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1-Chloro-4-Ethylbenzene

    • Product Name 1-Chloro-4-Ethylbenzene
    • Alias p-Ethylchlorobenzene
    • Einecs 202-444-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    394326

    Cas Number 4566-24-1
    Molecular Formula C8H9Cl
    Molecular Weight 140.61 g/mol
    Iupac Name 1-chloro-4-ethylbenzene
    Appearance Colorless liquid
    Boiling Point 198-200 °C
    Melting Point -22 °C
    Density 1.029 g/cm³ at 25 °C
    Refractive Index 1.513
    Flash Point 76 °C
    Solubility In Water Insoluble
    Vapor Pressure 0.32 mmHg at 25 °C

    As an accredited 1-Chloro-4-Ethylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle with secure screw cap, labeled "1-Chloro-4-Ethylbenzene, 500 mL," including hazard warnings and CAS number.
    Shipping 1-Chloro-4-ethylbenzene is shipped as a hazardous material due to its flammable and potentially harmful nature. It must be packed in approved, sealed containers and labeled according to the appropriate transport regulations (such as DOT, IATA, or IMDG). Ensure the shipping paperwork indicates all hazard classifications and emergency procedures.
    Storage 1-Chloro-4-ethylbenzene should be stored in a cool, dry, well-ventilated area away from direct sunlight, heat, and sources of ignition. Keep the container tightly closed and store separately from strong oxidizing agents, acids, and bases. Use approved, compatible containers and keep away from food and drinks. Clearly label the container and ensure proper secondary containment to prevent leaks or spills.
    Application of 1-Chloro-4-Ethylbenzene

    Applications of 1-Chloro-4-Ethylbenzene in Industrial Manufacturing

    Our factory produces 1-Chloro-4-Ethylbenzene for several targeted downstream sectors, each adhering to distinct regulatory, process, and product demands. As an upstream supplier, we work closely with formulators, process engineers, and technical teams in industries ranging from fine chemicals to specialty polymers to ensure precise integration and regulatory alignment.

    1. Agricultural Chemical Intermediates

    1-Chloro-4-Ethylbenzene is a core aromatic building block for the synthesis of advanced agrochemical actives, specifically in the formulation of certain selective herbicides and fungicides. Specialist processors introduce it via alkylation or chlorination reactions, resulting in intermediates optimized for crop protection product development. Our technical team ensures consistency for step-growth integrations and aligns supply with changing synthetic route specifications from leading agricultural solution providers.

    Industry compliance standards

    • European Union Regulation (EC) No 1107/2009 for Plant Protection Products
    • REACH Registration, Evaluation, Authorisation and Restriction of Chemicals
    • EPA Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA)
    • ISO 9001:2015 Certified Quality Management Systems

    Typical usage ratio

    • Formulators apply 1-Chloro-4-Ethylbenzene at 8–18% by weight in the precursor synthesis batch.
    • The precise ratio depends on the specific downstream active ingredient design, with adjustments based on target yield and byproduct formation control needs.

    Downstream process integration

    • Introduced during early chlorination or alkylation of substituted benzenes in multi-step agrochemical active ingredient synthesis.
    • Typically fed into continuous or semi-continuous reactors with in-line phase separation and nitrogen blanketing.

    Final product types

    • Selective pre-emergent herbicides (e.g., chloroethyl-substituted derivatives for broadleaf or cereal crops)
    • Systemic fungicide ingredients for cereals and fruits
    • Other crop protection active intermediates

    2. Fine Chemical Synthesis for Dyes and Pigments

    Leading colorant manufacturers utilize 1-Chloro-4-Ethylbenzene for the preparation of intermediate compounds in high-performance dyestuff and pigment lines. Through Friedel–Crafts acylation or nucleophilic substitution, this raw material enables precise control of chromophore precursor assembly and substituent positioning, supporting greater dye fastness and stability critical for textile and plastic coloration markets.

    Industry compliance standards

    • OEKO-TEX® Standard 100 for textile colorants
    • EN 71-3:2019 (Migration of certain elements, for pigments in toys)
    • ISO 14001:2015 Environmental Management Systems
    • Kosher and Halal certificates for products entering food contact packaging color lines

    Typical usage ratio

    • Usually included at 5–12% of the intermediate synthesis mass, adjusted depending on target dye molecular weight and the extent of ring substitution desired in the technical process.
    • Ratios tailored for mono-, di-, or poly-substituted benzene ring chromophores using validated lab-scale to commercial-scale procedures.

    Downstream process integration

    • Enters the process during the first or second stage of dye or pigment intermediate condensation/fusion, often in the presence of Lewis acid catalysts and chlorinated solvent recirculation systems.
    • Operators monitor purity for color shade consistency and control of byproduct isomers.

    Final product types

    • Anthraquinone-based pigments
    • Direct and acid dyes for polyester, cotton, wool, and nylon
    • Food-grade colorants and specialty fluorescent dye intermediates

    3. Pharmaceutical Intermediate Manufacturing

    Specialist pharmaceutical intermediate companies select 1-Chloro-4-Ethylbenzene as a key structure in the multi-step production of aromatic-based API intermediates. This raw material supports the controlled assembly of halogenated ring systems that serve as scaffolds for advanced synthesis, contributing to the final active’s functional groups relevant to therapeutic efficacy and biological targeting. Its reliable chemical profile is essential in tightly regulated pharma supply chains.

    Industry compliance standards

    • International Conference on Harmonisation (ICH) Q7 GMP for Active Pharmaceutical Ingredients
    • USP-NF and European Pharmacopoeia monographs as applicable for intermediates
    • 21 CFR Part 211 (cGMP for Finished Pharmaceuticals) for final API production
    • FDA Drug Master File (DMF) referencing for registered intermediates

    Typical usage ratio

    • Range: 6–14% of total reaction mass, as determined by specific API intermediate route and overall step yield targets.
    • Batches scaled based on kilogram-to-ton quantity, with analytical adjustment of input to maintain final impurity profile below 0.1% per process specification.

    Downstream process integration

    • Charged into closed system reactors during aromatic ring functionalization or halide exchange steps, often under inert atmosphere conditions to minimize oxidative byproducts.
    • Purity analysis performed prior to next sequence using GC/MS and HPLC methods.

    Final product types

    • Custom pharma building blocks (e.g., chloroethyl-benzene derivatives used in anti-inflammatory, CNS, and oncology drug candidates)
    • Bulk generic API intermediates for contract synthesis clients
    • Specialized advanced intermediates for small molecule new chemical entities (NCEs)

    4. Specialty Polymer and Resin Production

    Major polymer processing clients use 1-Chloro-4-Ethylbenzene to introduce halogen functionality and tailored alkylation into resin and thermoplastic systems, such as modified polystyrene and engineering resin blends. Its integration enhances specific chain properties, end-group reactivity, and processability. This results in improved thermal stability and modified flammability profiles which match technical demands in automotive, electronics, and construction polymer applications.

    Industry compliance standards

    • UL 94 Flammability Standard for Plastics Materials
    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances)
    • ISO 9001 and ISO 14001-certified production for major resin suppliers
    • REACH Annex XVII compliance (polymer additives and monomers)

    Typical usage ratio

    • 4–10% by weight as a monomer or as a modifier during bulk polymerization runs for specialty resins, with further variation by resin backbone design and final property targets assessed by QC testing.
    • Adjustment made according to desired chlorine content and chain branching.

    Downstream process integration

    • Enters at polymerization initiation, often blended with co-monomers or functionalized during reactive extrusion stages in continuous manufacturing lines.
    • Strict input purity and controlled reaction temperature maintained for product quality assurance.

    Final product types

    • Halogenated engineering resins for automotive interiors and electrical insulation
    • Impact-modified polystyrene with controlled chlorine content
    • Specialty resin blends for construction panels and anti-static housings

    5. Industrial Solvents for Chemical Processing

    1-Chloro-4-Ethylbenzene shows effective solvent capability for selected organic synthesis and extraction procedures, favored by processors requiring moderate polarity and inertness with certain reactivity profiles. Industrial users rely on its stability under reflux and compatibility with related halogenated aromatics, especially in closed-loop recovery systems and fine chemical plants operating specialized separations.

    Industry compliance standards

    • OSHA 29 CFR 1910.1200 for chemical hazard communication
    • EU Dangerous Substances Directive 67/548/EEC (for transport and handling use)
    • ISO 14001 Environmental Safety for solvent recovery and emissions
    • Site-specific VOC emissions permits and records

    Typical usage ratio

    • Variable: typically constitutes 15–30% of the total solvent blend depending on solubility and boiling point compatibility with other process reagents.
    • Adjusted by solute type and solvent recycle targets to minimize process waste.

    Downstream process integration

    • Fed into jacketed reactor vessels or used in liquid–liquid extraction columns for separation and purification steps.
    • Solvent recovery managed via fractional distillation and condensate recycling inline with process sustainability goals.

    Final product types

    • Purified fine chemical intermediates (maximizing yield and purity)
    • Solvent-recycled process streams for internal reuse
    • Specialty extracted aromatic compounds for downstream synthesis
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    Certification & Compliance
    More Introduction

    1-Chloro-4-Ethylbenzene: A Chemist’s Perspective on Quality and Application

    Manufacturing Commitment Behind Every Molecule

    Our focus on 1-Chloro-4-Ethylbenzene comes from years of experience as direct producers, not intermediaries. Through careful management of raw materials and consistently monitored synthesis conditions, we ensure each batch achieves high purity and reliability, essential for meeting the standards of downstream users. Our team has spent countless hours refining the process routes and purification methods, allowing for confident delivery of this chlorinated aromatic compound to customers who value integrity and predictable performance.

    Chemical Profile and Specifications that Reflect Experience

    The specific compound 1-Chloro-4-Ethylbenzene, with the molecular formula C8H9Cl and CAS number 106-43-4, stands out due to its precise substitution pattern. Our facilities focus on keeping impurities—such as isomers, residual starting materials, and trace inorganic content—well below generally accepted limits so that the finished product matches both technical grade and more demanding specification targets if required by formulators. The melting and boiling points match well-referenced values, confirming identity and batch uniformity, so when it arrives at your site, there are no surprises in handling or downstream synthesis.

    How We Control Impurities and Achieve Consistency

    Chlorinated aromatics like this one often carry concerns around by-products, catalyst residues, and inconsistent isomer ratios. We address these issues through investment in dedicated reactors, staged distillation columns, and online QC analytics operated in-house. It is not uncommon for new chemists to underestimate the significance even of trace by-products in downstream uses—yet, over time, persistent fine-tuning of process chemistry and separation sciences makes the difference between a compound that works and one that causes recurring headaches in production. Maintaining control over every variable, from the choice of chlorinating agent to reactor temperature programming, leads to fewer stoppages and clear analytical results.

    Production In-House Means Predictable Supply

    Being a manufacturer by trade, we do not chase spot market trends in sourcing or cut corners with recycled feedstocks. We have constant oversight from raw material receipt through to the final kilogram filled into drums. When demand spikes from sectors like polymers or active pharma intermediates, we make scheduling and logistics adjustments internally to ensure material arrives on the customer’s loading dock without delays or quality shortfalls.

    Where 1-Chloro-4-Ethylbenzene Finds Practical Use

    On the production floor, the bulk of this chemical ends up in processes related to advanced intermediates, specialty solvents and modifiers in organic synthesis, and specific resin formulations. Craftsmen in these sectors know how sensitive some reactions are—unexpected color changes, side-product formation, or regulator audit queries can derail entire shipments. This compound performs well in making ethylated and chlorinated intermediates, acting as a strong foundation for agricultural or dye chemistry, and as an essential additive or precursor wherever the ethyl and chlorine functionality present clear reactive handles.

    Recently, customers in our region using 1-Chloro-4-Ethylbenzene provided feedback regarding solid-state residue affecting sensitive glass-lined systems. We took this seriously, revisited filtration and drying parameters, and demonstrated lower non-volatile residue through both our and their independent labs. Problems can arise unexpectedly even in long-standing processes—direct oversight and willingness to adapt production steps to meet real use case demands remain our strong points.

    Comparing with Other Chlorinated Benzenes

    We receive regular questions about differentiation between this compound and more common isomers or other chlorinated benzenes, like 1-Chloro-2-Ethylbenzene, or the simple mono-chlorobenzene. Some downstream reactions require the para-ethyl substitution for selective activation or steric hindrance; this molecular arrangement grants specific reactivity distinct from its ortho- or meta-substituted counterparts. In manufacturing, we see how improper control can lead to problematic blends, so we emphasize robust isomer separation—unlike with broad commodity chlorobenzenes, deviations in isomer content can noticeably impact yield and product profile for the user.

    In a typical year, hundreds of tons of generic chlorobenzenes flow into commodity synthesis and solvents, but when customers demand the strict selectivity needed for fine chemical intermediates or certain API-related steps, the robust structure and purity of 1-Chloro-4-Ethylbenzene become crucial. Our facility can isolate and verify the specific isomer ratio far beyond the minimums listed in earlier pharmacopeias or industrial guides, bringing peace of mind to QA reviewers and lab process engineers alike.

    Supporting End Users in Complex Applications

    Every customer’s process stands out for its own reasons—high shear mixing, unusual temperature cycling, closed-system requirements, or tight traceability audits. Over the years, we have seen situations where minor halogen content can poison catalysts, or where improper storage of generic solutions causes oxidative degradation. By coordinating with users’ technical staff and running pilot samples in parallel, we’ve helped many resolve unexplained yield drops or batch consistency issues. We hold sample retention stocks for forensic checks, ensuring that any supply chain issue—should it arise—can be traced fully.

    Environmental and Regulatory Confidence

    One concern often voiced is alignment with environmental, health, and safety standards. Unlike legacy producers relying on unchecked waste streams, our teams have designed abatement controls for chlorinated volatiles and rigorously document effluent and emissions parameters to meet present-day compliance requirements. We do not simply run end-of-pipe monitoring; active scrubbing, process water recycling, and raw material analysis keep both the local environment and site teams safe. Our EHS colleagues conduct regular scenario trainings; continual investment in closed-loop and leak-resistant systems minimizes both immediate risks and potential regulatory headaches for supply chain partners.

    Shipping: Lessons from the Manufacturing Front Line

    Despite advances in chemical supply chain management, real-world logistics present persistent challenges. We have learned to avoid lightweight bulk packaging that can stress under temperature swings or impact during transit. For some customers—especially those operating far from major ports—custom drum or tote solutions reduce transfer losses and simplify on-site storage. Barcoding and real-time tracking of outbound lots provide direct evidence for regulators, and customers receive full origin and batch documentation rooted in our own continuous records, not reprinted from an upstream vendor.

    Addressing Sustainability and Resource Use

    Sustainability is more than a buzzword on our shop floor. Sourcing greener chlorinating agents and solvents, energy recovery from process heating, and continual VOC reduction rank as working targets, not abstract ideals. Several years ago, a review identified water use for cooling as a potential bottleneck in summer seasons; as a result, we invested in closed-cycle cooling units, saving thousands of cubic meters annually and reducing impact on local water systems. Such adaptations demand up-front cost and effort but yield long-term operational certainty and stronger supplier relationships—both with large-volume customers and innovative niche startups.

    A Perspective Forged from Hands-On Practice

    Manufacturers see firsthand the small, recurring issues that do not make it into spec sheets or external audits—sometimes a subtle odor difference, a coloration on the glass reactor lining, or a slow chromatographic shift pointing to an impurity. These observations ground our focus on minute process controls. Years of batch logs and close relationships with end-users reveal that what seems an insignificant deviation in a commodity catalog entry can make or break a high-stakes downstream synthesis or regulatory inspection.

    Direct production experience also helps us anticipate unusual use cases. Research labs, specialty polymer lines, and agricultural intermediate producers bring needs distinct from volume solvent buyers. For some, batch-to-batch consistency ensures that experimental data remain valid over long development cycles. For others, avoiding certain trace metals or halogen contaminants ensures compliance in final products that feed into sensitive consumer goods or regulated crop protection agents. We track customer feedback in detail, sometimes visiting plants to observe how our own intermediate flows through the real-world process, learning where further process innovation could deliver not only compliance but actual savings or efficiency improvements.

    Staying Ahead with Investment in Process Understanding

    No facility remains static; nor do the markets we serve. We have invested in upgraded analytical equipment—GC/MS, HPLC, and spectroscopic tools—so issues like isomeric purity and trace impurity speculation become tangible, measurable facts. Our staff turn these data points into actionable changes in reactor scheduling, solvent systems, or even handling and transport protocols. Problems faced by one customer spill insights into updated SOPs for another; close dialogue between labs, logistics, and EHS staff is part of daily work.

    Challenges Faced and Improvements Made

    The real world seldom grants the luxury of perfect batches or seamless distribution. We have run night shifts tracking anomalous pressure readings and chased root causes of rare but critical side reactions. In one case, a fouled distillation column produced trace cross-contamination that eluded early QC but surfaced in a customer’s chromatograph. Rapid internal tracing, joint sample sharing, and transparent problem description enabled us to correct the issue, replace affected stock, and restore customer confidence. Each such event receives full review from plant, lab, and shipping staff, making our organization more robust with every challenge—a resource we now share directly as advice or support to all customers.

    Looking Forward: Why Quality in 1-Chloro-4-Ethylbenzene Matters

    For some, chemicals like this serve as basic building blocks; for others, they underpin entire value chains. As a hands-on producer, we see every lot as an opportunity to reinforce trust among our partners—be they multinational companies sourcing for year-round manufacturing or agile startups chasing new molecules or materials. The tangible time, effort, and skill behind each delivered drum, the record-keeping and open communication with users, and the accumulated history of troubleshooting and adaptation, allow each sale to carry not just product but the assurance of responsive support and transparent expertise.

    A customer described our approach this way: "You do not just hand off a chemical—your team stands with us through real-world issues." For us, 1-Chloro-4-Ethylbenzene is more than a catalog offering. It is a reflection of manufacturing dedication, process stewardship, and the ongoing dialogue between supplier and end user that builds reliable supply chains—especially as regulatory and technical demands keep evolving.

    Closing Thoughts from the Production Floor

    Our ongoing investment in process, safety, and customer dialogue stems from real experience—the best source of lasting confidence for those who depend on our 1-Chloro-4-Ethylbenzene. More than molecular diagrams or catalog listings, what matters is the thread of reliability and purpose that starts with the raw material and ends in the successful completion of a customer's critical application, whether in dyes, resins, or tomorrow's pharmaceuticals.