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1-Docosanol

    • Product Name 1-Docosanol
    • Alias Docosanol
    • Einecs 205-765-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    700376

    Chemical Name 1-Docosanol
    Cas Number 661-19-8
    Molecular Formula C22H46O
    Molecular Weight 326.60 g/mol
    Appearance White, waxy solid
    Melting Point 74-78°C
    Boiling Point 226°C at 16 mmHg
    Solubility In Water Insoluble
    Logp 9.14
    Therapeutic Use Antiviral (topical, cold sore treatment)
    Synonyms Docosanol, Behenyl alcohol
    Odor Mild, fatty
    Storage Conditions Store at room temperature, dry place
    Iupac Name Docosan-1-ol
    Density 0.81 g/cm³

    As an accredited 1-Docosanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 1-Docosanol is packaged in a 25g amber glass bottle with a secure screw cap, featuring a clear, chemical-resistant label.
    Shipping 1-Docosanol is shipped in tightly sealed containers to prevent contamination and moisture exposure. It is transported under ambient temperature and standard conditions, following relevant regulatory guidelines. The packaging ensures stability and integrity during transit. Safety data and labeling are included according to chemical shipping regulations. Handle with care to avoid spills.
    Storage 1-Docosanol should be stored in a tightly closed container in a cool, dry, and well-ventilated area away from incompatible substances. Keep the storage area free from sources of ignition, direct sunlight, and moisture. The chemical should be protected from excessive heat and stored at room temperature or as specified by the supplier’s guidelines to maintain its stability and quality.
    Application of 1-Docosanol

    Applications of 1-Docosanol in Industrial Manufacturing

    1-Docosanol serves as a specialty fatty alcohol with targeted performance characteristics for select chemical, personal care, and pharmaceutical industries. We supply material manufactured under strict process controls, supporting formulation consistency and regulatory needs for advanced downstream production environments. Below are main industrial application areas based on our manufacturing expertise and verified markets.

    1. Pharmaceutical Antiviral Creams and Ointments

    Pharmaceutical manufacturers use 1-Docosanol as the primary active ingredient in topical creams for treating herpes simplex labialis (cold sores). 1-Docosanol exhibits direct antiviral action at the cellular membrane, and downstream users incorporate it during the emulsion phase for medicated skin products. Timing of addition, mixing method, and phase temperature are tightly controlled to maintain product quality in GMP settings. The ingredient’s final concentration aligns with regulatory licensing in target markets, and finished goods undergo batch release testing for active content and microbiological safety.

    Industry compliance standards

    • USP-NF (United States Pharmacopeia–National Formulary)
    • ICH Q7 Good Manufacturing Practice Guidance for Active Pharmaceutical Ingredients
    • FDA-approved Monograph: Docosanol Topical Cream
    • European Pharmacopoeia (Ph. Eur.)

    Typical usage ratio

    • 10% w/w in finished topical cream systems, per FDA and EMA guidelines; precise percentage adjusted based on excipient load and formulation viscosity requirements.

    Downstream process integration

    • Added during oil phase melting, combined with emulsifiers, then homogenized with aqueous phase under vacuum to control droplet size and product uniformity.

    Final product types

    • Prescription antiviral creams for herpes simplex
    • Over-the-counter cold sore medications
    • Medicated lip balms

    2. High-Performance Cosmetic Emulsions

    Cosmetic formulators value 1-Docosanol as a long-chain fatty alcohol for structuring rich emulsions, especially in premium creams and lotions. The ingredient stabilizes oil-water systems, modifies skin-feel, and imparts thickeness without clogging pores. Manufacturers blend it with cetyl and stearyl alcohols for tailored texture. Inclusion levels adjust with respect to final product viscosity, fatty phase percentage, and compatibility with actives. The raw material must meet cosmetic-grade impurity controls to avoid skin irritation or allergen risk, and finished emulsions are stability-tested under accelerated conditions.

    Industry compliance standards

    • EU Regulation (EC) No 1223/2009 on Cosmetic Products
    • Cosmetics Ingredient Review (CIR) Expert Panel Safety Assessment
    • China GB 7916 Hygiene Standard for Cosmetics
    • ISO 22716: Good Manufacturing Practices for Cosmetics

    Typical usage ratio

    • 0.5–3.0% by weight in creams, lotions, and skin milks; exact percentage depends on targeted skin-feel and oil phase composition.

    Downstream process integration

    • Introduced during lipid phase preparation, co-melted with other fatty alcohols and waxes before emulsification to ensure uniform texture and droplet stability.

    Final product types

    • Premium facial creams and moisturizers
    • Lipsticks and solid lip balms
    • High-end body butters and milks
    • Rich hand creams

    3. Industrial Lubricants for Metalworking Fluids

    Manufacturers of specialty metalworking and cutting fluids employ 1-Docosanol for its unique lubricity and anti-wear attributes. The long alkyl chain reduces friction under high loads and helps stabilize emulsions in water-miscible fluids. Formulators precisely adjust the addition rate based on the base oil system and end-user application, such as stamping or fine blanking. The material’s purity is crucial for minimizing smoke and residue in demanding environments. Lubricant blends with this raw material undergo QC for load wear index and corrosion inhibition properties before market release.

    Industry compliance standards

    • ASTM D4172 (Four Ball Wear Test)
    • REACH Regulation (EC) No 1907/2006 Registration and Safety Data
    • ISO 6743 Lubricants, Industrial Oils and Related Products (Class L)
    • RoHS Directive 2011/65/EU as applicable for technical fluids

    Typical usage ratio

    • 1–5% concentration in concentrate; optimized according to tool/material combination, operating temperature, and fluid longevity targets.

    Downstream process integration

    • Blended into the base oil or synthetic matrix during batch compounding, followed by homogenization and filtration to meet strict cleanliness standards.

    Final product types

    • Water-miscible metalworking fluids
    • Straight-cutting oils for precision applications
    • Die lubricants for forging and stamping

    4. Plastic Additive for Flexible PVC and Polymer Compounds

    Producers of flexible polyvinyl chloride and other thermoplastics use 1-Docosanol as an internal lubricant and fusion agent. Its high carbon chain enhances flow and mold release in the compounding stage, reducing processing temperature requirements and improving physical properties of the polymer. Formulations are customized depending on plasticizer levels, resin type, and desired flexibility. Material traceability and impurity screening are mandatory for products destined for food contact or medical applications. Additive dispersal must be uniform to prevent blooming or exudation in finished parts.

    Industry compliance standards

    • FDA 21 CFR 177.2600 for Rubber Articles Intended for Repeated Use (for any food-contact components)
    • EU Regulation (EU) No 10/2011 for Plastics Intended to Come into Contact with Food
    • ISO 9001: Quality Management System for Material Consistency
    • RoHS Directive 2011/65/EU for Electronics-related Polymers

    Typical usage ratio

    • 0.1–2.0% of total compound weight; exact proportion determined by formulation testing for fusion time, extrusion stability, and plasticizer compatibility.

    Downstream process integration

    • Introduced during high-intensity mixing with resin and plasticizers before extrusion, ensuring molecular dispersion throughout the batch.

    Final product types

    • Flexible PVC cables and insulation
    • Sheeting and film for packaging
    • Medical-grade tubing and bags

    5. Specialty Textile Softeners and Finishes

    Textile finishing plants incorporate 1-Docosanol in softener formulations to impart durable hand feel and antistatic effects on synthetic and blended fabrics. It contributes to the hydrophobic-lipophilic balance in emulsified softeners, improving fabric drape and surface appearance. Dosage varies based on fiber type, finishing method, and required handle. The raw material’s traceability, purity profile, and absence of allergenic residues are repeatedly verified for large-scale batch approvals. Finished softener dispersions are tested for pH, emulsion stability, and fabric compatibility before downstream application.

    Industry compliance standards

    • OEKO-TEX Standard 100 (Safety and human-ecological standards for textiles)
    • ZDHC Manufacturing Restricted Substances List (MRSL)
    • ISO 14001 for Environmental Management in production

    Typical usage ratio

    • 0.2–1.5% solids in softener formulations, adjusted by finish pickup and application method (exhaust, padding, or spraying).

    Downstream process integration

    • Emulsified with cationic or nonionic surfactants, incorporated into softener baths or finishing emulsions before direct fabric application.

    Final product types

    • Durable fabric softeners for synthetic fibers
    • Anti-static textile finishes
    • Wrinkle-resistant garment treatments

    6. Food Contact Release Agents and Surface Coatings

    Processors in the food packaging and baking industries use 1-Docosanol in release agent blends for direct food contact surfaces. Its high-purity, non-ionic chemical nature allows compatibility with edible oils and waxes, facilitating easy de-molding and reduced product sticking. Application rates depend on substrate, desired release characteristics, and regulatory food contact limits. Rigorous batch documentation and food safety analysis, including residual solvent and allergen screening, are enforced throughout manufacturing.

    Industry compliance standards

    • FDA 21 CFR 172.864, Fatty alcohols permitted in food for human consumption
    • EU Regulation (EC) No 1333/2008 on Food Additives
    • HACCP Food Safety Management

    Typical usage ratio

    • 0.1–1.2% of total release agent or coating, depending on food type, processing temperature, and contact time; finer tuned per regulatory migration limits.

    Downstream process integration

    • Combined with edible oils or wax emulsions at elevated temperature; applied to mold or tray surfaces by spraying, wiping, or dipping, followed by evaporation and quality inspection.

    Final product types

    • Baking mold release sprays
    • Food-grade pan coatings
    • Release films for confectionery production
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    Certification & Compliance
    More Introduction

    Introducing 1-Docosanol: A Reliable Fatty Alcohol for Modern Manufacturing

    Our Perspective on 1-Docosanol

    Producing 1-Docosanol offers a unique chance to connect experience in industrial chemistry with real-world applications. In our facilities, teams watch the transformation of raw feedstocks into a high-purity, unbranched saturated fatty alcohol with a 22-carbon backbone, recognized in the industry as docosanol or behenyl alcohol. Over the years, we have refined the process to produce 1-Docosanol with a purity above 98%, maintaining consistency across every production batch. Reliable outputs matter for formulators who demand high standards—batch after batch, our product quality stands up to rigorous lab checks and meets customer requirements.

    Production Method and Product Specifications

    The technique behind our 1-Docosanol often stems from hydrogenation of fatty acids derived from natural vegetable oils, including rapeseed and peanut oils. Steady access to high-quality feedstocks allows us to ensure each batch of 1-Docosanol produced keeps impurities low and performance steady. Our finished product appears as a white, waxy solid at room temperature, with a melting point around 75–80°C and minimal odor. This property profile matters for manufacturers who want predictable handling and stable results in their end applications.

    With an average chain length of 22 carbons, 1-Docosanol brings a set of features different from shorter-chain or unsaturated fatty alcohols. The long saturated chain means high melting point, improved hardness in waxy blends, and a boost in stability for finished formulations. Quality control covers residual solvents, moisture content, and metal traces, not simply the main active ingredient. We emphasize documentation and testing, which lets customers track and trust every kilo received.

    Distinct Advantages Over Other Fatty Alcohols

    Many customers approach us with questions on how behenyl alcohol compares to cetyl alcohol, stearyl alcohol, or unsaturated alternatives. Differences matter most for end product texture, melt profile, and regulatory preferences.

    1-Docosanol brings more hardness and a higher melting point than cetyl (C16) or stearyl (C18) alcohol. This property allows it to act as a potent thickener and viscosity modifier at much lower doses. In lipsticks, solid personal care bars, and pharmaceutical creams, this translates to smoother texture and longer shelf life. Formulators looking for a robust matrix-builder often select 1-Docosanol over softer, lower-melting fatty alcohols.

    When compared with unsaturated alcohols or polyols, 1-Docosanol holds up better against oxidative breakdown and color shift caused by heat or light. This stability profile means less need for added antioxidants or color stabilizers. For applications such as sunscreen sticks or high-performance emollient creams, formulators appreciate the resistance to rancidity and yellowing. In oil-in-water emulsions, our 1-Docosanol works alongside other co-emulsifiers to create stable, creamy dispersions that last on the shelf.

    Experience and Applications in Key Industries

    Our teams have collaborated with partners in personal care, pharmaceuticals, and industrial sectors. Each application places unique demands on product purity, texture, and compliance.

    In topical pharmaceuticals, 1-Docosanol enjoys recognition for its antiviral role. Finished creams made with our docosanol serve as over-the-counter solutions for labial herpes simplex virus (HSV-1), sold in many countries. We know from years in the field that regulated markets enforce strict purity and traceability standards. Our manufacturing workflows document each step from feedstock to packaged bulk, supporting the chain of evidence demanded by health authorities.

    Personal care formulators value how docosanol acts as a rich emollient, contributing to barrier creams, hand balms, and lipsticks with a dry, long-lasting feel. The long chain structure blocks water loss through the skin, keeping formulas lightweight but moisturizing. Repeated customer feedback points to better texture retention during months of storage—even in varying climates—thanks to the high melting point and oxidative resistance. In stick deodorants, docosanol helps maintain structure while resisting crumbling during hot days or shipping.

    Industrial users often request technical-grade docosanol as a lubricant component, anti-static agent, or slip additive for plastics and coatings. Our experiences supplying to cable, lubricant, and specialty wax producers taught us that a fine balance between melt point and hardness determines end-use performance. Incorporating 1-Docosanol brings a firmness and gloss prized in automotive polishes and molded items, while minimizing smoke and fume during extrusion.

    Quality Focus: Purity, Traceability, and Compliance

    From a manufacturer’s standpoint, any shortcuts in upstream selection or in-process filtration show up quickly—whether as off-odors, clumping, or variable melt behavior. Our QA lines run frequent checks for fatty acid residues, color, and presence of catalyst traces. Equipment cleaning and validated processing mean that customers do not see cross-contamination from plant equipment. Each lot leaves our facility with a batch-specific Certificate of Analysis.

    Documenting process steps ties directly into regulatory expectations. We have adopted international standards—such as Good Manufacturing Practice for pharmaceutical grades and ISO certifications for general industrial production. For companies exporting to multiple regions, our supply documentation helps answer questions for local health agencies and customs inspection. Detailed chain-of-custody records add value that bulk traders or brokers rarely match.

    Sustainable Sourcing and Environmental Concerns

    Recent shifts in environmental regulation and voluntary company initiatives put a fresh spotlight on supply chain origin. Customers want confidence that vegetable oil feedstocks come from well-managed, traceable sources and that hazardous emissions stay within permitted levels. Over the past five years, we have worked with suppliers to confirm non-GMO and sustainable cultivation of seedstock crops. Our hydrogenation and purification lines recover and recycle solvents, reducing waste to below industry averages.

    Real change shows up in how we source and run our processes. Investments in energy-efficient hydrogenation units cut fuel use and shrink process emissions. We monitor waste streams for both organic residues and process water, treating each to meet or exceed regional discharge standards. This internal effort meets growing customer requests: finished docosanol that stands up to environmental scrutiny and supports claims on sustainable sourcing.

    Common Challenges and Troubleshooting Tips

    Real production runs rarely go as textbook-perfect as theoretical process models would suggest. During summer heat waves, we noticed small upticks in melt point spread across bulk docosanol. This caused uneven handling in automated filling equipment for a few customers. We reviewed storage conditions and instituted new warehouse temperature controls to stabilize product characteristics before shipment.

    Another recurrent challenge shows up with color or odor drift in finished goods. These issues often track back to feedstock quality. Early on, batches using lower-grade oils sometimes picked up faint nutty or earthy scents. Fixing that required tight selection of input oils and a shift to multi-step deodorization. Now, random odors in output barely register outside lab thresholds.

    Some applications—like pharmaceuticals and color cosmetics—push for ultra-low trace metals and catalyst residues. We tightened purification and filtration on relevant grades, using specialty absorbents and customized filtration routines. The effort paid off, evidenced by cleaner toxicological profiles and improved heat stability in sensitive products.

    Research, Development, and Future Opportunities

    The field of specialty chemicals never stands still. Both our R&D teams and customer partners bring new requests for modified chain lengths, custom blends, and altered melting points. Most recently, we have explored co-processing 1-Docosanol with other fatty alcohols for improved spreadability in hair conditioner bases and lotion bars. Some projects call for infused active ingredients, others for tighter particle size controls.

    For personal care, the market trends point toward using higher natural content and safer alternatives to controversial emulsifiers. Docosanol’s simple, plant-derived nature and track record in topical applications fit the bill. On the pharmaceutical front, requests grow for improved topical delivery vehicles for other actives beyond antiviral applications—to exploit the robust skin barrier properties 1-Docosanol brings.

    We also track the emergence of biobased and biodegradable packaging, where docosanol-laced waxes serve as barrier coatings and food-safe wraps. Customer pilots in this space depend on our ability to tweak chain length blends for just the right melting point and stiffness profile. Every adjustment kicks off new lab runs and collaborative data sharing, backed by years of hands-on manufacturing practice.

    Global Market Influences and Customer Feedback

    We watch international price trends and supply chain interruptions. Climate disruption in oilseed-growing regions or economic shifts in producer countries can ripple into availability of high-purity docosanol. Relationships with multiple, audited suppliers enable us to keep commitments to multinational customers who run just-in-time inventories.

    Feedback from end-users drives incremental adjustment. Some perfume houses reported slight masking of key fragrance notes in high-behenyl bases, so our team developed low-odor variants relying on extra deodorization steps. Makers of pharmaceutical skin creams told us about variable viscosity in alternate suppliers, prompting more frequent in-process viscosity and melting point checks on all outgoing lots.

    A real-world grounding in manufacturing teaches us that customers notice small, practical details—how fast the drum opens, whether the flakes pour cleanly, if texture holds up between batches, or if paperwork matches customs declarations. Reliable supply depends on far more than any single lab value.

    The Role of Standards and Strict Internal Controls

    Repeated audits by buyers, regulators, and third-party certifiers demonstrate our commitment to tight process control. Beyond requirements for pharmaceutical-grade docosanol, we maintain in-house standards for every bulk shipment, whether it heads for a high-end personal care plant or an industrial wax formulator. Raw material traceability, controlled documentation, and consistent production workflows build confidence for customers whose brand reputations hinge on product integrity.

    From our vantage point as long-term bulk producers—instead of traders or brokers—these internal controls allow faster troubleshooting, greater flexibility in custom orders, and a known point of accountability. It also opens opportunities to customize blends or supply smaller pilot lots to startups who value process transparency over generic pricing.

    Potential Solutions for Emerging Industry Needs

    Shifting regulations, sustainability claims, and changing end-use trends prompt us to keep investing in better process management and closer customer collaboration. To meet tighter purity and sustainability targets, we have trialed refined hydrogenation catalysts that reduce both energy consumption and residual metallic traces. Customer feedback guides which process enhancements deliver the most downstream value.

    In markets where allergen claims or vegan status matter, careful segregation and non-animal raw material selection back up product claims. A strong technical team lets us answer formulation and regulatory questions directly, not with generic datasheets but with practical, experience-based solutions and documentation.

    To address ongoing customer worries about cost, lead times, and logistics in a volatile market, we invest in raw material contracts and inventory management. Using data from customer forecasts, we adapt production scheduling to keep up with both anticipated seasonal demand and unexpected surges. Flexible warehousing, regional storage hubs, and close coordination with shipping partners help meet global delivery expectations.

    Conclusion: Years of Practical Experience in Every Batch

    Decades of manufacturing 1-Docosanol taught us that consistency, transparency, and honest technical communication matter just as much as published specifications. The performance of behenyl alcohol for each downstream application—from life-saving topical medications to weather-resistant lubricants—reflects decisions made at every production step. Rigorous process controls, careful feedstock selection, and transparency throughout the supply chain protect both customers and end users.

    Our goal remains providing a dependable 1-Docosanol that matches real-world needs, not just catalog requirements. As global markets shift and regulatory standards evolve, hands-on production insight and direct customer engagement drive every improvement we make. Years of practice shape our approach—trust in in-house standards, visible traceability, and open support for partner innovation. That foundation forges strong relationships and reliable results for every batch of 1-Docosanol we deliver.