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1-Benzyl-3-Methyl-2-Thiourea

    • Product Name 1-Benzyl-3-Methyl-2-Thiourea
    • Alias NSC 18852
    • Einecs 248-542-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    768395

    Chemicalname 1-Benzyl-3-Methyl-2-Thiourea
    Casnumber 1117-87-1
    Molecularformula C9H12N2S
    Molecularweight 180.27
    Appearance White to off-white crystalline powder
    Meltingpoint 120-123°C
    Solubility Soluble in organic solvents, slightly soluble in water
    Density 1.16 g/cm³ (approximate)
    Smiles CN(C(=S)N)Cc1ccccc1
    Inchi InChI=1S/C9H12N2S/c1-11(8-9(10)12)7-6-4-2-3-5-7/h2-6H,8H2,1H3,(H2,10,12)

    As an accredited 1-Benzyl-3-Methyl-2-Thiourea factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The packaging is a 100g amber glass bottle with a white screw cap, labeled "1-Benzyl-3-Methyl-2-Thiourea" and safety information.
    Shipping 1-Benzyl-3-Methyl-2-Thiourea is shipped in tightly sealed containers, protected from moisture and direct sunlight. It should be handled using appropriate safety measures, with clear labeling to indicate its chemical nature. The package must comply with local and international transport regulations for laboratory chemicals, ensuring safe and secure delivery.
    Storage **1-Benzyl-3-Methyl-2-Thiourea** should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from sources of ignition, moisture, and incompatible substances such as strong oxidizing agents. Keep the chemical out of direct sunlight and store at room temperature. Properly label the container and ensure it is kept away from food and drink.
    Application of 1-Benzyl-3-Methyl-2-Thiourea

    Applications of 1-Benzyl-3-Methyl-2-Thiourea in Industrial Manufacturing

    As a manufacturer specializing in fine chemicals, we supply 1-Benzyl-3-Methyl-2-Thiourea of high purity for specialized applications. The following sections detail the main industrial pathways using this compound, including specific compliance requirements, formulation ratios, downstream engineering steps, and major end products in each sector.

    1. Pharmaceutical Intermediate for Thiohydantoin Synthesis

    Pharmaceutical companies use this thiourea derivative primarily in the synthesis of thiohydantoins, which serve as key intermediates for antiepileptic and anti-inflammatory drugs. The compound engages in cyclization reactions under controlled temperature and catalyst presence, facilitating selective construction of heterocyclic structures crucial for active pharmaceutical ingredients. The critical factor is maintaining batch-to-batch purity and minimizing byproducts to meet stringent pharmaceutical standards.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • USP General Chapters for process validation
    • Ph. Eur. 5.2.12 for impurity control
    • ISO 9001:2015 Quality Management Systems

    Typical usage ratio

    • 0.95 – 1.10 molar equivalents per target thiohydantoin intermediate in batch synthesis
    • Adjustment depends on desired yield and side product management

    Downstream process integration

    • Charged immediately after charging glycine derivatives in the main reactor
    • Thiohydantoin ring closure step in multi-stage batch processing

    Final product types

    • Hydantoin-based antiepileptic APIs (e.g., Phenytoin intermediates)
    • Anti-inflammatory API intermediates
    • Research pharmaceutical building blocks

    2. Vulcanization Accelerator in Rubber Additives

    This compound supports rubber formulators as a specialized accelerator in thiazole-based vulcanization systems. It acts as a secondary or tertiary accelerator, promoting efficient cross-linking in natural and synthetic rubbers while controlling scorch time and modulating cure rates. Consistent supply with low residual impurities is required to safeguard downstream mechanical properties and ensure capped nitrosamine release as defined by automotive and tire safety guidelines.

    Industry compliance standards

    • ISO 9001 and ISO/TS 16949 (Automotive Quality Systems)
    • EU Directive 2009/425/EC on tire safety
    • ASTM D3182 for rubber compounding and testing
    • REACH Annex XVII restrictions regarding hazardous impurities

    Typical usage ratio

    • 0.3–1.0 phr (parts per hundred rubber) in blend formulations
    • Proportion reduced in presence of primary accelerators or high-activity sulfur donors

    Downstream process integration

    • Added directly to the final mixing stage in internal mixers or open mills
    • Co-dispersion with other accelerators before curing

    Final product types

    • Automotive tires (passenger and truck)
    • Industrial conveyor belts and hoses
    • Technical molded rubber goods

    3. Corrosion Inhibitor Additive for Metalworking Fluids

    Industrial blenders incorporate the material as a sulfur-containing inhibitor to protect ferrous and nonferrous metals during machining and storage operations. Its performance relies on molecular adsorption onto metal surfaces, providing a barrier against aqueous and acidic attack. Users must ensure additive compatibility with other lubricant components to comply with environmental and safety regulations concerning worker exposure and disposal of spent fluids. Analytical QC in both bulk and in-use fluids is advisable.

    Industry compliance standards

    • OECD 301 for biodegradability testing
    • ISO 6743/7 for classification of metalworking fluids
    • REACH Annex XIV & Annex XVII for chemical restrictions
    • NIOSH 1977 for occupational exposure limits

    Typical usage ratio

    • 0.1–0.5% weight/weight in finished metalworking fluid blends
    • Adjusted upward for highly acidic or high-salinity environments

    Downstream process integration

    • Pre-blended with base oil and functional additives prior to emulsification
    • In-line addition possible during formulation recirculation

    Final product types

    • Semi-synthetic cutting fluids
    • Water-soluble metalworking fluids
    • Temporary corrosion prevention oils

    4. Analytical Reagent for Metal Ion Detection

    Analytical laboratories rely on this compound as a selective complexing agent in spectrophotometric determination of transition metals, such as copper and mercury. The distinct reactivity and high affinity for metal cations facilitate colorimetric or extraction-based analysis under controlled pH conditions. Laboratories observe rigorous handling and documentation practices, including precise solution preparation and regular instrument calibration, to ensure result traceability and meet accreditation body requirements.

    Industry compliance standards

    • ISO/IEC 17025 laboratory accreditation
    • ASTM E2879 for spectrophotometric analysis
    • GLP (Good Laboratory Practice) OECD Principles
    • NFPA 45 for chemical safety in laboratories

    Typical usage ratio

    • 10–100 μM in analytical test solutions depending on target metal concentration
    • Stoichiometric to slight excess relative to analyte ions

    Downstream process integration

    • Prepared in buffer or alcohol for direct addition to sample cuvettes
    • Post-sample acidification or extraction step for complex development

    Final product types

    • Pre-packed reagent vials for trace metal determination
    • Ready-to-use analytical kits for industrial water testing
    • Certified reference standards for research applications
    Free Quote

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    Certification & Compliance
    More Introduction

    Introducing 1-Benzyl-3-Methyl-2-Thiourea: Insight From the Source

    A Practical Overview From Those Who Make It

    Making specialty chemicals is a business rooted in details. Many compounds act as small cogs in much bigger machines, and we take pride in understanding the real function and end value behind the formulas rolled out of our kettles and reactors. One product that has picked up traction for technical users and researchers alike is 1-Benzyl-3-Methyl-2-Thiourea, a compound our facility has produced for years. The versatility of this thiourea derivative keeps it in demand, yet its niche application marks it as a compound for those who know exactly what they’re after.

    Product Snapshot: Characteristics and Model

    Our 1-Benzyl-3-Methyl-2-Thiourea leaves the reactors as a white to off-white crystalline powder, not sticky, dense, or prone to lumping. The physical properties set the handling and storage guidelines; it dissolves easily in most organic solvents but does not fare well in water, keeping cross-contamination with aqueous solutions to a minimum. Packing typically involves airtight drums or sealed polyethylene bags sheltered from sunlight, which prevents the product from yellowing or breaking down, a detail gained from batches that sat too long in warehouse corners or under poor conditions.

    Talking about model and batch quality, we rely on tested reaction routes that yield a consistent product with high purity. This isn’t a material pushed through at high volume for generic blending. Instead, it calls for precise raw material control—benzyl chloride, methyl thiourea, carefully monitored pH, and temperatures kept inside a fine window. The product does not stay pure if temperature runs too high or the process stops short. Years ago, resolving a series of off-spec batches taught us valuable lessons about humidity control and reagent sequence, making it clear that the hands-on operator’s role means far more than what any spec sheet might claim.

    Where 1-Benzyl-3-Methyl-2-Thiourea Hits Its Stride

    Most of our 1-Benzyl-3-Methyl-2-Thiourea ships directly to research laboratories, pharmaceutical intermediaries, and specialty material developers. Chemists find the benzyl and methyl groups on this thiourea backbone irresistible for reactions calling for nucleophilic sulfur donors. Classic textbook knowledge tells you that thiourea groups add a unique reactivity, and this compound’s structure increases selectivity in how it participates in synthesizing heterocyclic rings.

    While some thioureas work as basic ligands in metal extraction, 1-Benzyl-3-Methyl-2-Thiourea shows better results for tasks demanding sparing solubility or selective reactivity. Researchers in pharmaceutical R&D programs reach for this molecule during steps needing precise functional group swaps, control over byproduct formation, or specific pharmacophore additions. Users involved in electronics might use it in trace amounts, seeking sulfur-based functionalization or surface modification effects. Over years, requests from materials science teams pushed us to review and refine particle sizing, since inconsistent surfaces once caused aggregation during thin film development.

    Differences Compared to Other Thiourea Compounds

    Every manufacturer gets calls asking about differences between similar-sounding chemicals. We field many questions trying to untangle why 1-Benzyl-3-Methyl-2-Thiourea stands apart from classic thiourea or its dimethyl analogues. The simplest answer comes from direct process experience: the benzyl substitution dramatically alters both how the molecule joins in chemical transformations and how easily it handles in solid form.

    Typical thiourea serves as a basic sulfur source or soft nucleophile across industries. It dissolves easily, often too quickly, and its lack of bulk means it finds a home in gold leaching and textile auxiliary chemistry. We watched as customers new to 1-Benzyl-3-Methyl-2-Thiourea tried to swap it directly into their processes, only to encounter slower dissolution rates or different partitioning behavior in solvent extractions. This difference is not a flaw; instead, it reflects the role the benzyl moiety plays. The aromatic ring increases hydrophobicity and tunes selectivity toward certain substrates, which matters greatly for complex molecule building or surface interactions. In one example, a client intent on synthesizing rare thiazole rings found the regular methyl thiourea produced byproducts that the benzyl version avoided. That reduced work-up steps and improved final yields in a way that justifies the extra cost.

    We noted, through hands-on use in our application labs, that 1-Benzyl-3-Methyl-2-Thiourea stores more safely for long periods than unsubstituted variants. Lower hygroscopicity and more stable melting points cut down on caking and minimize reprocessing, which helps both in shipping and end-user handling. In a side-by-side comparison, standard methyl thiourea batches from outside suppliers lumped together during humid months, while our benzyl-methyl variant stayed free-flowing. The physical feel of a compound can signal a lot about how well it will behave during small-scale R&D synthesis or in multi-kilogram preps.

    Practical Notes on Production—What Sets the Manufacturer Apart

    Producing 1-Benzyl-3-Methyl-2-Thiourea calls for experience beyond just following a recipe. Selection of raw benzyl halides, in-house methyl thiourea, and steady agitation stop the process from devolving into a sticky mass or low-yield mixture. More than once, we saw that unknown inhibitors—even traces left in reused plant glassware—could slow or even kill the reaction, wasting whole kilo runs valued for months of customer trials. Lessons learned under our own roof led us to invest in closed-loop, jacketed vessels and real-time pH control, taking out much of the variability smaller outfits struggle to master. The success stories for a specialty molecule like this start in the reactor, not on paper.

    Quality assurance walks hand in hand with every batch. In our facility, senior chemists—some with two decades or more in sulfur chemistry—oversee QC by running not only finished product checks through NMR or HPLC, but also by reviewing color, texture, and even faint odor signatures that machines overlook. A misplaced valve turn or missed wash step stands out to any experienced nose. Our batch-to-batch consistency attracts customers who once shopped by price elsewhere but missed delivery targets due to unplanned purification steps.

    We put equal focus on staff training, workspace cleanliness, and traceability. Experience has taught us that unmonitored stockrooms or careless transfer steps seeded contamination that could skew analytical results at the client site weeks later. So our warehouse logs origin, transport, handling sequence, and even routine container audits, building reputational capital every time our chemical proves itself clean on delivery.

    Handling, Storage, and Real-Life Challenges

    The way 1-Benzyl-3-Methyl-2-Thiourea stores and moves speaks volumes. Users who received early lots in soft bags sometimes found fine dust escape, so now we opt for double-sealed packaging. We test containers by leaving them exposed under high-humidity warehouse conditions—if a lot stays clump-free for six months, it meets our shipping criteria. Transport managers know weather shifts on route can cause condensation, affecting a drum unsealed just once during transit. You learn to respect these hurdles bringing products from factory to bench, and systems adapt in response.

    Moisture is the most persistent enemy for such fine crystalline compounds. We run routine RH checks in storage and encourage every end-user to do the same. Our own in-house records show that even an extra 2% water in ambient air shortens shelf stability and leads to yellowing along drum edges, a change anyone can spot without lab gear. For long-haul customers, we reinforce packaging and offer handling tips learned through trial—keep containers off unsealed floors, reseal after every use, and rotate stock on a clear FIFO pattern, cutting unnecessary rework or waste.

    Supporting Client Applications: What We See Firsthand

    Most feedback on 1-Benzyl-3-Methyl-2-Thiourea’s real-world application comes straight from partnerships with R&D teams. Materials chemists value transparency, so we welcome technical visits and share actual production notes with trusted clients exploring new syntheses. Examples include work in organic semiconductors, where bench chemists mapped out subtle but crucial changes in electrical properties when incorporating our 1-Benzyl-3-Methyl-2-Thiourea versus other sulfur donors. Surprises like lower defect rates or more stable emission profiles turn up only through side-by-side use of genuinely comparable batches—not quick swaps for off-the-shelf thioureas.

    Students and industrial researchers occasionally report attempts to economize by purchasing similar sounding or lower-purity alternatives. Almost always, the cost of labor and process troubleshooting erases any savings when batch purity fluctuates. Correlating our purity tests with their finished product yields, we collectively learn which minor contaminants affect downstream reactions. This direct channel of feedback often drives tailored production improvements on our side—switching purification solvents, tweaking filtration cycle times, or even adjusting the fineness of powder for better solubility.

    Regulatory Expectations and Realistic Challenges

    Nobody records better compliance outcomes than a producer. Regulations impact our every decision, and the experience gained through surprise audits and shifting REACH or TSCA requirements steers our batch documentation and workplace standards. We invested early in staff certification and systemized hazard management so fewer interruptions occur. This proved wise particularly as incidents at the distributor stage or in customer facilities have, in the past, ended with full trace-back to manufacturers.

    We stick to authentic records for each batch of 1-Benzyl-3-Methyl-2-Thiourea, tying source materials and production runs to barcodes. In the event of a specification or supply dispute, our traceability limits disruption and keeps customers confident. In a real supply chain scare years ago involving a contaminated batch from another supplier, our own lot-by-lot logs helped downstream users identify the right material, slashing investigation times from days to mere hours. Accountability like this never comes from distributors—it begins at the source.

    Building Product Value Differently

    One fact is clear: the true value of 1-Benzyl-3-Methyl-2-Thiourea comes not from simply making it “to spec,” but from a cycle built on feedback and root-level process know-how. Rather than pursuing mere volume, we’ve found that success comes from refining production practices, staying ahead of regulatory shifts, and working hand-in-hand with end users who push the molecule’s boundaries with new ideas. Our own lines run trial batches before full-scale production, often adjusting parameters at chemists’ suggestion. In return, customers share pre- and post-reaction data that help us discover nuances which no off-the-shelf comparison can.

    Combining analytical rigor with practical trade knowledge, we monitor not just purity but the less quantifiable aspects—ease of handling, blending behavior, and even reaction end-product isolation. If off-notes or unexpected textures appear in a batch, we trace the answer back not just through raw data, but by walking the production floor and engaging the crew who know every valve and seal by hand.

    Commitment and Perspective

    Experience in the field—and the lab—shapes every viewpoint we share. From first trial runs to full-scale lots, our time in the specialty chemical business has shown that honest dialogue with users does more than even the best marketing. For 1-Benzyl-3-Methyl-2-Thiourea, every improvement springs from learning, whether through customer challenges, evolving regulations, or a deepening understanding of reaction science. Industry moves fast, but those crafting the compound up-close learn to anticipate change while keeping product value high and risk low.

    As a manufacturer with roots in hands-on chemistry rather than distribution, we stand behind every drum, bag, and shipment of 1-Benzyl-3-Methyl-2-Thiourea. Success in this field means blending regulatory vigilance, technical adaptation, and a readiness to solve real-world problems empty sales talk never touches. Clear records, careful processes, and truth in production define our approach to chemical manufacturing—especially with a specialty product that rewards those who know how to use it best.