protect from moisture, heat, and direct sunlight. Use appropriate chemical safety storage cabinets and clearly label containers to prevent accidental misuse or contamination.
    Application of 1-Naphthol-4-Sulfonic Acid

    Applications of 1-Naphthol-4-Sulfonic Acid in Industrial Manufacturing

    As a direct manufacturer, we supply 1-Naphthol-4-Sulfonic Acid for a number of specialized industrial sectors. This compound’s distinct chemical properties enable its integration into well-controlled production environments where regulated process conditions and traceability are critical. Real-world downstream applications are outlined below, with details on regulatory compliance, input ratios, process flow, and typical finished products for each segment.

    1. Azo Dye Intermediates for Textile Pigment Synthesis

    Large-volume textile dye operations use 1-Naphthol-4-Sulfonic Acid as a diazo coupling component. The sulfonic group promotes water solubility and fastness in acid dye processing, while the naphthol core delivers stable chromophores. Our material enters the azo dye synthesis sequence after diazotization of the matching diazo compound, ensuring controlled pigment shade and purity for downstream wet dyeing and printing of natural or synthetic fibers.

    Industry compliance standards

    • OEKO-TEX® Standard 100 Restricted Substances List (RSL)
    • ZDHC Manufacturing Restricted Substances List (MRSL) Level 3
    • REACH (EC) No 1907/2006 for textile chemicals
    • ISO 9001:2015 Quality Management in pigment production

    Typical usage ratio

    • 0.2 to 0.6 molar equivalents relative to diazo precursor depending on target dye class and color depth
    • Ratio adjusted by shade intensity and end-use wash fastness targets

    Downstream process integration

    • Introduced into the diazotization–coupling reactor after primary diazo formation
    • Critical for controlling pH-sensitive coupling and particle filtering post-reaction
    • Integrated with dispersing agents before spray drying or wet cake isolation
    • QC monitored for purity and sulfonation degree in final pigment cake

    Final product types

    • Azo acid dyes for wool, nylon, silk textile markets
    • Disperse dyes for polyester fibers
    • Direct dyes for cotton and cellulosics
    • Printing paste concentrates for digital and rotary printing

    2. Pharmaceutical Intermediate in Active Pharmaceutical Ingredient (API) Synthesis

    Pharmaceutical contract manufacturers use 1-Naphthol-4-Sulfonic Acid to build aryl sulfonate segments in certain APIs. The compound participates in sulfonation or direct coupling steps, especially for molecules where aromatic hydroxy- and sulfonic functions must be introduced with high regioselectivity. GMP-grade supply ensures tight control of residual solvents and heavy metals for regulated pharma synthesis.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for APIs
    • USP-NF Monographs (for related aromatic sulfonates)
    • 21 CFR Part 211—CGMP for finished pharmaceuticals
    • EU GMP Volume 4, Annex 8 (intermediate suppliers)

    Typical usage ratio

    • 100–120% molar equivalents based on the needs of particular API transformation route
    • Stoichiometry adjusted according to by-product management and yield optimization

    Downstream process integration

    • Added after first-stage aromatic substitution or sulfonation to achieve precise positional selectivity
    • Careful pH and solvent controls to avoid over-sulfonation
    • Integrated into multi-step continuous or batch synthesis lines
    • Full traceability and change control under GMP batch release

    Final product types

    • API precursors for cardiovascular and anti-inflammatory drugs
    • Sulfonate derivatives for finished injectable formulations
    • Aromatic building blocks in licensed pharmaceutical products
    • Sulfonated excipients where required by monograph

    3. Paper Dyeing and Coatings Additive

    Producers in the specialty paper and packaging industry use 1-Naphthol-4-Sulfonic Acid as a dye intermediate for high-fastness coloration. The sulfonic function increases binding to cellulose fibers, while aromatic groups contribute to brightness and shade uniformity in finished wet and dry-end coatings. Its introduction is carefully timed in colorant synthesis for surface-sized and vat-dyed grades.

    Industry compliance standards

    • EN 646:2019 Paper and board for food contact—color fastness
    • ISO 1831:1981 (Dyes for papermaking)
    • FDA 21 CFR 176.170 (paper additives, food contact)
    • FSC Chain of Custody for sustainable packaging operations

    Typical usage ratio

    • 0.5–1.0% by weight in pigment or secondary dye synthesis—optimized per coating thickness and brightness specification
    • Adjust based on pulp slurry loading and dry-end pigment retention efficiency

    Downstream process integration

    • Mixed with inorganic bases and oxidizers in colorant reactors
    • Dispersed immediately prior to coating kitchen or pigment make-down tank
    • Blended with starch or latex binders for surface application
    • Monitored at refiner or size press for shade and binder compatibility

    Final product types

    • Colorfast coated copy paper
    • Food-grade packaging board
    • Specialty art and office papers
    • Industrial label stock and wet strength papers

    4. Leather Tanning and Dyeing Chemical

    Industrial leather finishing units apply 1-Naphthol-4-Sulfonic Acid in the production of specific direct and acid dyes. These dyes provide wash durability, deep shade, and enhanced migration into collagen matrices. The material is involved in the post-chrome tanning dye bath formulation, often paired with tanning auxiliaries for even uptake and long-term durability.

    Industry compliance standards

    • BfR XXI Leather Recommendations (for consumer contact)
    • REACH Annex XVII (restricted azo dyes for leather goods)
    • ISO 17075:2017 (chromium VI determination in tanned leather)
    • LWG (Leather Working Group) audit protocols

    Typical usage ratio

    • 0.7–1.5% on shaved weight of raw hide in standard acid dye baths
    • Adjusted according to desired depth of color and retanning sequence

    Downstream process integration

    • Added to dye mixing tanks prior to heating and pH adjustment
    • Introduced after chrome retanning and before fatliquoring stage
    • Blended with leveling agents to stabilize shade in finished splits
    • Subjected to fixation steps to anchor colorfastness

    Final product types

    • Full-grain finished leathers for automotive interiors
    • Dyed leather shoes and accessories
    • Bookbinding, upholstery, and luxury goods leathers
    • Specialized glove leathers requiring sweat fastness
    Free Quote

    Competitive 1-Naphthol-4-Sulfonic Acid prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Understanding 1-Naphthol-4-Sulfonic Acid From the Manufacturer’s Perspective

    Introduction to 1-Naphthol-4-Sulfonic Acid

    Over the years, we’ve dedicated significant resources to mastering the manufacture of 1-Naphthol-4-Sulfonic Acid, a compound that meets the unique challenges our clients face in dye synthesis, pigment production, and pharmaceutical intermediates. Many decades back, naphthol sulfonic acids meant only coarse powders with plenty of impurities—lacking the purity or stability for modern processes. We took the approach of asking not just what the industry wanted, but what the chemistry genuinely needed. Our knowledge does not grow out of market rumor or trading connections, but from long hands-on work, troubleshooting and optimizing the chemical pathways ourselves in our own reactors, batch after batch.

    What Sets Real Manufacturing Apart—And Why It Matters

    Some view 1-Naphthol-4-Sulfonic Acid as one more link in the supply chain. To us, it represents the direct result of precise sulfonation and isolation, using raw starting materials that demand careful quality control at every stage. No shortcuts—because contaminants and variable crystal forms don’t just end up as "trivial issues" downstream. Even a modest shift in sulfonation temperature or pH can alter solubility, create side products, or cause color variations in the pigments our customers expect to deliver perfectly. This is the difference between owning the core chemistry and handling only third-party or off-the-shelf products.

    Examining Models and Specifications from a Chemist’s Viewpoint

    In manufacturing, we recognize that 1-Naphthol-4-Sulfonic Acid tends to arrive in more than one technical form. Over the last ten years, the two most requested grades in our catalog—the high-purity crystalline type and the free-flowing technical powder—came about because labs and formulators repeatedly asked to avoid headaches related to filtration and downstream blending. For high-end dye manufacture, the crystalline material gives consistent reactivity, while pigment and pharma batches often favor the technical grade for dispersibility.

    On our floor, analyzers constantly monitor for two benchmarks: sulfonic acid group placement (para over ortho substitution) and iron contamination. These affect finished dye shade, solubility, and overall yield, not just for our clients, but for our own downstream partners in printing inks and drug synthesis. Our technicians know, from thousands of batches, that the difference between an 85% and 98% assay isn’t just about numbers on an assay sheet—it’s about predictability when scaling up to metric- or ton-scale production. The right grade means fewer purification steps and less production downtime.

    Applications: Learning from Real-World Use

    Almost every season brings new requests, but 1-Naphthol-4-Sulfonic Acid keeps proving essential largely in azo dye chemistry, pigment manufacture (such as specific lake pigments), and as a pharmaceutical intermediate. In dye houses, this acid couples smoothly with diazonium salts to yield clean, strong chromophores for textiles, paper, and inks. Based on field feedback, batches synthesized using our high-purity crystalline grade produce richer hues and clearer shades. There’s little argument among plant chemists that even a minor impurity from a lower grade can throw off shade aim or require process adjustments downstream.

    Regarding pigment intermediates, consistent sulfonic acid placement and low metals matter even more. Sensitive manufacturing of β-naphthol pigments involves demands for both processability and hue target, so technical support often relies on direct discussion with their counterpart on our side to adjust specs before we load the drums. In pharmaceuticals, the path is equally demanding. User safety rests on how clean and stable our intermediate is, since their subsequent steps (napthylamines, coupling agents) often lack downstream purification. Our own experience drilling into batches after even minor raw material changes makes the case: reliable manufacturing of this acid means stronger guarantees for every finished formulation or tablet.

    Core Differences from Competitive Products in Actual Production

    The differences between properly manufactured 1-Naphthol-4-Sulfonic Acid and dealer-traded material become clear not just in the lab but at full production scale. Sourcing material from a true manufacturer, we manage not only raw input quality but exactly how the sulfonation ran, the temperature profile along the reactor, and how final isolation occurred. We can fingerprint each batch’s byproduct profile and guarantee a repeat purchase will respond exactly like the last shipment. Resellers and trading houses rarely monitor synthesis parameters closely. Often their warehouses carry stock synthesized at several plants, with shifting specs batch to batch. This inconsistency tripped up too many partners who switched to us after suffering unpredictable yield loss or erratic dye shade.

    Direct access to our skilled technicians means customers have confessed they work with more confidence—process chemists don’t have to call a distributor’s customer service and wait days for real technical answers. Our teams troubleshoot failures quickly because many of us have run the reactors with our own hands and studied where side reactions take off and how to avoid them.

    Specification Nuances and Real-World Impacts

    As manufacturers, not brokers, we talk about assays, water content, and color indices like practical shop talk, not just catalog numbers. Each 1-Naphthol-4-Sulfonic Acid batch comes off the line with a tight window for naphthol purity, typically above 97%, and controlled sulfonic acid placement above 95%. Water content can swing batch performance in pigment manufacture, impacting drying times and blend ratios. Iron and other trace metal levels stay well below 30 ppm, which our pigment clients recognize as crucial for producing consistent tones.

    We believe in offering both the analytical data and the operating knowledge gained from troubleshooting dozens of real-life process hiccups. For example, one long-term customer required a modified grade with less sodium chloride carryover to avoid streaking in their formulation. Our process engineers altered the wash cycle and drying curve. This kind of flexibility sets apart a manufacturer who can tinker at the source from dealers limited to what comes sealed in drums out of someone else’s plant.

    Supporting Facts: Years of Controlled Chemistry

    Every claim we make reflects both documented batch records and decades of direct manufacturing audits. Shortcuts or improvisations turn up later as unstable dyes or inconsistent tablet formulations. External audits and certifications do matter, but the real difference comes from hundreds of cycle runs and in-house analytical work: HPLC data recording retention times; IR spectra confirming substitution; melt points aligning across multiple seasons. These technical efforts do not stay filed away—they shape how we select our sulfonation solvents, optimize post-reaction neutralization, and choose multi-stage filtrations. We have seen customers caught off-guard by "bargain" material, either failing their shade targets or having to rework expensive finished products because of variable grades bought through distributors.

    Addressing Key Concerns Raised by Industry Users

    Uncertainty around consistency and contaminant levels stay at the top of customer concerns. Often, first-time buyers walk in demanding the “purest grade,” after learning the hard way how batch-to-batch drift can ruin whole lots of pigment or dye. Our answer always involves real test records and frequent lot-to-lot transparency. Having control over both raw material and every step of the manufacturing process lets us address these concerns quickly. If a pharmaceutical partner requests lower aromatic amine content, we have logged exactly which suppliers and processing tweaks influence this. Having no intermediary lets us respond rapidly, whether it’s a spec change, a pack size request, or clarifying a technical parameter.

    Customers and end users have called out two key dangers with non-manufacturer sources: false or inflated assay reporting, and lack of root-cause support in case of downstream failures. Third-party-supplied 1-Naphthol-4-Sulfonic Acid often lacks robust traceability. If their batch fails due to off-odors, unusual color, or issues during coupling, the trail typically ends at the last distributor, not at an accountable process chemist or technical manager. Here, years of manufacturing experience let us retrace any issue through both plant logs and analytical workups, reviewing every aspect from raw input certification to drying schedules. We work directly with partner chemists to isolate whether the trouble stems from changes in grade, blending, or final formulation.

    Opportunities for Process Improvement and Future Solutions

    As end-user demands grow, especially with REACH and other compliance drivers, we’ve aligned our 1-Naphthol-4-Sulfonic Acid process around both chemical purity and environmental responsibility. Rather than defaulting to old processes with heavy waste, we’ve shifted sulfonation step management for improved yields and reduced byproduct disposal. This has cut residuals that often trouble pigment or pharma applications. Improving the isolation and drying sequence trimmed off extra salts and lower-molecular-weight impurities, which can accelerate filtration or extend tablet shelf-life in pharmaceutical intermediates.

    Customers often share process friction or yield loss details from competitor products. This field intelligence shapes how we optimize at the plant, not as a marketing tactic, but to build reliability around each batch’s downstream use. Some pigment makers needed higher flowability for modern reactors; our engineers adapted crystallization rates and packaging methods to address this. When ink formulators complained about particle forming during storage, we upgraded purity checks and refined packing specs. Every improvement grew from the kind of direct technical conversations possible only with an accountable manufacturer.

    Industry Demands: Traceability and Integrated Support

    Direct traceability remains one of our proudest advantages. Unlike dealers or redistributors, we can provide full lineage, down to the actual reactor and day the lot was completed, and which technician signed off on final analysis. End users running food-grade pigment or pharma intermediates have tested us with complicated audit demands—including full batch records, impurity profiles extending up to three decimals, and sample storage that stretches several years. Many describe relief at being able to access decades of batch performance quickly during product recalls or regulatory inspections. That level of transparency grows only where manufacturers participate in each step of the process, not where lots are commingled from different origins.

    Having a long-term, two-way conversation with end users not only refines product details—it keeps us alert to changes in market mindset, from emerging eco-standards to the tightening definitions of "purity" in food and pharma applications. We often coordinate with user teams to tweak process conditions for better yields and less waste. Examples span everything from reducing ash and trace heavy metals for specialty dyes to providing tailored moisture levels for sensitive synthesis steps. This feedback loop rarely exists when supply happens indirectly through larger trading networks.

    Conclusion: Direct Manufacturing Means Stronger Partnerships and Products

    Decades of hands-on experience in producing 1-Naphthol-4-Sulfonic Acid taught us lessons not found in specification sheets or trade catalogs. Actual chemical manufacturing brings with it the need for tireless attention to detail, honest batch-to-batch reporting, and a willingness to keep learning directly from both our reactors and our customers’ feedback. Each order represents a genuine technical relationship, not a faceless transaction. The technical nuance around isomer placement, drying, impact of trace ions, and batch stability doesn’t just influence lab results—it turns into either production headaches or market-leading products, depending on who made the acid in the first place.

    We engage with industry partners—dyestuff engineers, pigment mixers, tablet formulators—because our own fortunes rise and fall with theirs. By controlling and understanding every step, from raw material procurement through sulfonation, isolation, drying, and packing, the product our customers receive stands apart from generic lots. Our plant teams see their work in every shade, every pigment batch, and every pharma intermediate. That’s the kind of difference only a dedicated manufacturer makes real.