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1,4-Dibromo-2-Butanol

    • Product Name 1,4-Dibromo-2-Butanol
    • Alias 1,4-Dibromo-2-hydroxybutane
    • Einecs 221-384-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    984640

    Chemicalname 1,4-Dibromo-2-Butanol
    Casnumber 5406-35-1
    Molecularformula C4H8Br2O
    Molecularweight 231.92
    Appearance Colorless to pale yellow liquid
    Density 1.904 g/cm3
    Solubility Slightly soluble in water
    Ecnumber 226-448-4
    Pubchemcid 12590

    As an accredited 1,4-Dibromo-2-Butanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, 100g, with hazard labels, screw cap, clear chemical name and CAS, manufacturer's name, tamper-evident seal.
    Shipping 1,4-Dibromo-2-Butanol is shipped in tightly sealed containers, compatible with brominated compounds, and clearly labeled according to hazardous chemical regulations. It is transported in accordance with UN, DOT, and IATA guidelines, protected from heat, moisture, and incompatible substances, and handled by trained personnel to ensure safety during transit.
    Storage **1,4-Dibromo-2-Butanol** should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizers. Keep the container protected from light and moisture. Store at room temperature and clearly label the chemical. Use appropriate personal protective equipment (PPE) when handling and storing.
    Application of 1,4-Dibromo-2-Butanol

    Applications of 1,4-Dibromo-2-Butanol in Industrial Manufacturing

    As a direct manufacturer, we support diverse sectors by supplying 1,4-Dibromo-2-Butanol for process-critical roles. Below, we detail verified downstream applications in specialized industries, specifying compliance guidelines, integration points, and resulting products for effective formulation choices.

    1. Active Pharmaceutical Ingredient (API) Intermediate for Cephalosporin Synthesis

    Pharmaceutical manufacturers use 1,4-Dibromo-2-Butanol as a synthetic intermediate in the multi-step production of certain cephalosporin antibiotics. Its dual-bromo functionality provides efficient halogen introduction during β-lactam ring construction. Strict impurity control is necessary, and all material batches undergo full traceable quality checks according to validated methods.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP, 21 CFR Parts 210/211, US FDA)
    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • Ph. Eur., USP, and JP relevant monographs for cephalosporin compounds
    • ISO 9001:2015 for quality management in pharmaceutical manufacture

    Typical usage ratio

    • Typically between 0.8–1.2 molar equivalents per target antibiotic cycle, adjusted for intermediate hydrolysis rate and residual bromide check

    Downstream process integration

    • Material is charged to the reactor during the alkylation or halogenation stage
    • Used ahead of the β-lactam condensation to introduce dual bromide groups precisely
    • Impurity purging with in-process controls is performed before subsequent synthetic steps

    Final product types

    • Oral and parenteral cephalosporin antibiotics (e.g., cefuroxime intermediates)
    • Bulk API substances for formulated pharmaceutical dosage forms

    2. Intermediate for Agrochemical Synthesis — Herbicide and Fungicide Manufacturing

    Major agrochemical producers select 1,4-Dibromo-2-Butanol as a key intermediate in the synthesis of brominated herbicidal compounds and select fungicide scaffolds. Manufacturers rely on its controlled reactivity during selective bromine introduction, supporting cost-effective, high-yield synthesis. Safe handling and environmental controls remain essential during integration in continuous production lines.

    Industry compliance standards

    • FAO/WHO Joint Meeting on Pesticide Specifications (JMPS)
    • ISO 9001:2015 for chemical and agrochemical production management
    • REACH Regulation (EC 1907/2006) for upstream chemical safety assessment
    • OECD Principles of Good Laboratory Practice (GLP) for analytical testing

    Typical usage ratio

    • Usually 1.0–1.3 molar equivalents per batch, depending on target bromination selectivity and required purity for downstream chlorination or coupling reactions

    Downstream process integration

    • Fed to the primary synthesis vessel during the halogen exchange or cyclization steps
    • Downtime minimized by inline monitoring for conversion endpoints and release tests for unreacted starting material

    Final product types

    • Brominated phenoxyalkyl herbicides
    • Certain substituted dicarboximide fungicides (non-consumer)
    • Protected intermediate stock for downstream formulation into crop protection agents

    3. Performance Polymer Synthesis — Specialty Polyurethane Chain Extender

    Specialty polymer producers employ 1,4-Dibromo-2-Butanol as a reactive chain extender during the manufacture of engineered polyurethanes. Its bifunctional brominated structure enhances flame retardancy and mechanical strength when incorporated at precise stoichiometry, supporting high-end application requirements. Operators perform continuous monitoring for possible crosslinking and batch consistency.

    Industry compliance standards

    • ISO 9001:2015 for polymer compounds QC
    • UL 94: Standard for Flammability of Plastic Materials
    • RoHS Directive (2011/65/EU) for allowed bromine content
    • Registration under REACH when exported in relevant volumes

    Typical usage ratio

    • Ranges from 0.2–0.6 molar equivalents relative to diisocyanate in prepolymer batches; ratio optimized for target flame retardant behavior and mechanical modulus

    Downstream process integration

    • Added after prepolymer formation in the polyurethane reactor line
    • Polyol mixture stirred with diisocyanate and 1,4-Dibromo-2-Butanol under controlled temperature
    • Conversion tracked using bromide residual and MDI/NCO titration methods

    Final product types

    • Fire-resistant polyurethane foams for public transit seating
    • Housings for specialized electrical equipment
    • Insulation panels for building safety applications

    4. Fine Chemical Intermediate — Synthesis of Specialty Brominated Additives

    Producers in the fine chemicals sector incorporate 1,4-Dibromo-2-Butanol for controlled preparation of downstream specialty additives, including polymerization inhibitors and process stabilizers. Detailed process control enables bromine placement for tailored end-use performance. Downstream partners require consistently low trace impurities for additive blending.

    Industry compliance standards

    • ISO 9001:2015 certification for fine chemical syntheses
    • REACH pre-registration and substance evaluation (for European market transfer)
    • Customer-specific impurity and trace metal profiles (as per supply agreements)
    • SDS and GHS-compliant labeling for chemical transport and handling

    Typical usage ratio

    • Generally 0.5–1.0 molar equivalents per finished additive, adjusted according to reaction sequence and required brominated end-group functionality

    Downstream process integration

    • Material is introduced at the initial step of the multi-stage synthesis route, frequently during nucleophilic substitution or etherification
    • Process chain maintained under inert conditions to prevent unplanned side-reactions
    • End batch undergoes rigorous purification before isolation as refined additive

    Final product types

    • Brominated process stabilizers for PVC piping
    • Bromine-containing anti-skinning agents for paint and coatings
    • Polymerization inhibitors for manufacturing of resins and adhesives
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    Certification & Compliance
    More Introduction

    Introducing 1,4-Dibromo-2-Butanol: Experience from Inside the Manufacturing Plant

    A Look at 1,4-Dibromo-2-Butanol

    In chemical manufacturing, you don’t just handle substances—you spend hours learning their character, watching how they behave in a reactor, and understanding the details that matter to customers downstream. 1,4-Dibromo-2-butanol has become a regular feature in our processing lines, not because it’s glamorous or rare but because it fills a technical need that other intermediates simply can’t touch. Our team works to keep the process running smoothly and deliver consistent quality, which is especially important for a compound used in applications where reliability matters.

    You may hear about 1,4-dibrominated compounds in classroom settings, but actually working with 1,4-Dibromo-2-Butanol shows you its unique balance: the two bromine atoms on its ends, paired with the central alcohol functionality, create a reactive platform for downstream chemistry. Those features shape both its opportunities and its demands during production. Over years of manufacturing, we’ve refined batch controls and crystallization approaches, tuned purification steps, and worked out storage best practices. These efforts pay off for companies that count on this molecule as a specialty intermediate for polymer, pharmaceutical, or fine chemistry synthesis.

    Specifications and Practical Handling

    Most partners ask for 1,4-Dibromo-2-Butanol in its purest state. Some reactions require more than 98% purity, and we invest in the equipment and testing to hit that standard batch after batch. The product typically takes the form of a pale crystalline solid, easy to dose by weight and manageable in standard chemical drums. While it flows well at room temperature, long-term storage at this scale always means staying mindful of moisture and temperature fluctuations. We consistently monitor for traces of dihalo or monobromo impurities, using gas chromatography and titrations, since even low levels of side products can skew downstream processes.

    The physical properties matter, too. With a melting point not far above room temperature, it requires careful scheduling during hot or humid spells. We've learned over the years to confirm that containers are dry and clean to avoid unwanted hydrolysis or discoloration. What ends up in your hands reflects a chain of practical decisions and real on-the-floor troubleshooting.

    Usage: Supporting Industrial Synthesis and R&D

    No single customer uses 1,4-Dibromo-2-Butanol in quite the same way. We deliver truckloads for pilot polymerizations but also receive requests from research labs for small bottles. Its symmetrical, bifunctional structure gives it clear advantages as a building block when companies look to bridge segments in specialty polymers. Some value the ability to dial in reactivity by exploiting both bromides and the alcohol handle. This can simplify synthesis by cutting out redundant steps or allowing more direct routes to sophisticated molecules.

    In our experience, the real-world uses stretch beyond technical data sheets. Beyond plastics, it has entered proprietary medicinal chemistry routes, agricultural intermediate manufacture, and even some adhesive technologies. Demand has grown in certain sectors where regulations on other halogenated feedstocks have tightened, making this molecule an increasingly important staple in chemical toolkits. It’s hardly a consumer-facing chemical, but it occupies a strategic place in supply chains that ultimately affect products people use every day.

    Differences from Related Compounds

    Plenty of brominated butanols show up in catalogues, but the specific positioning of the bromines and the hydroxyl defines application windows. For example, 2,3-dibromobutanol can participate in similar substitution reactions, yet it rarely gives identical products under industrial conditions; even minor variations in structure can force major adjustments in heat management, solvent choice, and post-reaction purification.

    From a manufacturing angle, 1,4-Dibromo-2-Butanol offers a sweet spot between reactivity and stability. Monobromo analogues often don’t deliver the same coupling efficiency and can require additional steps to match its performance. Diol analogues without bromines lack the same activation, which means slower or less selective transformations further downstream. In practice, end-users see fewer processing hiccups and less effort lost filtering out byproducts—these outcomes rest on small but crucial structural distinctions.

    Challenges in Manufacturing and Shipping

    Despite familiarity, each production campaign brings up its own set of challenges. On some lines, the reaction between butanediol and bromine calls for tight controls on temperature and stirring to fend off runaway side reactions. Early on, we learned that incomplete mixing or trace buffers could skew the ratio of mono- to dibromo species, forcing us to double down on analytical checks before filling any drums.

    Another real consideration is scale. At a few kilograms, almost any procedural hiccup feels manageable: scrubbers keep vapor at bay, waste treatment stays straightforward, and storage is uncomplicated. Scale that up to tons, and small mistakes—tiny leaks, a trace of water, a misjudged pH—take on a life of their own. We upgraded containment two years ago, not in response to any single incident, but after seeing slow but measurable increases in trace emissions. We now track worker exposure with real-time monitors, and we've learned to communicate with customers about what these investments mean for reliability and safety.

    Quality Control: On the Line, Not Just on Paper

    Quality isn’t just a certificate stapled to the carton. Our teams run batch samples through spectroscopic and chromatographic analysis, with techs trained to spot the faintest outliers. There’s a human element, too—experienced hands can notice slight color shifts or premature crystallization that instruments might miss on the first pass. It’s an ongoing process of improvement, not a checkpoint you stamp and forget.

    Customers tend to trust us to keep up standards exactly because our staff have spotted real-life issues before they escalated. A little extra vigilance catches odd smells, hints of decomposition, or a slight tackiness on the final dry product. These observations—gathered over thousands of runs—feed back into tweaks in our procedures, helping future orders show up without any unwelcome surprises.

    Environmental Responsibility and Worker Safety

    From our vantage point, managing a halogenated compound responsibly isn’t just about ticking compliance boxes. Each campaign starts and ends with equipment checks, exhaust ventilation readings, and personal gear reviews. We installed new scrubber units alongside remote sensors in key docking areas after hearing concerns from both staff and local regulators. Some of our long-term operators have suggested practical improvements—extra flush steps, revised training sessions—that actually reduce incidents on the floor.

    Waste management takes up more discussions than many people might guess. Instead of targeting dilution alone, we invested in reclaiming usable byproducts and neutralizing waste in-house. This approach cut haulage costs and reassured neighbors wary of chemical discharge. Our process returns water to a closed-loop system, with bromide recovery units installed last year. These upgrades reflect actual lessons learned over years of day-to-day operations.

    Looking Ahead: Adjusting to Industry Shifts

    Regulatory winds keep shifting, especially around brominated intermediates. Restrictions on persistent organic pollutants and environmental discharge have forced us to become more nimble. We track updates to REACH, EPA, and local environmental standards, and we work with compliance professionals to adapt. Customers, too, ask pointed questions now about trace contaminants, breakdown products, and even the recycled content in drums and shipping pallets.

    As regulatory and market landscapes evolve, our staff continues to meet regularly to stress-test our protocols and brainstorm new process adjustments. A recent initiative explored solvents with lower ecotoxicity, and we've swapped over 40% of our process cleaning agents to greener alternatives without missing a beat in throughput. These aren't overnight transitions; every operational change brings a week or two of recalibration, retraining, and close monitoring for bottlenecks.

    Technical Support and Responsive Cooperation

    It isn’t enough to manufacture and ship a product; partners expect timely help when questions pop up. We’ve seen some of our best long-term relationships grow from situations where a customer had a complex problem—sometimes a reaction that didn’t proceed, or a crystallization that turned out cloudier than expected. Direct communication helps both sides spot the root causes, whether it’s a hidden impurity, storage condition, or a subtle batch shift.

    Sometimes end-users push the compound beyond our standard process conditions or request data from unusual analytical runs. The flexibility to run extra testing on request, or to tweak shipping containers to suit hot climates or ocean transit, separates the manufacturer from a faceless supplier. The most rewarding part of this job remains seeing a partner’s innovation move from idea to reality, with our work as an integral support.

    Innovation Driven by Customer Demand

    Research divisions in client companies keep surprising us with new applications. One season, pilot projects explored custom polyelectrolytes where the dibromo motif acts as a cross-linker; another year, we supported a run of chiral derivatives targeting new catalysts. Each iteration in their work forces us to rethink purification, logistics, or even packaging. Our plant added new filtration steps after one group traced a reaction sensitivity back to minerals in shipping drums—a fix inspired by direct user feedback.

    Continuous improvement springs from this collaboration. Rather than set product specs in stone, we treat them as living documents—open to adjustment as new discoveries and needs surface. Not every suggestion leads to sweeping changes, but even minor tweaks—like adjusting drying cycles or ramping up final filtration—have tangible impacts on customer outcomes.

    Why Stability and Freshness Matter

    A brominated alcohol isn’t inherently unstable, but over time it picks up changes nobody wants. Heat, moisture, stray contaminants—even subtle ones like exposure to certain gaskets or container linings—can catalyze slow breakdown. In the plant, we rotate stock using a strict first-in/first-out approach and routinely spot-check older batches for physical and chemical integrity. Surveys showed customers valued this discipline more than any marketing brochure.

    Shipping also introduces risks. Unplanned customs holds, delays on the docks, or temperature spikes in containers can tip a batch into trouble. Our distribution staff coordinate with logistics partners to monitor environmental sensors and, if necessary, flag suspect lots before they reach the warehouse. These small steps add up, reducing customer complaints and helping us avoid costly returns or rework.

    Contributing to Downstream Safety and Reliability

    Risk management in chemical manufacturing is about more than protecting the plant. Poorly handled intermediates can trigger stoppages or safety incidents in high-volume downstream plants, with costs ranging from minor repairs to full recall scenarios. Over time, this focus on reliability became our strongest selling point. We noticed that partners who conducted site audits or requested sample shipments almost always decided to place follow-up orders after seeing first-hand the controls in place.

    Each batch of 1,4-Dibromo-2-Butanol carries with it a record of the people, decisions, and safeguards behind it. The end result is a more predictable, dependable process for everyone along the line. Direct feedback loops—honest conversations about what’s working and what isn’t—drive our incremental approach to making both the chemistry and the logistics work for real people in real supply chains.

    Reducing Footprint, Raising Standards

    Sustainability is no longer just a nice extra. At our scale, every process tweak and technical upgrade has real-world implications, from energy use to discharge quality. We shifted some bromine sourcing to partners with better capture technology, and our waste-treatment integration—while expensive—reduced our environmental liabilities measurably. We regularly analyze and update carbon footprint reports, tying improvements directly to operations on the floor.

    Some challenges in green manufacturing remain unsolved, particularly for brominated chemicals. Complete circularity isn’t always possible, but by actively pursuing process improvements—heat exchangers, solvent reuse, updated buffer chemistry—our plant reduces demands on raw resources over the course of each year. We share these results openly with any partner who asks, using hard data rather than vague promises.

    Collaborative Growth and Adaptation

    Long-term supply partnerships grow out of shared challenges. We’ve worked alongside firms racing to scale up novel synthesis, only to encounter an unforeseen processing quirk or regulatory shift. Rather than retreat from these obstacles, we stay involved—running pilot batches, identifying what works or doesn’t, and adapting together. This approach doesn’t lend itself to stock answers, but over time it delivers better, more resilient solutions.

    As a manufacturer, we see each campaign as a two-way street: lessons from the plant refine our product, and customer innovations push us to keep evolving. This feedback drives practical changes both in the plant and out in the world where our chemical ends up in industrial processes, R&D breakthroughs, and sometimes new materials markets altogether.

    Conclusion: What Sets Our 1,4-Dibromo-2-Butanol Apart

    Unlike many catalog chemicals, our 1,4-Dibromo-2-Butanol reflects years of practical experience—across engineering, safety, environmental stewardship, and customer collaboration. What reaches your site or laboratory isn’t just a batch number; it’s the end product of a team committed to continual refinement, transparent partnership, and hands-on involvement from start to finish.

    We see the subtle differences—high purity, smart packaging, prompt handling of feedback—as the real dividing line between commodity and substance. That’s shaped both our approach to manufacturing and our reputation with chemists, engineers, researchers, and production teams who need a supplier that acts as a partner, not just a source.