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1,4-Dihydroxy-2-Naphthoic Acid

    • Product Name 1,4-Dihydroxy-2-Naphthoic Acid
    • Alias DHNA
    • Einecs 204-195-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    667808

    Productname 1,4-Dihydroxy-2-Naphthoic Acid
    Casnumber 16721-39-4
    Molecularformula C11H8O4
    Molecularweight 204.18 g/mol
    Appearance Light yellow to tan solid
    Meltingpoint 276-280°C
    Solubility Slightly soluble in water, soluble in ethanol and DMSO
    Boilingpoint Decomposes before boiling
    Density 1.49 g/cm³
    Purity Typically ≥98%
    Synonyms 2-Carboxy-1,4-dihydroxynaphthalene
    Smiles C1=CC2=C(C(=C1O)C(=O)O)C(=CC=C2)O
    Inchikey LOFTAEOUHDSLOS-UHFFFAOYSA-N

    As an accredited 1,4-Dihydroxy-2-Naphthoic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 1,4-Dihydroxy-2-Naphthoic Acid is packaged in a 25-gram amber glass bottle with a secure screw cap, labeled for laboratory use.
    Shipping 1,4-Dihydroxy-2-Naphthoic Acid should be shipped in a tightly sealed, chemical-resistant container, clearly labeled, and protected from moisture and light. It must comply with local, national, and international regulations for chemical transport, including appropriate hazard labeling, documentation, and, if required, use of secondary containment to prevent leaks or spills during transit.
    Storage 1,4-Dihydroxy-2-naphthoic acid should be stored in a tightly sealed container, protected from light and moisture. Store at room temperature, ideally in a cool, dry, and well-ventilated area, away from incompatible substances like strong oxidizing agents. Proper storage prevents degradation and ensures safety when handling this organic compound. Always follow relevant safety regulations and guidelines.
    Application of 1,4-Dihydroxy-2-Naphthoic Acid

    Applications of 1,4-Dihydroxy-2-Naphthoic Acid in Industrial Manufacturing

    As a direct manufacturer, we supply 1,4-Dihydroxy-2-Naphthoic Acid (DHNA) to downstream sectors with established technical requirements. Our experience covers multiple application tracks where DHNA functions as an essential intermediate in regulated syntheses and specialty materials. Our technical and QC support aligns with detailed industry process controls and quality standards adopted by major multinational producers.

    1. Synthesis of Vitamin K2 (Menaquinone) for Pharmaceutical Manufacturing

    Pharmaceutical producers incorporate DHNA as a key intermediary in the synthesis pathway of Vitamin K2, particularly the menaquinone-4 (MK-4) and menaquinone-7 (MK-7) types. Fine chemical synthesis of these vitamins requires strict purity and quality controls. Our DHNA integrates midway through the multi-step condensation process, with final purification to pharmaceutical grade driven by GMP protocols. End users require batch-level traceability and validated supply chain documentation for regulatory filings and audits.

    Industry compliance standards

    • Good Manufacturing Practice (GMP) – EU EudraLex Volume 4 & US 21 CFR Part 210/211
    • ISO 9001:2015 Quality Management Systems
    • European Pharmacopoeia (Ph. Eur.) for Vitamin K2 endpoints
    • Japan Pharmaceuticals and Medical Devices Act (PMDA) for APIs

    Typical usage ratio

    • Ranges from 3% to 7% molar equivalent, depending on required yield and downstream step efficiency in Vitamin K2 synthetic routes.

    Downstream process integration

    • Introduced after primary naphthol derivatization, ahead of global methylation.
    • Reacted under controlled temperature and catalyst environment to generate intermediate precursors.
    • Subjected to chromatographic purification before subsequent condensation.
    • Real-time QC sampling required at integration stage for impurities.

    Final product types

    • Vitamin K2 pharmaceutical raw materials (MK-4, MK-7)
    • Finished Vitamin K2 tablets, capsules, ampoules
    • Vitamin K2 food supplements for nutraceutical markets

    2. Dye Intermediate for High-Purity Pigment Manufacturing

    Pigment and specialty dye manufacturers apply DHNA within the synthetic route for producing metal-complex and anthraquinone dyes. These applications involve controlled oxidative coupling and sulfonation reactions, with DHNA ensuring consistent hue and performance in high-value pigment formulations. Batch process design focuses on solvent compatibility, filtration efficiency, and downstream purity. Our supply supports strict colorant QC and traceability for the textile and plastic sectors.

    Industry compliance standards

    • REACH (EC 1907/2006) registration for chemical intermediates
    • ISO 9001:2015 for colorant production control
    • ETAD (Ecological and Toxicological Association of Dyes and Organic Pigments Manufacturers) Product Stewardship
    • OEKO-TEX® Standard 100 for finished textile dye applications

    Typical usage ratio

    • 0.5%–1.2% by weight of total batch, depending on desired chromophore intensity and final pigment shade.

    Downstream process integration

    • Dosed during primary oxidation or coupling with metal salts.
    • Acts as nucleation core for pigment molecule assembly.
    • Purification via solvent extraction prior to final milling and micronization.
    • Monitored for residual reactant by HPLC analysis to meet colorant specifications.

    Final product types

    • Anthraquinone-based textile dyes
    • High-stability organic pigments for plastics masterbatch
    • Metal-complex dyes for inkjet and industrial printing
    • Specialty coatings and paint colorants

    3. High-Performance Polymer Additive in Liquid Crystal Polymer (LCP) Synthesis

    Producers of high-performance engineering plastics utilize DHNA as a monomer or co-monomer in the synthesis of specialty liquid crystal polymers. Here, DHNA participates in polycondensation reactions, conferring rigidity, thermal stability, and dimensional strength required in high-temperature components. Our QC processes support precise functional group content and ultra-low metal residues tailored to polymer industry requirements. Integration into proprietary formulations ensures downstream property consistency.

    Industry compliance standards

    • ISO 9001:2015 and ISO 14001:2015 for polymer manufacturing
    • RoHS (EU Directive 2011/65/EU) for restricted substances in electrical applications
    • UL 94 flame rating for final LCP components
    • ASTM D789 for LCP resin evaluation

    Typical usage ratio

    • 2%–8% by molar ratio within total monomer feed for thermotropic LCP polymerization; optimized based on end-use mechanical properties.

    Downstream process integration

    • Charged into reaction vessel with other monomers and catalysts.
    • Subjected to step-growth polycondensation under reduced pressure and elevated temperature.
    • Removed unreacted DHNA via devolatilization post-condensation.
    • Incorporated into pelletizing and compounding steps prior to extrusion.

    Final product types

    • LCP granules for injection molding
    • High-temperature automotive and electronics connectors
    • Fiber optic cable sheathing compounds
    • Thin-wall microelectronic components

    4. Specialty Analytical Reagent for Chromatographic Application

    Laboratory reagent manufacturers incorporate DHNA as an analytical standard and derivatization reagent in specialized HPLC, TLC, and GC analyses. Its well-characterized structure allows use as a reference for naphthoquinone-related compound detection in food safety, pharmaceutical QC, and metabolomics. Formulation and packaging comply with analytical reagent grade requirements, supporting downstream customer demand for batch-to-batch traceability and purity documentation.

    Industry compliance standards

    • ISO 17034:2016 for reference material producers
    • USP <621> for chromatography suitability
    • IUPAC purity assessment protocols
    • ISO/IEC 17025:2017 for analytical laboratory reagents

    Typical usage ratio

    • 10–500 µg/mL for HPLC calibration solutions; varies with detection limit and solvent system.

    Downstream process integration

    • Dissolved in solvent matrix for reference calibration or derivatization.
    • Utilized as an internal standard in metabolite quantification protocols.
    • Dosed into analyte sample prior to chromatographic injection.
    • Packaging adapted to avoid photodegradation and contamination risks.

    Final product types

    • HPLC-grade analytical standards
    • Derivatization reagents for laboratory chemical testing kits
    • Prepared mobile phases and control samples
    • Certified reference material sets for research and compliance labs

    5. Agrochemical Intermediate for Plant Growth Regulator Synthesis

    Agrochemical manufacturers employ DHNA as a building block in the synthesis of plant growth regulators and selective herbicides. Reactions typically involve coupling with other aromatic precursors to create bioactive compounds that undergo further formulation for agricultural application. Production follows agrochemical GMP, emphasizing consistent impurity profiles and toxicity documentation for regulatory registration and end-user application safety.

    Industry compliance standards

    • FAO/WHO specifications for pesticide active ingredients
    • ISO 9001:2015 for agrochemical synthesis and QC
    • OECD Guidelines for the Testing of Chemicals
    • EPA regulations (40 CFR Part 180) for agricultural chemical residues and registrations

    Typical usage ratio

    • 1.5%–4% by weight of total formulation batch, adjusted based on target product and efficacy studies.

    Downstream process integration

    • Reacted during initial aromatic substitution steps with other active intermediate chemicals.
    • Processed through acidification, isolation, and solvent exchange before downstream blending with adjuvants.
    • Incorporated into microemulsion or granular formulations for field application trials.
    • QC sampling for trace residues and metabolite profiling prior to registration.

    Final product types

    • Active ingredient for plant growth regulator (PGR) formulations
    • Precursor to selective herbicides for row crop agriculture
    • Soil amendment products for specialty crop markets
    Free Quote

    Competitive 1,4-Dihydroxy-2-Naphthoic Acid prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    1,4-Dihydroxy-2-Naphthoic Acid: Straight from Our Chemical Plant

    From the Production Floor: What Sets 1,4-Dihydroxy-2-Naphthoic Acid Apart

    Down at our facility, we see 1,4-Dihydroxy-2-Naphthoic Acid as more than just a chemical compound with a long name. Among the line-up of naphthoic acids, this one earns regular demand from customers who work in dyes, pigments, and even in pharmaceutical research. We talk directly to researchers and engineers, not just distributors, so we get constant feedback on how each batch performs in actual applications. Batches stamped with model numbers like QX1048 or sometimes QX1120 reflect our own production schedules—each lot goes through full spectral analysis and impurity screening, and we keep records on every blend to ensure batch-to-batch consistency.

    Chemical purity serves as the dividing line in our industry. Any trace of unwanted ions or organic matter can send a synthesis reaction sideways or spoil finished pigments. With 1,4-Dihydroxy-2-Naphthoic Acid, we’ve learned a hard lesson: even a half percent of impurity can alter color strength or throw off downstream reactions. We maintain a typical purity well above 98.5%, and we monitor not just melting point but also moisture to levels often under 0.2%. Moisture control sounds trivial, but a batch that sails through lab testing might ruin a vat of finished dye if it carries hidden water.

    Physical Form and Handling Insights

    On the plant floor, this compound comes in off-white to pale tan crystals—sometimes with a hint of yellow depending on the trace iron left in the process stream. Unlike some clumpy industrial powders, our product grains pour easily, and we put time into processing at low humidity to stop caking or bridging inside storage drums. Packaging in sealed polyethylene-lined drums keeps the product protected from air. We don’t just slap a liner on for regulatory reasons; we’ve actually seen what happens when a cheap bag lets in atmospheric moisture—a ruined batch, wasted labor, and an unhappy customer.

    Many buyers want to compare granularity or flowability across naphtholic acids. Wet-milled batches often end up dusty and hard to pour. In contrast, our process includes a controlled cooling and drying step, which builds up a consistent grain size. This saves headaches during high-volume blending or feeding into reactors. Even minor reductions in dust levels make a difference—not only in plant hygiene but also in quality claims from downstream users.

    We’ve picked up feedback from pigment plants showing that the easier the material flows, the lower the loss per batch. Over the years, we’ve optimized particle size to a happy medium—not so fine that it cakes, not so coarse that it leaves residues in mixing hoppers.

    Applications in Everyday and High-End Industries

    On paper, 1,4-Dihydroxy-2-Naphthoic Acid hooks into several sectors: pigment manufacture, pharmaceutical research, and special dyes. From our vantage point, pigment developers contact us most. This acid serves as a backbone ingredient for azo pigments, as well as for lake pigments and specialty colorants. It reacts smoothly in diazotization and coupling processes, lending both depth and stability to orange and red hues. Customers in India and Germany have told us our material passes their batch screening tests for color strength and dispersion speed.

    Research outfits come to us when they need intermediates for vitamin K analogs or rare benzoquinone derivatives. They run small reactions first and often request technical samples straight from the line—same lot as the main production—so what they test in the lab matches what they receive at scale. Pharmaceutical ingredient processors ask sharply about elemental contaminants. We keep the heavy metals, especially lead and arsenic, below even the tightest global thresholds, running atomic absorption checks on every bulk shipment.

    Smaller customers often look for ease of dissolution in polar solvents for batch synthesis. Our material dissolves in warm methanol or ethanol, which speeds up charging reactors and eliminates clumping. As producers, we see firsthand how solvent and temperature play into plant safety and final product quality. Many pigments require a high-purity precursor to avoid toxic byproducts that occur from trace contamination, so our team works closely with R&D divisions to share lab data for every run. This gives our customers confidence that a change in process won’t end up costing them a small fortune in rework.

    A handful of newer applications are emerging as well. Some polymer engineers have begun testing this naphthoic acid in specialty polymers where conventional aromatic acids fail to hold up against heat and chemical stress. Feedback tells us that its two phenolic groups anchor well into complex polymer matrices, boosting weather resistance and lifespan. While this is a niche at the moment, we’re investing time in pilot batches to see how far the chemistry can stretch.

    Comparing 1,4-Dihydroxy-2-Naphthoic Acid with Other Naphthoic and Benzoic Acids

    We field many questions about the real-world differences between this naphthoic acid and competitors. To someone buying off a spreadsheet, 1,4 and 2,6 isomers of dihydroxynaphthoic acid might sound interchangeable. Our chemists know otherwise. Lab tests on color yield, solubility, and compatibility with amines show clear changes depending on isomer placement. Customers who switch from 2,6- to 1,4- find reaction rates shift and sometimes require recalibration of mixing and reaction times. Over the years, we’ve seen manufacturers save costs by switching to our 1,4- version because the lower impurity profile helps with higher yields and cleaner filtrates.

    Benzoic acid analogs sometimes compete for the same market. From batch records and customer feedback, we see that 1,4-Dihydroxy-2-Naphthoic Acid builds stronger pigment-metal complexes compared to hydroxybenzoic acids. These complexes survive harsher light and chemical attack, expanding the lifespan of finished pigments in outdoor and automotive applications. Across multiple shipments per year, our customers in coatings and plastics send us performance data pointing to a measurable drop in degradation rates when they switch over to this raw material.

    Quality Control and Traceability—From Raw Feedstock to Final Product

    Anyone who’s worked in a chemical plant knows quality control isn’t just paperwork—it’s a full-time job. Each drum that leaves our site comes from a batch charted from the moment naphthalene feedstock crosses our gate, all the way through synthesis, purification, and drying. We control raw inputs to avoid phenolic contamination, which is a perennial challenge if feedstock batches stray off-spec. Gas chromatography and HPLC results drive our accept/reject decisions, not sales quotas or outside pressure.

    Years ago, before we invested in new purification lines, we struggled with off-hue batches and poor reproducibility. That cost us customers, plain and simple. Now, we dedicate time after each run to cross-check melting point, pH, moisture, and particle size—not just once, but at multiple stages—so nothing slips through. Our operators check during, not after, filtration and crystallization. Cutting corners in process control only leads to customer complaints and wasted labor.

    We receive requests for individual certificates of analysis with every shipment. Our records go beyond regulatory compliance—they detail impurity profiles, trace solvent residue, and even test for batch-specific variables like non-organic chloride or iron. We hold samples from each lot for at least six months in controlled storage. Over the years, this has saved headaches for everyone—especially if a pigment maker or technical buyer comes back long after delivery and needs reference material for troubleshooting.

    Transport, Storage, and Environmental Footprint

    Our chemical plant ships 1,4-Dihydroxy-2-Naphthoic Acid locally and worldwide. We learned early that transport stress can damage the quality just as much as poor manufacturing. Drums spend time bouncing on trucks and inside containers, so we seal against not only moisture but also atmosphere exposure. Product that moves through shipping in breezy containers runs a risk of moisture gain and caking. Every shipment from our site includes not just labeling for regulations but solid packaging designed to protect product quality until the customer’s first opening.

    Proper storage once the product leaves our site protects both the material and the end user. This acid prefers a cool, dry environment with minimal temperature swings. Some customers in warmer climates ask about the effect of heat, and our data shows prolonged storage over 35°C can trigger degradation or color shift. That’s why we advise against warehousing near steam lines or in the top racks of non-ventilated facilities. In our own inventory, we monitor humidity constantly to mimic real-world conditions before units leave our factory.

    Workplace safety and environmental management are not afterthoughts. Workers handling 1,4-Dihydroxy-2-Naphthoic Acid use gloves and masks to prevent skin or inhalation exposure. We train every staff member in containment and quick response in case of spills. Waste from production enters a solvent recovery stream and the resulting residue gets sent for secure incineration. This limits our environmental emissions per ton produced. After hearing how coastal regulations grow tighter each year, we reviewed our own protocols and replaced outdated solvent wash processes with closed-loop systems, bringing our facility below new local emission thresholds.

    Listening to the Real Needs of End Users

    Raw material buyers often face a gap between what a supplier promises on paper and what production lines experience in real time. Over the years, we stopped focusing only on spec sheets and started talking directly with pigment engineers, formulation chemists, and lab directors. Input from these conversations guides our process changes and helps us prioritize improvements that matter. In one case, our team identified a recurring dusting problem at load-out; by adjusting our dryer cycle and implementing a custom sieving step, the user’s downstream filter clog issue disappeared.

    Working with academic labs has become part of our routine—graduate students and postdocs send us questions about reactivity, stability in various solvents, and safe waste disposal. This dialogue empowers us to provide application notes and technical assistance, not just product shipments. We see this as an ongoing loop rather than a one-time sale. Reliable feedback creates a cycle of mutual improvement; it leads to better production planning, fewer interruptions, and higher material utilization at both ends.

    A few years ago, a high-end pigment company reached out after running dozens of trial syntheses with commercial-grade naphthoic acid from another source—none passed their lightfastness tests. Our technical support team walked them through our purification steps, then provided direct data showing how our impurity control led to consistently stronger pigment-metal complexation. Within three shipments, they reported production yields up by over 8%, with a tangible decrease in on-site waste.

    Challenges We Face and How We Tackle Them

    No production process runs without rough patches. Sourcing high-quality naphthalene or keeping solvents pure costs time and money. Price swings in feedstock ripple across our operation, but we’ve learned not to chase the lowest-cost path at the expense of quality. Every time we tried that route in the past, claims and rework ate away any gains. Investing in reliable suppliers for key feedstocks and reinforcing our ties to local quality labs now saves on recall costs and keeps end-user trust high.

    Purification stands out as the most resource-intensive step. Traditional batch crystallization loses product yield and burns extra solvent. Over recent years, feedback from customers—especially those in low-moisture or chlorine-sensitive applications—has convinced us to switch to multi-stage purification. This takes more effort up front, but by re-circulating solvents and passing intermediate fractions through additional adsorption beds, we reach impurity reductions impossible by single-step purification.

    Another ongoing challenge involves documentation and traceability. Regulatory requests, especially from pharmaceutical companies and international pigment producers, have grown strict. Our record-keeping now captures everything from raw batch origin, processing logs, lab test results, and even drum seal verification. Auditors visit regularly; we welcome them not as an obstacle, but as a way to build long-term reliability across the chain.

    What We’re Working Toward

    Innovation in 1,4-Dihydroxy-2-Naphthoic Acid production doesn’t just mean process tweaks. We’re collaborating with pigment innovators exploring new color shades, stability enhancers, and even less hazardous processing conditions. Partnerships with academic groups keep us on our toes, prompting deeper investigations into catalytic pathways and greener purification.

    Feedback shapes new investment. Current efforts go into reducing energy use in drying steps and rethinking water management in cleaning cycles. We’re building energy recovery into our steam systems and optimizing utility use without sacrificing batch quality. Safety upgrades never stop; we refresh staff training annually and update PPE protocols ahead of regulatory shifts. Benchmarking our environmental numbers against regional competitors, we strive to steady our footprint even as production volumes grow.

    As a manufacturer, not a middleman, we stand by each drum we ship. The real measure of our 1,4-Dihydroxy-2-Naphthoic Acid comes from those who use it directly: pigment plants, drug ingredient labs, research teams, and increasingly, specialty polymer engineers. We welcome questions, complaints, and raw feedback, because continuous improvement is more than a slogan—it’s the reality of earning customer loyalty in the chemicals industry.