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1,3-Dichlorobutane

    • Product Name 1,3-Dichlorobutane
    • Alias 1,3-Dichlorobutan
    • Einecs 211-221-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    857407

    Cas Number 109-70-6
    Iupac Name 1,3-Dichlorobutane
    Molecular Formula C4H8Cl2
    Molar Mass 127.02 g/mol
    Appearance Colorless liquid
    Odor Characteristic chloroalkane odor
    Boiling Point 142-144 °C
    Melting Point -60 °C
    Density 1.15 g/cm³ at 20 °C
    Refractive Index 1.439 at 20 °C
    Solubility In Water Slightly soluble
    Flash Point 36 °C (closed cup)
    Vapor Pressure 5.3 mmHg at 25 °C
    Chemical Stability Stable under recommended storage conditions
    Ec Number 203-704-8

    As an accredited 1,3-Dichlorobutane factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, sealed cap, hazard labels; holds 500 mL of 1,3-Dichlorobutane. Includes handling and safety instructions.
    Shipping 1,3-Dichlorobutane should be shipped in tightly sealed, chemical-resistant containers, clearly labeled according to hazardous material regulations. It must be transported in compliance with local, national, and international regulations, typically as a flammable and potentially harmful substance. Avoid exposure to heat, sparks, and open flames, and ship with appropriate safety documentation.
    Storage 1,3-Dichlorobutane should be stored in a cool, dry, well-ventilated area, away from sources of ignition, heat, and direct sunlight. Keep the container tightly closed and properly labeled. Store separately from strong oxidizing agents and incompatible substances. Use chemical-resistant containers and secondary containment to prevent leaks or spills. Access should be restricted to trained personnel equipped with appropriate protective gear.
    Application of 1,3-Dichlorobutane

    Applications of 1,3-Dichlorobutane in Industrial Manufacturing

    1,3-Dichlorobutane serves as a targeted chemical intermediate in advanced chemical synthesis across several specialized industrial sectors. Its controlled reactivity and chain structure enable downstream manufacturers to utilize it within tightly regulated, specification-driven processes where batch consistency and regulatory compliance are crucial.

    1. Synthesis of Pharmaceutical Intermediates

    Leading pharmaceutical plants incorporate 1,3-dichlorobutane as a chlorinated building block during the synthesis of heterocyclic molecules, active pharmaceutical ingredients (APIs), and specific antiviral compounds. Chemists leverage its bifunctional reactivity—two terminal chlorines on a four-carbon backbone—to achieve high-purity intermediates after nucleophilic substitution steps. Operations use high-throughput reactors in compliance with validated GMP protocols, fully documenting batch genealogy to ensure traceability. Formulation and purification teams monitor residual chlorides and ensure compliance with residual solvent limits under ICH Q3C guidelines before further processing toward the final API.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • 21 CFR Part 211: Current Good Manufacturing Practice for Finished Pharmaceuticals (FDA)
    • European Pharmacopoeia (Ph. Eur.) for residual solvents and impurities
    • USP <467>: Residual Solvents Testing

    Typical usage ratio

    • 0.2 to 1.0 molar equivalent per target compound, adjusted according to nucleophile reactivity and yield optimization studies

    Downstream process integration

    • Introduced at the alkylation or cyclization step in multi-step API synthesis, often after initial solvent drying and before work-up/purification

    Final product types

    • Active pharmaceutical ingredients (APIs) such as anti-infectives, antiviral agents, and CNS drugs
    • Pharmaceutical intermediate salts and protected heterocycles
    • Chlorinated reference standards for analytical use
    • Precursor intermediates for custom synthesis projects

    2. Agrochemical Intermediate Manufacturing

    Companies in crop protection utilize 1,3-dichlorobutane for constructing specialized herbicide and insecticide intermediates, relying on its chain length and di-chlorination for regulated halogen introduction. R&D teams adapt formulation parameters—such as pH, solvent type, and reactor temperature—instance by instance to control product distribution and minimize polychlorinated byproduct generation. QC labs rigorously monitor halogen content and impurity profile to comply with agrochemical regulatory dossiers and prevent residue carry-over into the active ingredient stage.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • ISO 17025: Testing Laboratory Accreditation for analytical validation
    • EU Plant Protection Product Regulation (EC) No 1107/2009
    • EPA 40 CFR Part 158: Data Requirements for Pesticides

    Typical usage ratio

    • 25–40% by mole relative to total halogenated alkane feedstock, calibrated for process yield and target intermediate molecular weight

    Downstream process integration

    • Batch addition during stage-wise chain elongation, typically between acylation and ring closure or amination; excess controlled to recover unreacted material

    Final product types

    • Haloalkane intermediates for selective herbicides
    • Insecticide core skeletons containing butane bridge units
    • Synthetically modified fungicidal compounds
    • Precursor chemicals for custom crop protection agent synthesis

    3. Polymer and Specialty Elastomer Production

    Polymerization companies adopt 1,3-dichlorobutane mainly as a functional initiator and chain transfer agent during the synthesis of butadiene-based specialty elastomers. Process engineers specify this raw material for controlled molecular weight distribution, enabling production of block copolymers with desired crosslink density and halogen content. Material quality teams track trace contaminants and confirm compliance with downstream polymer safety regulations. Closed-system reactors and automated dosing modules handle the chlorinated intermediate to prevent atmospheric release, and integrated solvent recovery ensures safe, repeatable operations.

    Industry compliance standards

    • ISO 9001: Quality management systems for polymer production
    • REACH Regulation (EC) No 1907/2006 for hazardous substance handling
    • ASTM D2000: Classification System for Rubber Materials
    • GADSL: Global Automotive Declarable Substance List for elastomers

    Typical usage ratio

    • 0.5–3.0 weight % per batch, tailored based on desired molecular architecture and degree of halogenation in final polymer

    Downstream process integration

    • Incorporated into pre-polymer or co-polymerization step via continuous or batch addition protocols; chain transfer activity monitored in-line by gel permeation chromatography (GPC)

    Final product types

    • Chlorinated butadiene elastomers for high-performance seals and gaskets
    • Specialty block copolymers with tailored halogen functionality
    • Flame-retardant elastomeric blends for automotive and electronics
    • Modified poly(butylene) products with enhanced oil/solvent resistance

    4. Organic Synthesis for Fine Chemicals

    Contract manufacturing organizations (CMOs) and fine chemical producers select 1,3-dichlorobutane for constructing advanced specialty intermediates, such as complex alkyl or aryl substituted butanes, often used in pigment, fragrance, and electronic chemical formulations. Teams fine-tune reaction parameters including temperature, pressure, and catalyst loading to drive high conversion and selectivity. Post-reaction work-up comprises extraction, fractional distillation, and impurity control in line with buyer specifications or electronic chemical grade quality demands. Traceability and chain-of-custody documentation support batch validation for niche applications.

    Industry compliance standards

    • ISO 9001: Quality management systems for fine and specialty chemicals
    • SEMI C93: Specification for Specialty Chemicals for Electronics Industry
    • European Chemical Agency (ECHA) reporting for REACH-registered substances
    • OECD Guidelines for the Testing of Chemicals (purity, stability, handling)

    Typical usage ratio

    • 10–30% by weight per batch, varying with complexity of end molecule and required yield specification; adjusted upon analytical confirmation

    Downstream process integration

    • Dosed at key alkylation or halogenation stage, alongside phase transfer catalysts and solvent management protocols; residual material recovery for waste minimization

    Final product types

    • Organic pigment precursors
    • Special fragrance intermediates with chlorinated motifs
    • Tailored organic electronic chemicals (OLED and LCD applications)
    • Specialty chemical intermediates for dyes and plastic additives
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    Certification & Compliance
    More Introduction

    1,3-Dichlorobutane: Direct from the Manufacturer’s Floor

    Understanding 1,3-Dichlorobutane Inside the Chemical Plant

    Working in chemical manufacturing means knowing more than what sits on a spec sheet, and 1,3-dichlorobutane illustrates this point. For years, chemists treated it as a quiet workhorse in the plant, not flashing the reputation of some haloalkanes, yet carving out its own uses in organic synthesis and industrial development. As a producer, we track every batch, right from the reaction kettle through the distillation columns, to finished packaging—so every drum or tank that leaves our site means full accountability. This level of traceability creates reliability, and that means more to engineers and buyers compared to any string of fancy advertising phrases.

    Unpacking the Model and Specifications That Matter

    We produce 1,3-dichlorobutane in bulk, focusing on consistency in purity and moisture content. Most customers ask for a minimum assay of 99% by GC, with water kept below 200 ppm. For some applications, lower levels of monochlorinated or trichlorinated byproducts are a must, especially where the next reaction step is sensitive. By running in continuous and semi-batch processes, we hit those numbers lot by lot. Our standard product runs as a clear, colorless liquid, often packaged in steel drums, ISO tanks, or dedicated road tankers for those collecting in large volume. We never cut corners on inerting or ground handling, especially with chlorinated solvents. I see firsthand what happens if overlooked—a little air, a little moisture, and complaints land fast. Reinvestment in distillation equipment pays off in prevention, not repair.

    How Real Usage Shapes Day-to-Day Thinking

    1,3-dichlorobutane walks into synthesis labs and pilot plants as either a reagent or a starting block for more complex molecules. In pharmaceuticals, it acts as a building block for synthesis of compounds where a two-chlorine pattern can't be swapped by 1,4-dichlorobutane or 1,2-dichlorobutane, simply due to the needed spacing. In agrochemicals, developers count on its unique backbone for ring closure reactions—something that can vanish if the spacing changes by even one carbon. In specialty polymers, chain-length and chlorine placement mean different cross-linking potential. Anyone steeped in practical chemistry learns fast how a slight variance in molecular structure tilts the balance, and if you try to substitute other dichlorobutanes, yields drop, process lines foul, or products behave unexpectedly.

    Why This Specific Compound—Not Just “Any” Dichlorobutane

    As a maker, I get the demand for comparison—customers frequently want to know why not just use 1,2-dichlorobutane or 1,4-dichlorobutane. The differences don’t just live on paper; they show up in every downstream process tweaking. 1,2-dichlorobutane shares the butane skeleton but differs in reactivity and boiling point, so separation steps and byproduct profiles diverge. 1,4-dichlorobutane has a wider span between chlorines, which might make it better for some macrocyclizations but unworkable for tight ring closures. In a pipeline where a bromide or toluenesulfonate needs to be swapped directly for a chloride, the 1,3-dichloro structure fits the bill. In plant trials, using a cheaper or more common substitution might lead to off-brand impurities or resin tackiness—which cascades into costlier cleanups and lost yield. Good production doesn't come from compromise but from finding what actually works under the process steam and controls we've come to trust.

    Scaling Up and Consistency Every Time

    On the manufacturing side, scalability only comes if you truly understand your reactors’ quirks. We moved from kilo-lab scale to tens of metric tons per batch by measuring trace impurities, heat flow patterns, and gas releases on-site. Chlorination reactions can run hot and fickle, and thermal management separates successful production from disaster. Early batches picked up iron from old pipework, leading to color and odor issues—a real headache until we switched to new linings. Over time, we established tighter lot control by analyzing each raw material shipment and revalidating process steps every few months. Small variances in raw butane feed or chlorine quality result in off ratios in byproduct formation, so our team pulls reactor samples at each stage. Whenever we see drift, we halt and recalibrate, even if it sends shivers down the logistics manager’s spine. Reliable production is a whole-company commitment—and it can’t be faked for long.

    Navigating Market Regulations with Manufacturer Insight

    Chlorinated solvents haven’t escaped scrutiny. As manufacturers, we follow both local and international controls—REACH in the EU, EPA oversight in the US, and country-specific reporting everywhere else. Shipping 1,3-dichlorobutane requires not just paperwork but real testing, with certified results for purity, water content, and trace volatile byproducts kept with every outgoing lot. We don’t take shortcuts on labeling or transport documentation. I’ve seen customers caught flat-footed when regulators come knocking and they can’t trace a lot’s origin or test results. We partner with outside labs for secondary verification every quarter, which adds to cost but pays back in reputation and smoother movement through customs or safety audits.

    Supporting Customers Facing Technical Hurdles

    Many users call in after seeing unexpected reactions or side products, especially if they previously bought smaller lots or switched suppliers. We’ve opened our own labs for joint troubleshooting, sometimes running full trial syntheses and testing alongside customers’ in-house teams. This hands-on approach adds time up front, but it avoids repeated large-scale failures. Through real dialogue and on-site learning—we spot what analytical work alone can’t capture. Often, the challenge turns out to be a subtle difference in product specs: water too high, trace acids missed, or a batch packed with the wrong cap lining. Energy wasted on blaming the wrong factor gets saved, and process improvements become faster, since we share a commitment to real, usable chemical solutions, not abstracts promises.

    Handling Waste and Safety Right Where It Happens

    Dealing with chlorinated solvents is not for the casual handler. As a manufacturer, we invest in local recovery, incineration, and containment infrastructure. Every liter of 1,3-dichlorobutane generated “off-spec” or as spent process remains goes for approved treatment. There’s no wiggle room—neighboring communities, regulators, and insurance all demand real, auditable records. We run periodic environmental testing on our site wells and air to prove good practice isn’t just a slogan. Our senior shift operators receive yearly training in leak management and spill response, because over decades, you learn one persistent leak in a transfer line or an improper valve closure can ripple into major issues. In real-time production, muddling through isn’t an option—every experienced operator knows the cost of hesitation or skipping a step.

    Why Supply Stability Rests on Experience, Not Hype

    Supply chains for chlorinated intermediates have faced shakeups in recent years. Weather events, feedstock issues, and global shipping delays affected delivery schedules and pricing. In these turbulent times, longstanding manufacturer relationships make more difference than lowest-price bids. Our approach: buffer stock kept on site; backup chlorine suppliers contracted; and long-view investment in maintenance and plant safety. Because our customers draw up their schedules months ahead, being able to promise and meet a real delivery date wins far more trust than an extra fraction of a percent in purity. I’ve seen waves of buying triggered by rumors or speculative market moves, only for panicked downstream users to find themselves locked out or burned by expired or mishandled lots.

    Looking Ahead: Research and Process Adaptations that Flow into the Market

    Change never stops in this field. Researchers press us for ever tighter impurity specs, new packaging, or less environmental footprint. A decade ago, almost every lot shipped in steel drums. Now, more users want bulk containers and custom-wrapped liners to minimize transfer loss. We invest steadily in greener plant upgrades: closed-loop vapor recovery, real-time emissions monitoring, and improved wastewater treatment. These aren’t marketed as “extras.” They’re demanded by both our direct customers and their larger industry partners—whether in pharma, agchem, or tech manufacture. Our technical staff keeps pace with these demands by trialing new catalyst systems, integrating digital quality controls, and joining industry-wide workgroups to share and benchmark best practices.

    Partnering Beyond the Sale

    Building chemicals is a team effort that doesn’t stop at shipping. Supporting customer R&D, qualifying lots for regulatory dossiers, and post-sale technical troubleshooting become, for us, part of the product. Our chemists keep open books for clients’ analytical teams, not hiding behind formulas but comparing notes and samples in good faith. Sometimes, the greatest value comes from advice on how to adapt a process or improve a purification—not just from routine deliveries. We’ve seen innovation happen from shared pilot runs, where we tweak reaction times or swap drying protocols to maximize yield and minimize waste. Mutual success means fewer complaints, less utility consumption, and actual savings at the end of the month—the cycle continues, and everybody grows.

    Key Takeaways from Manufacturing the Real Product

    From daily management of reactors and production lines, to late-night troubleshooting and market uncertainty, hands-on manufacturing reveals every truth about what it takes to deliver dependable 1,3-dichlorobutane. Its specific placement of chlorine atoms isn’t just a point of curiosity; it holds real value in custom syntheses and critical industrial uses. As direct producers, we focus on practical safety, verifiable quality, and transparent business with customers, beyond the narrow selling points. Years in this field have shown that reputation builds slower than molecules react—and every shipment reflects the hard work and genuine accountability people count on in chemical supply.