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1,4-Di(2,2,2-Trifluoroethoxy)Benzene

    • Product Name 1,4-Di(2,2,2-Trifluoroethoxy)Benzene
    • Alias 1,4-Bis(2,2,2-trifluoroethoxy)benzene
    • Einecs 407-290-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    160653

    Compound Name 1,4-Di(2,2,2-trifluoroethoxy)benzene
    Molecular Formula C10H8F6O2
    Molecular Weight 292.16 g/mol
    Cas Number 2369-63-9
    Appearance Colorless liquid
    Boiling Point 199-200 °C
    Density 1.386 g/cm³ (at 20 °C)
    Refractive Index n20/D 1.411
    Solubility Insoluble in water
    Smiles FC(C)(C)COc1ccc(OCC(F)(F)F)cc1
    Inchi InChI=1S/C10H8F6O2/c11-9(12,13)5-17-7-1-3-8(4-2-7)18-6-10(14,15)16/h1-4H,5-6H2

    As an accredited 1,4-Di(2,2,2-Trifluoroethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, 25g, with tamper-evident cap; label displays chemical name, CAS number, hazard warnings, and storage instructions.
    Shipping 1,4-Di(2,2,2-Trifluoroethoxy)Benzene should be shipped in tightly sealed containers, protected from moisture, heat, and direct sunlight. Ensure appropriate chemical labeling and adhere to local, national, and international regulations regarding the transportation of chemicals. Use suitable protective packaging to prevent leakage or damage during transit. Handle with proper safety precautions.
    Storage **1,4-Di(2,2,2-Trifluoroethoxy)Benzene** should be stored in a tightly sealed container in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers and acids. Avoid exposure to moisture and direct sunlight. Store in a chemical storage cabinet designed for organic chemicals, with appropriate labeling and access restricted to trained personnel.
    Application of 1,4-Di(2,2,2-Trifluoroethoxy)Benzene

    Applications of 1,4-Di(2,2,2-Trifluoroethoxy)Benzene in Industrial Manufacturing

    As a direct chemical raw material manufacturer, we support specialized industries with consistent quality and process-focused supply of 1,4-Di(2,2,2-Trifluoroethoxy)Benzene. Below we outline primary industrial applications across several sector-specific downstream channels, providing detailed use scenarios, regulatory expectations, formulation guidance, and targeted integration points.

    1. Advanced Liquid Crystal Material Synthesis for Display Panels

    Manufacturers of liquid crystal compounds for TFT-LCD and OLED display panel production utilize this compound as a crucial aromatic ether intermediate. Its unique trifluoroethyl functionality imparts high dielectric anisotropy and thermal stability, essential for next-generation display performance and longevity. Chemical engineers integrate it at the functional group introduction phase, enabling precise control over mesogenic core properties.

    Industry compliance standards

    • RoHS Directive 2011/65/EU (for electronics applications)
    • IEC 61249-2-21 (halogen-free materials in electronics)
    • REACH Regulation (EC) No 1907/2006 (SVHC screening and registration)
    • Internal materials approval by major display OEMs (e.g., Samsung, LG, BOE)

    Typical usage ratio

    • 10–25 wt% in pre-polymer liquid crystal mixture formulations
    • Adjusted based on desired birefringence and phase transition temperatures per end-customer specification

    Downstream process integration

    • Reactant charged during mesogen core assembly in LC compound synthesis reactors
    • Further processed via column chromatography prior to purity-critical LC final blend mixing

    Final product types

    • High-performance liquid crystal mixtures (display industry grade)
    • Electronic display panels for consumer and industrial devices
    • Specialty LC alignment agents for advanced photonic components
    • OLED color filter elements

    2. High-Temperature Polymer Manufacturing for Specialty Films

    Polymer producers adopt this molecule as a difunctional monomer in co-polycondensation protocols to fabricate fluorinated polyarylene ether films. Its incorporation enhances low dielectric loss, chemical resistance, and optical transparency in advanced microelectronics insulation films and flexible electronics. Technical teams optimize monomer feed ratios during pilot trials to balance mechanical strength and processability.

    Industry compliance standards

    • UL 94 (Flammability of plastic materials)
    • IPC-4101 (specifications for base materials for printed circuit boards)
    • ISO 17025 (materials analysis in QC labs)
    • ASTM D3763 (polymer impact strength testing procedures)

    Typical usage ratio

    • 15–40 mol% in aromatic ether polymer monomer feed
    • Increased proportion for applications requiring higher fluorine content, reduced when targeting higher glass transition temperatures

    Downstream process integration

    • Added to high-shear melt polycondensation reactors with other bisphenol and halide monomers
    • Included in distillation and thin film removal steps to ensure residual solvent limits

    Final product types

    • Flexible and high-temperature resistant polymer films (FPE, PPE grades)
    • Microelectronics insulation layers
    • Flexible printed circuit base films
    • Specialty dielectric films for 5G and RF modules

    3. Synthesis of Fluorinated Aromatic Intermediates for Agrochemical APIs

    This compound serves agrochemical synthesis plants as a key trifluoroethoxy-substituted aromatic building block in selected herbicide and pesticide precursor routes. It introduces desirable electron-withdrawing effects for metabolic stability, and is directly condensed or substituted onto active ingredient scaffolds through site-selective reactions. Production lines leverage its purity and consistent reactivity to reduce batch variability in high-value API manufacturing.

    Industry compliance standards

    • FAO/WHO Specifications for Pesticides
    • Good Manufacturing Practice (GMP+ for agro, ISO 9001 for chemical QC)
    • OECD Testing Guidelines for Chemicals (screening intermediates and final products)
    • REACH intermediate use registration (if required in EU)

    Typical usage ratio

    • 5–20 mol% relative to total batch reactant load in multi-stage agrochemical synthesis
    • Adjusted in pilot according to desired trifluoroethyl substitution pattern on final API

    Downstream process integration

    • Solution-phase condensation into aromatic core during active ingredient synthesis
    • Sequential halogenation or alkylation steps as required to complete target molecule

    Final product types

    • Fluorinated herbicide intermediates
    • Custom-engineered pesticide APIs
    • Crop protection formulation precursors
    • Stabilizers for agrochemical blends

    4. Specialty Coatings and Crosslinker Formulations for Electronics Grade Coatings

    Electronics coatings manufacturers employ this raw material as a specialty crosslinker or oligomer precursor in formulations targeting high-performance conformal coatings and encapsulants for integrated circuits and MEMS packaging. Its fluorinated structure provides hydrophobicity and dielectric insulation while maintaining good adhesion and cure rates. Formulation chemists introduce it as part of the base resin modification phase, tuning proportions to meet thin film thickness or substrate compatibility requirements.

    Industry compliance standards

    • IPC-CC-830 (Conformal Coating Qualification and Performance)
    • IEC 60664-3 (Insulation coordination requirements for electronic equipment)
    • RoHS and halogen-free compliance per OEM contract
    • ISO 14644-1 cleanroom contaminant control during production

    Typical usage ratio

    • 3–12 wt% of resin base during oligomer prepolymerization
    • Varying input based on desired coating hydrophobicity or dielectric breakdown voltage

    Downstream process integration

    • Blended with other functionalized aromatic resins before solvent addition and dispersion
    • Fed continuously during in-line crosslinker activation or batching stage before application onto electronic substrates

    Final product types

    • Electronics grade conformal coatings
    • Dielectric encapsulant films
    • MEMS protective thin layer coatings
    • Specialty packaging adhesives for microassemblies
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    Certification & Compliance
    More Introduction

    1,4-Di(2,2,2-Trifluoroethoxy)Benzene: A Manufacturer’s Perspective

    Product Introduction

    1,4-Di(2,2,2-Trifluoroethoxy)benzene offers a unique blend of chemical stability and performance for customers aiming to raise the game in advanced material synthesis, liquid crystal technology, specialty coatings, electronics, and pharmaceutical development. Experience over two decades of production at scale has shaped our understanding of this molecule’s core role in enabling innovation across a demanding sector. From the outset, our facility has refined the process, making sure that each batch achieves purity, consistency, and physical properties valued by our most exacting partners.

    Specifications and Characteristics

    This aromatic ether sports two 2,2,2-trifluoroethoxy groups bonded to a benzene ring, giving it enhanced electron-withdrawing capability and elevated thermal and chemical resistance. Typical analytical reports show content above 99.5% by GC, low-moisure profiles, and narrow impurity windows. The physical properties demonstrate a liquid or crystalline solid that maintains stability through a wide temperature range—a feature our researchers utilize when recommending candidates for environments under mechanical or thermal stress. Empirical measurements in-house, derived from thousands of pilot and production runs, confirm a boiling point near 210–220°C and melting behavior suitable for blending or solution work. Our team tracks trace metals and halide impurities tightly, remembering always that markets like optoelectronics and pharmaceuticals have little patience for batch-to-batch variance. Customers who pursue downstream reactions or seek to formulate high-spec mixtures do not face setbacks from unknown contaminants since each lot follows a strict release protocol.

    Packing process receives close attention. Years ago, we learned that special fluorinated surfactants and extra-dry, filtered atmosphere rooms pay off in the form of fewer shelf stability complaints downstream. From barrel to small bottle, every filling operation includes process data capture. Shelf life has consistently met and exceeded the two-year mark under standard storage, substantiated by in-house logs and peer customer feedback.

    End Uses and Application Examples

    Product managers and R&D teams in liquid crystal development and organic electronics have long valued this molecule’s ability to modify dielectrics and tune refractive indices. Fluorinated ethers like 1,4-Di(2,2,2-Trifluoroethoxy)benzene brought flexibility to polymer blends year after year. Early on in our production, major display makers requested tailored grades with rigorous control of residual halogen levels, learning from past run-ins with dark spot formation and instability in screens. That feedback led us to select an extended purification train, introducing more rigorous washing, distillation, and fractional crystallization stages than industry average. Consistently, the upgraded process yielded product that met the high performance thresholds these industries demand.

    In advanced polymer manufacture, the molecule withstands harsh synthetic conditions. Multiple epoxide and imide resin systems depend on the benzene core’s backbone to anchor network structures, achieving light weight and excellent thermal resistance. As a producer, seeing the downstream success of our partners in aerospace and automotive proves the value of consistent specification. Our direct exchange with engineers at these companies guided the evolution of our analytical portfolio, moving beyond basic GC/MS to regular NMR and elemental analysis with every significant process modification.

    Chemical intermediates based on 1,4-Di(2,2,2-Trifluoroethoxy)benzene carry the unique advantage of high plasma etch resistance and strong hydrophobicity. These chemical properties show their worth as soon as manufacturers step beyond commodity materials. We continue to support research labs as they target higher margin coatings, smart device encapsulants, and next-gen thin-film dielectrics. Our earliest clients, often from small innovation-driven firms, showed that unique substitution patterns on this benzene core could open the door to new monomers with better weatherability or environmental stability.

    Comparisons and Points of Differentiation

    Working with hundreds of product families, our technical team often fields the question of how this molecule stands out from competitors or legacy solutions. Comparing it to dialkoxybenzenes or plain ether-substituted benzenes paints a revealing picture. Fluorinated ethers as a class deliver more than just low surface energy; they also resist oxidative degradation and provide unique dielectric constants. These properties, rooted in the carbon–fluorine bonds, drive industry adoption whenever a formulation needs a blend of hydrophobicity and thermal endurance. Our product especially leads in these grounds due to extensive quality monitoring downstream of the synthesis—gained by learning firsthand how even slight impurities could disrupt modern device fabrication.

    Experience working with legacy products, such as methyl or ethyl-substituted diethoxybenzenes, shows clear differences once tests reach elevated temperature, high voltage, or prolonged photo-aging. The fluorinated analog holds up with less yellowing and fewer breakdowns in resistivity. Large panel manufacturers once reported wasted time retesting entire module runs when non-fluorinated substitutes produced poor lamination or phase separation. Supplying a reliable stream of trifluoroethoxy-based product has cut those stops and starts from their production scheduling. Our continuous product improvement cycles have focused on learning from those setbacks, not just on the bench but during line-scale implementation.

    From the standpoint of supply chain partners in Japan, Korea, Europe, and North America, one clear contrast comes up: regulatory acceptance and environmental safety. While all halogenated organics deserve careful handling, our record of data-driven transparency, traceability, and in-depth regulatory submissions smooths the approval process. Key clients in the United States turned to our facility for clear batch records, fully documented RoHS and REACH compliance, and proven absence of regulated contaminants like short-chain perfluorinated carboxylic acids. Our technical support group invests regular time in helping downstream processors address evolving documentation requirements—an approach that sets our business model apart from resellers with weaker links to process control and product traceability.

    Production and Quality Control: Lessons Earned, Not Assumed

    Dealing with bulk chemistry involves managing hazards, optimizing yields, and investing in people who notice the details that others miss. In the early days, the process posed larger challenges managing the exothermic mixing of trifluoroethanol reagents, controlling water ingress, and ensuring complete reaction. Years bringing scale from lab glassware through steel reactors taught us the hard way about side reactions, degradation risks, and post-reaction cleanup. Both automated process controls and sharp-eyed production chemists proved essential—each year, shop floor knowledge feeds directly into procedural corrections or equipment upgrades.

    Customers never see the hidden corrective actions that underpin a reliable supply chain: tunes to distillation head temperature programs, moves toward corrosion-resistant alloy fittings, in-line drying upgrades, and constant revalidation of analytical standards. These lessons surface during audit visits, customer tours, or technical exchange meetings—practical trust built not from brochures but from real data about purity drift, recovery ratios after upsets, or minor deviations in color index that must be addressed locally, not after final QC. The practical expertise that stems from living with the chemistry year after year produces the stable, dependable material downstream users quickly notice.

    Our team invests in getting all staff, from operators to quality analysts, well-versed in not just technical numbers but the “why” behind process rules. This focus paid dividends when global supply chains came under stress or regulatory thresholds shifted. A customer’s confidence depends partly on the technical assurances we give and partly on meeting real-world delivery timelines backed by demonstrated inventory and batch-tested stock. We’ve seen more than one competitor falter under pressure, unable to connect traceability, specification, and real-time batch performance. Commitment to hands-on technical knowledge, supported by ongoing investment in analytics, earns an edge customers recognize.

    Continuing Innovation and Market Demands

    Trends in liquid crystal and advanced functional material industries keep moving. Product teams seeking higher clarity, tougher degradation resistance, or niche electrical or thermal profiles push us for tighter grades and better analytical support. Recently, shifts in environmental regulations surrounding fluorinated organics added scrutiny. Our approach responds by pairing stricter internal audit routines with collaborative R&D—never assuming specification will stand still even as the core molecule remains familiar. By working directly with users to test for fit in coatings, resins, display modules, or specialty elastomers, we don’t just ship commodity; we co-develop improvements, test in context, and keep refining grade by grade.

    Collaborations with universities and industry partners show new functions arising from subtle changes—either in substitution patterns or integration into higher molecular weight constructs for block copolymers and electrolytes. Feedback from these projects shapes not only production but also long-term sourcing for raw materials, redundancy in plant utilities, and disaster recovery preparations. Having stayed the course across economic cycles, we see that the best-performing molecules are only as useful as the supply chain and experience that supports them. As new application spaces open—next-generation semiconductors, wearable device substrates, advanced fluorinated surfactants—our ongoing practice stresses design with both performance and sustainability as priorities.

    Customers exploring flame retardants, hydrophobic coatings, or anti-fouling membrane technologies often discover the practical edge of 1,4-Di(2,2,2-Trifluoroethoxy)benzene. The molecule’s structure repels moisture and holds up against aggressive solvents, acids, and bases. This solves age-old issues in extending product lifetimes and maintaining performance after repeated exposure cycles. Unlike non-fluorinated alternatives, the chemical backbone does not succumb quickly to hydrolysis or radical-driven degradation. It also opens doors for the development of newer, lower-environmental-impact coatings and selective separation membranes, especially as sustainability imperatives shape purchasing choices.

    Addressing Practical Challenges

    Producing specialty fluoroaromatics asks more of every link in the chain—raw materials, analytical workflows, equipment reliability, and deep employee training. One recurring challenge arises with handling of reagents sensitive to moisture or trace acids, which can reduce yield or introduce colored byproducts. Decades of batch review records convinced us that robust pre-drying and segregated transfer lines offer the only viable way to run large campaigns without hiccups. Teams on the ground troubleshoot the smallest variances, intercepting potential drifts before they become out-of-spec waste. Their know-how underpins the supply reliability our key accounts rely on.

    Another long-standing concern involves upholding the environmental and occupational safety profile of fluorinated substances. We have invested consistently in updated scrubbing, contained waste streams, and ongoing environmental monitoring at and beyond the plant perimeter. Reporting and responding to community questions matters just as much as hitting batch targets—a lesson reinforced by both local partnerships and regulatory relationships. On the customer-facing side, material stewardship forms an everyday part of our technical dialogue, not a one-off compliance hurdle.

    Supporting technical excellence means being available when partners experience their own process issues that might touch our material. In-person visits, joint pilot runs, and rapid troubleshooting with sample analytics form backbone services we provide—practices developed through seeing firsthand how missed deadlines or material misapplications affect not just “orders” but long-term business relationships. By keeping dialogue lines open, teams on both sides adjust quickly, whether the problem stems from unplanned process changes, storage mistakes, or unpredictable raw material hitches.

    Trusted Supply and Real-World Impact

    Regulatory compliance has only grown more complicated as market geography widens. Our facility tracks evolving requirements globally, but—more critically—translates those shifting lines into actionable process targets rather than excessive documentation. Regular third-party audits and round-robin analytical proficiency testing remain essential. What really shapes our readiness is the design and execution of in-plant tests, calibrated equipment cross-checks, and front-line attention to documentation. When the question comes about batch lineage or a minor deviation in a test, production and lab teams draw directly from decades of harmonized SOPs and batch review outcomes.

    Large or small, customers expect responsiveness. Planners and purchasers can check on order status, batch details, or historical spec performance without delay—because our plant database and QC logs match what our marketing and sales teams promise. Practical experience shows that no standard order or logistics pathway survives unchanged; flexibility, honest dialogue about what’s possible, and a genuine willingness to fix problems underpin our repeat orders and long-term contracts.

    Globalization means new application ideas emerge each year. From Europe, interest in using this molecule as a co-monomer in biomedical surfaces has grown, pushing us to supply specialty grades with even lower biosolvent residue levels. In North America, demand continues to rise for eco-label-compliant grades addressing stricter air quality or leachability standards. Asian partners have set the bar high for process repeatability and just-in-time deliveries, matched by their relentless pace of new launches. Tracking all this, plant operators and technical directors iterate better workflows—leaning into both high-volume regular orders and the painstaking requests that come with specification upgrades.

    Future Outlook: Investments and Solutions

    Looking ahead, changes in fluorine chemistry and customer specification keep reshaping expectations for every specialty chemical producer. Recent upgrades involved a new plant section dedicated to high-purity fluorinated aromatics, fully isolated from other processes to minimize even remote cross-contamination risks. On-site R&D keeps pushing for greener reagents and more closed-loop solvent recovery, cutting overall carbon and waste footprints. This isn’t just a matter of following regulatory trends; these investments pay off directly when customers bring in new demands for lighter environmental impact certifications, or when community members visit and seek firsthand proof of safer practices.

    Producing and supporting high-performance molecules like 1,4-Di(2,2,2-Trifluoroethoxy)benzene relies as much on listening and learning as on technical prowess. Each uptick in demand, each reported issue downstream, and each positive milestone in our partners’ success stories feed back into both R&D and everyday plant life. The right technical, regulatory, and process investments stem from taking this dialogue seriously and refusing shortcuts. We commit to meeting today’s promises—by shipping each order with the reassurance that comes from real technical depth, reliable logistics, and the living knowledge that can only build up through decades at the bench and in the plant.