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1-Amino-2-Naphthol Hydrochloride

    • Product Name 1-Amino-2-Naphthol Hydrochloride
    • Alias 1-Naphthylamine-2-ol hydrochloride
    • Einecs 208-144-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    599507

    Chemicalname 1-Amino-2-Naphthol Hydrochloride
    Casnumber 2834-92-6
    Molecularformula C10H10ClNO
    Molecularweight 195.65 g/mol
    Appearance Light brown to beige crystalline powder
    Meltingpoint 245-247 °C (decomposes)
    Solubility Soluble in water
    Ph Approx. 3-4 (1% solution in water)
    Storageconditions Store in a cool, dry place, tightly closed container

    As an accredited 1-Amino-2-Naphthol Hydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250g of 1-Amino-2-Naphthol Hydrochloride is supplied in a sealed amber glass bottle with a secure screw cap for protection.
    Shipping 1-Amino-2-Naphthol Hydrochloride is shipped in tightly sealed containers to prevent moisture absorption and contamination. The chemical is packed in accordance with applicable regulations for hazardous materials. It should be stored and transported in a cool, dry place, away from incompatible substances, and handled by trained personnel using proper personal protective equipment.
    Storage Store **1-Amino-2-Naphthol Hydrochloride** in a tightly sealed container, in a cool, dry, and well-ventilated area, away from moisture, light, and incompatible substances such as strong oxidizers and bases. Ensure proper labeling and avoid exposure to air to prevent degradation. Use appropriate personal protective equipment when handling, and keep away from heat or sources of ignition.
    Application of 1-Amino-2-Naphthol Hydrochloride

    Applications of 1-Amino-2-Naphthol Hydrochloride in Industrial Manufacturing

    1-Amino-2-Naphthol Hydrochloride serves critical roles in specialty pigment, pharmaceutical, and fine chemical production. Our material integrates into downstream processes where precise quality, compliance, and formulation control are essential for high-value end products.

    1. Azo Dye Intermediates for Textile Pigments

    This compound operates as a core intermediate during diazotization and coupling synthesis for azo dyes. It directly participates in forming chromophore structures used in disperse, acid, and direct dye manufacturing. Factories deploy this ingredient to obtain stable coloration on cellulose and synthetic fibers. Precise pH control and raw material purity prevent unwanted by-products and ensure dye strength meets technical requirements for export textiles and garments. Batch and continuous processes adjust input ratios based on color depth targets and type of textile substrate.

    Industry compliance standards

    • OEKO-TEX Standard 100 (textile chemicals)
    • REACH (EC Regulation No 1907/2006)
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals)
    • ISO 9001:2015 (quality management systems in dye production)

    Typical usage ratio

    • 5-15% by weight of dye intermediate composition. Facilities calibrate loading by target tint strength and application method (pad-batch, exhaust, continuous dyeing).

    Downstream process integration

    • Introduced during the diazotization stage after dissolution in acidic aqueous medium, followed by coupling reaction with aromatic amines or phenols. Operators manage temperature and reaction sequence to maximize yield.

    Final product types

    • Disperse dyes (polyester and acetate fibers)
    • Acid dyes (nylon, wool, silk, leather finishing)
    • Direct dyes (cotton, viscose rayon)
    • Textile color pastes and printing inks

    2. Pharmaceutical Synthesis: Intermediate for Antipyretic Agents

    Chemical manufacturers use 1-Amino-2-Naphthol Hydrochloride as a building block in the synthesis of benzoxazine derivatives. One key downstream application lies in producing antipyretic and analgesic drug actives, including agents marketed in emerging markets. The stage requires stringent input purity and reaction tracking, as impurities may affect the pharmacological grade of the final API. Regulatory traceability and QC documentation form critical elements throughout synthesis and release.

    Industry compliance standards

    • Good Manufacturing Practice (ICH Q7, WHO GMP)
    • European Pharmacopoeia (Ph. Eur.) and US Pharmacopeia (USP) ingredient requirements
    • 21 CFR Part 210/211 (US FDA)
    • ICH Q3A/B (residual solvents and impurities)

    Typical usage ratio

    • 10-18% molar base for primary condensation reactions. Chemists adjust ratios to optimize conversion rate while controlling for potential side reactions based on batch scale and route of synthesis.

    Downstream process integration

    • Fed into starting reaction vessel with aldehydes or carboxylic acids under controlled temperature and pH, often under nitrogen to minimize oxidation. Material input logged and validated per batch record.

    Final product types

    • Benzoxazine-based antipyretic drug substances
    • Paracetamol and related over-the-counter intermediates
    • Speciality pain management APIs for contract manufacturing
    • Key starting materials for custom synthesis projects

    3. Hair Dye Base for Oxidation Colorants

    The aromatic amine structure of this compound supports the formulation of permanent hair coloring products via oxidative dye chemistry. Cosmetic manufacturers dissolve the hydrochloride form for pre-mix with hydrogen peroxide and couplers, controlling shade specificity and intensity. Its purity and batch consistency are monitored to ensure compliance with cosmetic safety directives and to avoid allergenic risks for end users. Process engineers manage metering and blending accuracy to secure reproducible shades at production scale.

    Industry compliance standards

    • EC Cosmetics Regulation (EC) No 1223/2009
    • Cosmetic Ingredient Review (CIR) Expert Panel
    • Health Canada Hotlist (ingredient restrictions)
    • ISO 22716:2007 (cosmetic GMP)

    Typical usage ratio

    • 0.5-3.0% w/w of total hair dye formulation, adjusted for coupler concentration and depth of shade requirements. Final ratio determined via lab pilot shading and dermal safety test results.

    Downstream process integration

    • Integrated at color base premix stage, solubilized in aqueous-alcoholic system under agitation. Blended with peroxide activator at point of use or during bulk fill, then pH balanced for consumer use stability.

    Final product types

    • Permanent oxidation hair dye creams
    • Professional salon colorants
    • Home-use hair coloring kits
    • Pre-mix color base concentrates for export markets

    4. Analytical Reagent for Metal Ion Detection

    Scientific, environmental, and industrial laboratories use this ingredient as a chelating agent in quantitative analysis of transition metals. Its naphthol group forms colored complexes, supporting spectrophotometric and visual endpoint analyses. Strict adherence to analytical reagent grade ensures accuracy in calibration and environmental release certification. Typical protocols document all batch parameters for audit and traceability, with compliance to standardized testing frameworks for water, soil, or industrial discharge samples.

    Industry compliance standards

    • ISO 17025 (laboratory competence)
    • EPA Method 6010/7000 series (metal analysis)
    • Standard Methods for the Examination of Water and Wastewater (APHA)
    • Analytical Reagent (AR) grade requirements

    Typical usage ratio

    • 0.01-0.1% w/v in analytical solutions, titration or colorimetry. Labs optimize within this range based on sensitivity of assay and concentration of target metal ion.

    Downstream process integration

    • Weighing and dissolution in buffer or acid medium preceding sample introduction. Often combined with masking agents or secondary reagents in stepwise protocols. Used in batch-tests and automatic analyzers.

    Final product types

    • Water and wastewater analytical test kits
    • Soil contamination monitoring reagents
    • In-house quality control solutions for plating facilities
    • Bulk laboratory reagent packs for academic and contract labs

    5. Organic Synthesis Building Block in Agrochemical Manufacturing

    Downstream formulators apply the material as a precursor for herbicide and fungicide active ingredient synthesis. Its amine and hydroxyl functionalities supply critical points for further substitution and cyclization reactions. Process chemists control feedstock quality stringently to meet pesticide technical standard specifications. Compliance with environmental and worker safety standards forms a principal part of documentation for both pilot and full-scale operations. Usage accounts for local regulation on process emissions and waste recovery in agricultural chemical plants.

    Industry compliance standards

    • FAO/WHO Specification for Pesticides
    • ISO 17065 (certified agricultural inputs)
    • China GB/T 1603-2008 Pesticide Technical Material Standard
    • EU Regulation (EC) 1107/2009 (plant protection product approval)

    Typical usage ratio

    • 4-8% as conversion precursor in technical grade synthesis routes. Adjusted per downstream target molecule, process yield, and byproduct control in multi-step sequences.

    Downstream process integration

    • Dosed to reaction vessels during oxidative coupling or ring-closure steps. Blending and transfer procedures monitored for traceability. Input tracked by batch to control residual levels and waste management.

    Final product types

    • Technical grade herbicide actives (e.g., substituted naphthoxazines)
    • Fungicide intermediates for rice and cereal crops
    • Synthetic precursors for phenolic agrochemicals
    • Custom intermediate packages for agro-input supply chains
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    Certification & Compliance
    More Introduction

    Experience Gained from Manufacturing 1-Amino-2-Naphthol Hydrochloride

    Introduction: What We See in the Industry

    Years in the chemical sector give perspective on what separates one compound from another. 1-Amino-2-Naphthol Hydrochloride belongs to a family of organic intermediates that keep showing up in projects where performance, purity, and reliability matter. As chemical manufacturers, we talk with process engineers, research chemists, and industrial users every week. Their everyday realities shape the way we work—and the way we think about materials like 1-Amino-2-Naphthol Hydrochloride.

    This compound, with the formula C10H9NO·HCl, offers a remarkable bridge between the world of synthetic dyes and pharmaceuticals. Most commonly supplied as pale brown or reddish crystals, its structure brings a unique mix of reactivity and stability, which influences its effectiveness as an intermediate. Over countless batches, small changes in raw materials, temperature, or moisture control have underlined how much care and knowledge go into delivering a consistent product.

    What Sets Our 1-Amino-2-Naphthol Hydrochloride Apart

    The models we provide focus on tight molecular weight range and a standard that prioritizes low-impurity content. We learned through testing that even subtle variations in iron or heavy metal traces can alter downstream dye yields or interfere with sensitive pharmaceutical synthesis. Strict batch monitoring, high-grade filtration, and the experience of our technical team keep impurities below the industry norm. Regular third-party verification backs up claims beyond what internal quality control alone can achieve.

    Some products in the market exhibit a variable color or have trace levels of byproducts, making them less predictable in application. These inconsistencies come from inadequate pH control, incomplete neutralization, or subpar starting material. Several customers who switched to us from distributors reported a sudden drop in off-hue batches and easier purification after chromatography. Laboratory teams have shared less trouble with batch-to-batch repeatability, something that directly affects efficiency on the production floor.

    We invest in granular moisture detection. Uncontrolled moisture content sometimes flies under the radar until trouble strikes—loss of yield in dye vats, or clumping in powder-handling. Adjustment at the initial stage prevents headaches for downstream users, and stories reach us directly from facilities that no longer need to spend extra time drying materials before use.

    Key Specifications — What Comes Off Our Line

    Starting with material itself, 1-Amino-2-Naphthol Hydrochloride runs from about 99.5% up to over 99.7% purity, depending on the batch style. Loss on drying gets held below 0.3% to help avoid lumping or flow problems. Most lots show a distinct melting point around 177°C, confirming the correct hydrate form. We keep iron content far lower than legacy standards, usually under 5 ppm, because iron can introduce unwanted color changes in challenging syntheses. Chloride assays help ensure correct titration and consistent yield.

    These figures do not end up on our production floor by accident. Every chemist and operator in our facility watches for shifts in batch curves, color, and pH. Much of this skill comes from years of repeating the same operations—and occasionally spotting problems before machinery or chromatographs confirm them.

    Usage: What Industries Rely on Real Consistency

    Large textile dye houses often depend on 1-Amino-2-Naphthol Hydrochloride to synthesize azo dyes. These compounds color everything from polyester fabrics to food packaging. In this setting, uneven purity or variable solubility can lead to batches that produce streaks or off-color results. Operators handling our material report improvements in color yield and a drop in reprocessing. Consistency saves time: there is less filtering, fewer washouts, and less sampling when materials behave predictably.

    Pharmaceutical labs, both in research and pilot production, use this intermediate for certain intermediates or as reducing agents. Purity goes beyond aesthetics in these contexts, because any excess or residual impurity complicates regulatory approvals and downstream purification. Our time spent auditing supplier chains and refining our batch work translates into a product that meets stricter pharmaceutical requirements, without multiple recrystallization steps.

    We sometimes hear stories from laboratories using resold or repackaged product, where moisture or storage mishaps led to caking or hydrolysis, which cost days to fix. Direct customers handle less of this. We have built a routine of packaging airtight, vacuum-sealed bags for bulk shipments and smaller HDPE containers for laboratory clients. This simple choice spares headache in most climates—from dry zones to humid coasts.

    Differences from Other Naphthol Derivatives

    Not all naphthol derivatives show the same reactivity or color response. Some users moving between 1-Amino-2-Naphthol Hydrochloride and 2-Amino-1-Naphthol Hydrochloride need different pH control, solvent compatibility, or solubility. You cannot always substitute one isomer for the other, even though chemical names may look similar. Customers tend to voice confusion over material switching promoted by traders. Chemical structure really does matter, and results on real-world equipment often highlight the consequences.

    Our 1-Amino-2-Naphthol Hydrochloride distinguishes itself by avoiding well-known pitfalls of its cousins. The hydrochloride salt, in particular, offers stronger aqueous solubility than the free base, and this property supports ease of blending and shorter reaction times in many dye and pharmaceutical syntheses. Users working with the free base sometimes report poor handling and variable reactivity; the hydrochloride form speeds up their process and reduces handling dust.

    Azo dye synthesis draws out critical differences in performance. The amino substitution at position 1 and the hydroxyl at position 2 produce a specific directing effect during diazotization and coupling reactions, making this version better for certain red, brown, and yellow azo dyes. Differences in coupling rates and byproduct formation become very clear in scaled-up production. What looks similar on a molecular diagram ends up acting differently on plant-scale glass-lined reactors.

    Why We Choose This Manufacturing Pathway

    Our technical pathway relies on nitro-naphthol reduction under controlled acidity, followed by precise neutralization and acidification steps to yield the stable hydrochloride salt. Earlier in our company’s history, attempts to shortcut this method for speed or cost led to more variable product, lower yields, and frequent customer calls about inconsistent results. Since switching to a slower, monitored approach, customer returns dropped and repeat orders climbed.

    We pay close attention to solvent grades and water purity, tracing both organic and inorganic impurity profiles at several stages. Many customers do not realize how fast metals can contaminate batches during unchecked synthesis, especially when older reactors leach ions under acidic or heated conditions. Our lab regularly monitors these contributors to guarantee downstream reliability. The extra time pays dividends in smooth production and reduced complaints.

    Environmental and safety factors shape our daily operations. Every solvent used undergoes recycling, with air-handling and effluent neutralization systems working overtime. Customers want sustainable material management, not just a clean supply, and we share full batch histories on request. Sharing this transparency wins loyalty from R&D teams who report into environmental officers, not just procurement.

    Feedback from Real Industry Practitioners

    Stories keep returning from downstream clients who previously tried cheaper or poorly controlled material, then dealt with entire batches of dye going pink or brown, or lab syntheses clogging chromatography columns. These costly mistakes tell us that penny savings in raw material choice evaporate fast. Over the years, we have gathered field data from dyehouses and syntheses to deepen our knowledge. Adopting their feedback into our operations, we tuned our process controls for better filtration rates and less unwanted particulate.

    Pharmaceutical teams often highlight our packing method as a key differentiator, because humidity control can make or break research timelines. The difference between a delayed shipment due to caked product and a timely, free-flowing delivery changes the economics of multi-stage synthesis.

    Direct access to knowledgeable technical support saves our customers time. Engineers and chemists on our side give out trouble-shooting tips, dosing protocols, and suggestions on equipment cleaning based on real-world cases. These sorts of conversations do not usually happen with anonymous distributors, and our open approach wins trust from both purchasing and technical teams.

    Continuous Improvement and Investment

    As direct practitioners, we meet with our research and plant engineering teams each quarter to analyze what the batch reports teach us. Every deviation, off-color, or yield dip leads to hands-on reviews. Our operators, some of whom have spent decades handling this chemistry, share intuition about seemingly minor tweaks—like order of addition, stirring speed, or feedstock source. It’s the kind of learning that only accrues over countless batches.

    We balance automation with skilled craftsmanship. Some competitors race to install sensors and remote controls, but over-automation sometimes leads to surprise faults and longer downtime. Technicians’ attention to subtle changes—unexpected fumes, hue shifts in filtrate, or changes in filter cake texture—continues to catch issues that digital controls can miss.

    Experience matters at the packaging and logistics step, too. Making sure material arrives safely in climates as varied as the tropics and the Arctic means investing in multi-layered packing materials and insulation. Knowing how long the product travels before reaching rural regions shapes the way we think about average container hold times and buffer inventories.

    Commitment to Safe Handling and Environmental Responsibility

    Making chemicals brings with it real obligations—not just to customers, but to staff and the community. Every year, we refresh our training on safe handling, monitored storage, and spill control. Our staff receive hands-on drills with mock scenarios, not just theoretical lectures. Partners from logistics companies receive the same briefings, and we refuse to ship without their demonstrated compliance.

    Waste minimization became a goal years ago, driven by both local regulations and our internal philosophy. All spent solvents move to recovery units, and product recovery from filter cakes gets monitored to control both cost and emissions. Mixed waste handling practices took years to refine, and engagement with local regulators means our plant’s record stays clean—no public complaints, no accidental discharges.

    We continue to expand our air and water monitoring. Equipment investments in emission control keep our neighborhood air clean, and community feedback shapes our transparency reporting practices.

    Looking Forward: Supporting Innovation and Reliability

    Emerging markets and application areas place new demands on 1-Amino-2-Naphthol Hydrochloride every year. More pharmaceutical companies seek traceability and sustainable practices. Textile and pigment producers want finer control for shades and batch-to-batch matching. We keep up by periodically reviewing formulation compatibility and offering application-specific versions on request.

    Because we manufacture at scale, our team spots trend shifts before they become widespread issues. We watch for regulatory updates, emerging supply risks for starting materials, and evolving technical requirements in the user base. Several times, our early notice of shifts allowed customers to buffer stocks or adjust production before disruptions hit.

    Our real strength rests with the people and technical know-how built up over years. Users who choose direct connection to a manufacturer access not just product, but a source of ongoing advice and partnership. The difference shows up in their smoother operations and higher yields.

    Summary: Direct Experience Shapes 1-Amino-2-Naphthol Hydrochloride Quality

    Working directly in manufacture, we see every day how attention to detail and willingness to listen to feedback shape a product that serves more than just a chemical supply need. 1-Amino-2-Naphthol Hydrochloride stands out not because it sits in a datasheet, but because real people rely on it to power their industries—turning out textiles, stepping up pharmaceutical innovation, and driving color chemistry into new ground. Our promise is to meet their challenges with solutions rooted in experience, responsibility, and a commitment to continual improvement.