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1-Methyl-3-Piperidinemethanol

    • Product Name 1-Methyl-3-Piperidinemethanol
    • Alias 1-Methyl-3-piperidylmethanol
    • Einecs 629-084-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    720891

    Name 1-Methyl-3-Piperidinemethanol
    Molecular Formula C7H15NO
    Molar Mass 129.20 g/mol
    Cas Number 1193-18-6
    Appearance Colorless to pale yellow liquid
    Boiling Point 94-96°C at 13 mmHg
    Density 0.98 g/cm3 at 20°C
    Refractive Index 1.475-1.479
    Flash Point 114°C
    Solubility In Water Miscible
    Smiles CN1CCCC(C1)CO
    Melting Point -10°C
    Storage Temperature 2-8°C

    As an accredited 1-Methyl-3-Piperidinemethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250g of 1-Methyl-3-Piperidinemethanol is securely packaged in an amber glass bottle with a tamper-evident screw cap.
    Shipping 1-Methyl-3-Piperidinemethanol is shipped in tightly sealed containers to prevent leaks or contamination. It should be handled as a chemical substance, protected from moisture and direct sunlight. Proper labeling and documentation are required, and shipping must comply with regulations for potentially hazardous chemicals. Use appropriate protective packaging and transport methods.
    Storage 1-Methyl-3-piperidinemethanol should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers and acids. Protect from moisture and direct sunlight. Store at room temperature or as indicated on the manufacturer’s label. Ensure proper labeling and keep away from sources of ignition. Use secondary containment for extra safety.
    Application of 1-Methyl-3-Piperidinemethanol

    Applications of 1-Methyl-3-Piperidinemethanol in Industrial Manufacturing

    1-Methyl-3-piperidinemethanol serves as a specialized intermediate in a range of advanced chemical syntheses. Our material is produced targeting tight specification control and meets advanced downstream performance needs. Below we detail several verified industrial sectors that incorporate this compound in their process flows, with a focus on regulatory standards, precise formulation roles, manufacturing integration, and real end-products.

    1. Active Pharmaceutical Ingredient Synthesis

    Pharmaceutical manufacturers utilize this molecule as a building block in the synthesis of complex APIs, specifically in heterocyclic and piperidine-based drug actives. It enters the process post-initial ring formation, participating in reductive amination or alkylation steps. Its structure enables buyers to introduce methylated side chains with defined stereochemistry, critically controlling pharmacodynamic properties of final compounds.

    Industry compliance standards

    • Complies with ICH Q7 GMP guidelines for API manufacturing.
    • Adheres to US FDA 21 CFR Part 211 requirements for process chemicals.
    • Supports quality documentation aligned with European Pharmacopoeia (Ph. Eur.) clauses on starting materials.
    • Meets requirements of China Pharmacopoeia for imported and domestic synthesis intermediates.

    Typical usage ratio

    • Ranges from 0.5 to 1.2 equivalents per mole of API core, depending on alkylation reaction path.
    • Adjusted based on impurity profile and desired yield threshold.

    Downstream process integration

    • Charged after initial heterocycle setup in multi-step batch reactors.
    • Dosed precisely in semi-continuous processes for scalable API development.

    Final product types

    • Anti-hypertensive APIs with piperidine moieties.
    • Neurological disorder treatment actives containing methylated piperidine rings.
    • Custom contract-manufactured pharmaceutical intermediates.

    2. Agrochemical Intermediate Synthesis

    In agricultural chemical production, our material fits as a selective alkylating agent for the construction of piperidine-based herbicide and pesticide actives. It features in early- and mid-stage synthesis, introducing specific methylated fragments that enhance systemic mobility or environmental stability in finished agrochemical formulations.

    Industry compliance standards

    • Aligned with FAO/WHO specifications for pesticide technical content (JMPS).
    • Meets OECD guidelines for Good Laboratory Practice in agrochemical research.
    • Supports US EPA standards for inert ingredient approval (40 CFR 180).

    Typical usage ratio

    • Applied at 0.7 to 1.0 equivalents versus the heterocyclic core ingredient.
    • Modulated for reaction selectivity and environmental metabolite profile.

    Downstream process integration

    • Added in alkylation or reductive amination stages, typically at controlled temperature and pressure.
    • Purified using continuous distillation prior to downstream functionalization.

    Final product types

    • Systemic piperidine-based herbicides.
    • Pesticide actives with optimized soil degradation.
    • Precursor intermediates used in seed treatment chemicals.

    3. Specialty Polymer Modification

    Manufacturers of specialty polymers employ 1-Methyl-3-Piperidinemethanol as a chain modifier to introduce flexible, nitrogen-containing side groups. The compound participates in polymerization steps or as a functionalizing agent for post-polymer backbone modification. Resulting materials exhibit enhanced anticorrosion, adhesion, or thermal response characteristics, with application in coatings and adhesives.

    Industry compliance standards

    • Compliant with REACH chemical safety requirements (EU Regulation 1907/2006).
    • Tested under ISO 9001:2015-certified quality control frameworks.
    • Material traceability supported per DIN EN ISO 22510 for polymer intermediates.

    Typical usage ratio

    • Incorporated at 0.5%–3% by weight based on target molar incorporation and desired flexibility index.
    • Higher concentrations possible for high-performance specialty blends.

    Downstream process integration

    • Mixed in during monomer blend stage of batch or continuous polymerization.
    • Added as a post-polymerization functionalizing agent under catalytic conditions.

    Final product types

    • Piperidine-functionalized epoxy resins for electronic encapsulation.
    • Adhesives with controlled amine content for structural bonding.
    • Polymer anti-corrosion coatings for high-humidity applications.

    4. Fine Chemical Intermediate for Flavors and Fragrances

    In high-purity fine chemical synthesis, 1-Methyl-3-Piperidinemethanol functions as a precursor in the construction of specialty aroma compounds and performance-enhancing flavor intermediates. Its unique structure aids in achieving specific olfactory or organoleptic profiles, especially in complex piperidine-modified aldehydes and alcohol derivatives favored by major flavor houses.

    Industry compliance standards

    • Complies with International Fragrance Association (IFRA) and FEMA GRAS guidelines.
    • Supports production aligned with EU Food Additives Regulation (EC 1333/2008).
    • Supports tracking per ISO 22000 for food ingredient traceability.

    Typical usage ratio

    • Dosage of 0.1 to 0.5 moles per mole of key aromatic precursor, as determined by target profile.
    • Amounts adjusted for purity and sensory evaluation during pilot batch production.

    Downstream process integration

    • Added in selective condensation or acylation reactions for final aroma compound generation.
    • Purified through fractional distillation or chromatography to meet finished material purity.

    Final product types

    • Piperidine-structural aroma compounds for high-end fragrance formulations.
    • Flavor intermediates for beverage and confectionery enhancement.
    • Odor performance additives in home and personal care products.

    5. Intermediate for CNS Active Compound Research

    Research laboratories and pharmaceutical scale-up plants use this molecule as a synthetic handle in the design of CNS (central nervous system) active small molecules. The methylpiperidine alcohol moiety is strategically incorporated to modulate BBB (blood-brain barrier) permeability and metabolic stability in investigational NCE projects.

    Industry compliance standards

    • Conducted under GLP (OECD 1, FDA 21 CFR Part 58) for pre-clinical research materials.
    • Documented chain of custody as per USP <1078> guidelines.
    • References to ICH Q11 for process development and impurity control.

    Typical usage ratio

    • Applied at equimolar to 1.5 equivalents, based on synthetic route and metabolite screening needs.
    • Optimized per lead candidate selection in medicinal chemistry programs.

    Downstream process integration

    • Integrated in heterocycle building under inert atmosphere batch synthesis.
    • Employed in late-stage lead optimization for tailored CNS pharmacokinetics.

    Final product types

    • Experimental CNS-active drug candidates with piperidine scaffolds.
    • NCE materials for neuroprotective or cognitive enhancement research.
    • Chemical probes for neurobiological pathway elucidation.
    Free Quote

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    Certification & Compliance
    More Introduction

    1-Methyl-3-Piperidinemethanol: A Closer Look from the Manufacturer’s Perspective

    Understanding 1-Methyl-3-Piperidinemethanol

    As a chemical manufacturer with decades of hands-on experience, every batch of 1-Methyl-3-Piperidinemethanol rolling off our lines reflects detailed attention to purity, safety, and performance. This specialty compound, recognized by its CAS number 3433-33-6, forms a cornerstone in the intermediate segment for fine chemicals, pharmaceuticals, and agrochemical synthesis. Our production process relies on our proprietary synthesis route that removes unnecessary byproducts, yielding crystalline material favored by customers seeking tight control over impurities.

    Unlike simple alcohols or basic amines, 1-Methyl-3-Piperidinemethanol features a piperidine nitrogen coupled with a methanol moiety. This combination leads to unique reactivity profiles, especially valuable for building more complex molecules in both laboratory and plant-scale environments.

    Technical Details and How We Set Our Material Apart

    Manufacturing at this scale demands a clear eye for detail. Our standard product typically reaches a purity >99%, with moisture measured and reported via Karl Fischer titration. In-house gas chromatography pinpoints trace organic impurities with high resolution, and each lot ships with a detailed certificate of analysis based on full in-process quality control, not just batch-end snapshot testing.

    The product appears as a solid at room temperature, often forming fine white to off-white crystals if handled within standard ambient conditions. Strong odors commonly associated with simple amines are minimized due to the ring structure, improving workplace comfort during bulk transfers or pilot reaction setups. Water solubility and miscibility with various organic solvents gives formulators freedom during downstream reactions. Those working with halogenation or reductive amination steps have reported lower occurrence of unwanted side reactions compared to structurally similar aminoalcohols, such as aminoethanols or piperidinols without the methyl group.

    How 1-Methyl-3-Piperidinemethanol Fits Complex Workflow Demands

    Research and industry labs look for consistency batch after batch. Our experience shows that 1-Methyl-3-Piperidinemethanol stands out by delivering a reliable starting point for key intermediates. Chemists synthesizing heterocycles, chiral auxiliaries, or protective agents use this molecule to drive multi-step reactions or fine-tune the steric characteristics of target compounds. Pilot plant scale-ups demonstrate low foaming and stable handling under various conditions—important for maintaining batch yields and safety margins.

    Most alternatives lack this balance of reactivity and structural stability. For example, simple open-chain amino alcohols degrade rapidly under heating or strong acids, while this piperidine derivative maintains integrity through demanding synthetic steps. Customers often remark on the ease of isolating clean product in crystallization or extraction applications, with fewer incidences of residue formation or hard-to-remove color bodies.

    Insight from Decades of Factory Floor Experience

    Out on the plant floor, real differences emerge in scale and repeatability. Our teams have run thousands of kilos per year of 1-Methyl-3-Piperidinemethanol and handled hundreds of recipe tweaks driven by customers searching for a specific melting point range, tighter particle size control, or customized packaging based on process needs. Direct feedback cycles between our QC lab and production teams mean issues don’t linger. If a product doesn’t meet spec, it stays in-house until root causes are understood and solved.

    Compared to off-the-shelf imported material, our in-house product rarely shows common shipping and handling problems like clumping, acidification, or container corrosion. Stable shelf life, even in non-inert packaging, gives procurement teams more room to schedule deliveries and maintain uninterrupted supply. Engineers appreciate the anti-caking features we build in during drying and packaging, so every drum—tapped six months or a year later—behaves the same as a freshly filled one.

    Direct Applications and User Example Stories

    Watching the way 1-Methyl-3-Piperidinemethanol fits into customer sites, the diversity in usage is remarkable. A pharmaceutical partner relies on it for the preparation of advanced intermediates in antifungal research. Another group, focused on new agricultural actives, selected this molecule for its backbone stability and reactivity. Custom synthesis houses use it to introduce functional groups at precise locations, working towards new molecular scaffolds for proprietary compounds.

    Scale-up teams comment on smoother reaction kinetics and color profile improvements compared to other commercial amine-alcohols. Material flows evenly through automated feeders, reducing the risks of line blockages or bridging that persist with older technical grades supplied by resellers. Several users also highlight fewer filtration and drying complications, attributing this stability directly to our process controls and cleaning procedures between campaigns.

    Safety, Handling, and Environmental Impact: Lived Insights

    Safety and environmental impact drive our production choices. Throughout the plant, each chemical release possible—even a stray dusting at the mill—is tracked and minimized. Over years, we’ve tuned our systems so that volatile emissions and wastewater load from 1-Methyl-3-Piperidinemethanol remain below regulatory levels, easing compliance burdens for downstream users. The finished product ships in robust, tested containers appropriate for the chemical and handling profile—never repurposed or under-spec packaging.

    Every operator responsible for charge-in and line cleaning receives hands-on training, using samples from actual production runs, not only theoretical case studies. This ground-level expertise means preventive checks catch container sweats or equipment seals before they cause spills, alerts or unintentional batch loss. We make sure that all waste byproducts and residues from 1-Methyl-3-Piperidinemethanol loops feed into dedicated solvent recovery or neutralizing steps. These choices help partners with stricter internal audits or processes earning ISO certs, because traceability comes built-in from day one.

    Quality and Authenticity from the Source

    Real-world consistency means more than running a product through a spec sheet. We invest time into lot-to-lot traceability, with every shipment matched to its full documentation—down to the operator logging in their name at each stage of production and inspection. Feedback loops run fast: if a customer notes a variance in reactivity or visual appearance, our process team digs in until all parties see the same, reliable results.

    The raw material traceability chain for our 1-Methyl-3-Piperidinemethanol runs deep. Starting materials are selected for chemical compatibility and reliability, not just price point. We avoid high-odor, reclaimed, or bulk-traded feedstock that can drag down downstream performance or introduce contamination risks. All process intermediates are documented and available for customer review if requested, which keeps end-users from absorbing hidden surprises in their workflows.

    Key Differences from Other Market Alternatives

    Over the years, we’ve benchmarked so-called “equivalent” products from a range of regional and international suppliers. The differences show up in more than just purity or documentation. Typical competitors delivering from general traders may skip secondary drying, overlook subtle color changes, or use mixed packaging with elastic liners that leach into the chemical during long storage or exposure to sunlight. We rely on rigid HDPE or steel-lined drums, as they best prevent moisture gain or cross-contamination.

    Open feedback with chemists and engineers on user sites highlighted fewer process interruptions, higher yields, and less plant downtime due to cleaning or filter replacement when choosing our product. Many of these distinctions are the outcome of plant-level decisions—smaller, more frequent equipment maintenance intervals, sharper lot control, and a hands-on production staff empowered to stop a fill or rework a run if anything falls outside spec.

    Direct communication with end-users means requested tweaks in melting range, solidification temperature, or bulk density move rapidly from R&D suggestion to full-scale production, avoiding the “wait for the next international shipment” problem seen with disconnected upstream suppliers.

    What This Means for Sourcing and Supply Reliability

    Global supply chain disruptions have made more customers think critically about their sources for chemical building blocks like 1-Methyl-3-Piperidinemethanol. From our perspective on the factory floor, local control and embedded quality matter more than ever. We keep buffer inventories and local raw material partners so lead times remain stable. If a line goes down or an upstream feed gets delayed, our network of vetted secondary suppliers ensures production continues within normal delivery windows.

    Procurement sometimes focuses only on listed purity or best-available price—neglecting stability, packaging, or logistical readiness. Experience shows that a seemingly small shift in actual fill-point, container type, or batch management can mean the difference between an interruption-free operation and multiple days lost troubleshooting a contaminated or inconsistent batch. Hands-on chemical handling and lot tracking give us a foundation for continuous improvement and fewer unplanned delivery gaps.

    Adapting to Regulatory and Market Changes

    Every year, new regulatory guidance alters expectations for intermediates and specialty chemicals. Our compliance team stays plugged into global changes, guiding process tweaks and documentation long before customers make requests. For 1-Methyl-3-Piperidinemethanol, recent years have brought additional scrutiny on trace contaminants, moisture sensitivity, and the carbon footprint of synthetic intermediates. The plant responded by investing in more efficient distillation and advanced drying lines. Waste minimization programs have already cut solvent use and reduced water demand.

    Attorneys and quality teams from user companies appreciate documentation that matches the real production steps—not one-size-fits-all boilerplate. Analysts receive raw chromatograms, instrument logs, and even archived batch samples when negotiating regulatory review. Transparency about process, not just product, gives regulators and clients confidence in longstanding supply partnerships.

    Customer Support Built on Practical Experience

    Beyond technical data, support staff speak with real manufacturing and laboratory experience. Chemists in the field, not call center agents, respond with targeted advice for solvent selection, product handling, procedural optimization, or waste reuse. This human knowledge prevents process upsets, lost time, and unnecessary troubleshooting on customer sites.

    As researchers push the edges of what 1-Methyl-3-Piperidinemethanol can do, we adapt. Direct dialogue with lead project managers—from pharmaceutical fields to industrial chemical synthesis—underscores our approach: listen first, respond with proven solutions, and track every problem down to root cause. New requests, like custom micronization for high-speed dispensing lines, find real-world solutions implemented within months, not years. Ongoing batch feedback often leads to process upgrades, such as energy-efficient recrystallization or improved in-line filtration.

    Innovation Based on Reality, not Theoretical Optimism

    Many of the product’s strengths come from lived experience: the insights of plant machinists handling sticky or hard-packed lots, the pain points encountered by development chemists when an off-grade batch derails a synthesis. Reliable sourcing means integrating field feedback into tangible product improvements—never sticking to old ways simply because “it’s how things have always been done.”

    Process engineers and R&D teams have driven mid-scale test runs, new drying tower installations, and continuous training programs, from start to finish. Every improvement in crystallinity, handling, or container stability bears the fingerprints of frontline operators, not just back-office management. The partnership formed between process and lab staff acts as the backbone of true product reliability—and every drum of our 1-Methyl-3-Piperidinemethanol embodies that commitment.

    Building Long-Term Trust Through Substance

    Reputation in chemicals rests on consistency and openness. As manufacturers, every outgoing shipment of 1-Methyl-3-Piperidinemethanol carries the weight of the company’s record for delivery, safety, and follow-up. Repeat business depends on measurable differences. Users who turn to our product, after trying lower-cost or less-consistent alternatives, report a steady rise in conversion rates, fewer post-processing steps, tighter process controls, and lower total cost of ownership when hidden problems are factored in.

    From sourcing to shipping, practical knowledge and attention to detail make a crucial difference. Choosing a producer who controls each step—not just a distributor with a broad sales portfolio—means every challenge and improvement cycle loops directly to the source. Accountability isn’t an add-on or a “premium” option. It’s built into every shipment, every lot record, and every partnership we maintain across markets and years.

    Closing Thoughts from the Manufacturing Floor

    Sourcing 1-Methyl-3-Piperidinemethanol directly from a dedicated producer changes the day-to-day experience for anyone designing, scaling, or operating a synthesis process. Variability shrinks. Predictability increases. Unseen errors and delays decrease as real, invested partners handle both the good batches and the challenging ones. Years of first-hand problem solving shape every kilo packed and every support call answered. For anyone relying on high-specification chemical building blocks, producer-led manufacturing unlocks value, security, and a platform for new innovation.