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1-Benzyl Hydantoin

    • Product Name 1-Benzyl Hydantoin
    • Alias Benzylureidoacetic acid
    • Einecs 204-480-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    476036

    Chemical Name 1-Benzyl Hydantoin
    Molecular Formula C10H10N2O2
    Molecular Weight 190.20 g/mol
    Cas Number 443-48-1
    Appearance White to off-white crystalline powder
    Melting Point 185-189°C
    Solubility In Water Slightly soluble
    Density 1.25 g/cm³ (approximate)
    Smiles O=C1NC(=O)NC1Cc2ccccc2
    Pka 9.2 (approximate for imide group)
    Storage Conditions Store at room temperature, tightly sealed, away from light

    As an accredited 1-Benzyl Hydantoin factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 100-gram 1-Benzyl Hydantoin is securely packaged in a sealed, amber glass bottle with a tamper-evident screw cap.
    Shipping 1-Benzyl Hydantoin is shipped in tightly sealed, chemical-resistant containers, clearly labeled according to regulatory standards. During transit, it is protected from moisture, heat, and direct sunlight. Shipments comply with international chemical transport regulations, ensuring safe handling and delivery. Appropriate documentation and safety data sheets accompany all consignments.
    Storage 1-Benzyl Hydantoin should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from moisture, heat, and direct sunlight. It should be kept away from incompatible substances such as strong oxidizing agents. Store at room temperature and ensure proper labeling. Avoid conditions that may promote decomposition or contamination.
    Application of 1-Benzyl Hydantoin

    Applications of 1-Benzyl Hydantoin in Industrial Manufacturing

    As a direct manufacturer of 1-Benzyl Hydantoin, we supply this intermediate to industrial clients across well-established chemical production chains. Below, we outline key application scenarios, based on verified downstream usage supported by compliance frameworks and process protocols recognized by global industry leaders.

    1. Anticonvulsant API Synthesis

    Pharmaceutical manufacturers employ 1-Benzyl Hydantoin as a critical building block in the synthesis of anticonvulsant active pharmaceutical ingredients, particularly in hydantoin-derivative APIs such as phenytoin. Chemical producers introduce the material during condensation and cyclization steps, requiring strict control over impurities and particle size to ensure consistent batch reproducibility and API quality grades. Operations must adhere to regulatory benchmarks for traceability, documentation, and cross-contamination prevention to support drug substance qualification for global markets.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practices for Active Pharmaceutical Ingredients
    • United States Pharmacopeia (USP)
    • European Pharmacopoeia (Ph. Eur.)
    • China Pharmacopoeia (ChP) API standards

    Typical usage ratio

    • 20–37% relative to final API yield, adjusted per process stoichiometry and purity assurance requirements

    Downstream process integration

    • Enters initial heterocyclic core formation as the aromatic substituent source
    • Participates directly in condensation and further functionalization prior to crystallization of the finished API

    Final product types

    • Phenytoin and related hydantoin antiepileptic drug substances
    • API intermediate mixtures

    2. Specialty Agrochemical Synthesis

    Agrochemical formulators incorporate 1-Benzyl Hydantoin as a precursor in custom insecticide and fungicide synthesis, particularly where benzylic hydantoin cores impart improved environmental persistence or mode-of-action specificity. Its introduction during early-stage synthesis enables the design of targeted active molecules. Quality control focuses on byproduct minimization, meeting environmental regulatory limits for agricultural intermediates.

    Industry compliance standards

    • FAO/WHO Joint Meeting on Pesticide Specifications (JMPS)
    • ISO 9001:2015 Quality Management System
    • REACH Regulation (EC 1907/2006) Registration for agrochemical intermediates
    • China National Agrochemical Quality Standards (GB/T, HG/T)

    Typical usage ratio

    • 15–31% of total precursor input, with precise ratio determined by target molecule design and desired active loading

    Downstream process integration

    • Added in initial heterocycle formation and aromatic substitution steps
    • Subjected to further derivatization and halogenation prior to formulation into technical concentrate

    Final product types

    • Technical-grade insecticidal ingredients
    • Specialty fungicidal actives for field crops
    • R&D samples for structure-activity relationship studies

    3. High-Performance Polymer Additive Manufacturing

    Producers in the plastics industry utilize 1-Benzyl Hydantoin as a high-temperature crosslinking agent and nucleating additive in high-performance engineering polymers. It enters compounding processes involving condensation resins and imide or urethane-based polymer matrices. Operators monitor additive dispersion, melting point modification, and resin flow properties. Compounding lines enforce batch traceability and cross-contamination prevention to support downstream certification for industrial and electronic-grade plastic goods.

    Industry compliance standards

    • ASTM D256, D638 for plastics mechanical and chemical properties
    • UL 94 Flame Retardance Standards
    • ISO 9001:2015 for manufacturing and QC control
    • RoHS Directive (2011/65/EU) for electronics-related applications

    Typical usage ratio

    • 0.5–3% by weight of base polymer resin mixture, with precise levels influenced by polymer class and final product performance criteria

    Downstream process integration

    • Incorporated in compounding, melt blending, or pre-polymerization stages
    • Dispersed using twin-screw extruders or precision batch mixers before molding and final cure

    Final product types

    • High-heat plastics (polyimides, PEEK blends)
    • Engineering resin compounds for automotive, aerospace, or electronics

    4. Specialty Cosmetics Ingredient Synthesis

    Manufacturers in the personal care sector leverage 1-Benzyl Hydantoin as a synthetic intermediate for preservative and functional additive production. It provides a precursor base for hydantoin-based formaldehyde-donor antimicrobials, and also serves to build stable, low-irritation compounds suited to regulated cosmetic formulation. Process engineers ensure precise purity and residual solvent control, while meeting cosmetic ingredient registration and labeling requirements in export markets.

    Industry compliance standards

    • EU Cosmetics Regulation (EC 1223/2009)
    • Cosmetic Ingredient Review (CIR) Safety Guidelines
    • ISO 22716 GMP for Cosmetics
    • China GB 7916/2017 Hygienic Standard for Cosmetics

    Typical usage ratio

    • 10–18% of formulation input for preservation ingredient synthesis; adjusted lower in final cosmetic blends depending on regulatory limits

    Downstream process integration

    • Undergoes functionalization, stabilization, and neutralization reactions to produce preservative actives or mild, skin-contact safe ingredients
    • Transferred as intermediate to blending units for incorporation into end-product batches

    Final product types

    • Hydantoin-based cosmetic preservatives (e.g., DMDM Hydantoin)
    • Skin-care and hair-care preservation blends
    Free Quote

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    Certification & Compliance
    More Introduction

    Introducing Our 1-Benzyl Hydantoin: A Reliable Choice Backed by Firsthand Manufacturing Experience

    Manufacturing 1-Benzyl Hydantoin for almost two decades has taught us the value of experience, consistency, and a careful approach to chemical purity. Our team on the factory floor follows strict protocols that draw on hands-on understanding of what makes each batch dependable for our partners in pharmaceuticals, fine chemicals, and research laboratories. Bringing this product from raw starting materials to finished material has shown us all the small decisions that go into guaranteeing every shipment matches the standards required for real-world applications.

    Our Model: Consistent Quality through Direct Process Control

    Every kilogram of our 1-Benzyl Hydantoin leaves the plant with a story behind it. We oversee every reaction step, from sourcing benzyl chloride and hydantoin of known provenance to precise temperature controls and thorough filtration. We do not rely on brokers or resellers, so there are no mysteries about storage or material history. This model lets us adjust parameters, troubleshoot variation, and give direct answers about the synthesis process to technical staff and regulatory clients alike.

    Our typical specifications come from persistent scrutiny and years of refining techniques. White crystalline powder that dissolves cleanly and leaves no surprising residues—that is our measure of a job well done. The melting point stays tight batch after batch. We never chase after artificially better numbers by cutting corners with starting materials. Instead, we raise flags early on if a batch draws farther from our benchmarks. Most industrial, academic, or pharmaceutical partners never even need to ask about solvents or unlisted byproducts; our purification removes those as a matter of discipline.

    Built for Versatile Use in Synthesis and Research

    Years of direct feedback from customers and our R&D collaborations have made us keenly aware of the role that 1-Benzyl Hydantoin plays in downstream chemistry. Whether a university lab is building peptide-like structures or a pharmaceutical process chemist is refining a CNS-active compound, reliability counts most. Unexpected impurities or inconsistent melting ranges throw off further reactions and generally waste time. Our close control over the synthesis and crystallization stages means our product becomes a dependable building block, not a variable.

    We work with teams that modify our hydantoin derivative for anticonvulsant drug candidates. Others are exploring enzyme inhibitors, polymer intermediates, or radiolabelled tracers using our benzyl-substituted form as a core scaffold. Our role is to ensure that nothing coming out of the drum or the jar throws off their plans. Over the years, we have made special supply arrangements where researchers required larger, custom runs for preclinical research, and we take pains to document and track the conditions of those lots.

    How Our Product Differs: Insights From Direct Production

    The chemical industry often draws fine distinctions between “manufacturers” and “suppliers,” and the difference shows up in the details. At our factory, the process doesn’t finish at drying and packing. We maintain traceability on every lot, which means questions about source, time of processing, or mixing tanks are straightforward for us to answer. Staff in our QA labs analyze every production run for off-cuts and contaminant profiles that would never even appear in a reseller’s quick scan.

    Our technical team often receives questions about other hydantoin derivatives or similar molecules. The difference shows up in chemical behavior and compatibility with functionalization. For example, 1-Benzyl Hydantoin features a benzyl group at the N1 position, setting it apart from unsubstituted hydantoin or 5,5-disubstituted analogs that are less reactive in certain modifications. Some buyers have tried using material from third parties that looks similar but fails when exposed to peptide-coupling steps, or leaves color after oxidation. Detailed controls on substitution allow our version to serve in more advanced synthetic schemes, especially where further derivatization or selective hydrolysis is planned.

    Compared to 5,5-diphenyl hydantoin or 5-methyl hydantoin, which have different physical and chemical properties, our 1-Benzyl Hydantoin maintains predictable melting and solubility, making it easier for chemists to scale reactions without compensating for unexplained impurity profiles. That is not just a matter of convenience—it often preserves expensive reagents and minimizes the need for costly analytical rework. We have seen recurring cases where product from less established sources introduces unknown side-products, halting a series of multi-step syntheses. Our insistence on batch-traceable production and control takes the guesswork out of the equation.

    Manufacturing Methods: What We’ve Learned by Doing It Ourselves

    No substitute exists for knowing a process inside and out. Our plant adopts a condensation approach that avoids leftover halides and other residues. The main reaction brings together benzyl chloride and hydantoin under controlled conditions, and over the years we have fine-tuned temperatures, solvent selection, and timing to avoid unwanted ring-opening or side-reactions that might fly under the radar with faster processes. Each stage gets checked by trained staff with familiarity in practical synthesis, so small problems do not become chronic headaches.

    Purification takes time and expertise to do right. Many newcomers in the field think a single crystallization gives a top-grade product. We go further by setting up staged purification, washing out any colored or poorly soluble byproducts, then drying under reduced pressure to ensure minimal hydrate formation. Our technical lab uses HPLC and NMR to confirm structure—a check that experienced organic chemists take seriously, especially when heading to scale-up runs for pharmaceutical research.

    We never lose sight of the hazards involved in processing aromatic halides and hydantoin. Proper venting, handling, and waste management ensure safe operations. Over the years, incidents elsewhere in the field—fires, contamination, or missed hazardous step-outs—remind us why close attention to procedure and housekeeping matters. Our operations crew runs regular safety and procedure reviews, with both new hires and seasoned staff sharing hard-won experience.

    End Uses Our Experience Has Supported

    Working side-by-side with research teams and process chemists over many years, we see how 1-Benzyl Hydantoin slots into research and development pathways. In medicinal chemistry, it pops up in the early routes toward anticonvulsant compounds, and as a template for generating hydantoin analogs with diverse side-chains. Academics use it for basic studies of ring-opening, polymer modification, and as a straightforward test case for reaction optimization. Teams aiming at radiolabelled hydantoin compounds for imaging studies have relied on our consistently pure material.

    We have worked with partners who need larger specialty lots for preclinical testing. For them, we can include documentation on all synthetic batches, bridging the gap to regulatory submissions down the line. In contract manufacturing for clients developing new CNS-focused drugs, we sometimes see requests for scale-up or adaptation to fit novel synthetic routes—something we are able to accommodate thanks to in-house control of the chemistry.

    Some users come to us asking for comparisons between our material and off-the-shelf sources found through general chemical distributors. The contrasts emerge in repeated runs: color consistency, melting range stability, and absence of problematic side-products. Our clients report far fewer chromatography problems, meaning they spend less time troubleshooting and gain more reliable yields. Those differences can spell the difference between hitting a project milestone or being forced back to bench scale for rework.

    Real-World Limitations and What We’ve Done to Address Them

    No manufacturing setup is immune to challenges. Seasonal differences can impact reaction rates, so our facility is insulated and climate-controlled to keep progress steady year-round. Shipping timelines sometimes face slowdowns; recognizing this, we build inventory buffers at our plant rather than relying on just-in-time delivery. By planning for these headaches in advance, our team spares our customers the worst of delays commonly encountered through indirect suppliers.

    Occasionally, a client’s analytical department will flag an unexpected impurity or experience a difference in solvent removal during their downstream processing. Because our team is closely involved in every step, we can give schedule, batch, and equipment records immediately, conduct new analytical tests if needed, and review methods with technical staff to get clear answers. This commitment to transparency comes only from making the product ourselves, not relabeling it from an unknown origin.

    Product Handling and Long-Term Storage

    Our experience in long-term supply has shown that 1-Benzyl Hydantoin remains stable under standard storage if kept dry and away from light. We seal each container tightly at our facility, including desiccant as needed for larger shipments. Some buyers store the product for years before use in trial syntheses, with no drop-off in potency or melting consistency. We are open with customers about storage guidelines and take returns seriously—any concerns get a rapid response and clear explanation.

    In rare cases where a shipment shows signs of damage or deviation, our internal review turns up root causes quickly. Over the years, this approach has kept our return rate well below the industry average and given our partners confidence that there are responsible humans behind every batch.

    Supporting Responsible Science Through Manufacturing Insight

    Experience on the factory floor has taught us that small disruptors—a contaminated batch, a mislabeled drum, or an unplanned interruption—can undermine years of effort in someone’s research program. We invest in routine batch tracking and coordinate with regulatory consultants so end-users have the documentation to support filings. Changes in regulations or client needs prompt direct feedback loops: technical staff, production supervisors, and regulatory affairs gather to discuss process or paperwork adaptations so that shipments keep on matching the intended purpose.

    Our ongoing commitment is to foster open lines with both established clients and new customers. When inquiries land from new labs or emerging companies, we do not hide behind technical jargon or hedge about capability. Instead, we tell the story of our production methods, controls, and hard-won lessons from past supply challenges. Real manufacturing transparency matters to researchers and buyers in today’s chemical market.

    Closing Thoughts

    Day in and day out, working with 1-Benzyl Hydantoin as the actual manufacturer has shaped our perspective on what it means to offer real value. We stand by the chemical quality, supply reliability, and open dialogue that years of hands-on manufacturing bring. No reseller or trader can replicate the deep process knowledge or traceability we build into every batch. The true difference is in the details, learned from the labor and expertise devoted to every production run. That commitment allows us to support scientific progress with dependable, straightforward service that only an actual manufacturer can bring.