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1-Naphthaleneacethydrazide

    • Product Name 1-Naphthaleneacethydrazide
    • Alias NAH
    • Einecs 211-599-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    709746

    Chemical Name 1-Naphthaleneacethydrazide
    Molecular Formula C12H12N2O
    Molar Mass 200.24 g/mol
    Cas Number 6747-95-1
    Appearance White to off-white solid
    Melting Point 186-189 °C
    Solubility Slightly soluble in water, soluble in organic solvents
    Storage Conditions Store in a cool, dry place, keep tightly closed
    Synonyms 1-Naphthylacetylhydrazine
    Purity Typically ≥98%
    Smiles C1=CC=C2C(=C1)C=CC=C2CC(=O)NN
    Inchi InChI=1S/C12H12N2O/c13-14-12(15)8-10-6-4-7-11-5-2-1-3-9(10)11/h1-7H,8,13H2,(H,14,15)

    As an accredited 1-Naphthaleneacethydrazide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 1-Naphthaleneacethydrazide is supplied in a 25g amber glass bottle with a secure screw cap and tamper-evident seal.
    Shipping 1-Naphthaleneacethydrazide is shipped in tightly sealed containers, protected from light, moisture, and incompatible substances. It is packed per regulatory requirements for hazardous chemicals. The packaging ensures safe transport, minimizing risks of leaks or spills. All shipping complies with local, national, and international chemical transport regulations. Safety documentation is included.
    Storage 1-Naphthaleneacethydrazide should be stored in a tightly sealed container in a cool, dry, and well-ventilated area, away from direct sunlight and incompatible substances such as strong oxidizers and acids. Protect from moisture and sources of ignition. Label the container clearly and handle using appropriate personal protective equipment to prevent inhalation, ingestion, or skin contact. Store according to standard laboratory chemical storage protocols.
    Application of 1-Naphthaleneacethydrazide

    Applications of 1-Naphthaleneacethydrazide in Industrial Manufacturing

    1-Naphthaleneacethydrazide is a specialty organic intermediate widely adopted in the synthesis of fine chemicals. Below are key end-use scenarios in which this material has proven performance in real-world manufacturing environments. Detailed compliance references, process guidance, and end-use formulations are presented for each industrial segment.

    1. Commercial Synthesis of Fungicide Intermediates

    Production facilities employ 1-naphthaleneacethydrazide during the manufacture of key intermediates required for certain systemic agricultural fungicides. It participates as a selective nucleophile in the construction of hydrazone frameworks, under controlled batch or flow chemistry conditions, to yield intermediates that enhance final product stability and bioactivity. This step is performed at elevated temperatures with closely monitored reaction parameters to comply with crop protection industry requirements, ensuring precise conversion to registered active compounds.

    Industry compliance standards

    • FAO/WHO Specifications for Agricultural Pesticides
    • ISO 9001:2015 Quality Management System for Agrochemical Production
    • Regulations (EC) No 1107/2009 (European Union Plant Protection Products Regulation)
    • US EPA 40 CFR Part 158 (Pesticide Registration Data Requirements)

    Typical usage ratio

    • 0.8–1.3 molar equivalents relative to aldehyde or ketone reactant; formula ratio adjusted to minimize excess and manage hydrazide conversion efficiency based on process scale.

    Downstream process integration

    • Added after the condensation of naphthyl precursors, specifically during hydrazone intermediate synthesis prior to cyclization or oxidation stages in the fungicide synthesis route.

    Final product types

    • Intermediates for azole or strobilurin fungicides (e.g., hydrazone-carrying precursors for DMI or SDHI pesticide registration dossiers).

    2. API Key Intermediate Manufacturing for Oncology Drugs

    Chemical process developers utilize 1-naphthaleneacethydrazide in pharmaceutical ingredient synthesis, particularly during the route development for targeted oncology compounds featuring hydrazone or naphthyl motifs. The material enables selective introduction of functional groups and provides exceptional purity control, essential for downstream cGMP compliance and subsequent hydrogenation or cyclization. In API manufacturing, traceability and impurity profiling trace back to this stage, so process validation and analytical methods center on this transformation.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.)/USP monographs for intermediate and impurity levels
    • 21 CFR Part 211 (US FDA GMP for finished pharmaceuticals)
    • Chinese Pharmacopoeia ChP 2020 requirements for chemical APIs

    Typical usage ratio

    • 0.95–1.10 molar equivalents relative to target carbonyl input molecule; may vary ±5% based on purity of charge and desired product batch yield, with inline HPLC monitoring.

    Downstream process integration

    • Introduced in the early-stage synthesis immediately after naphthalene functionalization, enabling formation of hydrazone-linked API precursors prior to resolution and final API finishing.

    Final product types

    • Key intermediates for anticancer actives such as naphthyl-substituted hydrazones or tricyclic analogs processed into injectable and oral oncology formulations.

    3. Specialty Dye Manufacturing

    Textile and ink producers select 1-naphthaleneacethydrazide as a building block for the creation of azo and hydrazone dyes exhibiting strong lightfastness and chemical resistance on cellulose and synthetic fibers. During colorant synthesis, it operates as a diazo coupling partner under controlled pH, optimizing shade and compound stability. Rigorous safety, effluent, and color strength specifications drive tight process control and waste minimization on dyeing lines.

    Industry compliance standards

    • OEKO-TEX Standard 100 for harmful substance limitations
    • EU REACH Annex XVII on azo dye safety requirements
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals Manufacturing Restricted Substances List)
    • ISO 105 series (textile color fastness standards)

    Typical usage ratio

    • 0.7–1.2 equivalents relative to aromatic diazonium salt, with exact ratio set by desired chromophore concentration and required fastness specifications.

    Downstream process integration

    • Engaged during the coupling reaction in batch or semi-continuous dye reactors, after diazotization and before neutralization or filtration steps in colorant synthesis.

    Final product types

    • Synthesized hydrazone dyes for cellulosic, nylon, and polyester fiber applications; industrial inkjet colorants; pigment dispersions for plastics and coatings.

    4. Chemical Sensor Material Fabrication

    Analytical instrument and sensor component manufacturers employ 1-naphthaleneacethydrazide as a key material for the production of reagent layers in chemical sensors designed for aldehyde or ketone detection. Its hydrazide functionality offers high reactivity and stable sensor response, supporting integration into optical strips and microfluidic cartridges. Cleanrooms maintain strict validation of each step, from in-line coating to packaging, to uphold precise calibration and detection standards.

    Industry compliance standards

    • ISO 13485:2016 (Medical Device Quality Management for diagnostic sensors)
    • FDA 21 CFR 820 QSR (Quality System Regulation)
    • EN ISO 15189 (Medical Laboratories—Requirements for quality and competence)
    • RoHS 2015/863/EU (Restriction of Hazardous Substances for sensor componentry)

    Typical usage ratio

    • 10–50 mg per sensor strip or 0.01–0.1% w/w in batch-printed formulations, adjusted per detection sensitivity and analyte calibration requirements.

    Downstream process integration

    • Formulated during the sensor reagent coating or immobilization step, often via solution-casting, inkjet deposition, or lamination onto optical substrate films before device assembly.

    Final product types

    • Chemical sensor pads for environmental monitoring; disposable test strips for medical diagnostics; aldehyde/ketone optical reagent modules for laboratory analysis.
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    Certification & Compliance
    More Introduction

    1-Naphthaleneacethydrazide: A Closer Look at a Distinctive Chemical Solution

    Unlocking the Practical Side of Synthetic Building Blocks

    Working every day in chemical manufacturing has taught us to pay attention to details and craftsmanship that often escape notice. With 1-Naphthaleneacethydrazide, we see a unique tool for chemists and formulators aiming to bridge aromatic and hydrazide chemistry. Our experience on the shop floor reveals how this compound stands out for its stable naphthalene framework and reactive hydrazide group, which deliver both structure and adaptability for downstream synthesis.

    Product Overview and Model Specifics

    The model we produce consistently features high purity, meeting demanding industry needs. Synthesized using batch-controlled procedures and tested at various production stages, our 1-Naphthaleneacethydrazide maintains a fine white to off-white crystalline appearance. Typical specification packages include only minimal trace residues—our daily quality control routines push below 0.5% moisture and keep impurities well within accepted limits. Each lot comes from monitored reaction vessels, not bulk commodity blending, giving our technical team full command over every kilo that leaves our site.

    Why the Naphthalene Backbone Matters

    We’ve seen first-hand how the double-ring structure of naphthalene delivers robustness under heat and processing stresses that would compromise other aromatic hydrazides. Our reactors handle plenty of requests for alternative hydrazides, but few offer the thermal and oxidative stability that 1-Naphthaleneacethydrazide brings. This backbone resists unwanted ring opening during reactions, and we rarely see side-products during work-up or purification—a benefit that cuts down on waste and headaches for chemists scaling up lab trials.

    Real-World Usage and Process Insights

    Chemical manufacturing isn’t a world of maybes and hypotheticals—it’s about repeatable output, process reliability, and minimizing surprises between lab-bench concepts and ton-scale production. 1-Naphthaleneacethydrazide frequently serves as an intermediate for specialty colorants, pharmaceuticals, and certain agricultural protectants. Customers report smoother acylation and condensation steps when using our material. In some routes, it helps drive the formation of new heterocycles, thanks to its well-calibrated nucleophilicity and solubility characteristics.

    Our synthesis teams have optimized the work-up so filtration proceeds rapidly and crystals form in manageable, free-flowing form. This is not always the case with semicarbazides or aliphatic hydrazides, which often cake up or hold onto solvents. We regularly receive feedback: switching to our naphthalene-based hydrazide trims hours from downstream purification, which means customers avoid bottlenecks and unpredictable variability in yield.

    Key Differences From Other Hydrazide Products

    People sometimes ask why 1-Naphthaleneacethydrazide, and not an alkyl or benzoyl hydrazide. Over years in production and scale-up support, several points come up repeatedly. One, the aromatic naphthalene core changes the electronics of the hydrazide group, pushing reactivity in directions not easily matched with simpler backbones. This matters when synthesizing targets where selectivity is crucial. Two, the melting point generally runs higher, which helps users avoid premature decomposition in multi-step processes.

    We manufacture hydrazides with different backbones, and the comparison is clear. Take benzoyl hydrazide—cheap and available, but its reactivity profile and process impurities often complicate precision chemistry. Aliphatic hydrazides bring flexibility but lack the contribution to aromatic stacking or rigidity in final products, limiting their utility where product consistency or mechanical strength is needed. The naphthalene variant addresses both issues, often enabling reactions that either fail outright or return poor yields with other agents.

    Quality Control and Direct Manufacturing Oversight

    We see a difference when chemicals move through too many hands before reaching a user. By synthesizing, purifying, and packaging 1-Naphthaleneacethydrazide entirely in-house, our team controls contamination risks and variable handling. Batch records remain accessible, our QC chemists personally verify samples, and we keep traceability tight. This approach builds trust with repeat customers and shields them from common pitfalls seen with merchant resellers or poorly tracked imports.

    Trace metals and solvent residues tell experienced eyes whether a compound has changed hands too many times. Because we do not outsource critical process steps, we’ve nearly eliminated post-shipment complaints about fouled equipment or contaminant peaks. For researchers or production plants running months-long programs, this consistency means repeatable data and more predictable costs.

    Handling and Shelf Life From the Manufacturer’s View

    Our formulation teams advise users to store 1-Naphthaleneacethydrazide cool and sealed, not because it’s unstable, but to maintain optimal reactivity. Experience shows the material stays free-flowing and non-hygroscopic for extended periods on the right racking. Odd lumps or off-odors often trace to poor handling upstream; our packaging technicians rely on robust lining and double-seal techniques to keep each batch protected from air and light swings. In our own accelerated stability assessments, properly packed batches show negligible change even after a year under controlled conditions.

    Safety and Environmental Responsibility

    Our team works under strict compliance with workplace safety and environmental rules. We’ve implemented closed filtration and dust-extraction systems to keep air levels well below recommended limits. Our wastewater treatment systems are set to neutralize all mother liquors, so any hydrazide residues reduce well before plant discharge. Plant workers receive regular exposure training, and we take feedback from line operators seriously—frequent glove changes, proactive skin protection, and clear PPE standards exist for a reason, based on lessons learned during plant operations over the years.

    In our market, responsible manufacturing means minimizing off-gassing and solvent carryover. Since we work with hydrazide intermediates regularly, our facilities prioritize recyclability and emission controls. Clients sometimes ask for advice on downstream waste handling, and we provide real-world insights—not just recitations from safety data sheets. True environmental stewardship in chemical production takes active monitoring, root-cause investigations when issues arise, and clear accountability on batch records.

    Supply Chain Transparency and Market Dynamics

    Global chemical supply chains have faced bottlenecks from unexpected logistics disruptions and shifting regulatory requirements. Over the past decade, we have invested continuously in upstream integration—sourcing naphthalene and acetic hydrazide precursors through traceable origins and maintaining ample production stocks. This approach carried us through periods where traders and blenders encountered significant delays or shortages. End-users of 1-Naphthaleneacethydrazide rely on steady deliveries from us because their own processes cannot halt for raw material gaps. By keeping raw material qualification and final packaging inside a closed loop, our customers avoid the surprise of specification deviations or missed shipments.

    Some clients have switched from brokered hydrazide options after encountering unpredictable performance or impurity blips that crippled ongoing projects. Our production flexibility allows us to adjust batch size or package format for projects from small scale R&D to multi-ton campaigns. Rather than guessing material provenance, our partners can count on transparent batch histories and ready technical support from developers who understand the intricacies of hydrazide chemistry from source to shipment.

    Practical Application Scenarios, Supported by Real Experience

    Contract manufacturing outfits handling active pharmaceutical ingredients use our hydrazide to initiate ring-closure in heterocycle construction, benefiting from the clean reaction signatures and manageable work-ups. Several pigment makers depend on our batch-controlled product to anchor azo coupling steps, achieving chromatic intensity and purity hard to replicate with other precursors. We’ve helped formulators in agrochemical development troubleshoot late-stage processing by recommending processing tweaks based on long-term batch trends.

    We also field questions from resin and polymer labs seeking rigid, aromatic hydrazides for their network-forming chemistry. Our direct technical service team shares case-specific insights, such as solvent selection, temperature ramp protocols, and work-up tips, based on practical challenges observed at the plant. Years on the production line have shown that open communication can shorten development cycles and keep scale-up projects on track.

    Customer Feedback Shaping Our Production

    We have learned the most listening to customers describe their hurdles in scaling up reactions, purifying products, or managing variable impurity loads. One frequent report: batches of 1-Naphthaleneacethydrazide compare favorably to commodity variants, especially during downstream conversion to carboxamides, ureas, or triazoles. Our flagged feedback loops reach the production manager and quality assurance team, who quickly adjust drying or seeding protocols in response to on-the-ground needs. This hands-on approach keeps our product aligned with evolving application requirements, rather than drifting into complacency.

    We treat every batch as a partnership with the end user. If anomalies show up—an unusual melt range, solubility issue, or filtration hiccup—our team mobilizes to uncover the cause and prevent recurrence. Such quality vigilance helps the community of users build confidence and enables faster adoption in demanding synthetic routes. The lessons we pick up from these dialogues refine our processes well beyond regulatory minimums.

    Supporting Data Integrity and Regulatory Confidence

    Manufacturing chemistry that holds up to both internal audits and third-party review means careful recordkeeping and documentation. Our control labs operate with full transparency, logging calibration, raw data, and verification signatures. When a customer prepares for a regulatory filing or needs substantiation for QC trends, our archive delivers the actual batch records—not marketing paraphrasing but technician records from original runs.

    We focus on making sure customers never have to question the identity or purity of their raw material. Our instrument calibration logs remain open for examination, and we provide authenticated samples when needed for method validation or cross-lab confirmation. Building trust by open documentation proves essential in regulated markets, and our manufacturing protocols reflect this expectation.

    Overcoming Process Hurdles and Adapting to Demands

    Adjustments for scale-up, regulatory shifts, or market needs occur all the time. Some product managers require tighter particle size distribution for rapid slurry filtration; others need alternate solvent systems for environmental compliance. Our teams have responded with targeted tweaks—either by varying crystal seeding in reactors or custom packaging changes to protect batches during transportation in humid climates.

    We do not simply replicate commodity hydrazide protocols but adapt process steps and purification as new data emerges. When end-users need guidance, they get real insight—not generic advice, but distilled know-how from our synthesis and QMS experts who monitor lot-to-lot variation and setup root-cause reviews for any deviation. Robust feedback and adaptation keep our 1-Naphthaleneacethydrazide consistently high-performing across diverse usage environments.

    Market Expectations and Long-Term Relationships

    Chemical users today value predictability and accountability. Our repeat business comes from years of stable supply and the ability to explain both strengths and limitations honestly, without embellishment. Over the years, the product has found a place with innovators who push synthetic chemistry forward. They count on raw materials that do not force process stoppages or generate out-of-spec intermediates.

    We stay in close contact with both long-term partners and newer clients piloting novel reactions. Their constructive criticism and support keep us focused on incremental improvements. As market needs shift—tighter regulatory controls, evolving analytical requirements, or new application ambitions—our approach remains grounded in the practical know-how gained from hands-on manufacturing.

    Outlook for the Chemical Manufacturing Community

    Every ton of 1-Naphthaleneacethydrazide we ship represents a chain of choices—upstream integration, disciplined process management, active listening to customers, and a commitment to environmental and worker safety. The insights that shape our approach come from people who run the reactors, test the batches, field the calls for technical troubleshooting, and carry accountability for each delivery.

    Chemical manufacturing works best when transparency, responsiveness, and technical rigor go hand in hand. Our daily commitment to these values enables the community of synthetic chemists, formulators, and process engineers to trust in our product as more than just a specification in a catalog, but as a partner in their innovation pipeline. This trust, built batch by batch over years of collaborative work, defines our contribution to the evolving world of specialty chemicals and advanced intermediates.