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1,4-Dihydroxynaphthalene

    • Product Name 1,4-Dihydroxynaphthalene
    • Einecs 202-321-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    265927

    Cas Number 83-72-7
    Molecular Formula C10H8O2
    Molecular Weight 160.17 g/mol
    Iupac Name naphthalene-1,4-diol
    Appearance white to beige crystalline powder
    Melting Point 220-224 °C
    Boiling Point 404 °C
    Solubility In Water slightly soluble
    Density 1.34 g/cm³
    Refractive Index 1.692
    Pubchem Cid 71397
    Synonyms 1,4-naphthalenediol; para-naphthalenediol
    Odor odorless
    Flash Point 221.1 °C
    Stability stable under recommended storage conditions

    As an accredited 1,4-Dihydroxynaphthalene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 1,4-Dihydroxynaphthalene is provided in a sealed, amber glass bottle containing 250 grams, clearly labeled with handling and hazard information.
    Shipping 1,4-Dihydroxynaphthalene is shipped in tightly sealed containers to prevent moisture absorption and oxidation. The containers are clearly labeled and protected from light, heat, and incompatible substances. Handling and shipping comply with relevant chemical transport regulations, ensuring safe and secure delivery, typically via ground or air freight, according to hazard classification.
    Storage 1,4-Dihydroxynaphthalene should be stored in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizers. Keep the container tightly closed and protected from light and moisture. Use appropriate chemical-resistant containers. Store at room temperature and label containers clearly to avoid accidental misuse. Ensure easy access to safety data and equipment.
    Application of 1,4-Dihydroxynaphthalene

    Applications of 1,4-Dihydroxynaphthalene in Industrial Manufacturing

    1,4-Dihydroxynaphthalene serves as a critical intermediate in specialized chemical production. The following downstream applications reflect its effective use in dye synthesis, specialty polymer manufacturing, pharmaceutical intermediates, and antioxidant systems, each requiring detailed process considerations and compliance alignment.

    1. Synthetic Dye Manufacture

    As a key building block in the synthesis of vat and azo dyes, 1,4-Dihydroxynaphthalene enables stable chromophore development for dark blue and black shades. It enters coupling reactions or oxidative processes to yield dyes used in textiles and leather. Manufacturers integrate the raw material post-nitration step, controlling temperature below 80°C to prevent decomposition. Selection of coupling agent and pH directly influences shade intensity and product yield. High-purity grades support compliance with textile safety directives, minimizing the risk of extractable impurities in finished goods.

    Industry compliance standards

    • OEKO-TEX® Standard 100
    • REACH Annex XVII (Aromatic Amines Restrictions)
    • ZDHC MRSL 3.1 Textile Chemical Module
    • ISO 105-C06:2010 for wash fastness

    Typical usage ratio

    • 10–20% of total chromophore content for vat dyes
    • 5–15% in diazo coupling; adjusted to achieve desired color strength and fastness

    Downstream process integration

    • Addition to reaction vessel after initial nitration and reduction steps
    • Control feed during oxidative condensation or diazotization
    • Solubilization in alkaline phase prior to precipitation
    • Filtration and purification before downstream dye blending

    Final product types

    • Vat blues and blacks for cotton textiles
    • Azo dyes for wool, silk, and blends
    • Leather finishing dyes
    • Industrial printing inks

    2. Specialty Polymer and Resin Additives

    Polymer manufacturers incorporate 1,4-Dihydroxynaphthalene to introduce naphthalene-based units into advanced engineering plastics and resins. Inclusion enhances thermal stability and color properties, particularly in high-performance polyimides and phenolic resins. Strict moisture and particle size control during pre-blending ensure consistent polymer characteristics. The additive is introduced at prepolymerization, with mole ratios adjusted for desired crosslink density. This facilitates use in insulation, automotive parts, and electronic encapsulants requiring certified fire and electrical properties.

    Industry compliance standards

    • UL 94 Flame Class Requirements
    • RoHS Directive 2011/65/EU
    • ISO 1183-1 (Density of Plastics)
    • IEC 60695-2-11 (Glow-wire flammability test)

    Typical usage ratio

    • 0.5–2 mol% for polyimide backbone modification
    • 2–4% by weight for phenolic resin enhancement; adjusted for circuit board or adhesive resins

    Downstream process integration

    • Blend with precursor dianhydrides or phenols during monomer preparation
    • Controlled addition during melt or solution polymerization
    • Post-curing with temperature ramp for network stabilization
    • Granulation or extrusion prior to final molding or lamination

    Final product types

    • High-performance polyimide films and sheets
    • Phenolic-based circuit boards
    • Automotive resin composite panels
    • Electronic encapsulation materials

    3. Pharmaceutical Intermediate for Antineoplastic APIs

    In the regulated synthesis of antineoplastic active pharmaceutical ingredients, 1,4-Dihydroxynaphthalene provides a distinct aromatic core for specific heterocycle precursors. Its controlled oxidation and alkylation steps yield critical intermediates for small-molecule oncology drugs. Batch traceability, residual solvent minimization, and cross-contamination control are strictly enforced under GMP protocols. Accurate stoichiometry and purity levels support consistent API yield, and all manufacturing documentation can be audited from raw material intake to final finished intermediate.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for APIs
    • USP-NF Monographs (where applicable)
    • EU GMP Vol. 4 Part II, API Section
    • EDQM CEP Certification requirements

    Typical usage ratio

    • Equimolar to limiting reagent in intermediate synthesis; usually 1:1–1.2:1 per API batch size
    • Adjusted according to final API route and impurity profile

    Downstream process integration

    • Direct addition to heterocyclic ring construction vessels
    • Sequential oxidation/alkylation in closed GMP systems
    • Intermediate isolation and purification via preparative HPLC
    • Full analytical QC prior to API step-up

    Final product types

    • Intermediates for antineoplastic agents (e.g., naphthalene-based kinase inhibitors)
    • Specialty starting materials for bulk APIS
    • Batch-registered pharmaceutical intermediates
    • Reference standards for regulatory submissions

    4. Industrial Antioxidant Blending for Lubricants

    Lubricant formulators use 1,4-Dihydroxynaphthalene as a synergistic antioxidant to extend service life in high-temperature grease and synthetic oil products. The compound scavenges radical species that degrade base stocks under thermal stress. Addition takes place during the blending phase, ensuring full dissolution and stability in mineral or synthetic matrices. Adjustment of dosage ensures balancing of oxidation resistance without compromising lubricant viscosity or foaming properties. Analytical confirmation of dispersion stability forms part of standard QC release.

    Industry compliance standards

    • ASTM D943 Oxidation Stability Test
    • DIN 51517 (Industrial Lubricant Standard)
    • API Base Oil Group III–V Guidelines
    • ISO 6743 Lubricants and Related Products

    Typical usage ratio

    • 0.05–0.25% by weight in finished lubricant; increased to 0.4% for synthetic ester bases
    • Formulator may adjust concentrations based on base oil volatility

    Downstream process integration

    • Solution blending during final compounding
    • Solubilization at elevated temperatures (60–80°C)
    • Homogenization with mixing systems before package filling
    • Laboratory QC for antioxidant dispersion and LB value

    Final product types

    • High-temperature lithium complex greases
    • Hydraulic fluids for heavy machinery
    • Synthetic ester and PAO-based crankcase oils
    • Special-purpose compressor oils
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    Certification & Compliance
    More Introduction

    1,4-Dihydroxynaphthalene: Reliable Raw Material Backed by Direct Manufacturing Experience

    Our Deep Roots in the Production of 1,4-Dihydroxynaphthalene

    In over two decades spent developing and optimizing our process for 1,4-Dihydroxynaphthalene, we have seen firsthand what matters most to customers and fellow manufacturers. It’s easy to talk about purity and consistency, but we’ve learned exactly how traced origins and tightly-controlled conditions make a difference at every downstream stage—whether someone’s running a pharmaceutical synthesis or blending a specialty pigment.

    Our focus goes beyond ticking boxes for assay, loss on drying, or color standards. Every kilogram that leaves our site tells a story of controlled temperature, monitored pH, and feedback from chemists who actually run the reactions. The result: 1,4-Dihydroxynaphthalene (cas 104-48-3), recognized by its chemical structure as C10H8O2, in powder or crystalline form, hitting an assay typical of 99.5% and higher, with our color controlled to the pale tan or off-white required by refiners and formulators alike. This particular profile not only meets, but supports the fine needs of technical users.

    Key Reasons Customers Rely on Directly Manufactured 1,4-Dihydroxynaphthalene

    Handling 1,4-Dihydroxynaphthalene calls for attention to both purity and physical appearance. We see how a lot can go wrong with product handled too many times or moved through a patchwork of third-party traders: contamination, inconsistent batch color, or mysterious variations in particle size. “Off” batches mean lost time for you—reprocessing, extra dissolution steps, or, in the worst cases, scrapping entire lots. More than once, our clients told us that switching to manufacturer-direct material fixed these chronic headaches.

    From a technical side, the depth of our process control—careful timing on oxidation steps, multiple filtration passes, regular GC and HPLC checks—marks the real contrast with generic, trader-grade lots. We have had customers send us comparative samples: shadows of fine tan powders beside crude yellows, aging greys under poor storage, and crystalline chunks with variable solubility. End-users see the difference in how powders dissolve and react: uneven material can mean undissolved particles settling out, or side-products showing up in your own analytics. Real purity is evident in the reaction flask, not just on a CoA.

    Specifications That Reflect Real-World Chemistry

    We have standardized on tight assay, water-content, and impurity controls, but that doesn’t tell the whole story. Every batch we produce gets verified for key characteristics that matter when the ingredient moves to dye or pharmaceutical use. Usually, this means pushing for 99.5% to 99.9% assay by HPLC, keeping residual napthol (1-naphthol and 2-naphthol) under strict limits, and making impurity profiles transparent. In the case of a reactive intermediate like 1,4-Dihydroxynaphthalene, small amounts of these by-products can cause downstream reactions to stall or introduce colors nobody wants.

    Our customers often ask for specific particle size targets. We manage crystallization conditions so the powder is easy to handle and quick to dissolve at production scale. For some clients, we supply air-tight, lined packaging that guards against oxidation during storage—a request that came from real feedback about delayed oxidation shading material brown. This sort of concrete, bench-level requirement gets incorporated into our workflow.

    Applications Backed by Direct Manufacturing Know-How

    Manufacturers choosing 1,4-Dihydroxynaphthalene use it for a few key purposes: as a building block for synthetic dyes, a precursor for pharmaceutical intermediates, and as a reagent for analytical and organic transformations. The dye industry depends on the intact dihydroxy-naphthalene skeleton for producing azo and anthraquinone pigments. Synthetic routes demand a product that dissolves smoothly, not just for lab-scale but on industrial reactors where time and batch turnover count.

    In pharmaceutical applications, the presence of even minor impurities can complicate chiral resolution or side-product control during critical steps, especially when working with an active moiety as sensitive as naphthalene derivatives. Our plant’s feedback loop with major pharma clients underscores why nothing substitutes for strict, lot-by-lot documentation—not just a certificate, but supporting chromatograms and real explanations for any deviation.

    Other sectors turn to 1,4-Dihydroxynaphthalene for its redox chemistry—antioxidant additives, stabilizers for plastics or rubbers, and even as a reference standard for analytical methods in quality labs. In all cases, it’s years of practical supply, not sticker-label promises, that build trust.

    Quality Built From the Ground Up (Not Just On Paper)

    Maintaining strict quality demands more than standardized procedures. Our team—several of whom have stayed with the company since the first commercial batch—views every stage as part of a closed feedback loop. This means raw material inspection, pre-reaction checks, post-crystallization drying, and fingertip-level daily assessment of environmental controls. Our process chemists spot small pH deviations before they snowball. The operations crew knows the color and feel of a right batch. QC teams test each drum for both expected and out-of-spec characteristics.

    We hear from our partners that these steps separate us from dealers offering untracked, relabeled lots. Our manufacturing data logs, repeatable lab methods, and control charts all serve to eliminate guesswork, not simply generate paperwork. We’re able to document deviations, explain them honestly, and adjust on the fly. This hands-on approach means fewer surprises for users and more reproducible performance in their own applications.

    Some clients request low-residue, fine-particle grades because their equipment demands it; others need a granular or nearly dust-free product because they handle multi-tonne bins. We respond to these requirements—not by rewriting brochures, but by running real process trials and adjusting conditions. This hands-on development creates material users can work with, batch after batch.

    Key Differences: Direct-Manufacture vs. Resold 1,4-Dihydroxynaphthalene

    One frequent discussion we have with technical buyers concerns the visible and hidden differences between direct-manufactured material and product sourced through many trading layers. In day-to-day practice, we see that trader-supplied lots often lack batch-level traceability. Without origin records and fresh analysis, buyers risk receiving mixed or outdated material. Direct manufacturing creates a level of transparency that becomes critical if anything unusual turns up in downstream testing.

    Physical appearance and reactivity also differ. With a fresh batch—produced, tested, and shipped under our own control—expect consistent color, minimal caking, and single-lot documentation. Traders often break bulk, combine partial lots, or repackage; uncontrolled exposure leads to brown or grey off-shades, and moisture-laden clumps. This is not just an aesthetic issue: discoloration or moisture content directly impacts solubility and reaction rates.

    A second point involves the impurity profile. Our manufacturing process manages typical impurities well below industry thresholds, targeting them specifically because even sub-percent levels have triggered customer complaints: slow dissolving powder, visible insolubles in solution, or analytic interference in end-products. Other sources might not report these levels in detail or pool lots from multiple productions, creating risks of outliers.

    Dye makers in particular highlight how a slight yellow tinge can shift color shades, throwing off batch-to-batch reproducibility. Our continuous feedback from these users lets us fine-tune our own QA triggers and batch-release criteria. All our efforts aim at reliability, not just minimum compliance.

    Addressing Challenges Raised by Chemists in the Field

    We keep a continuous dialogue with formulation chemists and plant engineers. Over the years, they shared recurring issues that arise with non-manufacturer 1,4-Dihydroxynaphthalene: excessive fines causing filter clogging, non-uniform reactivity leading to variable dye output, or unanticipated by-products in pharmaceutical syntheses. To tackle these concerns, we revisit our own process with each genuine issue raised—modifying crystallization, adjusting drying temperatures, or improving post-packaging air barriers.

    One issue flagged by pigment blenders came down to bulk density inconsistency, which caused dosing errors on automated lines. In response, we invested in process controls to deliver repeatable tap densities with each lot. Another story comes from a pharmaceutical partner who faced regulatory questions about trace-level contaminants. Our direct records—not only on the lot in question, but several previous lots—provided the traceability they needed.

    Storage and transport present their own issues. Aromatic compounds like 1,4-Dihydroxynaphthalene can undergo slow oxidation if left exposed. Learning from cargo returns, we implemented robust, moisture-proof packing with color-change indicators to guarantee product reach unaffected. Feedback also highlighted needs for tamper-evident sealing, a change we brought in years ago, now industry standard among our clients.

    Continuous Process Improvement: Sharpened by Real-World Use

    Adjusting to user experience, we fine-tune our plant protocols to create a product tailored to your application—not just compliant, but actively supportive of your manufacturing flow. Our R&D team evaluates each production run for learnings. Large-scale dye-makers need assured solubility and consistent color, and we tweak process water content and filtration cycles based on feedback. For API (Active Pharmaceutical Ingredient) synthesis, reagent purity and residual moisture move from “nice to have” to mission-critical, so our control plans double down on these parameters before approval.

    Once in a while, novel uses pop up—resins, specialty coatings, niche antioxidant blends. Each new market brings a different set of physical demands, and our scale allows quick adjustments. If a paint-maker faces graininess in the mill, we dig in with them, run grind tests, and modify drying or screening steps to solve the real-world problem. Creative solutions often emerge from the lab floor, not just office meetings.

    Long-term customer relationships mean open exchanges of application trial results: analytics of how different impurity levels or morphologies affect their overall product. Both sides learn and adapt, improving end output and moving the industry forward.

    Upholding Safety, Regulatory, and Environmental Commitments

    Having worked with regulated clients worldwide, we get that compliance doesn’t start and end in paperwork. Our facility follows a strict internal hazard communication standard—labels, material handling instructions, and storage protocols—alongside day-to-day monitoring of environmental markers. All team members receive practical training in spill response and personal protective equipment.

    From an environmental standpoint, process analytical tools track by-product formation and effluent at every stage, allowing us to minimize chemical losses and environmental impact. Beyond compliance, this means smaller waste streams, leaner operations, and safer workplaces. Waste management includes solvent recovery and secondary by-product capture, turning former liabilities into secondary revenue streams.

    Packaging and logistics adapt to regional requirements—including tamper-evidence, restricted substance disclosures, and specific transport modes for sensitive cargoes. We support downstream regulatory efforts by providing full origin and compositional documentation—backed by years of experience handling audits and site visits from global partners.

    Loyalty Built on Experience: The Manufacturer’s View

    Longevity in manufacturing teaches hard lessons. Whenever new options flood the market, cost pressures tempt buyers to take chances on unproven suppliers. Direct experience shows that shortcuts on source and process history lead to higher downstream risks—recalls, lost batches, regulatory headaches. End-users come back to our team once they realize the value in working with the original source: immediate answers to technical queries, site audits if needed, open access to batch manufacturing records, and transparent handling of any complaint or issue. Building trust pays back in long-term dependability you can plan on.

    Our strength in making 1,4-Dihydroxynaphthalene, tested across millions of kilograms shipped, anchors not just our market position but helps stabilize supply chains for clients who demand quality “from the ground up.” Through open collaboration, ongoing technical field support, and regular process improvement, we help ensure that your raw material fits your workflow—so your own output keeps meeting the standards your field, and your reputation, demand.