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1-Hexylimidazole

    • Product Name 1-Hexylimidazole
    • Alias N-Hexylimidazole
    • Einecs 252-214-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    205146

    Cas Number 3076-75-5
    Molecular Formula C9H16N2
    Molecular Weight 152.24 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 256-258 °C
    Density 0.951 g/mL at 25 °C
    Solubility In Water Slightly soluble
    Refractive Index 1.484 at 20 °C
    Purity Typically ≥98%
    Flash Point 118 °C (closed cup)

    As an accredited 1-Hexylimidazole factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 1-Hexylimidazole is supplied in a 100 mL amber glass bottle with a secure screw cap and tamper-evident seal.
    Shipping 1-Hexylimidazole is shipped in tightly sealed containers, protected from light and moisture, and in accordance with applicable chemical safety regulations. Ensure containers are clearly labeled and handled by trained personnel. Shipping typically follows standard hazardous material guidelines due to potential chemical hazards; consult the Safety Data Sheet (SDS) for detailed transport recommendations.
    Storage 1-Hexylimidazole should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible materials such as oxidizing agents. Protect it from direct sunlight and moisture. Follow all relevant safety protocols, including proper labeling, to avoid accidental exposure or contamination. Use appropriate personal protective equipment when handling and storing.
    Application of 1-Hexylimidazole

    Applications of 1-Hexylimidazole in Industrial Manufacturing

    As the direct manufacturer and bulk supplier of 1-Hexylimidazole, we provide this specialty intermediate to global partners prioritizing industrial consistency, process safety, and performance. Its unique imidazole structure, with a hydrophobic n-hexyl group, enables specific reactivity and compatibility critical in several downstream industrial fields. Below we document the primary application scenarios, technical formulation practices, process roles, and final product integration for industrial users.

    1. Catalytic Phase Transfer Agent in Pharmaceutical Synthesis

    Leading pharmaceutical manufacturers use 1-Hexylimidazole as a phase transfer catalyst in alkylation, acylation, and condensation reactions involving poorly soluble organic halides and salts. It is particularly favored in the synthesis of imidazolium-based compounds, active pharmaceutical ingredients, and API intermediates where controlled nucleophilic substitution is essential. Its efficacy in organic–aqueous systems supports high reaction yield with minimized waste generation.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice
    • USP General Chapter <1078> Good Manufacturing Practices for Bulk Pharmaceutical Excipients
    • FDA 21 CFR Part 211 (Finished Pharmaceuticals)
    • Relevant MAH requirements for residual solvents and catalyst traces

    Typical usage ratio

    • 0.5–2 mol% relative to the limiting reactant; proportion must be adjusted based on specific solubility and process throughput

    Downstream process integration

    • Charged directly into the reactor after initial solvent charge; removed by aqueous workup post-reaction or recycled as appropriate

    Final product types

    • Pharmaceutical API intermediates: imidazolium derivatives, alkylated imidazoles, heterocyclic drugs
    • Bulk drug substances for further formulation

    2. Corrosion Inhibitor Additive for Industrial Water Treatment

    Water treatment plants and heavy industry facilities formulate 1-Hexylimidazole as an additive in closed-loop and open recirculating water systems to inhibit corrosion of ferrous and copper-alloy surfaces. The molecule’s imidazole ring adsorbs strongly to metal oxides, building a barrier layer that reduces metal ion leaching and pitting, supporting long-term protection with low toxicity profile under standard regulatory frameworks.

    Industry compliance standards

    • ANSI/AWWA B451-18 Standard for Corrosion Inhibitors
    • EU Biocidal Products Regulation (BPR, Regulation (EU) 528/2012)
    • Germany DVGW W 512 Guidelines for Cooling Water Treatment
    • REACH (EC No 1907/2006) substance registration

    Typical usage ratio

    • 10–80 ppm (parts per million), titrated based on system volume, corrosion rate, and water chemistry

    Downstream process integration

    • Dosed into circulating water at the chemical feed pump station and monitored via online corrosion coupons or probe analysis

    Final product types

    • Industrial cooling water treatment formulations
    • Closed-loop heating/cooling system chemicals
    • Corrosion inhibitor concentrate packs

    3. Ionic Liquid Precursor for Electrochemical Processes

    Electrochemical device manufacturers utilize 1-Hexylimidazole as a starting material for the synthesis of specialty ionic liquids. Quaternization and subsequent anion exchange yield room-temperature ionic liquids (RTILs) used as electrolytes in advanced batteries, electroplating baths, and supercapacitors. Controlled side-chain engineering enables precise tuning of ionic conductivity, thermal stability, and electrochemical window.

    Industry compliance standards

    • IEC 62660-2 Performance Standards for Secondary Lithium Cells
    • RoHS Restriction of Hazardous Substances Directive (EU 2011/65)
    • SOCMA ChemStewards for specialty chemical manufacturing
    • ISO 9001:2015 Quality Management System

    Typical usage ratio

    • Stoichiometric feed to cationization (e.g., 1.05–1.15 equivalents relative to alkyl halide), adjusted for reaction yield and residual purity specification

    Downstream process integration

    • Fed into cationization reactor; product subsequently undergoes metathesis with desired anion-forming agent; final ionic liquid isolated by distillation or extraction

    Final product types

    • Imidazolium-based ionic liquids: hexylmethylimidazolium chloride/bromide, hexylmethylimidazolium bis(trifluoromethylsulfonyl)imide
    • Electrolyte solutions for rechargeable lithium cells and supercapacitors
    • Environmentally friendly electroplating bath fluids

    4. Polymerization Accelerator for Epoxy and Polyurethane Systems

    Producers of advanced epoxy and polyurethane coatings introduce 1-Hexylimidazole as a polymerization accelerator, targeting controlled cure profiles for specialty resin systems. The non-volatile, low-odor imidazole moiety catalyzes epoxy ring opening, accelerates isocyanate–polyol reactions, and supports consistent viscosity and mechanical properties across industrial flooring and anti-corrosive coatings.

    Industry compliance standards

    • ASTM D16 Standard Terminology for Paint, Related Coatings, Materials, and Applications
    • ISO 9001:2015 Quality Management (coating manufacturing validation)
    • REACH (EC No 1907/2006) registration and Annex XVII safety restrictions
    • GB 18582-2020 Limits of Harmful Substances in Interior Decoration Materials

    Typical usage ratio

    • 0.1–1.5 wt% in formulated system; adjustment depends on resin solid content, ambient conditions, and final cure hardness required

    Downstream process integration

    • Added during premix stage before final blend; thorough dispersion ensures homogeneity; compatible with robotic or batch mixing equipment

    Final product types

    • Industrial epoxy floor coatings
    • PU self-leveling materials for warehouse and commercial buildings
    • Protective anti-corrosive paints for marine and heavy steel

    5. Intermediate for Agrochemical Formulations

    Agrochemical manufacturers employ 1-Hexylimidazole as an intermediate in the synthesis of imidazole-derived fungicides and plant protection agents. The C6-alkyl chain introduces balanced lipophilicity, improving bioactive compound membrane permeability for more efficient delivery of active ingredients to targeted plant tissues. Stringent impurity control and traceability are maintained at all production stages.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products (PPP)
    • European Council Directive 91/414/EEC (Regulation of Plant Protection Products)
    • ISO 25198:2018 Agrochemical Synthesis Good Practices
    • China NY 1107 Quality Standard for Pesticide Intermediates

    Typical usage ratio

    • 1.2–1.5 equivalents as intermediate relative to target product, based on stepwise conversion efficiency and downstream impurity profile

    Downstream process integration

    • Introduced into multi-step synthesis at the N-alkylation step; crude product refined by recrystallization or chromatography before formulation

    Final product types

    • Imidazole-based fungicides (e.g., hexaconazole, prochloraz)
    • Seed treatment and foliar application agrochemical products

    6. Functional Monomer for Specialty Resin Synthesis

    Resin producers select 1-Hexylimidazole as a functional monomer to impart ionic or hydrophobic properties to custom polymers. Through copolymerization or post-polymerization modification, it participates in synthesizing resin matrices for antistatic coatings, membrane materials, and specialty adhesives. The long alkyl side chain tunes surface tension and compatibility with both aqueous and non-aqueous phases.

    Industry compliance standards

    • ISO 14001 Environmental Management for chemical plant operations
    • EU REACH (EC No 1907/2006) compliance for monomer use
    • ASTM D6100-19 Practice for Polymerization of Imidazole-Containing Resins
    • Japan Chemical Substances Control Law (CSCL) reporting

    Typical usage ratio

    • 5–25 mol% as co-monomer in specialty resin blends; ratio varies by desired hydrophobicity and ionic content

    Downstream process integration

    • Pre-added to monomer feed tank in batch or continuous reactors; initiator system added subsequently; molecular weight monitored in real time for quality consistency

    Final product types

    • Antistatic and conductive resin systems
    • Membrane materials for filtration and separation
    • Performance adhesives for electronics assembly
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    Certification & Compliance
    More Introduction

    1-Hexylimidazole: Reliable Performance Driven by Practical Experience

    Introduction

    Every day in our plant, we work with molecules that play critical roles in the background of modern industry. 1-Hexylimidazole stands out among these, and over years of manufacturing and customer feedback, we have seen the impact that pure, well-prepared imidazole derivatives can deliver for users involved in synthesis, catalysis, and advanced coatings. Many might only know this compound from catalogs or datasheets, but we believe first-hand production brings a different perspective—one rooted in the discipline and challenges of actually making the product, not just trading it.

    Manufacturing 1-Hexylimidazole: Our Actual Process Matters

    Consistency and reliability with 1-hexylimidazole begin on the factory floor. From the initial charging of imidazole and hexyl halide, precise reaction control is essential. Many organic bases fluctuate in batch-to-batch purity, affecting downstream yield and color stability. We manage this by using high-grade raw materials and by monitoring critical variables—temperature, agitation, reaction time—at every stage. Technical teams regularly sample and check each lot for residual moisture and trace byproducts. It’s tempting to cut corners when demand spikes, but shortcuts always show up later as foaming during customer reactions or colored side-products in polymer curing. We maintain a clear batch record not because a certificate says so, but to troubleshoot root causes quickly and save wasted time for everyone down the chain.

    Our model, known in-house as HI-06, reflects not just an item number but a set of production guidelines tested across years of commercial runs. Each kilogram draws on controlled syntheses, vacuum distillation, and filter protocols refined after real-life missteps—fouled heat exchangers, stubborn tars clogging retention columns, and more. Our experience confirms: only careful craftsmanship keeps purity above 99% and water content low enough to avoid hydrolytic instability, especially where 1-hexylimidazole serves as a phase-transfer catalyst or ionic liquid precursor.

    Key Specifications: Details That Impact Results

    Dry 1-hexylimidazole appears as a pale liquid with an aromatic, slightly earthy scent. In real-world applications, color and clarity matter as much as numbers on a page. We target a clear, almost water-white appearance, since persistent yellowing often traces back to leftover reagents or metallic contaminants. Our typical product maintains a low residual chloride standard—an issue we faced early on, which led customers to mysterious catalyst deactivation in their cross-coupling chemistry. Working directly with their technical groups, our team traced these failures to sub-ppm ionic contaminants. Today, every lot gets checked for halide ions with sensitive analytical methods borrowed from pharma partners, even though downstream users might not require that specification on paper.

    Specifications by themselves don’t guarantee customer satisfaction; reproducibility does. We monitor boiling range, specific gravity, and GC-MS fingerprint to track even small batch drift. From experience, GC impurity peaks above 0.2% sometimes predict trouble: an odd-smelling solvent headspace, gelling during storage, or unpredictable UV absorption in coating intermediates. Rather than hiding flaws in footnotes, we’ve found open communication about specification challenges builds trust. If a lot falls outside our strictest standards, we call longtime users first—usually resulting in earlier detection of new requirements or unexpected project constraints.

    Real-World Uses: Solutions, Not Just Ingredients

    End-users draw 1-hexylimidazole into wide-ranging tasks. Many employ it as a ligand in metal complexation, notably for homogeneous catalysis. Others use it for nucleophilic substitution or as a base in specialty pharmaceuticals. Those working in epoxy curing value its ability to promote strong bond formation without catalytic residues creeping into the final product. Each application brings its own set of headaches.

    In some resin formulations, trace acidity or high volatility has led to inconsistent cure times—something we fought in early runs. By lowering the residual acid number below industry norms, then testing product stability under simulated aging, we managed more predictable results for users who never see our plant, but who rely on stable, uniform batches. Some electronics materials developers order drums directly from us to ensure their 1-hexylimidazole extends shelf life in advanced adhesives and minimizes ionic migration risk. We don’t chase trends for “universal use”—our product solves specific pain points revealed through years of technical collaboration and problem-solving.

    Product Differentiation: Real Substance Over Hype

    Lots of chemicals look similar on a table. In reality, minor impurities or process shortcuts define performance. Unlike generic importers or repackagers, we control synthesis from base imidazole up, giving us a unique window into process refinements. Many traders focus on price; we have learned customers will pay more for reliability and support, especially after a failed batch disrupts their own value chain. When customers approached with filter plugging or tank corrosion issues, routine analysis on our side sometimes revealed contaminant traces from other sources, underlining the importance of keeping all nonvolatile residues as low as feasible—even if it complicates purification steps and lowers yield.

    On occasion, buyers ask whether they could substitute alternative imidazole derivatives, such as 1-butyl or 1-octyl analogs, because of price or availability shifts. From firsthand testing and feedback, our lab teams observed pronounced differences in reactivity profiles, volatility, and compatibility. 1-hexylimidazole balances solubility with processability; too short an alkyl chain often limits solubility in nonpolar systems, while longer chains may become waxy at ambient temperatures or introduce unwanted migration in final films. Our approach bases product recommendations on real-life use data, not catalog descriptions. When end-users share their applications—whether they need a mild base for esterification, a ligand for coordination chemistry, or a phase-transfer promoter—we respond with targeted technical guidance, not generic claims.

    Supporting Claims With Evidence, Not Just Promises

    As manufacturers, we face the daily realities of supply chain challenges, regulatory changes, and innovations in downstream sectors. Customers tend to trust product claims when they see evidence, both in the form of analysis and real-world performance. We regularly supply users with independent third-party or customer-commissioned tests comparing different lots. For example, differences in water content make a visible difference in moisture-sensitive syntheses; persistent high moisture leads to lower conversion or inconsistent purities, something we mitigate with on-site Karl Fischer titration and vacuum-drying at scale.

    Sourcing 1-hexylimidazole directly from the manufacturer means full chain-of-custody transparency. Over years of inbound audits from multinational partners, we’ve documented every process improvement—from vent scrubber upgrades that eliminated trace halogen emissions, to real-time viscosity checks that catch early signs of polymer growth. These investments don’t always show up in certificates, but they prevent problems from reaching customer sites, lowering overall risk and supporting a more robust product pipeline.

    Addressing Common Issues and Solutions

    Users sometimes report batch settling or unexpected color formation after longer storage, especially in partially drained drums or when stored outside recommended temperature ranges. We faced similar problems in our own inventory. Through root-cause investigation, we tied this to slow-forming oxidation products. Solutions included inert gas blanketing during filling, reinforced sealing, and continuous training for warehouse staff. Openly sharing these best practices with customers, along with clear “first in, first out” logistics, keeps everyone on the same page and reduces waste.

    Occasionally, customers share feedback about incompatibility with certain solvent systems, notably highly fluorinated media, which can precipitate or destabilize imidazole derivatives. We run side-by-side solvent compatibility trials to provide practical guidance, not just theoretical tables. In a recent collaboration with a materials science group, iterative sample testing identified minor formulation tweaks—such as delayed addition sequence and gentle warming—that restored full clarity without resorting to more drastic synthetic modifications.

    Supply disruptions have always challenged raw material chemistry. Some regions restrict export of starting imidazole or precursor halides. We maintain close ties with upstream suppliers, track regulatory shifts, and regularly requalify incoming lots of core feedstocks. By doing so, we can anticipate issues before they ripple out to our own customers, informing them well in advance rather than scrambling at the last minute. This proactive stance supports robust risk management and upholds long-term partnerships.

    Responsible Manufacturing and Environmental Considerations

    Producing 1-hexylimidazole at scale requires vigilance not just to quality, but to safety and environmental footprint. Regulatory bodies have increased attention to emissions and byproduct disposal. We collect and treat all mother liquors, recovering as much material as possible. Our plant operates closed-loop solvent reuse to limit VOC losses, an initiative originally started to save costs but since expanded because it also minimized regulatory reporting headaches. Waste streams undergo neutralization to render them nonhazardous, and we actively document all process streams for local compliance.

    We’ve participated in community consultations to understand concerns about chemical manufacture near residential zones. In response, continuous air monitoring and noise reduction measures have been put in place. These adjustments may not drive immediate financial return, but they reduce social risk and build community confidence. Our workers attend regular safety training sessions on handling and emergency response, not just once a year, but as part of a rolling safety culture program—because living next to our plant means our neighbors’ well-being is inseparable from how we operate.

    Why Direct Manufacturing Experience Matters

    Some market voices treat 1-hexylimidazole as a commodity, interchangeable and forgettable. Those opinions often come from desk-bound trading or simple sales operations, not from hands-on synthesis, logistics, and field troubleshooting. Having solved real-world failures—blocked process filters, persistent odors, unexplained side reactions—we draw on lessons not found in textbooks.

    Discussions with global users highlight simple truths: reliability, support, and openness outperform hollow marketing. When a project deadline looms and product quality wavers, you need a partner who understands the subtleties of molecular behavior and supply realities. Having a direct line to someone who knows the product’s lifecycle—from reactor charge through to finished packing—can prevent one-off surprises from cascading into lost product batches, missed certifications, or customer recall.

    Our support starts before shipping, and carries through project troubleshooting, sometimes years after the first order. This is woven into our daily operation. Manufacturing requires constant learning, with every batch and every customer exchange advancing the shared knowledge base. User feedback shapes everything from packaging choices to quality release criteria.

    Looking Ahead: Innovation Rooted in Practicality

    We approach process innovation as an ongoing cycle, not a one-time upgrade. Currently, our R&D team is exploring greener synthetic routes—reducing use of halogenated intermediates and trialing bio-based feedstocks. For now, regulatory and yield constraints temper the pace of change, but test results look promising for both safety and cost-effectiveness. We invest in new process controls and real-time analytics, shrinking the lag between deviation detection and correction. These improvements come from years of running live production under pressure rather than isolated pilot runs.

    We see increasing requests for custom formulation support: customers seeking 1-hexylimidazole blends pre-adjusted for viscosity, color, or other application-specific parameters. On-site pilot reactors let us run real-world simulations, so off-the-shelf solutions remain relevant as user needs evolve. Rather than force users into rigid specification boxes, we work together to adjust parameters, document lessons learned, and improve future runs.

    Trust Through Transparency

    We recognize that product stewardship relies on being forthright—about strengths, weaknesses, and the changing landscape in specialty organics. Sharing full test data, inviting customer audits, and reporting near-misses openly help prevent repeating mistakes and raise the standard across the industry. By offering direct access to our technical teams, we align our output tightly with customer goals.

    The value in 1-hexylimidazole comes not just from the base chemical, but from a full support system built from experience—direct, measurable, and honest. Each kilogram produced is shaped by the challenges we’ve overcome, the partnerships we sustain, and the lessons we learn on the production line every day.