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1-(Bromomethyl)Naphthalene

    • Product Name 1-(Bromomethyl)Naphthalene
    • Alias alpha-Bromomethylnaphthalene
    • Einecs 208-063-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    837139

    Chemicalname 1-(Bromomethyl)naphthalene
    Casnumber 4391-17-9
    Molecularformula C11H9Br
    Molecularweight 221.09 g/mol
    Appearance Colorless to pale yellow liquid
    Boilingpoint 143-145°C at 14 mmHg
    Meltingpoint 5-7°C
    Density 1.43 g/cm³ at 25°C
    Refractiveindex 1.638-1.640
    Flashpoint 109°C
    Solubility Insoluble in water, soluble in organic solvents
    Smiles C1=CC=C2C(=C1)C=CC=C2CBr

    As an accredited 1-(Bromomethyl)Naphthalene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 25 grams of 1-(Bromomethyl)naphthalene, sealed with a PTFE-lined cap and labeled with hazard warnings.
    Shipping 1-(Bromomethyl)naphthalene is shipped as a hazardous chemical due to its potential toxicity and reactivity. It must be packed securely in airtight, chemical-resistant containers, clearly labeled, and transported in accordance with local and international regulations. Appropriate documentation and safety data sheets should accompany the shipment to ensure safe handling and compliance.
    Storage **1-(Bromomethyl)naphthalene** should be stored in a tightly sealed container, protected from light, moisture, and incompatible substances such as strong oxidizers. It should be kept in a cool, dry, and well-ventilated area, away from ignition sources and direct sunlight. Store in a chemical storage cabinet specifically designed for hazardous or organic chemicals, following all relevant safety guidelines.
    Application of 1-(Bromomethyl)Naphthalene

    Applications of 1-(Bromomethyl)Naphthalene in Industrial Manufacturing

    As a manufacturer of 1-(Bromomethyl)Naphthalene, we supply this specialty intermediate to several key industrial sectors that rely on precise formulation and controlled processing steps. Below, we detail the main downstream application fields, highlighting procedural, compliance, and material integration specifics for each segment.

    1. Agrochemical Intermediate for Herbicide Synthesis

    Agrochemical producers use 1-(Bromomethyl)Naphthalene as a brominated substrate in multi-step synthesis of selective herbicides, particularly arylnaphthalene-based actives. Integration typically occurs at the stage of nucleophilic substitution to introduce functional groups on the naphthalene ring, followed by further derivatization. Quality monitoring ensures residual bromide levels remain within regulatory targets and that the intermediate profile aligns with the downstream route specifications. End-use products must demonstrate batch consistency and regulatory compatibility for environmental safety.

    Industry compliance standards

    • EU REACH Regulation (EC) No 1907/2006
    • US EPA TSCA Inventory listing & PMN review
    • China MEE Environmental Risk Assessment for New Chemical Substances
    • ISO 9001:2015 Certified Quality Management System

    Typical usage ratio

    • 0.15–0.40 molar equivalents as a coupling agent per synthetic batch, adjusted by target herbicide scaffold and downstream functionalization requirements

    Downstream process integration

    • Charged to reactor during nucleophilic aromatic substitution or alkylation step
    • Process includes temperature-controlled batch reaction (100–140°C)
    • Purification via crystallization or distillation before next coupling step
    • Residue tests and heavy metals analysis completed post-reaction

    Final product types

    • Selective pre- and post-emergence herbicides for cereal crops
    • Arylnaphthalene-based pesticide intermediates
    • Chemical building blocks for proprietary crop protection molecules
    • Registered actives for the European and US markets

    2. Pharmaceutical Precursor for Naphthalene Derivatives

    Pharmaceutical synthesis plants utilize 1-(Bromomethyl)Naphthalene as an alkylation agent during the early stages of producing naphthalene-based APIs and advanced intermediates. Its controlled release and purity profile support strict cGMP requirements, with processing typically requiring low moisture and minimized impurities to avoid undesired side reactions. The material is introduced during the functionalization of benzylamine cores, enabling the production of complex naphthalene-ring pharmaceuticals for further downstream elaboration, including scale-up for clinical-stage compounds.

    Industry compliance standards

    • ICH Q7A: Good Manufacturing Practice Guidance for Active Pharmaceutical Ingredients
    • USP, Ph. Eur. purity profile (where relevant to synthetic intermediate stage)
    • FDA 21 CFR Part 211 (for controlled intermediates integration)
    • GMP audit trails & full traceability documentation

    Typical usage ratio

    • 0.20–0.30 molar equivalents relative to nucleophilic partners; adjusted based on conversion efficiency and impurity threshold assessments

    Downstream process integration

    • Reacted in controlled-ventilation glass-lined reactors
    • Added during early-stage C-N or C-O coupling with strict temperature and pH monitoring
    • Analytical HPLC/QC confirmation before release to next synthesis stage
    • Residual solvent and bromide checks following quenching

    Final product types

    • Advanced pharmaceutical intermediates (naphthalene core derivatives)
    • Candidate small molecule APIs
    • Specialty drug substances for oncology or CNS applications
    • Chiral intermediates for further downstream resolution

    3. Organic Electronic Chemicals: OLED and Photoconductor Materials

    Producers of organic semiconductor materials incorporate 1-(Bromomethyl)Naphthalene in the manufacture of charge-transport compounds used for OLED emitting layers or electrophotographic drums. The compound’s reactivity profile enables site-specific introduction of naphthalene units with controlled bromination, critical for subsequent polymerization and ensuring product purity for high-performance electronics. Material handling must follow strict cleanroom and ESD guidelines, with detailed characterization of bromine content to avoid device degradation.

    Industry compliance standards

    • JEITA EM-3600 (LCD/OLED Material Purity Standards)
    • RoHS Directive 2011/65/EU (for finished product)
    • QC processes per IPC-5704 for organic electronic materials
    • ISO 14644-1 Cleanroom Integration

    Typical usage ratio

    • 0.10–0.35 weight fractions depending on molecular doping plan and target charge mobility

    Downstream process integration

    • Dosed into batch organic synthesis reactor under inert atmosphere
    • Bromine contained closely monitored to assure final polymer chain purity
    • Purified via preparative chromatography prior to monomer polymerization step
    • Final QA with multi-stage impurity screens and spectroscopy

    Final product types

    • OLED emitting and transport materials
    • Photoconductors for laser printer drums
    • Organic field-effect transistor (OFET) active layers
    • Electronic grade intermediate monomers and dimers

    4. Specialty Dyes and Pigment Manufacturing

    Colorant producers employ 1-(Bromomethyl)Naphthalene as a halomethylation reagent in the synthesis of complex naphthalene dyes and pigments. By selectively functionalizing the aromatic backbone, this intermediate enables the formation of high-stability chromophores needed for automotive coatings, plastics, and industrial inks. The process emphasizes precise stoichiometric control and environmental monitoring, ensuring compliance with global chemical regulations on aromatic amines and halogenated groups. Downstream purification produces colorants with controlled shade intensity and resistance properties.

    Industry compliance standards

    • OEKO-TEX® Standard 100 for hazardous substance limits (applicable to dye final goods)
    • EU Regulation (EC) No 1272/2008 (Classification, Labelling and Packaging of Substances)
    • ISO 787-24 and ISO 105-A02 for pigment and dye testing
    • IFRA Standards for ink and pigment chemicals in specific markets

    Typical usage ratio

    • 0.12–0.28 mole equivalents, determined by chromophore intensity specifications and end-use substrate compatibility

    Downstream process integration

    • Reacted with aromatic amines in closed reactor systems
    • Integrated during halogen functionalization prior to color intensification steps
    • Yield optimized by monitoring pH, reaction time, and molar ratios
    • Product isolation by solvent extraction and drying cycles

    Final product types

    • High-performance naphthalene-based pigments for plastics
    • Synthetic dyes for automotive finishes
    • Industrial colorants for offset and inkjet printing
    • Specialty pigments for high-end textile applications
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    Certification & Compliance
    More Introduction

    1-(Bromomethyl)Naphthalene: Manufacturer’s Perspective on a Core Fine Chemical

    Bringing Precision to the Specialty Chemicals Market

    As a manufacturer with decades of experience refining organic intermediates, the importance of accuracy and purity shapes every decision made on the production floor. In our lineup, 1-(Bromomethyl)Naphthalene stands out for its steady demand and vital role in downstream chemical synthesis. The compound, with a chemical structure built around the naphthalene ring substituted with a bromomethyl group, forms the backbone for a range of applications in agrochemicals, pharmaceuticals, and advanced material science.

    What We Actually Make: Authenticity and Transparency in Production

    We manufacture 1-(Bromomethyl)Naphthalene in our own reactors, not sourced from third parties or brokers. This involves careful control over batch size, reagents, and temperature profiles, resulting in a product that consistently meets the standards expected by research chemists and industrial formulators alike. The final material is crystalline, with high purity and traceability from raw input to package shipment.

    Packing Specifications: Balancing Practicality and Safety

    In an era where transparency is more than an industry buzzword, we report key specifications upon request. Our typical batch exceeds 98% purity as measured by GC, with moisture levels held under 0.5%. Packing takes place in tightly sealed, light-safe bottles or drums, tailored to the scale required by our partners in R&D or pilot-scale manufacturing. Although some of our competitors offer wide-ranging packaging formats, we keep our offerings focused on volumes that maintain simple handling and limit unnecessary waste. Our production runs use stainless steel reactors for the halogenation step, ensuring that corrosion and contamination from metallic surfaces do not jeopardize batch consistency.

    Real Uses, Real Impact: How This Molecule Matters in Practice

    Over the years, we have watched research groups and industrial innovators transform 1-(Bromomethyl)Naphthalene beyond the textbook examples. Its role begins with the reliability of the naphthalene scaffold. When functionalized, it acts as a versatile building block in the preparation of complex aromatic compounds. In pharmaceutical labs, chemists value its bromomethyl group for nucleophilic substitution, commonly exploiting this functionality to introduce a range of nitrogen, oxygen, or sulfur-based substituents. This versatility supports both advanced synthetic methods and routine preparative recipes. Our own technical support team has fielded questions that underscore the practical nuances, whether a customer is pursuing C–C coupling in a combinatorial synthesis campaign or working through the challenges of scaling up Grignard reagent formation.

    We have witnessed increased interest from material scientists who look for molecular fragments that provide both rigidity and reactivity. In this context, 1-(Bromomethyl)Naphthalene takes on roles in the synthesis of specialty dyes, advanced coatings, and even molecular probes. Its presence in the toolkit of academic and industrial chemists reflects a need for both structural diversity and reliability in performance.

    Why 1-(Bromomethyl)Naphthalene Stands Apart from Generic Brominated Intermediates

    Much has been said about bromomethyl chemistry, though not all brominated compounds behave the same way. Many bromomethyl-substituted benzenes or other alkyl bromides offer similar reactivity on paper, but the naphthalene nucleus brings distinct electronic and steric effects. In side-by-side reactions, our customers report that the larger aromatic framework of the molecule improves selectivity in some alkylation reactions or slows decomposition during storage—nuances that surface only through experience in the lab rather than review articles.

    We also recognize that not every application values the same features. Some higher molecular weight bromomethyl derivatives suffer from poor solubility in organic solvents, while lighter ones may lack the aromaticity required for advanced materials science. This molecule gives a balance—aromatic character high enough for physical stability, yet not so bulky that it resists classic nucleophilic substitution pathways.

    Manufacturing and Quality: Facts Behind Everyday Decisions

    Producing specialty intermediates starts long before the reaction flask. Our sourcing priorities keep quality consistent: we draw on stable supply chains for naphthalene, brominating agents, and solvents that meet established quality benchmarks. Every batch begins with a risk assessment—years ago, we saw the effect that a single off-spec drum of raw material could have on downstream conversion rates.

    During the synthesis process, controlling temperature and dosing rates forms a major piece of our reliability pledge. Bromination reactions can produce side products and over-brominated naphthalenes at high temperatures or with excess reagent. From our data, tighter control over process variables (like maintaining the bromination reaction below 10°C) means higher yield and easier downstream purification. Our chemists have designed protocols with phase separation, multi-stage extraction, and column chromatography, resulting in high-purity final product confirmed by both NMR and HPLC analysis.

    Practical Challenges and Solutions: What Really Happens Beyond Lab Scale

    Scaling up brings questions that never appear in small-scale synthesis. We address solvent recovery, containment of volatile bromides, and safe handling protocols for exothermic halogenation steps. Our reactors feature custom-designed venting systems and allow efficient in-process sampling, so that QC teams can intervene immediately if conversion looks out of spec.

    During packaging, staff monitor for off-odors, visually inspect every lot for discoloration, and take pride in eliminating packaging errors. We switched from standard seal designs to vacuum-tight stoppers after noticing trace air infiltration in early shipments, which preserved purity longer during international transport. These small details add real value to labs experiencing variability from imported or poorly handled chemicals.

    User Feedback Shapes Product Evolution

    Trust grows from direct communication. Over the years, several customers have reached out to discuss challenges they face—not only about our product, but also about handling, reaction workup, and waste management. Some reported minor issues with solubility in certain solvents during scale-up; hearing this, our technical team tested performance in a range of commonly used solvents, and now we include solvent compatibility recommendations upon request. Open feedback helped us switch to recyclable packing materials for many clients, aligning operational choices with both customer needs and wider sustainability goals.

    Comparisons with Other Bromomethyl Compounds: Where This Molecule Wins and Loses

    Experience makes it clear that bromomethyl derivatives display a spectrum of properties. Compared to benzyl bromide, 1-(Bromomethyl)Naphthalene resists hydrolysis somewhat better in moist air, giving it a slight advantage in humid or tropical shipping environments. The aromatic naphthalene system supports greater structural rigidity, which benefits certain cross-coupling reactions where the benzyl analog can lead to undesired side reactions.

    On the other hand, for users prioritizing price and who do not need naphthalene’s unique electronic properties, more common and generic products may suffice. Some of our clients initially tried to swap with lower-cost benzyl or simple alkyl bromides, only to find reduced yields or unstable intermediates. These case studies show that component selection shapes both synthetic route economics and reliability.

    Ensuring Regulatory Compliance and Worker Safety

    Strict controls run through every layer of our process, from sourcing bromine to final shipment. Our team monitors regulatory changes in both local and international frameworks. Brominated organic compounds attract attention due to disposal and toxicity risks. We have invested in closed-loop waste recovery and encourage users to follow waste minimization best practices.

    Training stands as the backbone of our safety system. New hires learn the hazards and safe practices of brominated intermediates early in their tenure. We use real life case studies from chemical accident reports to keep standards realistic and actionable, not theoretical. All workers wear personal monitoring badges while handling raw or finished bromomethyl products, not only to satisfy external audits but because continuous data collection has demonstrated drops in worker exposure over the years.

    Supporting Research and Scale-up: Beyond Selling a Drum

    Our direct collaboration with research users, contract manufacturing organizations, and university labs has shaped our development priorities. Early on, we worked with an academic group scaling up synthesis of a photoreactive dye that required extensive troubleshooting with 1-(Bromomethyl)Naphthalene as a key handle. Their feedback on side-product challenges drove improvements in both our purification process and the information we provided on product trace components.

    For process engineers at pilot sites, our technical staff consult on optimal reagent ratios, solvent handling tips, and purification strategy. We keep comprehensive batch records for every lot, enabling rapid troubleshooting or certificate provision if something unexpected arises in the customer’s operation.

    Navigating Market Pressures: Keeping Integrity and Quality

    Competition from low-cost, low-purity suppliers presents ongoing pressure. We have seen buyers try to cut costs by turning to alternative vendors, only to return after facing challenges with contamination, batch variability, or incomplete documentation. No third party guarantees supply chain security or regulatory traceability like an original manufacturer with complete process control. Institutions conducting regulatory submissions rely on batch uniformity and complete quality dossiers—requirements only achievable with responsible in-house production and full chain-of-custody documentation.

    Environmental Responsibility: Minimizing Impact Where It Matters

    As environmental expectations rise both from regulators and customers, the focus shifts to process improvements that limit pollutant discharge, reduce reactant excess, and capture waste bromine. Our plant operates with multiple containment and scrubbing stages. Atmospheric emissions remain below industry benchmarks for brominated hydrocarbons, and we share our practices at peer industry meetings.

    Improving filtration, switching to higher-purity reagents, and refining solvent recovery have cut total waste output per kilo produced. Recycled solvents now loop back into new runs wherever possible, and we actively seek partners who want to move toward greener synthesis and circular chemical use.

    Continuous Investment in People & Technology

    Our success builds on both legacy expertise and new talent. Chemists, plant engineers, and maintenance professionals collaborate daily to innovate at the production line. We invest in analytical instrumentation, such as high-resolution NMR and LC-MS, that provides rapid feedback and continuous improvement data. Operator insight remains crucial: automation has expanded, but the real-time decisions and careful monitoring of experienced staff prevent issues that automated checks sometimes miss.

    Reassessing Specifications: Dialog With Customers

    Regular audits and supplier reviews prompt us to keep all product specifics transparent. Customer requests often inspire improvements: after a major pharmaceutical company needed micro-impurity profiles for regulatory filing, we added new documentation and invested in a higher-sensitivity UPLC system. For academic users working on high-impact publications, we can provide spectral data or additional analytical results.

    We welcome technical questions openly—our team offers custom solution guidance for new synthesis challenges, testing alternative purification routes and offering insight based on direct analytical and process experience.

    Evidence, Not Hype: Building Reputation With Results

    Supply chain reliability depends on documented process control, not on speculative claims. Each shipment includes batch-specific documentation and, upon request, purity and impurity profiles that stand up to third-party laboratory validation. Several global R&D labs and major drug development companies have built decade-long relationships around our ability to deliver without repeated QC problems.

    Uncompromising documentation may not sound glamorous, but chemical development success hinges on reproducible starting materials. This focus brings real savings by preventing delays due to off-spec batches, wasted resources, or failed production runs.

    A Manufacturer’s Commitment Beyond the Final Product

    Manufacturing 1-(Bromomethyl)Naphthalene takes more than reactors and standard operating procedures. Every technical decision, raw material qualification, and customer feedback cycle informs our process. In all areas of operation, from plant floor to end-user support, we focus on traceability, process refinement, and transparent dialogue. This holistic approach has real, measurable benefits: more reliable chemistry for researchers, cleaner production practices, and long-term trust between our team and those who depend on our material.