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1-Bromo-2-Chloro-1,1,2-Trifluoroethane

    • Product Name 1-Bromo-2-Chloro-1,1,2-Trifluoroethane
    • Alias HCFC-231
    • Einecs 214-004-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    838775

    Chemicalname 1-Bromo-2-Chloro-1,1,2-Trifluoroethane
    Casnumber 354-56-3
    Molecularformula C2BrClF3
    Molarmass 215.38 g/mol
    Appearance Colorless liquid
    Density 1.971 g/cm3
    Boilingpoint 80-81 °C
    Meltingpoint -85 °C
    Vaporpressure 220 mmHg at 25 °C
    Refractiveindex 1.395
    Solubilityinwater Low
    Flashpoint Non-flammable
    Synonyms Halon 1231, FE-2411

    As an accredited 1-Bromo-2-Chloro-1,1,2-Trifluoroethane factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 500 mL amber glass bottle with a tightly sealed cap, labeled "1-Bromo-2-Chloro-1,1,2-Trifluoroethane, hazardous, handle with care."
    Shipping 1-Bromo-2-chloro-1,1,2-trifluoroethane must be shipped as a hazardous material, following all relevant regulations (such as DOT, IATA, IMDG). The chemical requires secure, leak-proof packaging, proper labeling, and shipping documentation. It should be stored upright, away from heat or flames, and handled only by trained personnel using appropriate protective equipment.
    Storage 1-Bromo-2-Chloro-1,1,2-Trifluoroethane should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from heat sources and incompatible materials such as strong oxidizers. Protect from moisture and direct sunlight. Store under inert gas if possible, and clearly label the container. Appropriate safety measures, including secondary containment, should be applied to prevent leaks or spills.
    Application of 1-Bromo-2-Chloro-1,1,2-Trifluoroethane

    Applications of 1-Bromo-2-Chloro-1,1,2-Trifluoroethane in Industrial Manufacturing

    1-Bromo-2-Chloro-1,1,2-Trifluoroethane supports critical manufacturing processes across several industrial sectors as a high-purity halogenated organic intermediate. Each application relies on its controlled reactivity, purity, and physical properties to meet strict operational requirements.

    1. Pharmaceutical Active Ingredient Synthesis

    Major pharmaceutical producers utilize this compound as a halogenating agent and fluoroalkyl building block in the multi-step synthesis of advanced intermediates. Its defined molecular structure and high selectivity reduce unwanted byproducts during fluoroalkylation and halogen exchange reactions, which are essential for APIs in anti-viral and anti-cancer drugs. Precision dosing and close process control ensure that downstream purification steps meet trace impurity requirements.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceuticals Ingredients
    • 21 CFR Parts 210/211 (US FDA regulations for pharmaceuticals)
    • EU Regulation (EC) No 1907/2006 (REACH)
    • USP General Chapter <922> Residual Solvents and Impurities

    Typical usage ratio

    • 0.5–2.5 molar equivalents, adjusted by API synthesis stoichiometry and impurity profile control

    Downstream process integration

    • Introduced during the halogen exchange or fluoroalkylation stage within reaction vessels, under closed agitation and temperature control, followed by in-line quenching and purification

    Final product types

    • Pharmaceutical intermediates for oncology, anti-viral, and central nervous system (CNS) therapeutics
    • Registered Active Pharmaceutical Ingredients (APIs)

    2. Agrochemical Intermediate Manufacture

    Agrochemical manufacturers employ this compound as a key halogenated intermediate in the synthesis of trifluoromethylated herbicides and fungicides. Its reactivity supports selective incorporation into target structures, providing desirable biological activity and chemical stability. The process design requires control over addition rate and reaction temperature to achieve pure, crop-safe downstream molecules.

    Industry compliance standards

    • FAO/WHO Good Laboratory Practice (GLP) for Pesticide Active Ingredients
    • ISO 9001:2015 Quality Management for Agrochemicals
    • EPA 40 CFR Part 158 (US Environmental Protection Agency data requirements for pesticide registration)
    • CLP Regulation (EC) No 1272/2008

    Typical usage ratio

    • 3–7% by mass of total reaction charge, tuned for individual crop protection active synthesis steps

    Downstream process integration

    • Used in the main halogenation phase prior to formation of active pesticide backbone, followed by solvent extraction, neutralization, and crystallization

    Final product types

    • Trifluoromethyl-substituted herbicides
    • Selective fungicide technical concentrates

    3. Polymeric Fluorocarbon Specialty Resin Production

    Producers of high-performance fluorinated polymers use our material as a reactive co-monomer to introduce both bromine and trifluoromethyl functionality into specialty resins. Its precise incorporation enhances chemical resistance and modifies polymer thermal properties. Accurate dosing in the prepolymer feed is crucial to achieve target molecular weight and functional group density in the final resin.

    Industry compliance standards

    • ISO 14001 Environmental Management for Chemical Manufacturing
    • IEC 61249-2-21 for halogen-free electronic base materials
    • ASTM D543 for Chemical Resistance of Plastics
    • RoHS Directive 2011/65/EU (when used in electronic applications)

    Typical usage ratio

    • 1.5–8% by weight, determined by desired bromine and fluorine loading in copolymer matrix

    Downstream process integration

    • Fed as a liquid monomer to batch or continuous polymerization kettles, with temperature-controlled addition and concurrent co-monomer feed

    Final product types

    • Printed circuit board laminates
    • Chemically resistant valve coatings
    • Fluoropolymer specialty films

    4. Refrigerant Blend Component in R&D and Testing

    Refrigeration research groups utilize this compound in the development of new HFC/HFO-based refrigerant blends, particularly for low-ozone-depletion and reduced global warming potential (GWP) systems. Its thermodynamic properties contribute to fine-tuning the pressure-temperature relationship and flammability characteristics during testing phases. Utilization remains strictly within laboratory- or pilot-scale closed system environments due to regulatory constraints.

    Industry compliance standards

    • ASHRAE Standard 34 (Designation and Safety Classification of Refrigerants)
    • EPA SNAP Program (Significant New Alternatives Policy) for refrigerant evaluation
    • EN 378-1:2016 (Safety and Environmental Requirements for Refrigerating Systems)
    • ISO 817:2014 Refrigerant Safety Classification

    Typical usage ratio

    • 1–12% by mass in proprietary refrigerant blend formulations, strictly limited to laboratory-scale experimental blends

    Downstream process integration

    • Charged into test benches and experimental system loops as part of the total refrigerant charge, under controlled conditions and full emission capture

    Final product types

    • Prototype refrigerant formulations for compressor and environmental performance evaluation
    • R&D-scale refrigerant blends for safety, flammability, and thermodynamic testing

    5. Precision Electronic Cleaning Formulation

    Manufacturers of advanced precision cleaning fluids employ this halogenated hydrocarbon as a controlled-evaporation carrier and solvency enhancer for degreasing applications in microelectronics and aerospace assembly. Its use supports selective removal of non-polar residues from sensitive circuits. Compliance with sector-specific purity and emission controls is mandatory for safe facility operation.

    Industry compliance standards

    • IPC-CH-65B Guidelines for Cleaning of Printed Boards
    • SAE AMS 1526C for Aircraft Cleaning Compounds
    • REACH Annex XVII for restricted chemicals in cleaning agents
    • OSHA 29 CFR 1910.1000 Air Contaminants in Workplace

    Typical usage ratio

    • 8–22% by mass in formulated specialty blends, composition varies by cleaning target and substrate compatibility

    Downstream process integration

    • Dosed into cleaning bath or vapor degreaser system along with co-solvents, recirculated through filtration and monitored for purity loss or residue build-up

    Final product types

    • Microcircuit board cleaning fluids
    • Precision aerospace instrument degreasers
    Free Quote

    Competitive 1-Bromo-2-Chloro-1,1,2-Trifluoroethane prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    1-Bromo-2-Chloro-1,1,2-Trifluoroethane: An Operator’s Perspective on a Versatile Fluorinated Solvent

    Decades of Experience with 1-Bromo-2-Chloro-1,1,2-Trifluoroethane

    From the floor of our own production facility, we have handled 1-Bromo-2-Chloro-1,1,2-Trifluoroethane under close scrutiny, watching how its properties translate from a line in a chemical catalogue to integral operations in various industrial applications. We know it by its chemical formula, C2HBrClF3, but we also recognize it instinctively by the way it weaves itself into the workflows of electronics, specialty cleaning, and niche synthesis. Our teams measure, distill, and assess every lot, controlling for clear color, consistent boiling point, and the ultra-low non-volatile residue demanded by customers facing increasingly strict performance targets.

    Key Features and Handling Realities

    This compound enters our process lines as a clear, colorless liquid, with a boiling point that sits comfortably in the range needed for vapor-phase applications. Every tank and drum shipped from our site undergoes GC purity analysis and moisture checks; we see regular calls for levels above 99 percent, which our batch processes deliver with consistency. Our QC experts check for trace contamination by related halocarbons, pursuing ppm-level precision, because contamination even in small amounts can undermine storage stability and performance—something our operators never take lightly.

    Handling 1-Bromo-2-Chloro-1,1,2-Trifluoroethane in our plant requires strict protocols for containment and proper ventilation. Even at low concentrations, workers respect personal protection, as this material brings moderate volatility and, if mishandled, can cause irritation. Our long familiarity with fluorinated solvents has taught us the importance of robust infrastructure and routine leak checks. With the right storage, stability problems stay minimal. Over the years, we have seen that stainless steel or lined vessels best preserve product integrity, avoiding reactions with trace water or metal ions.

    Benchmarking Against Similar Halocarbons

    Operators who come to us for consultation often want to compare 1-Bromo-2-Chloro-1,1,2-Trifluoroethane to more ubiquitous products like trichloroethane, trichlorofluoromethane, or newer hydrofluoroolefins. We've tracked the adoption of each, watching market forces and regulatory changes upend the popularity of some molecules and propel others into focus.

    Where this compound sets itself apart is its intricate balance of polar and non-polar character. The placement of bromine and chlorine atoms flanking its trifluoroethane core gives it a unique solvent profile. In practice, that means it can dissolve residues that resist breakdown by straight-chain fluorocarbons or simpler chlorinated solvents. Yet, it doesn't cross-react with so many plastics or delicate elastomers, making it a go-to for precision cleaning. Our own experience confirms reports from labs and assembly lines—this molecule frees up stubborn fluxes and oils in microelectronics and photonic components far more readily than low-molecular weight HFEs or HFCs.

    Comparing volatility, we see it occupies a sweet spot—not so persistent as perfluorocarbons, not so fleeting as lighter hydrocarbons. That translates into a precise working window for vapor degreasing, something customers from aerospace and automotive sectors appreciate. Feedback often centers on short cycle times and high yield of clean, dry parts. In our own testing, we have pitted it against popular HFE-7100 and HFE-7200. Its higher density gives it an advantage in crevice cleaning and lift-off of particulate contaminants, without trailing significant residues.

    End-Use Stories from Manufacturing and Cleaning

    We have partnered with electronics firms soldering increasingly fine-pitch PCBs—machines now deliver 01005 packages, and traditional cleaning agents have trouble reaching and clearing residues under low standoffs. Here, the wettability of 1-Bromo-2-Chloro-1,1,2-Trifluoroethane proves essential. Lab staff reported a dramatic drop in rework rates ever since they upgraded their solvent bath composition, guided by small-scale trials in our test tanks. They found less ionic contamination and more reliable insulation resistance in finished assemblies. Taking these bench-scale results, large OEMs scaled up to in-line vapor phase systems, and saw the same outcome—reduction in post-solder cleaning failures and greater throughput.

    We have also supported photonics manufacturers using high-performance lasers and sensors, where even microscopic particulate can cut equipment life short. Each shipment we send serves their need for a cleaning agent that flashes off without watermarks, streaks, or residues. This fluorinated bromo-chloro compound answers that call, something our team validates with in-house surface tension and residue measurement. Half a micron of residue can disrupt sensitive optics, but samples consistently show blank, ready-to-coat surfaces after immersion in this solvent.

    Surface preparation engineers in the medical device field also look to us for a material that won’t attack specialty polymers or deform thin metal components. This solvent stands out for that type of compatibility. Our application trials, run alongside clients, have documented negligible swelling or embrittlement in polymethyl methacrylate, polyether ether ketone, and key elastomers. Devices pass biocompatibility and functional testing with repeatable outcomes—no surprising film formation or odor transfer. Working with OEMs in vivo testing labs has proven the point: even in implants, cleaning agents leave no unexpected residues.

    Production Insights and Quality Control

    We have refined our own manufacturing routes for this product over the years, always optimizing for purity, low moisture, and safety. The base raw materials—trifluoroethanol, bromine, and chlorinating agents—demand careful handling and reaction controls. Each batch involves an exothermic halogenation step; our automated reactor system maintains precise temperature and pressure, monitored in real time by senior team members who have lived through more than one runaway reaction in the early years.

    Distillation columns separate product from by-products and unreacted feedstock, and we direct extra attention to packing cleanliness. Trace organics, esters, or acid chlorides must remain out of the final product. In our experience, even a small amount of these can catalyze decomposition or interact with elastomer seals used in customer process lines. Every batch receives FTIR, NMR, and GC-MS confirmation of structural integrity. We keep records for every lot, giving our partners in regulated industries a complete chain of custody and analytical data. This commitment to transparency and real-time QC reflects the demands of both customers and regulators.

    Practical Approaches for Safe Storage and Handling on Site

    Visitors sometimes ask us why our loading bays have such elaborate ventilation and spill containment. It stems from lived experience; a minor spill years ago reminded us that halogenated solvent vapor, even below exposure limits, can elicit strong sensory warning. We redesigned our containment and air turnover accordingly. Staff now cycle through annual training on emergency controls and PPE, not out of regulatory habit, but from an awareness of how quickly routine transfers can go off-script if vigilance lapses.

    Inventory control goes beyond good recordkeeping. We date every drum and bulk container, rotating stock on a tight schedule. We have observed that shelf life stability correlates closely with temperature and headspace oxygen. Our advice for end users: store at or below ambient room temperatures, and seal containers immediately after use to avoid slow hydrolysis or color shift. On-site blending, a practice some customers use for custom cleaning blends or co-solvent mixtures, benefits from a dry nitrogen purge and closed mixing vessels—another detail that came from hard-earned field knowledge.

    Environmental Considerations and Regulatory Pressures

    Working inside a chemical plant, you see how regulatory policy shifts can reshape entire product lifecycles. 1-Bromo-2-Chloro-1,1,2-Trifluoroethane once benefitted from a reputation as a lower-ozone-impact alternative to classic CFCs and many HCFCs, but it now faces scrutiny under evolving global conventions targeting persistent halogenated compounds. We track these developments closely, updating hazard communication and collaborating with industry bodies to ensure our practices and offerings align with the phase-out schedules and freshly proposed limits.

    We have installed abatement equipment to control fugitive emissions; activated carbon beds and custom scrubbers absorb and neutralize process vapor before it leaves the stack. Our operators perform regular stack testing, and we invite third-party auditors on site for annual reviews. We transitioned to closed-loop loading and offloading, both to meet new requirements and because shop-floor input made it clear that open handling posed unnecessary risk. Our investment in flameless incineration and solvent capture systems has reduced our plant’s halocarbon footprint, but the work continues. Breaking down old norms and investing in modern controls means not just meeting compliance needs, but demonstrating leadership to customers who increasingly weigh supply chain sustainability alongside solvent performance.

    In recent years, we have started exploring catalytic decomposition methods and recycling programs for off-spec and spent product. Customers now ask about take-back programs; we work directly with them on return logistics and purification streams, aiming to keep the compound from joining broader halocarbon waste. The data we see from these efforts—trace contaminant removal, solvent recovery yields—shows promise but requires fresh capital and patient troubleshooting. This aligns with market trends, as major clients embed circular economy principles and demand proof that upstream partners design with end-of-life in mind.

    Comparing 1-Bromo-2-Chloro-1,1,2-Trifluoroethane to Alternatives

    We openly discuss the direction of the cleaning market with buyers. Some customers explore HFE, HFC, or even non-halogenated options, aiming to align with future regulatory guidance. Our observations tell us that while alternatives excel in certain metrics—lower GWP, easier handling—they rarely match the solvency power or balanced compatibility profile that this compound brings. Its intermediate evaporation rate avoids the extremes; users get reliable cycle times without chase planes or extra drying stations.

    Cutting trials head-to-head with emerging solvents, some clients find that drop-in replacement proves elusive. Those who substitute with pure HFEs or lightweight hydrocarbons report mixed results—often, residue remains, especially in intricate geometries or under surface-mount devices. We have worked on blends, pairing 1-Bromo-2-Chloro-1,1,2-Trifluoroethane with other solvents to harmonize performance and regulatory standing. From our production perspective, blending involves not just pouring liquids together but validating storage, transport compatibility, phase behavior, and safety for both operators and downstream users.

    In photonics and micro-mechanic sectors, end-users stick with this molecule for its ability to clean optical assemblies and high-tolerance parts cleanly and in fewer passes. Some move to new offerings only to return—frustrations with secondary residues, increased cleaning cycles, or material incompatibility drive many back. We do not oversell—these are stories repeated to our sales and technical teams year after year.

    Supporting Customers in Evolving Environments

    Our technical support teams spend as much time on customer sites as in our own labs. We troubleshoot cleaning outcomes, blockage issues in vapor degreasers, and performance hiccups in batch processes. Customers face changing regulations and new demands for lifecycle data; our own records and batch-to-batch consistency play a direct role in their peace of mind. We supply analytical data going back over a decade, tracing every production variable from base feedstock to finished material, because real-world operations regularly uncover nuances missed by standard supplier documentation.

    Our approach places as much emphasis on safe, steady supply and practical technical advice as on chemical benchmarks. Whether a client wants to optimize for throughput or minimize rework, we walk through options: process adjustments, custom blends, even on-site small-scale distillation plans. Cross-training between operations, QC, and customer-facing staff means that anyone picking up a call can discuss batch traceability, performance history, and field feedback.

    Field technicians provided feedback leading us to update product labels, refine package sizing, and update closure design for better resealability. This human-level approach did more to reduce onsite exposure and drum loss than any policy update. Listening to operators matters as much as reacting to audits or regulatory filings.

    Future Paths for Fluorinated Solvents

    Fluorinated hydrohalocarbons like 1-Bromo-2-Chloro-1,1,2-Trifluoroethane remain essential in several manufacturing chains. The properties enabling it to solve persistent challenges—balanced solvency, vapor phase potential, inertness to many substrates—do not vanish with regulatory change. Innovation will shape its future. We are already developing more targeted blends and next-generation recovery systems, integrating lessons from years on the plant floor and customer site.

    More manufacturers push for closed-loop, zero-loss processes and tougher QC windows on incoming and outgoing shipments. The work means adapting both product and process, and creating new ways to address cleaning, materials prep, and solvent disposal without raising production costs or environmental risks. Our priorities are clear: balance performance with responsibility and build partnerships anchored in openness, technical support, and shared improvements.

    In sum, our experience as a direct manufacturer, from earliest product runs to today’s sophisticated operation, shapes every drum that leaves our plant. 1-Bromo-2-Chloro-1,1,2-Trifluoroethane continues to prove itself where technical demand and quality expectations run high. As the landscape changes, our commitment does not—solving problems, listening to feedback, and moving forward with knowledge earned through years in the field and years at the bench.