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HS Code |
742276 |
| Iupac Name | 1-[5-(4-chlorophenyl)-2-methyl-3-furyl]ethan-1-one |
| Molecular Formula | C13H11ClO2 |
| Molecular Weight | 234.68 g/mol |
| Cas Number | 66346-01-8 |
| Appearance | White to off-white solid |
| Melting Point | 94-96°C |
| Solubility | Soluble in common organic solvents |
| Smiles | CC1=C(C=CO1)C(=O)CC2=CC=C(C=C2)Cl |
| Purity | Typically >97% |
| Storage Conditions | Store in a cool, dry place, away from light |
| Hazard Statements | May cause skin and eye irritation |
| Synonyms | 4-Chloro-α-methyl-5-acetylfurfurylbenzene |
As an accredited 1-[5-(4-Chlorophenyl)-2-Methyl-3-Furyl]Ethan-1-One factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle labeled "1-[5-(4-Chlorophenyl)-2-Methyl-3-Furyl]Ethan-1-One, 25g" with hazard pictograms and tamper-evident seal. |
| Shipping | The chemical `1-[5-(4-Chlorophenyl)-2-Methyl-3-Furyl]Ethan-1-One` is shipped in tightly sealed, chemically resistant containers to prevent leaks and contamination. Packages are clearly labeled and transported under controlled conditions, compliant with international regulations for hazardous materials, ensuring safe handling, storage, and delivery to the designated destination. |
| Storage | 1-[5-(4-Chlorophenyl)-2-Methyl-3-Furyl]ethan-1-one should be stored in a tightly sealed container, away from light, moisture, and incompatible substances such as oxidizing agents. Store at room temperature in a cool, dry, well-ventilated area, and clearly label the container. Ensure it is kept out of reach of unauthorized personnel, and follow institutional and legal safety guidelines for handling and disposal. |
Applications of 1-[5-(4-Chlorophenyl)-2-Methyl-3-Furyl]Ethan-1-One in Industrial ManufacturingAs a dedicated producer of 1-[5-(4-Chlorophenyl)-2-Methyl-3-Furyl]Ethan-1-One, we supply global manufacturers seeking reliable inputs for established industrial pipelines. The following sections provide application-focused reference on this intermediate's integration into core industrial production routes, detailing compliance control, formula ratios, process fit, and resulting end-products. 1. Pharmaceutical Intermediate SynthesisThis raw material serves as a key building block in specialty pharmaceutical APIs, particularly furan-based antimicrobials and anti-inflammatory agents. Medicinal chemistry teams leverage this molecule's furanone scaffold during multi-step synthesis to introduce specific aromatic functionalities required in finished compounds. Industry compliance standards
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2. Fine Fragrance & Aroma Chemical Production1-[5-(4-Chlorophenyl)-2-Methyl-3-Furyl]Ethan-1-One contributes to specialty aroma formulations, valued by perfumers for its subtle spicy-woody and slightly floral notes. Industrial aroma houses employ this ingredient as a fixer and character builder in both synthetic fragrance and flavor compositions. Industry compliance standards
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3. Agrochemical Synthesis (Herbicide and Fungicide Intermediates)Downstream agrochemical manufacturers deploy this substance as a precursor in the synthesis of furan-based herbicides and fungicidal actives. Its aromatic profile facilitates key derivatizations that tune biological activity against targeted plant pathogens and weeds. Industry compliance standards
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4. Specialty Polymer & Resin ModificationHigh-performance materials engineers use this ketone derivative in the synthesis of specialty resins and functional polymers that call for targeted aromatic insertion, typically to improve mechanical, UV, or thermal resistance in formulated plastics and coatings. Industry compliance standards
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5. Analytical Reference Material PreparationQuality control and research laboratories source pure lots of this compound for use as GC/MS, HPLC, and NMR reference standards in both method development and routine quality assurance for structurally related furan or chlorophenyl substances. Industry compliance standards
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Working in chemical manufacturing means growing alongside each molecule produced and refined on the shop floor. 1-[5-(4-Chlorophenyl)-2-Methyl-3-Furyl]Ethan-1-One has been a distinctive product in our lineup for years, defined not just by composition but by the lessons it’s taught us about process control, purity, and effective application. Our facility handles every step, from acquiring base materials to the involved stages of synthesis, filtration, quality assurance, and packaging. This singular approach ensures each batch of this compound upholds consistent quality, which makes a difference in laboratory and industry settings alike. As a producer, direct control lets us trace every lot, troubleshoot with real accountability, and reliably document the outcome. We don’t speculate—our experience with this compound stretches from equipment calibration to firsthand conversations with clients facing unique technical challenges.
To anyone familiar with fine chemicals, the structure reveals much about how a material will behave. 1-[5-(4-Chlorophenyl)-2-Methyl-3-Furyl]Ethan-1-One brings together a furan moiety, a methyl substitution, and a chlorophenyl group—a layout that offers both stability and reactivity where it counts. These structural features translate into performance for end users. During synthesis, careful temperature and solvent controls help steer away from side products, delivering a cleaner final yield. Over years of optimizing our process, we’ve learned the reaction doesn’t tolerate half measures; impurities in solvents or minor shifts in pH can affect both purity and crystallization. Experienced teams, with the right instrumentation and troubleshooting mindset, are essential. Many clients count on the assurance that we can replicate outcomes, whether the end use is in pharmaceutical intermediates, research, or fine chemical synthesis. That consistency starts at the reactor and ends with every package that leaves our dock.
Our relationship with this molecule isn’t just theoretical; it comes from hands-on production, regular analytical testing, and constant discussion with end users. High-performance liquid chromatography (HPLC) and NMR spectroscopy form the backbone of our QC routine, verifying identity and purity before anything gets labeled for shipment. We track melting point ranges and monitor for traces of common organic impurities, informed by patterns we’ve observed after years on the line. Such tight control helps maintain purity often exceeding 98%, measured lot by lot. Any batch that doesn’t meet spec goes back for further processing or, in rare cases, safe disposal. Most of the technical issues customers encounter trace back to insufficient purity or mischaracterized impurity profiles, so we’ve invested heavily in instrumentation and operator training. Having this testing framework onsite, rather than outsourcing, cuts delay and allows real-time adjustments.
Over a decade, we’ve compared 1-[5-(4-Chlorophenyl)-2-Methyl-3-Furyl]Ethan-1-One to cousins in the same chemical family. Subtle differences in substitution patterns or in how the side chains are oriented might not jump out in a spec sheet, but hands-on synthesis reveals the unique handling needs of this molecule. Unlike compounds with more labile groups, this one exhibits better bench stability, resisting hydrolysis and side reactions during workup and storage. Bulkier analogs demand longer reaction times or additional purification. Customers regularly comment on the ease of working with our product compared to lower-grade imports or off-spec material from smaller, less-experienced operations. That comes down to batch size, ongoing process tweaks, and the ability to respond quickly when processes deviate. While some see an organic intermediate as a generic input, we see every lot’s performance play out in client results—yield, side products, and reproducibility all trace back to initial manufacturing quality.
This molecule mainly serves as an intermediate for pharmaceutical and specialty chemical synthesis. As someone involved in its production, I see its utility spanning medicinal chemistry, agrochemical exploration, and even advanced materials research. It’s not just about selling product—it’s about providing something that lets others create new therapeutics or improve chemical processes. Production-level feedback from our partners working in drug discovery has repeatedly been that the material delivers consistent reactivity in their coupling or cyclization protocols. Researchers highlight not just the yield they get but the predictability of side-products. That allows them to manage scale-up better, save on labor, and hit timelines. When a batch meets the right standard and gets delivered on time, a laboratory chemist can trust their results reflect true chemistry, not a hidden contaminant or an unstable precursor.
Add value to a product by making it predictable—even boring—from a process perspective. Labs relying on this type of building block want to avoid surprises. Our ongoing technical service isn’t an add-on; it grew out of lab staff running into questions that only the manufacturer could answer. How does the substance behave during long-term refrigerated storage? What solvent system gives tighter retention times on HPLC? Which trace-level impurity is showing up on LC-MS data? That type of troubleshooting is only possible when every detail of production is open for discussion. A distributor can relay basic information, but only a manufacturer understands why one synthesis route leaves a contaminant or why two lots might differ slightly under the microscope. We spend time walking through what happens batch to batch, tracking minor process variables, and helping clients benchmark our material alongside internal controls. There’s no shortcut to building that type of technical trust. It helps us respond rapidly when someone needs a tailored lot or modified processing parameters—situations that happen more than anyone outside the industry might expect.
The provenance of a compound can shape more than just the balance sheet. Labs that depend on reliable intermediates quickly learn that origin sets the tone for project success. Years ago, manufacturers like us noticed recurring headaches with certain imports—trace impurities, inconsistencies from lot to lot, and shipping delays that threw off synthesis planning. That directly drove our decision to keep synthesis onsite and invest in QC that far exceeds minimum regulatory thresholds. It was never about chasing a certification or badge. It was daily conversations with chemists and engineers who want to fix issues at their root. The experience of actually operating the reactors, watching filtration profiles in real-time, and adjusting conditions based on previous batch learnings gives insights no spreadsheet or spec sheet can capture. With this molecule, even routine production teaches lessons—operator vigilance during distillation can affect eventual purity, and ambient humidity influences crystallization. Every change becomes a data point in a bigger story. That record helps us spot trends, prevent problems, and share hard-won advice with those using the material at scale.
Occupational safety never stays an afterthought. Day in and day out, we adapt work practices to meet the realities of chemical processing. This intermediate, thanks to its stability, carries fewer handling quirks compared to some more sensitive furan analogs. Sensible storage—cool, dry, sealed in chemically compatible containers—keeps it ready for use. We’ve built up procedures for accidental contact or spill management based on real events, not just theoretical risks. Over time, that means safety data sheets move from compliance paperwork to actual training programs for staff. Safe production rides on anticipation: having ready access to fume hoods, reliable PPE, and emergency cleanup materials wherever this product is handled has kept incidents rare. Our ongoing workshops for process safety are informed by decades on the floor, not just boilerplate OSHA guidance. Factory teams play an active role in updating protocols as the process evolves, so we capture new risks alongside ongoing production experience.
Responsible manufacturing shapes the way we think about waste streams and environmental stewardship. Over the years, recycling solvents and capturing byproducts has shifted from regulatory requirement to a source of operational pride. This particular ketone intermediate doesn’t present extreme hazards, but its production benefits from close control of process effluents and off-gases. Early years of operation brought surprises—solvent losses, minor vapor leaks—and each has translated to improved closed-loop setups or more aggressive scrubber usage. We continually audit our waste streams, tracking both absolute volumes and concentration of any organic residues. Any material outside our purity standards is reprocessed whenever feasible. Only if the impurity burden proves too high does product get directed to licensed disposal. Minimizing off-spec output, tracking emissions, and working with local agencies all form the routine fabric of running a modern chemical facility. Discussions with peers across the industry suggest that continual investment in better waste treatment and solvent recovery doesn’t just protect the brand; it saves real money and reduces regulatory headaches over the long haul.
Price fluctuations, evolving regulatory standards, and the global supply chain crunches challenge any manufacturer. This compound is no exception. As a producer, watching markets morph almost overnight has forced a tighter focus on efficiency and process reliability. Building a strong working relationship with customers helps smooth out some of that turbulence. Regular feedback has guided us to tweak both volume offerings and packaging options to fit customer needs—from small, research-scale vials to large containers for kilo-lab resupply. Adapting to that range, without sacrificing spec or adding complexity in logistics, requires experience from the ground up. Part of that adaptability comes from staff retention; operators who’ve run the same syntheses for years know what small shifts in yield or filtration rates really signal. They spot issues in real time and help solutions take root before problems get out of hand. Commitment to high-grade, consistent quality, regardless of batch size or order frequency, has ensured that even as markets shift, end users aren’t caught out by sudden variation.
Looking back over years of production, no batch is ever truly routine. We’ve made stepwise improvements to both yield and resource input across multiple cycles. For this furan ketone, minor tweaks—such as refining mixing speeds, shifting the grade of catalytic additives, or adjusting quench conditions—have led to measurable improvements in both throughput and product quality. Process engineers and synthetic chemists keep a running log of every experiment, every shift, every bottleneck. Much of the evolution comes from listening: operators suggest promising tweaks based on deviations they see with their own eyes and hands. Integrating new analytical methods has also driven us forward. For example, upgrading to real-time GC-MS helps spot impurities earlier, allowing corrective measures during the same shift. Equipment upgrades—stirrer redesigns, improved filtration setups—pay for themselves through less downtime and safer operations. None of these shifts happen overnight, but decades in the field teach one lesson: small steps, made regularly, build a foundation for safe, scalable, and cost-effective manufacturing.
Open lines of communication make all the difference in the business of chemical manufacturing. Most customers aren’t just looking for a raw material; they’re investing in reliability, predictability, and support. We spend time visiting client labs, troubleshooting application-specific questions, and learning where our material fits into larger workflows. By sharing observations from both sides, we strengthen our approach on the production line. Feedback loops, such as returns data and quality metrics from end users, drive continual quality improvements. We don’t shy away from tough conversations about problems—recalls, complaints, or oddities in reactivity all provide a chance to improve production and customer support. Real expertise is measured not just by the purity of a product but by resilience when things don’t go as planned. Our customers know they can reach out with technical questions, delivery requests, or concerns about material performance and get a grounded, first-hand response based in experience and data, not generic scripts. That creates partnerships that last beyond a single order or project.
Not every day runs smoothly on the factory floor. Batch process disruptions, unanticipated equipment maintenance, or fluctuations in incoming raw materials all test the durability of any manufacturing plan. Years manufacturing this compound have shown that proactive monitoring, paired with responsible stock management, makes the difference between meeting demand and scrambling for substitute supplies. Our investment in real-time analytics, responsive maintenance crews, and redundancy in critical systems enables us to recover quickly from most hiccups. New regulatory guidance or client-driven specification updates can translate to more frequent validation, but we approach those shifts with the benefit of lived experience. Long-term partnerships with raw material suppliers also provide a buffer against price and quality shocks. Even with shifting external conditions, we maintain focus on delivering the same tight specs, clean profiles, and carefully packaged material batch after batch. Solving the unforeseen draws heavily from a seasoned workforce and leadership invested not just in volume but in quality at every handoff.
Regular training and skill-building serve as the backbone of safe, reliable chemical manufacturing. Every new hire learns both the science and the spirit of working with specialty chemicals. Experienced hands pass along not only protocols but practical know-how that comes only with time spent at the reactor or packing station. We update our training whenever process adjustments or equipment upgrades alter day-to-day routines. Staff earn responsibility by mastering both the technical and safety-critical details of production, always supervised and evaluated with care. Our leadership encourages professional development in chemistry, engineering, and quality assurance—paying for webinars, courses, even academic partnerships. By empowering staff, we create a culture of investment in quality that transcends shifts or management changes. A strong training program transforms regulatory compliance from box-ticking into real-world risk management and product reliability. The people who handle this compound every day are the best source of process improvements and safety updates, driving innovation from the floor up.
In a marketplace where the unexpected often becomes routine, resilient manufacturing, tight process control, and unvarnished communication shape the difference between commodity suppliers and true partners. 1-[5-(4-Chlorophenyl)-2-Methyl-3-Furyl]Ethan-1-One has served as both a product and proving ground for skills, technology, and process dedication. Our firsthand experience underscores that real quality starts long before a bottle gets labeled—and continues through delivery, application support, and technical follow-up. The constant learning that comes from managing every variable in production, adapting to fresh challenges, and listening directly to the chemists using the material keeps us grounded. Our approach has always focused on incremental improvement, practical technical support, and doing the right thing by both customer and workforce. As the role of specialty chemicals grows and industry standards tighten, we meet tomorrow’s demands by building on yesterday’s lessons. The work, day in and day out, creates the trust and reliability that our customers expect—and that we’ve set our reputation on as a manufacturer.