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1-Chloro-1,2,2-Trifluorocyclobutane

    • Product Name 1-Chloro-1,2,2-Trifluorocyclobutane
    • Alias Perfluorocyclobutyl chloride
    • Einecs 214-076-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    187891

    Chemicalname 1-Chloro-1,2,2-Trifluorocyclobutane
    Molecularformula C4H4ClF3
    Molarmass 144.52 g/mol
    Casnumber 341-56-0
    Appearance Colorless liquid
    Boilingpoint 56 °C
    Density 1.387 g/cm³
    Meltingpoint -72 °C
    Refractiveindex 1.363
    Solubilityinwater Insoluble
    Vaporpressure 173 mmHg (20 °C)
    Flashpoint -21 °C

    As an accredited 1-Chloro-1,2,2-Trifluorocyclobutane factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 1-Chloro-1,2,2-Trifluorocyclobutane is supplied in a 100g amber glass bottle with a secure screw cap and safety label.
    Shipping 1-Chloro-1,2,2-Trifluorocyclobutane should be shipped in well-sealed, chemical-resistant containers. Ensure packaging complies with hazardous material regulations. Ship at ambient temperature, away from heat, sparks, or open flames. Proper labeling, documentation (including Safety Data Sheet), and adherence to transportation guidelines are mandatory to ensure safe handling, storage, and delivery of this chemical substance.
    Storage 1-Chloro-1,2,2-Trifluorocyclobutane should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizers. Keep away from sources of ignition, heat, and direct sunlight. Store under inert atmosphere if possible to prevent decomposition. Ensure containers are clearly labeled and handle with proper personal protective equipment.
    Application of 1-Chloro-1,2,2-Trifluorocyclobutane

    Applications of 1-Chloro-1,2,2-Trifluorocyclobutane in Industrial Manufacturing

    As a specialized manufacturer of 1-Chloro-1,2,2-Trifluorocyclobutane, we supply this advanced chemical intermediate to critical sectors with well-defined downstream requirements. Its molecular structure provides unique reactivity profiles, enabling precise integration into high-performance chemical production streams. Addressing specific segment needs, we support formulation, safety, and QC protocols, helping clients optimize their yield and compliance in regulated markets.

    1. Pharmaceutical Intermediate Synthesis

    Pharmaceutical manufacturers often utilize 1-Chloro-1,2,2-Trifluorocyclobutane as a halogenated intermediate in the synthesis of small-molecule APIs, where precise control over selectivity and purity is critical. The compound supports fluorination steps in the construction of active pharmaceutical compounds with complex cyclobutane motifs. Our quality management ensures traceable lot-level documentation to support drug master files.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • 21 CFR Part 210/211 (USA): cGMP for Finished Pharmaceuticals
    • EU GMP EudraLex Volume 4
    • USP General Chapter <821> (Chlorinated Organic Compounds)

    Typical usage ratio

    • 5-18% w/w in targeted fluorinated API intermediate reactions; precise ratio customized per route and batch size

    Downstream process integration

    • Dosed into the fluorination or halogen-exchange step of multistep organic synthesis lines, typically after initial cyclobutane framework construction, with in-process QC for residual halide monitoring

    Final product types

    • Non-steroidal anti-inflammatory API intermediates
    • Fluorinated antiviral drug raw materials
    • Specialty cardiovascular agent precursors
    • Oncology drug component building blocks

    2. Agrochemical Active Ingredient Formulation

    Agrochemical producers apply 1-Chloro-1,2,2-Trifluorocyclobutane as a base compound for novel fluorinated herbicide and fungicide synthesis. Its selective reactivity assists in constructing active ingredients with sustained field stability and crop protection efficiency. Raw material integration is performed under full traceability and field formulation audits.

    Industry compliance standards

    • FAO/WHO Code of Conduct for Pesticide Management
    • ISO 9001:2015 for Agrochemical Formulation Facilities
    • Chinese GB 2763 residue standard for edible crops
    • US EPA Pesticide Registration Regulations (40 CFR)

    Typical usage ratio

    • 12-26% w/w depending on downstream molecule reactivity and targeted formulation loading, fine-tuned by formulation chemists

    Downstream process integration

    • Reacted in the heterocyclic backbone assembly or direct substitution reactions, followed by technical concentrate formulation and microencapsulation where needed

    Final product types

    • Fluorinated herbicide AIs for broadleaf crop applications
    • Fungicides with enhanced environmental persistence
    • Seed treatment concentrates
    • Crop protection premixes for integrated pest management

    3. Refrigerant and Specialty Gas Precursor

    Specialty gas manufacturers use 1-Chloro-1,2,2-Trifluorocyclobutane as a building block in synthesizing low-global-warming-potential (GWP) fluorocarbons and halofluorinated refrigerants. Its controlled conversion gives access to refrigerant blends with tightly specified boiling points and thermodynamic profiles. Stringent process safety and batch analytics govern its usage at this stage.

    Industry compliance standards

    • AHRI Standard 700: Refrigerant Purity Specification
    • EN 378-1:2021 Refrigeration Systems – Safety and Environmental Requirements
    • ISO 14001: Environmental Management System for Fluorochemical Manufacture
    • F-Gas Regulation (EU) No 517/2014

    Typical usage ratio

    • 15-40% molar feed for conversion reactions in refrigerant precursor synthesis, ratios calculated based on desired product volatility

    Downstream process integration

    • Feedstock for halogen-exchange and fluorination reactors, serving as a direct precursor to HFC and HCFO refrigerant molecules, typically under pressure-controlled, closed-loop processing units

    Final product types

    • HFC-347mcc refrigerants
    • HCFO-1234yf base intermediates
    • Specialty fire suppression gases
    • Low-GWP refrigeration system blends

    4. Electronic Chemicals for Photolithography

    Electronic chemical producers integrate 1-Chloro-1,2,2-Trifluorocyclobutane in proprietary etchant and cleaning formulations for advanced semiconductor photolithography processes. This raw material delivers tailored volatility and pattern-transfer precision at nanoscale features, meeting the purity and stability demanded by wafer fabrication plants.

    Industry compliance standards

    • SEMI C93-0912: Specifications for Advanced Cleaning Chemicals
    • ISO 14644-1: Cleanroom Process Control
    • IEC 62474: Materials Declaration for Electrical and Electronic Equipment
    • RoHS Directive 2011/65/EU (if downstream assembly is required)

    Typical usage ratio

    • 2-7% v/v in photoresist strippers and etching baths; adjusted based on wafer geometry and process step

    Downstream process integration

    • Injected into immersion or vapor-phase cleaning and etching modules during wafer preparation and circuit patterning, typically under ultra-clean conditions to minimize trace contamination

    Final product types

    • Photoresist removal chemistries for logic and memory fabs
    • Wet etchant blends for advanced packaging
    • Ultra-clean process chemicals for photomask making
    • Specialist lithography grade cleaning fluids
    Free Quote

    Competitive 1-Chloro-1,2,2-Trifluorocyclobutane prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

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    Certification & Compliance
    More Introduction

    1-Chloro-1,2,2-Trifluorocyclobutane: A Closer Look from the Manufacturing Floor

    Every day on our production line, batches of 1-Chloro-1,2,2-Trifluorocyclobutane roll out under careful supervision. We monitor each step with a focus that grows from decades of handling complex cyclobutane derivatives. Chemists here understand that materials like this perform much more than chemical tricks—they anchor safety, performance, and innovation in downstream applications.

    High-Purity from Source to Drum

    We take pride in consistently delivering 1-Chloro-1,2,2-Trifluorocyclobutane with tight purity controls. By tuning our fluorination and chlorination steps, we keep impurities like non-cyclic by-products and partial fluorination products well below detrimental thresholds. Past experience taught us that even trace impurities change the behavior of cyclobutanes in sensitive formulations. This commitment stems as much from our own troubleshooting as from listening to process engineers who need reproducibility, not guesswork, in their feedstocks.

    Product Details and Batch Consistency

    Our batches of 1-Chloro-1,2,2-Trifluorocyclobutane bear the model reference CFCB-1131. This identifier isn’t just for paperwork—it tracks production parameters, impurity scans, and customer feedback tied to every shipment. The molecular structure, C4H4ClF3, looks straightforward on a chalkboard but behaves with complex character in practice. We target a minimum purity of 99%, and independent labs back up our in-house gas chromatography results. Operators run routine NMR confirmation both for compliance and as a check on their own craftsmanship.

    We store the finished product under dry, inert gas to prevent hydrolysis and keep storage drums at moderate temperatures. Years ago, we learned the hard way that exposure to moist air leads to acid formation, risking corrosion and process fouling. Customers who handled similar cyclobutanes often ran into similar headaches, so we worked upstream to minimize halide hydrolysis products during filling. The result is a drum that arrives with specification exactly as you ordered, not a can of corrosion trouble waiting to spill.

    How Our Product Fits in the Real World

    Chemists in the field draw on 1-Chloro-1,2,2-Trifluorocyclobutane for specialty syntheses where both halogen blocking and fluorination count. In-house, we’ve seen demand spike for this compound in advanced materials synthesis, especially where high dielectric properties and chemical resistance matter. More than once, customers have explained how small differences in cyclobutane ring substitution radically shift insulation breakdown voltages or solvent stability. Instead of just filling an order, we talk directly with their process engineers. This feedback loop focuses our process design—removing halogen sources with slow dissociation, polishing the last trace of unsaturation, and tuning our purification columns to remove side products that only show up in end-use field tests.

    This chemical stands out when compared to traditional tetrafluorocyclobutanes or less-substituted analogs. The presence of chlorine on the ring brings a new set of reaction pathways, especially for downstream substitution or when grafting new side chains. In comparison, all-fluorinated cyclobutanes lack certain reactivity but offer improved stability. By contrast, less-fluorinated types carry higher reactivity but at a cost of resistance to solvents and acids. We keep these trade-offs in mind, knowing the real decision-makers weigh performance, reactivity, and cost across the whole production lifecycle.

    Lessons from Decades of Synthesis

    Making fine fluorinated cyclobutanes has taught us that lab-scale tricks often break down at ton-scale. Side reactions that appear manageable in a round-bottom flask can spiral out of control under pressure. For our 1-Chloro-1,2,2-Trifluorocyclobutane, we redesigned our reactor liners and distillation columns after residue fouling repeatedly threatened patch batches. Frequent scale-up headaches—fouling, contamination, trace acid generation—spurred us to revisit every step with a forensic mindset. Solvents and by-products must be recaptured, not just for compliance but because leakages eat into our bottom line, and waste never looks good to a sustainability auditor.

    Our team often fields questions about specification creep—why push so hard for an extra fraction of a percent on purity, or why bother logging trace impurities that regulations don’t even mention? Our answer is simple. People using this material in polymer synthesis or electronic-grade resins report measurable changes in performance at those fractions of a percent. Polymer gelling, dielectric breakdown, or outgassing in reflow ovens all tie back to starting material quality. Traceable, repeatable, and well-characterized product isn’t just an extra—it becomes the difference between passing a field test and bringing a multimillion-euro line down for cleaning.

    Working with Complex Regulations

    We live with evolving expectations from environmental and health regulators. Several years ago, our team had to overhaul scrubbing and capture systems for fluorinated vent emissions, not just to meet legal requirements but because the overall environmental costs weighed on our conscience. On top of that, downstream users expect detailed documentation for every lot. Instead of just shipping a generic drum, we supply lot-specific analytical data, even for minor impurities. This level of detail didn’t come out of nowhere; customer audits and regulatory visits pushed us to lay all our cards on the table. Today we know it’s better to stay ahead in transparency than scramble to explain a compliance issue after the fact.

    Some of our long-term partners in Europe and Asia pointed out differences in allowable impurity levels for certain halogenated by-products. Rather than blending to suit the lowest common denominator, we invested in better fractionation and real-time monitoring, so our baseline product matches the strictest regime. Decades on this production floor taught us that today’s optional documentation becomes tomorrow’s requirement, and the market never rewards catch-up players.

    Supporting Innovation in Downstream Chemistry

    One of the reasons we keep supporting 1-Chloro-1,2,2-Trifluorocyclobutane, even when niche volumes could push it out of the catalog, lies in its value for process innovation. Once, a partner organization approached us with a need for a cyclobutane variant that could offer higher reactivity for a cross-linking resin. Standard tetrafluorocyclobutanes proved too inert, while chlorinated variants without fluorination contributed to by-product colors and instability. Our version, with both fluorine and chlorine substitution, balanced these needs. Not only did the new resin pass rigorous performance tests, it opened a new market segment for the partner. We marked this up as a win, not just for having the right molecule but for solving a problem with years of accrued production expertise.

    Our chemical often serves as a building block in synthetic routes that require precise electronic properties. The balance of chlorine and fluorine substituents influences both nucleophilic and electrophilic reactivity, making it easier for R&D chemists to introduce new functionalities. As a result, we've seen it used in everything from specialty coatings to insulation systems for aerospace wiring. The combination of volatility control, chemical resistance, and site-specific substitution offers project chemists more than just one more option—it unlocks design spaces previously blocked by thermal instability or poor compatibility.

    Product Differences with a Chemical Manufacturer’s Perspective

    Often, our team hears this straightforward request: why use your product instead of an off-the-shelf alternative? To answer this, we draw on the actual pain points reported back to us from the shop floor and R&D benches. Standard trifluorocyclobutanes often lose stability under UV or high redox conditions, which limits their options in sensitive electronic encapsulants. Adding chlorine to the ring structure modifies this balance, enabling more robust performance under real-world aging and process stress. Those working with industrial solvents or aggressive cross-linkers know how critical small changes in cyclobutane backbone can be. Lousy performance creeps up not just during synthesis but during storage, transport, and long-term field use.

    Some practitioners worry that extra halogen content might complicate disposal or recycling. We address these concerns by keeping full process records and supporting end-users on compliant waste handling. Years of small but persistent feedback, especially from partners in regions with tough waste regulations, taught us to build safe handling guides and closed-loop recycling steps into our process flow. This doesn’t just keep the regulators happy; it lets our customers focus on their downstream business instead of firefighting permit issues.

    What We’ve Learned about Handling and Storage

    Careful handling of 1-Chloro-1,2,2-Trifluorocyclobutane ensures downstream process stability and workplace safety. We don’t just follow textbook rules—every ill-fated episode with leaky seals or contaminated batches forced us to re-examine storage conditions. Our method relies on pressurized containers formed from compatible alloys to avoid corrosion and material leaching. Labeling and batch traceability systems mean that operators on both the shipping and receiving ends can quickly pinpoint the origin and condition of each drum.

    In our plant, standard practice involves oxygen-free, moisture-free storage and rapid transfer into process streams. Our logistics partners receive thorough training in safe drum handling specific to this molecule’s vapor and reactivity profile. Routine safety drills uncovered gaps that never show up in written procedures—experience proved that mistakes here have real consequences, from downtime to safety incidents. We share lessons learned with our partners, closing the loop between technical documentation and day-to-day operations.

    Looking Beyond Today

    No one on our production team assumes this chemistry will stay static. The move toward greener substitutes, less halogenated intermediates, and biodegradable alternatives grows each year. From the manufacturing side, we put energy into R&D exploring potential uses for by-products and validating reclamation methods that shrink our waste footprint. Internal process audits—sparked by both self-driven improvement and customer questions—have led to changes in solvent selection, vent capture, and residue management. These shifts were unglamorous but real steps toward safer and more sustainable operations.

    As more manufacturers pursue closed-loop manufacturing, we've invested in recycling and safe conversion methods for both finished and residual 1-Chloro-1,2,2-Trifluorocyclobutane. This means not only reusing excess material within our plant but also providing clear documentation and transfer protocols to customers aiming to reduce their own chemical wastage. We've experimented with catalytic defluorination and low-temperature decomposition routes that turn unusable fractions into recoverable feedstocks. The results improve our own margins, and just as important, reduce the environmental load associated with halogenated organics.

    Supporting Technical Collaboration

    We treat every request for application advice or analytical detail as another chance to strengthen the partnership between manufacturer and user. Our technical team doesn’t stop at checking checkboxes. We regularly work through application-specific queries, from vapor pressure data at odd temperatures to compatibility guidance for new polymer matrices. The most productive relationships happen when process chemists, purchasing managers, and environmental compliance teams share feedback. Real projects rarely fit a chemistry textbook, and we draw on field experience as much as analytical data. This hands-on support explains why customers return—even as new alternatives crop up on the market, service and trust win repeat business.

    Sometimes the challenges are unexpected—the introduction of a new catalyst, a line change in a mixing operation, or a shift in solvent regime can all tip the balance. We dig through our historical production and test data to help customers troubleshoot. One recent example involved identifying a seemingly trivial impurity that caused unexpected color formation in a high-value polymer. Because we kept deep records and open lines with the original end-user, the solution came faster than it would with a disconnected supplier.

    Comparing to Other Cyclobutanes from the Manufacturer’s Lens

    From inside the factory, we see first-hand the tradeoffs between 1-Chloro-1,2,2-Trifluorocyclobutane and related compounds. Pure tetrafluorocyclobutane offers top-tier chemical inertness but misses reactivity in downstream reactions. Chlorinated cyclobutanes without fluorination run into stability and off-gassing issues, especially under processing heat. Our experience says that this particular balance—three fluorines for chemical resilience and one chlorine for reactivity—hits a sweet spot for process flexibility. We see project chemists choosing this chemistry for make-or-break steps: introducing a reactive site, tuning a thermal threshold, or stepping through complex multi-functional intermediates. Each project imposes its own specification, but feedback from these diverse uses helps us fine-tune our manufacturing setup.

    A few years ago, R&D teams working in specialty elastomers approached us about residual moisture pickup in alternative cyclobutanes. That warning helped us re-engineer our drying procedures for our product line, improving not only our own operations but those of everyone downstream. The core lesson: success rarely comes from the molecule alone, but from the iterative improvement cycle we share with the people who put our chemicals back into the world.

    Experience-Backed Commitment: The Manufacturer’s Promise

    Looking across our line, pride comes from more than just volumes sold or certifications achieved. People recall the bottlenecks, the ‘ghost’ impurities that fought every QA test, the midnight equipment overhauls to rescue an urgent order. We keep learning from these trials, knowing that 1-Chloro-1,2,2-Trifluorocyclobutane owes as much to dedication in the plant as to creativity in the lab. Customers come to us not just for a drum of material, but for a partnership that bends with their process, supports their documentation, and values open communication. In an industry that rarely stops moving, this flexibility and experience matter as much as any molecular property.

    As demand shifts and regulations evolve, our manufacturing team stands ready to adapt. We don’t just ship product; we provide knowledge and access to direct support—the kind that comes only from those who have made, packaged, and lived with the chemistry for years. In the world of advanced materials and specialty chemicals, each step counts, and those closest to the production floor carry the insights to support both progress and safety, batch after batch.