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1,3-Diphenyl-1-Butanone

    • Product Name 1,3-Diphenyl-1-Butanone
    • Einecs 207-347-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    700145

    Cas Number 2046-22-6
    Molecular Formula C16H16O
    Molecular Weight 224.30 g/mol
    Appearance White to off-white crystalline powder
    Melting Point 58-61 °C
    Boiling Point 184-186 °C at 14 mmHg
    Density 1.070 g/cm³
    Solubility In Water Insoluble
    Refractive Index 1.589
    Smiles CCCC(=O)C1=CC=CC=C1C2=CC=CC=C2
    Pubchem Cid 32947

    As an accredited 1,3-Diphenyl-1-Butanone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 1,3-Diphenyl-1-Butanone is packaged in a 100g amber glass bottle with a secure screw cap and safety labeling.
    Shipping 1,3-Diphenyl-1-Butanone should be shipped in tightly sealed containers, stored in a cool, dry, and well-ventilated area. The container must be clearly labeled. Handle with appropriate protective gear and comply with all local regulations on chemical transport. Avoid exposure to heat, sparks, or direct sunlight during transit.
    Storage **1,3-Diphenyl-1-butanone** should be stored in a tightly sealed container, away from direct sunlight and sources of heat or ignition. Store in a cool, dry, well-ventilated area, separated from strong oxidizing agents and acids. Ensure the storage area is clearly labeled and equipped with appropriate spill containment. Avoid prolonged exposure to air and moisture to maintain chemical stability.
    Application of 1,3-Diphenyl-1-Butanone

    Applications of 1,3-Diphenyl-1-Butanone in Industrial Manufacturing

    1,3-Diphenyl-1-Butanone serves as a key process intermediate in multiple industrial sectors, providing value in fragrance synthesis, pharmaceutical preparation, specialty polymer modification, and fine chemical production. As a direct manufacturer, we ensure our material meets process requirements unique to each downstream industry user.

    1. Fragrance Intermediates Production

    Perfumery chemical producers select 1,3-diphenyl-1-butanone as a central intermediate for complex musky and floral aroma compounds. In multi-stage synthesis routes, it reacts with nitriles or aldehydes for advanced molecular construction. Quality parameters such as low impurity profile and consistent bulk handling play a decisive role in batch yields. Our product’s high purity ensures consistent reaction selectivity and minimized rework rates at scale.

    Industry compliance standards

    • Cosmetic Ingredient Review (CIR) Panel recommendations
    • International Fragrance Association (IFRA) Code of Practice
    • Regulation (EC) No 1223/2009 on cosmetic products (EU)
    • Good Manufacturing Practice (GMP) ISO 22716

    Typical usage ratio

    • 5–30% in total fragrance batch weight, adjusted based on process yield and molecular blending requirements

    Downstream process integration

    • Enters as a condensation substrate during aroma building block synthesis after the solvent charging phase
    • Batch-fed into reactor under inert atmosphere at pre-controlled temperature profiles
    • Followed by downstream purification, solvent recovery, and fractional distillation

    Final product types

    • Musky ketone fragrance bases for fine perfumery
    • High-grade aromatic ingredients for detergents and home care
    • Intermediates for luxury cosmetic aromas

    2. Pharmaceutical Intermediate

    Manufacturers employ 1,3-diphenyl-1-butanone as a tailored intermediate in the synthesis of select antihistaminic and central nervous system (CNS) active APIs. It acts as a scaffold in Grignard and Friedel–Crafts reactions, supporting regioselective transformations for new chemical entity (NCE) development and commercial drug API scaling. Controlled handling and traceability are critical for cGMP process compliance and finished drug safety.

    Industry compliance standards

    • EU GMP Part II (ICH Q7) for active substance manufacture
    • 21 CFR Part 211 (US FDA cGMP for Finished Pharmaceuticals)
    • USP/NF and Ph. Eur. monograph requirements for purity control
    • Active Pharmaceutical Ingredient (API) audit traceability

    Typical usage ratio

    • 10–40% in key reaction steps, depending on multi-step process scale, reaction excess requirements (stoichiometry), and impurity minimization

    Downstream process integration

    • Introduced post-primary reaction, often under inert atmosphere for catalyst addition
    • Employed in critical condensation or acylation steps preceding purification
    • Subsequently subjected to multi-stage filtration and chromatography

    Final product types

    • Pharmaceutical intermediates for antihistamine drugs
    • Scaffold for CNS acting drug API production
    • Building block for select benzyl-derivative APIs

    3. Specialty Polymer Modification Additive

    Custom polymer compounders leverage 1,3-diphenyl-1-butanone as a plasticizer precursor or chain transfer agent to achieve specific molecular weight control and mechanical properties in engineering resins. Its aromatic structure enables reactivity with functionalized polyolefin or polystyrene blends, supporting process customization for automotive, electronics, and advanced materials customers. Consistent material quality minimizes off-spec batches and improves extrusion outcomes.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006 for chemical safety
    • ISO 9001:2015 certified quality management
    • RoHS 2015/863/EU (Restriction of Hazardous Substances) for electronics polymer applications
    • UL 94 certification (where flame retardancy is relevant)

    Typical usage ratio

    • 0.5–3% of resin weight; varies by molecular weight targets and desired flexibility or processing window expansion

    Downstream process integration

    • Blended during melt compounding phase post primary pre-polymerization
    • Metered addition in twin-screw extrusion with in-line mixing
    • Supports end-phase reactivity for chain termination or branching

    Final product types

    • Modified ABS and polystyrene engineering plastics
    • Customized polyolefin blends for automotive interiors
    • Electronic housing composite materials

    4. Fine Chemicals & Agrochemical Intermediates

    Producers of agrochemicals and fine specialty molecules utilize 1,3-diphenyl-1-butanone in stepwise synthesis of advanced phenyl-substituted compounds. The material plays a pivotal role in constructing diketones, phenylureas, and other high-value actives. Batch-specific quality documentation enables regulatory submissions and supports downstream technical dossier development required in crop protection registration.

    Industry compliance standards

    • ISO 9001:2015 and related site GMP protocols for chemical processing
    • Regulation (EC) No 1107/2009 (EU plant protection product regulation)
    • FAO/WHO Manual on Development and Use of FAO and WHO Specifications for Pesticides
    • Chemical hazard and transportation labeling GHS/CLP

    Typical usage ratio

    • 2–15% of active intermediate batch; adjusted based on target formulation and synthesis pathway design

    Downstream process integration

    • Added after solvent charging for key condensation or alkylation steps
    • Participates directly as phenyl source in aromatic substitution reactions
    • Subjected to post-reaction solvent extraction and solid-liquid separation before further conversion or isolation

    Final product types

    • Advanced intermediates for phenylurea herbicides
    • Precursors for fine chemical diketones and aromatic ketones
    • Raw material for agrochemical active substances registration
    Free Quote

    Competitive 1,3-Diphenyl-1-Butanone prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Experience-Driven Production of 1,3-Diphenyl-1-Butanone

    Real Hands Behind the Molecule

    1,3-Diphenyl-1-Butanone is more than a formula in our books—it's a chemical that’s shaped by years of know-how here on our shop floor. Our team handles its synthesis batch by batch, watching every step as raw materials take on a new life through precise reactions and careful purification. This attention to detail is what sets apart our product from commodities passing through generic channels. Unlike a trader only concerned with paperwork and logistics, we wrestle with real-world chemistry: heat transfer, reaction kinetics, solvent selection, and the fine balance between quality and yield. Every bottle we ship draws on this foundation.

    Where 1,3-Diphenyl-1-Butanone Shows Its Worth

    Across decades, we’ve watched 1,3-Diphenyl-1-Butanone find a stronghold in specialty synthesis. Its carbonyl group brings predictable chemistry to the workbench, letting researchers build up more complex molecules without the risk of runaway side reactions. With two phenyl rings, the compound’s scaffold resists unwanted reactivity while still offering sites for functionalization. In the lab, this often means smoother product isolation, fewer problems with contaminant peaks on the HPLC, and more reproducible results overall.

    From talking face-to-face with our users, we know the comfort that comes from opening a fresh bottle and finding clear, pale crystals, free from oxidation or strange tints. Chemists who rely on pure feedstocks don’t want to troubleshoot byproducts or mystery peaks. Formats may sometimes vary—customers may need different pack sizes, but we don’t shift our purification steps to cut costs. That’s a real difference compared to generic stock prepared to hit a price point. In our experience, small choices at the reactor—choice of solvent, timing of work-up, degree of vacuum on the final drying—become big quality factors down the line.

    How We Approach Production and Quality Control

    Sourcing the building blocks for 1,3-Diphenyl-1-Butanone always begins with consistency. We watch the quality of benzene-based starting materials and manage storage conditions aggressively to avoid hydrolysis or polymerization. It means controlling everything from supplier batch testing to storage temperature. Even something simple, like atmospheric moisture sneaking into a drum, sometimes leaves an imprint you can smell or see in a batch. We rotate inventories to avoid these slip-ups.

    Our reactors rarely rest. Operators pay as much attention to stirring and temperature control as to their own safety. The key transformation—alkylation leading to the butanone backbone—runs best with ready access to analytical tools. As reaction curves build, technicians track conversion by GC or NMR. Throughout, we pull intermediate samples to see if color or viscosity changes warn of any trouble.

    Once the final crude is in hand, we don’t shortcut recrystallization or filtration. Even with efficient synthetic routes, batches sometimes show differences—one will filter fast, another slow; particle sizes can drift wider than expected. This is where hands-on experience fills in. Choosing the right filter medium, adjusting solvent ratios or chilling times, these factors don’t show up in black-and-white spec sheets but matter to how readily researchers can use the final product.

    Our quality checks run deeper than formal certificates require. Routine GC analyses and HPLC purity assays confirm the product profile. Most importantly, our team knows what a clean batch looks like. If a lot doesn’t meet our standards, it doesn’t leave the facility, period. We find that direct oversight works far better than trusting to remote labs or third-party brokers, especially for compounds prone to subtle degradation.

    Not Just Another Building Block

    Some see 1,3-Diphenyl-1-Butanone as just another intermediate, but the difference between a bulk chemical and a carefully managed specialty reagent can mean days or weeks in research and production settings. We’ve heard from more than a few colleagues who lost time tracking down reaction failures, only to discover odd impurities at the bottom of a vendor’s drum, never mentioned except in tiny footnotes. That’s the cost of losing touch with the source.

    As producers, we control the entire path, starting from selection of raw materials all the way to the packaging. Customers receive a compound that comes straight from the synthesis line—not repacked, not relabeled, and not handled by middlemen who may not notice a subtle off-color or slight crystallization problem.

    Specifications That Reflect Real Needs

    Researchers and manufacturers request high purity, verified by both instrumental analysis and hand-inspection. Typical batches surpass 99% purity; water and volatile organics get pushed down by targeted drying, vacuum stripping, and by minimizing microexposures to air and light in storage. Our team’s routines include triple-checking for trace metals or residual solvents, always chasing after that clean chromatogram trace.

    Packaging stands as an often-overlooked factor. We send out 1,3-Diphenyl-1-Butanone in shatter-resistant containers with tight seals, because a little humidity can lead to clumping or surface spotting. Feedback from customers has steered us toward pack sizes that match frequent project needs, avoiding both overstocking and too-frequent reordering. Bigger projects call for larger drums, but the handling precautions don’t relax as the drum size increases.

    Working with bulk users, we provide technical backup—actual chemists on our staff ready to respond to incidents of off-color or impurities, not just generic call center scripts or stock responses. Our process R&D group can, if warranted, adjust the process to solve a recurring user-side issue, such as unexpected reactivity in downstream chemistry.

    Differences That Add Up

    Compared to other ketonic intermediates, 1,3-Diphenyl-1-Butanone stands apart because of its dual phenyl design. This structure shrugs off atmospheric degradation more effectively than aliphatic analogs. Double phenyl rings lend stability, which reduces the workload for chemists during handling and storage. Side-by-side, aliphatic ketones break down more quickly from exposure to light or air, while our product keeps its purity longer sitting on a research shelf.

    From a practical perspective, downstream transformations—like reductive amination or cross-coupling—proceed more smoothly. Fewer interfering peaks show up in analytical tracks, and yields track more predictably. Clients making more complex targets, especially in pharmaceuticals, like the reliability of starting from such a well-characterized building block. We’ve also seen less off-spec product returned for quality questioning, compared to experience with less robust molecules.

    Applications and Real-World Usage

    The mainstay use of 1,3-Diphenyl-1-Butanone is as a stepped intermediate in the synthesis of pharmaceutical candidate molecules. Contract research organizations value how reproducible its reactivity is, which allows them to build complex molecules with fewer unexpected failures. It also crops up in agrochemical exploration and fragrance design, where the balance between stability and reactivity matters.

    Unlike products that need elaborate stabilization agents or special storage instructions, 1,3-Diphenyl-1-Butanone maintains integrity in standard chemical storage rooms. Our own stability data, reflecting years of real storage, confirm its resistance to short-term process upsets, which is uncommon among more delicate intermediates. Warehousing teams don’t stress over rapidly expiring inventory, and chemists don’t have to re-test every few weeks, saving both time and money.

    R&D groups want flexibility—some may push the molecule into large-scale pilot runs, while others rely on it for just a few grams in rare academic syntheses. Our approach adapts to both, and we take care not to treat smaller clients as an afterthought in a market driven by bulk contracts. Each batch draws from the exact same raw material pool and core production method, rather than dividing ‘premium’ and ‘commodity’ lines based on customer size.

    Working With Feedback and Continuous Improvement

    Nothing beats feedback from people who’ve actually put our chemical to work. We welcome reports about odd odors, discoloration, or even packaging issues. Every return, every complaint is reviewed in the same place the batches are made—on our production floor by the people who made it. This loop keeps the cycle of improvement alive and direct, without delays from layers of distribution or blame-shifting.

    Some of the most significant tweaks in drying steps or filtration procedures have come straight from customer labs. A routine chiller adjustment made only a few degrees difference on our line, but downstream users saw that it solved a stubborn clumping issue. Adjustments like these happen fast because the knowledge sits in-house, not outsourced to consultants or remote management. That’s the practical benefit of manufacturing under our own roof.

    As the field moves toward tighter purity standards and increased environmental regulation, we’ve stepped up monitoring for microcontaminants, even if they aren’t yet required. Trace analysis for halogens, heavy metals, and organic acids crosses our desks before shipping, not just when something goes wrong. We log this data for years, making it possible to track subtle drifts which could portend future trouble.

    Environmental Responsibility Backed by Direct Oversight

    Operating reactors and managing the wastes and emissions that come with them brings its share of challenges. No regulatory agency waits for perfect compliance, and neither do we. We treat every process batch—liquid, solid, or vapor—with controls built from direct daily experience. Neutralizing waste streams happens on the same site as production, letting us adapt disposal methods as process conditions change, not waiting for quarterly reviews.

    Any byproducts heading for destruction get sampled, logged, and tracked in real time. Leaks or spills are rare but handled under clear SOP, with teams drilling response actions regularly. This reduces the scale and spread of any incidents and improves long-term safety for our staff as well as the local environment. Responsible chemical manufacturing can’t come from distance or outsourcing; it grows out of direct, daily attention to each corner of the plant.

    Why Being a True Manufacturer Matters

    Chemists in the field feel the difference when their supplier stands behind both the process and the product. We don’t hide behind technical jargon or generic labels. Problems find real solutions, not just reassurances. If a user finds something off—a strange melting point, a lingering odor—we can retrace every production step and make needed corrections at the source. This responsiveness isn’t possible for resellers disconnected from the realities of chemical reactions and quality management.

    We meet questions with answers rooted in the real world, not canned responses or web links. Staff chemists know the granular details—down to how long a particular solvent drum sat near the loading bay, or whether a valve began to leak during the most recent shut-down. Our records reflect hands-on knowledge as much as procedural compliance.

    Our team handles all logistics in-house, so there’s no finger-pointing between supplier and shipper. Quick action, especially in urgent research or process scale-up scenarios, keeps client timelines on track. This full accountability comes from handling the product from first reaction flask to final package.

    Ongoing Commitment and Industry Trends

    Looking forward, new developments in green chemistry and process intensification challenge every manufacturer to improve. We review each process step for waste minimization, solvent optimization, and energy reduction. We monitor options for continuous flow or microreactor operations. Some early pilots show promising reductions in cycle times and solvent waste, while also improving the consistency of product output from one batch to the next.

    Supporting client efforts toward sustainability means sharing data on environmental impact and offering alternatives when demands shift. If a customer’s project mandates lower-VOC or requires documentation on raw material origin, our systems already handle these requests. Transparency isn’t just a promise on a webpage, but a piece of living practice in how batches are logged, tracked, and audited.

    The landscape of specialty chemical supply can feel crowded, with claims of quality and compliance floating from every corner. In our experience, only those with true manufacturing skin in the game consistently meet the higher bar. We produce, purify, and stand behind every molecule of 1,3-Diphenyl-1-Butanone, drawing on knowledge built up across years on the laboratory bench and plant floor.

    Informed Choices Benefit Everyone

    We recognize that our chemical ends up as part of someone else’s story—a reaction pathway, a published paper, a pilot campaign, or a scaled-up process. Our role isn’t just finished at shipping. We stick around to answer questions, resolve problems, and find better ways to help chemists, engineers, and R&D directors reach their goals. This sense of partnership, grounded in actual production experience, makes a critical difference in an industry that demands both accuracy and accountability.

    Real-world manufacturing isn’t always neat or predictable. We learn from every batch, every challenge, and every word of user feedback. Our 1,3-Diphenyl-1-Butanone isn’t just a reagent; it’s a reflection of continuous effort, engagement, and respect for the work our customers perform. We look forward to advancing both our product and our process, staying close to the needs and challenges faced by chemists everywhere.