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1-Cyclohexene-1-Acetonitrile

    • Product Name 1-Cyclohexene-1-Acetonitrile
    • Alias 1-cyclohexenylacetonitrile
    • Einecs 221-415-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    296210

    Iupac Name 2-Cyclohexen-1-ylacetonitrile
    Cas Number 4007-49-6
    Molecular Formula C8H11N
    Molar Mass 121.18 g/mol
    Appearance Colorless to pale yellow liquid
    Density 0.940 g/cm³
    Boiling Point 222-224 °C
    Melting Point -36 °C
    Flash Point 88 °C
    Solubility In Water Insoluble
    Refractive Index 1.500-1.506
    Smiles N#CC1=CCCCC1

    As an accredited 1-Cyclohexene-1-Acetonitrile factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A sealed amber glass bottle containing 100 mL of 1-Cyclohexene-1-acetonitrile, labeled with safety warnings and product details.
    Shipping 1-Cyclohexene-1-Acetonitrile is shipped in tightly sealed containers, protected from moisture, heat, and direct sunlight. It should be handled as a hazardous chemical, following all relevant safety and regulatory guidelines. Ensure the container is clearly labeled and includes safety information for transport. Avoid incompatible substances during shipping to prevent dangerous reactions.
    Storage **1-Cyclohexene-1-acetonitrile** should be stored in a cool, dry, and well-ventilated area, away from direct sunlight, heat sources, and incompatible materials such as strong oxidizers and acids. Keep the container tightly closed and clearly labeled. Store at room temperature and avoid humidity. Use appropriate, compatible containers, preferably glass or high-quality plastic, to prevent chemical reactions or degradation.
    Application of 1-Cyclohexene-1-Acetonitrile

    Applications of 1-Cyclohexene-1-Acetonitrile in Industrial Manufacturing

    As a specialty chemical producer, we supply 1-Cyclohexene-1-Acetonitrile to select downstream industries where its chemical properties fit advanced formulation needs. Below are the principal industrial application scenarios supported by established use, compliance standards, process integration, and well-documented finished goods production.

    1. API Intermediate for Central Nervous System (CNS) Pharmaceuticals

    Pharmaceutical manufacturers use this raw material as a key intermediate in multi-step syntheses for CNS-active drug molecules, especially cyclic nitrile derivatives in antidepressant and antipsychotic development. Its unique structure enables introducing specific functional moieties not accessible through simple acetonitrile. Production facilities apply stringent GMP controls from the step where it enters to ensure batch-to-batch consistency and regulatory traceability through the API synthesis workflow, including hydrogenation, amidation, and further cyclization reactions.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • US FDA 21 CFR Part 210/211 for finished pharmaceuticals
    • USP–NF, Ph. Eur. monographs for relevant APIs
    • EDQM CEP documentation (when applicable in Europe)

    Typical usage ratio

    • 0.8–1.2 molar equivalents relative to target pharmaceutical intermediate; precise load adjusted based on route-specific reactivity and impurity profile management

    Downstream process integration

    • Added at the initial condensation or cyclization stage of API synthesis
    • Undergoes purification and transformation in multi-kilogram GMP reactors
    • Batch and continuous manufacturing setups both in active use
    • Process monitored for residual starting material as a critical control point

    Final product types

    • Generic and innovator CNS pharmaceuticals (tablet, capsule, injectable forms)
    • Specialty intermediates for drug development in research pipelines

    2. Synthesis of Agrochemical Active Ingredients

    Agrichemical formulators specify cyclohexene-acetonitrile derivatives as essential intermediates for new-generation herbicides and insecticides. The material enters production at the cyclization or nitrilation stage of key active intermediates, followed by further functionalization such as halogenation or etherification. Downstream plants align quality with international crop protection chemical standards and invest in multi-ton handling units to adjust for viscosity and reactivity during continuous production.

    Industry compliance standards

    • FAO/WHO specifications for agrochemical actives
    • ISO 9001:2015 Quality Management Systems for specialty chemicals
    • REACH Regulation (EC) No 1907/2006 for EU market access
    • China GB/T 1604-2008 for agrochemical intermediates

    Typical usage ratio

    • 5–10% by mass in step reactions; volumes may be reduced in high-purity end formulations based on final impurity tolerances

    Downstream process integration

    • Dosed at cyclization or nitrile-introduction stages of technical-grade agrochemical synthesis
    • Continuous stirred-tank reactor (CSTR) and plug-flow reactor designs commonly adopted
    • Quality control sampling focused on nitrile conversion rates
    • Finished batch dried and milled to prepare technical concentrate

    Final product types

    • Herbicidal active ingredients (pre-emergence and post-emergence herbicides)
    • Systemic insecticidal concentrates for field formulation

    3. Precursor in High-Performance Polyamide Synthesis

    Manufacturers of specialty polymers leverage 1-Cyclohexene-1-Acetonitrile as a feedstock for high-performance polyamides, especially in demanding automotive, electrical, and consumer durable applications. The compound acts as a controlled-chain initiator, facilitating the incorporation of rigid, thermally stable units into the polymer backbone. Process integration focuses on precise stoichiometric addition during polymer melt or solution-phase polymerization, followed by continuous or batch downstream extrusion.

    Industry compliance standards

    • ISO 9001:2015 for polymer production facilities
    • UL 94 flammability standards for electrical plastics
    • ASTM D4066 for polyamide engineering plastics
    • RoHS Directive 2011/65/EU for electrical/electronic end uses

    Typical usage ratio

    • 2–4 wt% relative to polymer-forming monomers, with fine-tuning based on the mechanical and thermal requirements of the target application

    Downstream process integration

    • Directly charged at monomer mixing stage ahead of polycondensation
    • Melt or solution-phase integration in nitrogen-purged reactors
    • Copolymerization or terpolymerization as needed for specialty properties
    • Quality checks emphasize molecular weight distribution and end-group conversion

    Final product types

    • High-modulus polyamide resins
    • Injection-molded automotive and electrical parts
    • Extruded specialty films

    4. Intermediate for Fragrance and Flavor Chemicals

    Industrial fragrance ingredient producers employ cyclohexene-acetonitrile in the synthesis of cyclic musk analogs and other complex aroma compounds. The nitrile group enables building specialized cyclic frameworks, which, after catalytic hydrogenation and esterification, yield odor compounds with high thermal stability. All process steps align with the IFRA Code of Practice and relevant food contact guidance, addressing traceability and sensory panel consistency throughout production.

    Industry compliance standards

    • IFRA (International Fragrance Association) Code of Practice
    • FEMA GRAS status for flavor applications (when applicable)
    • ISO 9235 for aroma chemical raw materials
    • EU Regulation (EC) 1334/2008 for flavoring substances in foods

    Typical usage ratio

    • 0.5–2 molar equivalents in cyclic musk and macrocyclic lactone synthesis, adjusted for desired ring size and olfactory profile

    Downstream process integration

    • Starts as a key intermediate at the ring-forming or nitrile conversion stage
    • Integration with hydrogenation and acid/ester-catalyzed steps
    • Final purification to aroma chemical grade required
    • Batch production dominant for high-value low-volume specialty ingredients

    Final product types

    • Macrocyclic musks for fine fragrances
    • Flavor modulators for confectionery and beverage bases
    • Odorant intermediates for household and personal care products

    5. Synthesis of Cycloalkylamine Catalysts

    Chemical producers select this nitrile as a starting material for the generation of cycloalkylamine catalysts through controlled hydrogenation and amination pathways. These catalysts exhibit high selectivity and stability in base-catalyzed polymerization and fine chemical synthesis. Integration focuses on the initial nitrile hydrogenation under pressure, followed by further purification and conversion in dedicated isolation units. The manufacturing workflow supports critical sectors where catalyst purity and trace residuals are process-determining parameters.

    Industry compliance standards

    • ISO 9001:2015 for catalyst production
    • Responsible Care® Management System
    • REACH (for European chemical manufacturing)
    • Food Contact Guidelines (where used in food-grade polymerization)

    Typical usage ratio

    • Baseline 1.0 molar equivalent in catalyst precursor stage; fine-tuned by desired amine selectivity and downstream application specs

    Downstream process integration

    • Fed into fixed-bed hydrogenation reactors for nitrile-to-amine conversion
    • Product stream isolated and purified before onward use as a catalyst
    • Further functionalized where promoter groups are needed

    Final product types

    • Alkylamine polymerization catalysts
    • Specialty amine curing agents used in epoxy systems
    • Fine chemical synthesis catalysts for pharmaceutical intermediates
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    Certification & Compliance
    More Introduction

    Introducing 1-Cyclohexene-1-Acetonitrile from the Manufacturer's Perspective

    Shaping Chemistry with Reliable Compounds

    Working at the heart of chemical manufacturing, I watch the world of organic synthesis evolve each year. Compounds like 1-Cyclohexene-1-acetonitrile (CAS 13947-72-9), sometimes overlooked in broader chemical conversations, often deliver more value than expected. Each batch, from raw material selection to final packaging, demands a methodical approach. Our product, produced to strict internal standards, reflects our experience in meeting the needs of demanding research and manufacturing environments.

    Model and Chemical Profile

    For those less familiar, 1-Cyclohexene-1-acetonitrile bears the formula C8H11N with a molecular weight of 121.18 g/mol. It stands out in our intermediate range because of its specific balance between reactivity and molecular resilience—qualities shaped by its cyclohexene ring bound to an acetonitrile group. The substance presents as a colorless to pale yellow liquid, and anyone who has worked with nitriles recognizes the distinct, sharp aroma. Its stability allows for shipment across a range of environments without rapid degradation, opening opportunities for both domestic and export supply chains.

    Specifications That Matter in Real Application

    Precision matters when producing chemicals intended for specialized uses. Our standard for 1-Cyclohexene-1-acetonitrile dictates a purity above 98% by GC, which consistently meets the threshold required by pharmaceutical, agrochemical, and specialty material manufacturers. Water content stays below 0.2%, reducing side reactions and yield losses for downstream users. We maintain tight controls on residual solvents and byproducts, directly tying these efforts to feedback from chemical engineers whose processes rely on predictable, clean input materials.

    Real-World Usage and the Importance of Reliability

    Chemists and production engineers working with this nitrile often cite its utility in crafting high-value intermediates. Its applications cover a diverse range, from the synthesis of pharmaceuticals to the development of new agrochemical agents. One consistent point from our customers: small impurities or solvent residues can throw off entire process chains, especially in the later stages of API synthesis or when scaling up plant runs. We address this demand not by chasing unattainable specs but by investing in purification, tracking analytical trends over every season, and remaining responsive to users who need specs dialed in for their unique recipes.

    What Makes This Nitrile Unique

    After decades working with thousands of organics, I've seen how subtle shifts in structure ripple through entire supply lines. Comparing 1-Cyclohexene-1-acetonitrile to basic cyclohexanecarbonitrile or benzonitriles highlights its distinct set of reactivity. The double bond in the cyclohexene ring significantly alters reactivity compared to the saturated ring of cyclohexanecarbonitrile. In pharmaceutical discovery, that double bond often invites unique cycloaddition or functionalization reactions not possible with other nitriles.

    Our customers developing new drug candidates often remark on shorter synthetic routes or increased selectivity using this compound. The balance between ring strain and double bond placement translates into more options for selective transformations, forming building blocks not readily available through other intermediates. In agricultural chemistry, it maintains both chemical stability during formulation and sufficient reactivity under specific reaction conditions, supporting the creation of new, more targeted molecules for crop protection.

    Practical Differences in Processing and Handling

    From a manufacturing angle, 1-Cyclohexene-1-acetonitrile brings a manageable volatility profile—high enough to enable straightforward recovery or solvent exchange in continuous systems, but not so high that handling or storage creates safety headaches. We package it in sealed containers fitted with PTFE gaskets, responding directly to corrosion and migration issues our logistics team encountered during early projects. Nothing replaces hands-on experience discovering how materials behave in the real world, circulating through warehouses and global shipping lanes.

    Distinguishing this product from bulk industrial nitriles like acetonitrile or adiponitrile makes sense for anyone moving between commercial and research chemistry. Bulk nitriles, produced in thousands of tons, focus on fuel, plastics, or solvent markets, lacking the controlled reactivity and precise impurity profiles needed for specialty chemistry. Our 1-Cyclohexene-1-acetonitrile, by contrast, targets end-users who demand customization and support. We routinely field technical requests, from tailoring impurity levels to adjusting stabilizer content, all grounded in dialogue with experienced chemists who’ve spent years fine-tuning their process variables.

    Manufacturing From the Ground Up

    Producing this compound at scale calls for more than textbook chemistry. Each step, starting from safe handling of reagents like cyclohexanone and acetonitrile, through precise catalysis, reflects a series of hard-earned adjustments. Our team has faced every stage: optimizing reaction times for reduced byproducts, adjusting distillation points based on ever-changing climate conditions, and calibrating quality controls to catch potential off-spec runs before shipment. These on-the-floor experiences drive real-world trust, not theoretical purity values.

    We pay attention to each batch’s analytical data and compare trends across production lots. This continuous feedback, both from internal lab instruments and from customer comments, feeds process improvements. Purity targets, color stability, smell, and even subtle physicochemical characteristics shape ongoing adjustments and reflect a genuine loop between manufacturer and end user. Over the years, this approach has raised both our technical bar and the confidence of scientists relying on our shipments to keep their syntheses on schedule.

    Supporting Pharmaceutical and Crop Science Innovation

    Modern pharma and agrochemical labs rely on rare intermediates that hold up under regulatory scrutiny. Regulators investigate not only the intended compound but also trace impurities, potential genotoxins, and stability over time. We invest in analytical development—NMR, MS, and up-to-the-minute GC analysis—because we sit in the front line of responsibility. False positives, unexpected degradation products, or even an off-tint can cost customers millions in lost time or failed product launches.

    Feedback cycles form the backbone of our progress. Scientists working with 1-Cyclohexene-1-acetonitrile often report subtle but significant shifts in downstream reactivity compared to other nitriles. In route scouting or medicinal chemistry, these nuances change the path to a final API. We work with external labs for additional impurity analytics to provide deeper insight into reaction byproducts, supporting customer-driven compliance and documentation.

    Commitment to Safety and Responsible Use

    Handling nitriles always draws attention to health and environmental safety. Our production line follows industry best practices for ventilation and personal protective equipment. We monitor emissions and effluent to safeguard both our team and the communities nearby. Training is ongoing for everyone involved, from raw material receipt to shipment, as results come not only from paperwork but also from genuine care and vigilance. Our waste management reflects years of regulation and self-imposed discipline—nothing leaves the site unchecked or undocumented.

    We support downstream users with best practices, grounded in actual handling experiences, not just printed labels. For scale-ups, we openly share lessons learned about reactivity spikes or incompatibilities. For small-scale laboratories, we give proven advice on storage timeframes and contamination prevention, always based on real shipments and conversations, not mere theory.

    Adapting to Market Demands and Supply Chain Shocks

    Supply chain upheavals are a fact of modern manufacturing. Sourcing starting materials, managing price spikes, and absorbing logistic delays challenge every chemical maker. With 1-Cyclohexene-1-acetonitrile, we maintain backup sources and buffer inventory, not just on paper but in actual, accessible storage. Our raw material partners are vetted with site visits, ensuring reliability not only in specification but also in delivery commitments.

    Recent years emphasized the need for local adaptability. Natural disasters, regulatory changes, and logistical bottlenecks taught us that agility outperforms mere volume. Instead of betting on single suppliers, we build relationships that outlast price swings, keeping open lines with specialty reagent makers and alternative raw material providers. Manufacturing this compound in-house lets us flex production schedules in response to customer rushes or market slowdowns. We never treat customer requests as just another order line—they reflect lab projects, production timelines, and sometimes the difference between R&D momentum and stalled pipelines.

    Building Trust Through Consistency

    Repeat orders are built on more than specification sheets. We know that our users, whether in research or industrial settings, run their operations on predictability. Consistency in 1-Cyclohexene-1-acetonitrile production means tracking every variable: tank cleaning records, fresh filter installations, even ambient plant temperature or humidity on days of sensitive synthesis steps. We trace each shipment to individual production batches, cross-checking analysis with both manufacturer and end-user methods.

    We recognize the anxiety that comes with swapping sources, especially with critical intermediates. Our open communication policy means users get answers to technical queries within realistic times—engineers speak to engineers, chemists to chemists, not a faceless queue. We document every batch, sharing certificates of analysis, and invite feedback on purity, color, and performance in actual reactions. These habits, built over years, keep our focus sharp and underline our core mission as actual manufacturers, not faceless intermediaries.

    Addressing Unique User Needs

    Not every user requires the same purity, volume, or stabilizer package for their processes. We adapt to requests as varied as kilogram-scale pilot runs to tonne-level commercial batches. Our flexibility grows from real production experience: sometimes regulatory registrations drive demand for tighter impurity control, in other cases, innovators need alternate packaging for automated feed systems. Open discussion of such needs, rather than rigid catalog models, keeps us responsive.

    We learn from every project. Requests for micro-impurity breakdowns or lot-specific spectral data spark ongoing refinement of both our production and analytical toolkit. We’ve custom-packed product for continuous-flow reactors, adapted labels for international regulations, and shared technical bulletins stemming from user trials. For every batch, meticulous tracking lets us identify and solve any root issues quickly, making us confident partners for innovation-driven users.

    Why Direct Manufacturing Makes the Difference

    Being a direct producer of 1-Cyclohexene-1-acetonitrile means every improvement, challenge, or technical request lands with people who have hands-on responsibility. Quality control is not a remote concept but a daily lived reality, informed by workers who deal with every drum, flask, and kilogram. We understand the difference between a variable spec and a consistent lot, because it impacts yield, safety, and even regulatory submission schedules.

    Our ability to adapt flows from manufacturing our own feedstocks, controlling process chemistry, and knowing the seasonal challenges that can shape product characteristics. Instead of waiting for third-party answers, our technical team solves and answers questions directly. This advantage is not abstract; it's the backbone of user satisfaction, reflected in ongoing collaborations and trust.

    Looking Forward in a Changing Chemical Landscape

    Demand for 1-Cyclohexene-1-acetonitrile grows as customers innovate new ways to employ its reactivity. Its structure remains key for next-generation synthesis, whether for unique pharmaceutical scaffolds or greener process chemistry in agrochemicals. We stay alert to new regulatory, analytical, and environmental standards. Each year, changing customer needs and emerging green chemistry guidelines challenge us to push our in-house skills, from raw material selection to more sustainable synthesis methods.

    We see growing interest in sustainable handling, lower residual solvents, and advanced impurity mapping. Our R&D team follows these signals, adjusting production and collaborating with both startups and multinationals exploring new applications for this core intermediate.

    Walking the Path With Our Users

    Few chemicals blend practical utility with such rich reactivity as 1-Cyclohexene-1-acetonitrile. Our work as the original producer never stops. Every shipment, analytical improvement, and technical conversation continues to shape the compound’s role in both research and industry. We look forward to deeper partnerships, greater transparency, and better outcomes for everyone who puts our product to the test, driving discoveries, scaling breakthroughs, and building the next generation of applied chemistry.