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1-Benzofuran-5-Carbaldehyde

    • Product Name 1-Benzofuran-5-Carbaldehyde
    • Alias 5-Formylbenzofuran
    • Einecs 242-519-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    435677

    Productname 1-Benzofuran-5-Carbaldehyde
    Casnumber 40385-77-9
    Molecularformula C9H6O2
    Molecularweight 146.15
    Appearance Light yellow to yellow powder
    Meltingpoint 77-80°C
    Purity Typically ≥98%
    Solubility Soluble in organic solvents such as ethanol and DMSO
    Smiles O=Cc1ccc2occc2c1
    Inchikey NUOCFDVDNUHDLX-UHFFFAOYSA-N
    Storageconditions Store at room temperature, keep container tightly closed

    As an accredited 1-Benzofuran-5-Carbaldehyde factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 25 grams of 1-Benzofuran-5-Carbaldehyde, tightly sealed, labeled with hazard warnings and product information.
    Shipping 1-Benzofuran-5-Carbaldehyde is shipped in tightly sealed containers, protected from light and moisture. Transportation complies with all chemical safety regulations. It is labeled as a laboratory chemical, and shipping restrictions may apply based on local and international guidelines. Handle with care and store in a cool, ventilated area upon arrival.
    Storage 1-Benzofuran-5-carbaldehyde should be stored in a cool, dry, and well-ventilated area, away from direct sunlight and sources of ignition. Keep the container tightly closed and store it in a chemical-resistant, compatible container. Segregate from strong oxidizing agents and acids. Store at room temperature, and ensure proper labeling and access restrictions to prevent accidental exposure or contamination.
    Application of 1-Benzofuran-5-Carbaldehyde

    Applications of 1-Benzofuran-5-Carbaldehyde in Industrial Manufacturing

    1-Benzofuran-5-carbaldehyde serves as a targeted chemical building block in diverse industrial manufacturing segments. Our production expertise and stringent quality management enable reliable integration into specialized downstream applications where its unique molecular structure brings value to the formulation and synthesis steps required by end-users in regulated environments.

    1. Pharmaceutical Intermediate for Benzofuran Derivatives

    The pharmaceutical sector utilizes 1-benzofuran-5-carbaldehyde during the synthesis of benzofuran-based active pharmaceutical ingredients (APIs), such as antifungal, anti-inflammatory, and anticancer molecules. Its reactive aldehyde function permits selective modification in multi-step synthesis, supporting scalable batch and continuous flow operations. Our cGMP-compliant facilities support global pharmaceutical grade needs.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP/NF and EP monographs for related APIs and intermediates
    • Chinese Pharmacopoeia (ChP) relevant chapters
    • 21 CFR Part 211 (FDA Drug GMP regulation)

    Typical usage ratio

    • Batch processes use 0.8–1.4 mol equivalents in coupling reactions; ratios adjusted based on yield optimization and presence of side-product formation.

    Downstream process integration

    • Introduced during Grignard reactions, aldehyde condensations, or cyclization steps under inert atmosphere conditions; integrated via automated reactor feed systems where purity and controlled addition are monitored closely.

    Final product types

    • Benzofuran-based antifungal APIs (e.g., Amiodarone intermediates)
    • Explore further processing into anti-inflammatory lead compounds
    • Custom synthetic targets for oncology pipelines and generic drugs
    • Reference standards for analytical use

    2. Fine Chemical Building Block for Agrochemical Synthesis

    Agrochemical manufacturers incorporate 1-benzofuran-5-carbaldehyde in the development of specialty herbicides, fungicides, and plant growth regulators featuring benzofuran motifs. The molecule’s reactivity streamlines the synthesis of functionalized benzofurans, supporting efficient process yield and downstream product purity in pilot and full-scale production.

    Industry compliance standards

    • ISO 9001:2015 (Quality Management Systems for agrochemicals)
    • FAO/WHO specification guidelines for pesticide active substances
    • EU Regulation No 1107/2009 (Plant Protection Products)
    • China GB 2763 Maximum Residue Limit standards (for downstream use)

    Typical usage ratio

    • Introduced at 2–6% by molar content of final active ingredient; process designers adjust based on targeted functionalization and conversion rates.

    Downstream process integration

    • Dosed at the intermediate building block synthesis stage, entering via batchwise or semi-continuous systems directly coupled to downstream purification columns for target product isolation.

    Final product types

    • Benzofuran-based herbicide intermediates
    • Fungicide precursor molecules
    • Agrochemical R&D diagnostic standards
    • Plant growth regulator additives

    3. Fragrance and Aroma Chemical Ingredient

    The fragrance manufacturing industry exploits the aromatic and heterocyclic character of 1-benzofuran-5-carbaldehyde to develop sophisticated top notes and long-lasting fixatives for fine perfumes, flavor additives, and personal care fragrances. Its incorporation at controlled concentrations provides nuanced olfactory attributes and supports customized scent design.

    Industry compliance standards

    • IFRA (International Fragrance Association) Guidelines
    • REACH Regulation (EC) No 1907/2006 for registration and assessment
    • ISO 9235:2013 (Aromatic Natural Raw Materials)
    • Food Chemicals Codex for food-grade flavoring (where applicable)

    Typical usage ratio

    • Added at 0.01–0.1% weight of total fragrance compound; specific loadings depend on the target scent intensity, stability requirements, and regulatory thresholds for consumer safety.

    Downstream process integration

    • Incorporated during the compounding phase with other aromatic aldehydes and ketones; handled under ventilated blending environments to protect product integrity and operator safety.

    Final product types

    • Top note and heart note bases for luxury perfumes
    • Fragrance ingredients for soaps and detergents
    • Flavor additives for beverages and confectionery (where allowed)
    • Personal care product fragrances

    4. Dye and Pigment Synthesis Intermediate

    Dye manufacturers select 1-benzofuran-5-carbaldehyde as a reactive intermediate for the synthesis of chalcone-based dyes and advanced pigments. Its specific aldehyde functionality provides a reliable site for aldol condensation and related transformations, central to tailoring color tone, fastness, and molecular stability characteristics in specialty colorants.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (Textile Dye Safety)
    • EN 71-3 (EU Toy Safety requirements for dyes)
    • ISO 9001:2015 for dye and pigment production
    • REACH Regulation Annex XVII for dye handling and registration

    Typical usage ratio

    • Applied at 1.5–3.5 mol equivalents per target dye synthesis; adjusted based on chromophore structure, desired absorption maxima, and downstream purification yield.

    Downstream process integration

    • Reacted during early-stage aldol condensation to yield intermediates for further structural modification; introduced directly into jacketed glass-lined reactors with real-time pH and temperature control.

    Final product types

    • Textile dyes for natural and synthetic fibers
    • High-performance pigments for coatings and plastics
    • Analytical stains for laboratory diagnostics
    • Specialty organic colorants for printing inks

    5. Research Chemical and Analytical Reference Material

    Academic, contract research, and industrial laboratories require 1-benzofuran-5-carbaldehyde as a structurally defined reference material for developing and validating analytical methods, and for structure-activity relationship (SAR) studies in heterocyclic chemistry. Our manufacturing and analytical documentation ensures traceability for regulated research environments.

    Industry compliance standards

    • ISO/IEC 17025 (Laboratory Accreditation)
    • GLP (Good Laboratory Practice) for research and development
    • USP standards for analytical reference materials (where relevant)
    • Documentation traceability compliant with OECD Test Guidelines

    Typical usage ratio

    • Prepared as pure neat reference substances or at 10–1000 ppm in analytical control mixtures, with adjustments based on detection limit requirements and instrument calibration curves.

    Downstream process integration

    • Dissolved or spiked into analytical test runs during method development, impurity profiling, or SAR protocol initiation; reference material prep follows documented weighing, dilution, and storage procedures in line with SOPs.

    Final product types

    • Laboratory-certified analytical reference materials
    • Heterocycle SAR research samples
    • Synthetic standards for HPLC, NMR, GC validation
    • Target compound for method robustness studies
    Free Quote

    Competitive 1-Benzofuran-5-Carbaldehyde prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

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    Certification & Compliance
    More Introduction

    1-Benzofuran-5-Carbaldehyde: Directly from the Manufacturer’s Perspective

    Introducing Our Approach to 1-Benzofuran-5-Carbaldehyde

    At our facility, we have spent years refining the process that yields high-purity 1-Benzofuran-5-Carbaldehyde. The team here deals with the day-to-day reality of producing this compound, not just moving it through warehouses. So, every batch we make tells a story about quality, repeatability, and rigorous control—values that form the backbone of our approach.

    The Importance of Purity and Consistency

    Experienced chemists and operators at our site know that the smallest change in starting material purity or synthesis conditions can introduce complications downstream. We select our benzofuran sources based on trace impurity profiles, studying not only what’s present in each lot but also how those traces influence reactivity, color, and yield. Our in-house analytics—ranging from gas chromatography to advanced NMR checks—keep quality deviations off the table. From a manufacturer’s perspective, the assurance is not marketing fluff; it’s practical and comes directly out of the work we do on the production floor.

    Product Details from the Manufacturer’s Bench

    We manufacture 1-Benzofuran-5-Carbaldehyde to specification—not just to meet a number, but to perform optimally where it counts, whether in pharmaceutical intermediates, fine chemical synthesis, or academic research. Our typical batches offer high purity, frequently exceeding 98% by GC, with main contaminants controlled to trace levels.

    Our own operators handle the packaging in inert atmospheres, fully aware that exposure to air or moisture can degrade performance in sensitive reactions. We have chosen amber-glass containerization not only for light protection, but because standard plastics sometimes promote unwanted side reactions, especially in long-term storage conditions.

    Production Scale and Batch Size Realities

    We run batch campaigns calibrated to our reactor systems, most commonly in the 10–250 kg range. Requested quantities outside this volume fall outside our normal workflow for a simple reason: we design our runs for yield optimization and minimal cross-contamination. People often underestimate the way reactor loading and the scale itself can affect the kinetic behavior of the reaction. Our operators have found time and again that pushing for multiple small runs or overloading a reactor introduces inefficiencies that ultimately show in product reproducibility. This kind of discipline is hard-won and sets the manufacturer’s viewpoint apart from that of traders and resellers with no real stake in outcome variables.

    Regulatory, Real-World Standards, and Traceability

    From the start, we have aligned our processes to traceability. We keep reaction logs, batch records, and full data trails for every shipment. Regulators visiting our site don’t get boilerplate answers—they review the exact steps, from solvent sourcing to reactor cleaning protocols. We don’t believe in cutting corners with recycled solvents that introduce unknown grades, so we source and document every input.

    We maintain open channels with customers who have experienced product variations from less vigilant sources. One incident, a few years back, involved a run of aldehyde with a faint but unmistakable impurity profile not matching our normal data—a subtlety missed by high-volume repackagers. Investigation showed the value of hands-on oversight that is only possible when you own the process from start to finish, enabling real root-cause analysis and correction. A distributor wouldn’t have caught that; a hands-on manufacturer does.

    Use Cases and Application Insights: Shared Experience

    We regularly hear from teams synthesizing heterocycles, medicinal agents, and agrochemical intermediates who depend on the reaction predictability offered by genuine 1-Benzofuran-5-Carbaldehyde, not a blend adulterated along a lengthy supply chain. Take the Suzuki coupling—the reaction outcome swings based on trace aldehyde impurity and moisture. Short-cuts in handling or less rigorous purification mean failed reactions, costly reruns, and timeline delays. Lab-scale and pilot-plant chemists accustomed to this reality appreciate our philosophy: make less, better; never let material hang around between processing steps longer than necessary; keep environmental conditions scrupulously dry and oxygen-free.

    It’s not unusual for us to provide technical feedback to customers attempting unfamiliar transformations using our material, explaining which purification approach may work better, advising on light sensitivity, or clarifying storage practices. We’ve seen how a seemingly small insight from one plant avoids days of troubleshooting at another; this is direct knowledge passed on, not hearsay or catalog-speak.

    Differences That Matter: Manufacturer vs. The Rest

    The chemical landscape is full of entities that trade and re-bottle 1-Benzofuran-5-Carbaldehyde, frequently mixing materials from different origins or handling them in uncontrolled conditions. They talk about “stock on hand” and “on demand” availability, but those phrases are disconnected from genuine process-backed reliability. We notice their batches sometimes arrive with unknown headspace gases, packages loosely sealed, or even material transluminated by office lights while waiting for packing. This kind of exposure chips away at product stability in subtle but real ways.

    In our plant, batch tracking begins with our own raw material monosourcing—no “blending to spec.” Once processed, product spends the minimum possible time in holding tanks, then moves immediately to packaging under an inert hood. By contrast, traders often juggle multiple containers, some opened several times before they even leave the warehouse. These differences accumulate as very real performance variables at the end-user’s bench.

    People often underestimate how much residual moisture, peroxides, or unnoticed low-level oxidants can shift from batch to batch. Having manufactured this compound for years, our process improvements have targeted exactly these pitfalls. The proof isn’t just in specifications, but in the feedback loop from users who rely on batch-to-batch predictability for new route scouting and process development.

    Safety, Storage and Stability from the Factory Floor

    There’s an assumption that “all chemicals are handled safely,” but those who have produced 1-Benzofuran-5-Carbaldehyde on scale know that each substance carries its quirks. This aldehyde needs darkness, cool stable conditions, and oxygen exclusion at every stage, or its sensitive carbonyl backbone begins to shift toward side products or slow polymerization.

    While others may store the aldehyde in nondescript bottles under shelf lights, we always rely on temperature-monitored, low-light warehouses, with real-time recording and physical moisture protection. Early on, we tracked stability under various fail-safe conditions, so our packaging reflects what genuinely resists breakdown, not just what’s quick to purchase for the season or looks tidy in a warehouse. These are tradeoffs a producer makes, because returns or product failures hurt reputation and partnerships over years, not weeks.

    Pioneering Solutions to Persistent Process Problems

    Many customers seek help after repeated troubles with off-spec aldehyde batches. Years ago, we saw an increase in complaints about chromatic impurities and shifting melting points from buyers using low-purity or poorly-handled aldehyde from consolidators. We collaborated on trials, running carefully controlled syntheses with our own material versus theirs, documenting every variable. Results consistently showed our manufacturing team’s discipline—detailed cleaning between campaigns, verified tubing and vessel compatibility, and tight environmental control—enabled reliable yields and cleaner downstream reactions.

    Our hands-on approach led to further process improvements: continuous-flow purification runs instead of large static extractions, and inline moisture stripping as a routine QC step. By iterating quickly and feeding results straight back to production, we adapt much faster than an entity simply sourcing and reselling via catalog. This approach shortens lead times without sacrificing quality, because we know all too well the cost of “orphaned” product stuck for months awaiting dispatch: instability, color drift, diminishing value.

    The Role of Direct Manufacturer Feedback

    In our position, we encounter requests for customization that highlight why being close to the process matters. Customers working with automation, parallel chemistry, or scale-ups often need not just the compound but reproducible behavior regarding weight, dispersion, and reactivity. Our technical crew regularly communicates insights about ideal storage, compatibilities with different reaction solvents, and how trace impurities can manifest in unexpected ways in later stages.

    A distributor can’t provide this level of data or problem-solving because they rarely have access to the realities of batch synthesis. Their focus, understandably, is on moving product; ours is on making it perform as promised, for each specific chemistry challenge customers face.

    Supporting Responsible and Transparent Chemistry

    Trust builds when buyers know suppliers actually make what they sell. Recalls, downtime, or reruns caused by blended or inconsistent material come at a significant price—missed milestones and even regulatory scrutiny. A practical commitment to responsible chemistry doesn’t stop with the bulk container; it extends to how we train every operator, how we keep documentation accessible, and how we pre-emptively identify potential handling or storage pitfalls.

    Instead of handwaving impurities, we dig into their root cause, working backward through supply chain errors or workflow tweaks to eliminate sources of trouble. This drive for transparency and accountability comes directly from the mindset of those who manufacture, not just move inventory.

    Comparing to Alternative Sources: A Manufacturer’s Perspective

    Competing sources sometimes try to differentiate product by purity claim alone, but if the source can’t explain resin behavior under humid conditions or describe real-time analytics used, the claim rings hollow to our ears. Trace nitriles, background peroxides, or even residual solvents left from hasty purification attempts have shown up in some off-market material, leading to lost productivity or failed scale-ups. Our process design weeds out these risk factors at the outset through double distillations or custom profile chromatography.

    We dislike the word “commoditization” in specialty chemistry production. The goal should always be to make genuinely reliable material, supporting advanced user applications where variability can wipe out entire research or process runs. In this sense, manufacturer oversight is non-negotiable.

    Ongoing Challenges and How We Address Them

    1-Benzofuran-5-Carbaldehyde remains a demanding material for process chemists. Every season brings shifts in raw material quality, ambient humidity, or supply chain risk. Experienced manufacturers face these hurdles not with generic fixes, but with active mitigation: dual-supplier verification for rare precursors, on-the-fly parameter adaptation, and retention of pilot-batch archives for reference.

    Supply interruptions—caused by regulatory changes, logistics bottlenecks, or vendor-grade issues—are managed directly by the production team, not deferred to anonymous brokers. In an industry where even a delayed batch can mean weeks of lost lead time for a customer, this level of supplier commitment isn’t the exception, but the standard that keeps projects moving in the right direction.

    Reflections on Real-World Customer Experience

    A steady stream of feedback comes our way from research groups, pharmaceutical developers, and custom compound users. The central theme in their experience: process-backed product simply works better, with fewer failures, and more predictable results. For bench chemists, each successful reaction validates their source choice and reduces rework; for production plants, every smooth run translates to fewer interruptions and lower overall costs.

    Direct dialogue with users also keeps us innovating. Complex projects push us to develop new purification strategies, invest in state-of-the-art monitoring, and rethink everything from packaging to logistics. Instead of waiting for complaints, we engage proactively, providing support and updates as soon as new insights or batch improvements become available.

    Looking Forward: Our Manufacturer’s Commitment

    For those manufacturing, the job is never quite finished. Synthesis improvements, raw material fluctuations, and evolving customer requirements keep us in a continual cycle of review and renewal. The intent with our 1-Benzofuran-5-Carbaldehyde is simple: keep the process transparent, consistent, and open to adaptation. We work to deliver material the right way—from the first stage of synthesis through to the moment the sealed container reaches the end-user, hands-on and informed at each step.

    By focusing on details that matter to working chemists—purity, reactivity, traceability, and practical handling—our team aims to offer more than just a reagent. We seek to enable breakthroughs and smooth transitions for those who rely on real materials, manufactured with care, for truly demanding applications.