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1-[4-(Trifluoromethyl)Phenyl]Ethanol

    • Product Name 1-[4-(Trifluoromethyl)Phenyl]Ethanol
    • Alias 4-(Trifluoromethyl)phenylethanol
    • Einecs 214-669-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    127138

    Iupac Name 1-[4-(Trifluoromethyl)phenyl]ethanol
    Molecular Formula C9H9F3O
    Molecular Weight 190.16 g/mol
    Cas Number 54038-16-3
    Appearance White to off-white solid
    Melting Point 48-53°C
    Boiling Point 222-224°C
    Density 1.24 g/cm³
    Solubility In Water Slightly soluble
    Smiles CC(O)c1ccc(cc1)C(F)(F)F

    As an accredited 1-[4-(Trifluoromethyl)Phenyl]Ethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle with a secure screw cap containing 100 grams of 1-[4-(Trifluoromethyl)Phenyl]Ethanol, labeled with hazard symbols.
    Shipping 1-[4-(Trifluoromethyl)phenyl]ethanol is shipped in tightly sealed, chemical-resistant containers to prevent leaks and contamination. The package is labeled according to applicable hazardous material regulations, protected from moisture, heat, and direct sunlight, and handled with appropriate documentation to ensure safe, compliant transit and storage during shipping.
    Storage 1-[4-(Trifluoromethyl)phenyl]ethanol should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from direct sunlight and sources of ignition. Keep separate from strong oxidizing agents and acids. Store at room temperature, avoiding extreme temperatures and moisture. Ensure proper labeling and comply with local chemical storage regulations to maintain safety and chemical integrity.
    Application of 1-[4-(Trifluoromethyl)Phenyl]Ethanol

    Applications of 1-[4-(Trifluoromethyl)Phenyl]Ethanol in Industrial Manufacturing

    1-[4-(Trifluoromethyl)Phenyl]Ethanol is a specialty chemical intermediate relied upon in multiple advanced manufacturing sectors. As the original producer, we supply tailored grades that support integration into complex downstream processes. Below are the primary industrial fields where direct application of this material drives compliance, consistent formulation, and targeted end-product performance.

    1. Pharmaceutical Intermediate Synthesis

    This raw material functions as a key building block for synthesis of active pharmaceutical ingredients, especially within APIs incorporating trifluoromethylated aromatic alcohol motifs. Its unique structure enables selective introduction during condensation steps or as a coupling partner in multi-step processes. Application includes antihypertensive, CNS, and oncology API manufacturing, where stringent impurity profiles and traceability are enforced under GMP production.

    Industry compliance standards

    • ICH Q7A Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients
    • EU EudraLex Volume 4 Annex 1
    • USP <795> and <797> compounding guidance for intermediates
    • FDA 21 CFR Part 211 for finished pharmaceuticals

    Typical usage ratio

    • Normally 0.2–0.5 molar equivalents relative to key substrates; ratio optimized per API synthetic route and impurity tolerance defined by pharmacopoeial monographs

    Downstream process integration

    • Material charged directly to reaction vessels after incoming QC release, usually dissolved in polar aprotic solvent during condensation, reduction, or alkylation phases; tracking via batch record and LIMS

    Final product types

    • Trifluoromethylated pharmaceutical actives
    • Advanced medicinal intermediates for CNS or oncology
    • Fine chemicals registered as pharmaceutical intermediates
    • High-purity final APIs for regulated markets

    2. Agrochemical Synthesis (Herbicide and Fungicide Active Manufacturing)

    This compound supports agrochemical R&D and bulk manufacturing as a key aromatic alcohol source for certain selective herbicides and fungicides. The trifluoromethyl group confers both stability and bioactivity, making it preferred for integrating into aromatic rings or reduction precursors when producing patent herbicidal scaffolds. Process control focuses on maintaining trace contaminants within regulatory maximum tolerances.

    Industry compliance standards

    • OECD Principles of Good Laboratory Practice (GLP)
    • FAO/WHO Joint Meeting on Pesticide Specifications (JMPS)
    • ISO 9001:2015 Quality Management for agrochemical manufacturing
    • EU Regulation (EC) No 1107/2009 concerning the placing of plant protection products on the market

    Typical usage ratio

    • 0.15–0.35 molar equivalents, typically adjusted based on target yield and downstream purity specifications of active substances; jetting for continuous or slurry phase synthesis

    Downstream process integration

    • Added at initial coupling phase within batch reactors or continuous flow units; monitored via in-process GC/MS and HPLC to control conversion rate and meet downstream purity specs before formulation or granulation

    Final product types

    • Trifluoromethylated herbicidal actives (e.g., phenoxy and benzoic acid derivatives)
    • Fungicidal components for seed treatments
    • Bioactive intermediates for selective agro-formulation bases
    • Registered generic or proprietary crop protection agents

    3. Specialty Polymer Additives Manufacturing

    Downstream polymer compounding units utilize this phenylethanol derivative as a monomer modifier or functional group introducer, particularly in engineering plastics and advanced coatings. It facilitates the incorporation of fluorine into the polymer backbone or side-chain, imparting enhanced chemical resistance and anti-fouling properties to the final resin. Addition streams and dosage levels are controlled via extruder or reactor dosing systems, ensuring product uniformity for industrial consumers.

    Industry compliance standards

    • ISO 9001:2015 for polymer production
    • REACH Regulation (EC) No 1907/2006 for chemical safety in the EU
    • UL 94 for flammability in finished plastics
    • ASTM D256 and D638 for mechanical performance validation

    Typical usage ratio

    • 0.5–2.5% w/w in polymer mass, calculated based on target fluorine incorporation and application-specific durability standards; downstream compounding may require batchwise adjustment

    Downstream process integration

    • Metered to melt-phase feeders or pre-mixer in extrusion lines; addition point selected to maximize copolymerization and minimize thermal decomposition; QC monitors repeating unit distribution and residual monomer

    Final product types

    • High-performance engineering thermoplastics
    • Cross-linked coatings with stain resistance
    • Membranes for advanced filtration
    • High-durability fluorinated surface treatments

    4. Liquid Crystal and Organic Electronic Material Production

    Chemical formulators in the display and organic semiconductor sectors select this material as a precursor for synthesizing specialized liquid crystal compounds and organic transistor components. The trifluoromethyl-phenyl and ethanol group allow precise tuning of molecular dielectric properties, stability, and processability within LC mixtures or conjugated organic frameworks. Specifications prioritize batch purity and optical performance to support high-value device fabrication.

    Industry compliance standards

    • RoHS Directive 2011/65/EU for substance restrictions in electronics
    • IEC 60068-2-45 for environmental testing of electronics
    • ISO 14644-1 cleanroom standards for optoelectronics
    • REACH Registration for intermediate handling in the EU

    Typical usage ratio

    • 5–15% w/w of total liquid crystal or up to 0.3 molar equivalents in organic electronic couplings; set based on application-specific mobility or dielectric constant requirements

    Downstream process integration

    • Material enters as a precursor in high-vacuum reactors for LC synthesis or as a coupling partner in organic semiconductors; process involves micro-filtration, distillation, and final QC by NMR and HPLC for trace impurity control

    Final product types

    • Low-voltage twisted nematic liquid crystal mixtures
    • High-mobility organic thin-film transistor layers
    • Display-grade organic semiconductor materials
    • Pre-polymers for optoelectronic substrates

    5. Fine Chemical Intermediates (Fragrance and Performance Additive Synthesis)

    Fine chemical manufacturers apply this aromatic alcohol when constructing complex molecules for high-purity fragrance bases and specialty performance additives. Its electron-withdrawing CF3 group influences aroma profile evolution and chemical stability, making it valued in the synthesis of advanced aromatic ethers and esters. Usage is regulated by sector certification to ensure product traceability and avoid banned substances in performance consumer products.

    Industry compliance standards

    • IFRA Code of Practice for fragrance ingredient safety
    • EU Regulation (EC) No 1223/2009 on cosmetic products
    • ISO 22716:2007 Cosmetics – Good Manufacturing Practices
    • Registration under TSCA for U.S. performance chemical usage

    Typical usage ratio

    • 0.2–2.0% w/w for base blends or as a synthetic intermediate on a 1:1 molar basis in functional group conversion steps; ratio based on required endpoint activity/volatility

    Downstream process integration

    • Charged at condensation or esterification stages, typically under inert atmosphere to protect aromatic integrity; monitored under HPLC and GC for fragrance intermediate purity

    Final product types

    • High-purity fragrance ether intermediates
    • Performance esters for surface care
    • Stabilized aromatic solvents for specialty coatings
    • Functional additives for industrial consumer formulations
    Free Quote

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    Certification & Compliance
    More Introduction

    1-[4-(Trifluoromethyl)Phenyl]Ethanol: Quality from the Production Line

    Introduction to Our Product

    Every batch of 1-[4-(Trifluoromethyl)phenyl]ethanol that leaves our plant traces its origin to the experienced hands and carefully monitored reactors of our own manufacturing facility. We have invested heavily in process controls and analytical methods, pushing for rigorous consistency in both purity and physical properties. Our team knows this molecule—the smell, its crystalline shine, its reliable melting behavior. Customers have demanded high standards, and so do we.

    What Makes 1-[4-(Trifluoromethyl)Phenyl]Ethanol Distinctive

    This compound stands apart from basic aromatic alcohols. The addition of a trifluoromethyl group to the para position of the phenyl ring drives up its electron-withdrawing power, making it far more robust in many downstream applications. Fluorinated alcohols like this show a higher chemical stability and their hydrophobic character opens new doors in both research and synthesis. We focus on keeping the water content and residual solvent levels low, something that not all sources succeed at. The trifluoromethyl group shifts both the solubility and the reactivity profiles; many labs come back to us because generic phenylethanols don’t deliver the same performance in specialty synthesis or advanced intermediates work.

    Specifications Shaped by Real-World Demand

    We have heard repeatedly from R&D chemists and production teams—the market simply expects better traceability and analytical transparency. Our lots show single-digit ppm for common impurities, and each shipment leaves with a chromatogram. Typical melting range is 40-42°C, and we monitor optical clarity and color to help customers avoid headaches in formulation or scale-up. In our experience, even subtle deviations in purity can mean huge jumps in side product or purification costs downstream.

    We have also taken feedback from long-term partners about convenience. Instead of large, unwieldy containers, the product leaves our site in well-sealed, light-resistant drums or bottles according to customer scale. As the scale of innovative chemistry grows, we find packaging flexibility becomes just as important as product chemistry.

    What Sets Our Manufacturing Process Apart

    Sourcing and processing drive quality. We run our own controls on every incoming raw material rather than rely on outside paperwork. Our reactor operators have optimized a stepwise temperature program to guarantee completion. Routine checks for organofluorine contamination and metal residues—especially iron or nickel—keep the product as clean as possible. Colleagues in the field have told us horror stories about bulk products that look fine until they hit an NMR or HPLC, but raw data from our QC lab demonstrates that we bring down typical aromatic-ethanol byproducts by a factor of ten.

    Our factory makes this product year-round. The equipment is dedicated for fluorinated specialties, avoiding cross-contamination from unrelated lines. We cover both kilo-lab and larger campaigns, and have invested in real-time analytics so operators never “fly blind.” Instead of mystery barrels, our customers know exactly what they receive, with specs confirmed by actual lot-specific testing.

    Applications Seen from the Manufacturer’s View

    Over the years, we have seen researchers and industry teams use our 1-[4-(trifluoromethyl)phenyl]ethanol for a surprising variety of purposes. In the field of pharmaceutical intermediates, the CF3 group offers improved lipophilicity and metabolic stability; several clients use this molecule as a building block in active drug candidates. Crop protection companies often request this alcohol for introducing a strong electron-withdrawing group during lead optimization. Other markets involve advanced materials—some customers leverage the unique polarity of the alcohol to achieve novel polymer functionalization or create specific surface coatings.

    We work directly with formulators scaling up hydrogenation or Grignard reactions, and have seen how impurities in purchased raw material can throw off entire runs. Our focus—keeping color, water, and by-products in tight range—avoids scenarios where researchers lose weeks investigating errant reactivity or unexplained by-products. In the end, lab success pivots on quality, not just supply agreements or paperwork. This is why we prefer to control the entire production process ourselves, so we never have to explain away “typical” variances.

    Direct Answers to Common Customer Questions

    We often answer queries about shelf-life and storage. The stability of 1-[4-(trifluoromethyl)phenyl]ethanol matches or surpasses most comparable alcohols; we recommend a cool, dry place and containers kept tightly closed. Our containers meet these storage needs right out of the box. Some prospective partners ask about scaling up or whether they face issues at higher temperatures—routine thermal cycling during formulation, for example. We have studied this in-house, and can confirm that the trifluoromethyl group protects against unwanted oxidation or polymerization. That means less product loss or headache years down the line.

    Customers running sensitive analytical or medical syntheses have commented on the need to avoid generic byproducts. Because we process under controlled conditions from end-to-end, there’s less risk of unanticipated side-reactivity—critical for clients whose end-uses cannot tolerate surprises.

    Supporting Data, Not Just Marketing

    We supply certificates of analysis reflecting the actual lot, not some theoretical average. Each batch passes both in-house NMR and GCMS for purity, plus Karl Fischer for water content. We trained our own team to look for trace abnormal signals that may indicate incomplete manufacture, so that problems get caught on our end—not in a customer’s laboratory. Purity typically registers at 99.5% or greater, but we actively communicate early if a deviation occurs.

    Unlike lines sourced from brokers or contract manufacturers, our controls reflect deep experience with this molecule’s quirks. Our team tracked changes in melting point and optical properties when seeing early signs of subpar upstream raw material. We have spent years dialing in reaction and workup conditions; these refinements translate into a noticeably different consistency compared to products sourced on the open market.

    What We Learned Working with Customers

    Over the years, some surprising lessons emerged by monitoring how chemists approached this molecule. Speed-to-market pressures often push teams to chase lowest price or quickest delivery, yet trouble downstream often eats up those savings. Delayed project timelines due to inconsistent raw material, failed purifications, or scale-up glitches often trace back to overlooked quality gaps. Working directly as a real chemical manufacturer, we field calls from customer labs—not call centers or third-party resellers—so we get immediate feedback about what’s working and what is not.

    Our relationships matter. A development chemist may spot a sub-ppm impurity the hard way, and reach out for insight. We walk through our process controls, tracking lot history and even providing data from archived batches when needed. We see value in simply picking up the phone or visiting a customer’s plant floor to troubleshoot real problems. Those conversations drive our next round of process improvements, ranging from changing a distillation profile to catching a minor shift in raw material specification.

    Differences Between Our Product and Commodity Chemicals

    Every manufacturer likes to claim their product rises above the pack. The exacting quality we deliver stems from knowing the consequences of missed details. Our team continues to tweak and optimize because no downstream customer wants the uncertainty that comes from heterogeneous product sources. We also see rising requests for regulatory dossiers or custom documentation, particularly in pharmaceutical and agrochemical sectors. Our internal systems track each delivery, so audit requests never send us scrambling. This wouldn’t happen if we simply resold bulk tanks or low-bid imports.

    Commodity phenylethanols often lack that critical CF3 group. While some applications attempt to substitute with basic derivatives, those projects risk both reactivity and regulatory setbacks. For example, fluorinated alcohols often change pharmacokinetics or binding affinities in ways plain aryl ethanols cannot. It makes sense—fluorine moves not just polarity, but also steric and metabolic profiles. We keep up with literature and partner research to support our claims with emerging facts.

    We have seen firsthand the difference that trace iron or chloride contamination can make to sensitive synthetic runs. Our dedicated fluorination lines, combined with batch purity data, let us draw clear distinctions compared to bulk manufacturers. If a customer is developing a regulated drug or high-value crop protection lead, that confidence means next-step development progresses without unplanned chemical surprises.

    Continuous Improvement Bearing Customer Results

    Sticking with the same process year after year breeds complacency. After seeing how new applications stress purity, solubility, and reactivity, we invest in periodic review cycles for our process. For example, a customer reported a narrow-spectrum impurity that could only be caught by high-field NMR, inspiring us to revise both our purification train and quality test thresholds. Those changes did not just benefit that one client—the improved process now supports everyone downstream.

    Our technicians also record data on product handling—how minor changes in container materials or sealing technique affect shelf-life and transport stability. Even the smallest leak or difference in cap can evolve into a real headache for a formulation scientist working to precise standards. We have seen that direct manufacturer feedback cycles like ours actually produce better material both for in-house and outside use. Material left in sunlit storage or with minor seal defects can drift in quality; we work proactively to understand those risks and blunt their impact at the source.

    Future Outlook and Ongoing Challenges

    Demands for specialty aromatic alcohols continue to evolve. We see customers diversifying outside traditional pharmaceutical and agrochemical uses, exploring new high-performance materials, advanced surface modifiers, or specialty resins. As data accumulates on the unique effects of fluorinated moieties, our team tracks emerging requirements and regulatory changes. Working as a real chemical manufacturer, we find it crucial to invest not just in production equipment, but also in compliance and analytical resources. Our future business depends on how we adapt to changing customer needs, regulatory requirements, and scientific understanding.

    Supply chain disruptions present fresh difficulties. Maintaining year-round production and securing critical precursors requires persistent negotiation and technical adjustments as new challenges emerge. By controlling raw material and process contingencies in-house, we’ve weathered interruptions that have stalled competitors relying on outside networks.

    As environmental and sustainability pressures grow, we continue searching for greener process routes. We run pilot projects, tweak solvent systems, and consider residue minimization steps. Customers have asked about lifecycle data and environmental footprints, and as manufacturers, we know these questions are only going to become more common and more pressing.

    Closing: Our Commitment from the Shop Floor

    Producing 1-[4-(trifluoromethyl)phenyl]ethanol not as a commodity, but as a specialty building block, demands accountability at every stage. Years of experience, coupled with constant learning from customer feedback, shape how we approach chemical manufacturing. Laboratories and production firms can find many sources online, but few offer the direct assurance and technical transparency grounded in real production knowledge.

    As the team behind this product, we believe in open communication, actual analytical proof, and ongoing refinements matched to changing technologies and applications. This approach doesn’t stay in the sales brochure; it gets tested against the expectations of chemists, formulators, and engineers who rely on us every day. The path from raw material to final product passes through our hands, our decisions, and our commitment to building value with each batch.

    That’s the difference our customers gain—1-[4-(trifluoromethyl)phenyl]ethanol manufactured by a company that actually controls, understands, and supports each molecule that ships. We look forward to helping your programs succeed, grounded on the simple promise of manufacturer-driven quality.