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1,3-Dichloro-4-Iodobenzene

    • Product Name 1,3-Dichloro-4-Iodobenzene
    • Alias 1,3-Dichloro-4-iodobenzol
    • Einecs 249-137-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    782553

    Cas Number 22981-50-4
    Molecular Formula C6H3Cl2I
    Molecular Weight 272.90
    Appearance White to off-white powder
    Melting Point 71-74°C
    Boiling Point 273°C (estimated)
    Density 2.00 g/cm3 (at 20°C, estimated)
    Solubility In Water Insoluble
    Purity Typically ≥98%
    Smiles Clc1cc(I)ccc1Cl

    As an accredited 1,3-Dichloro-4-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle with secure cap, labeled "1,3-Dichloro-4-Iodobenzene, 25g"; includes hazard symbols and safety information.
    Shipping 1,3-Dichloro-4-Iodobenzene is shipped in tightly sealed containers, protected from light and moisture. It must be labeled as a hazardous chemical and handled according to local, national, and international regulations. Ensure transportation is via a licensed carrier and that all safety data sheets accompany the shipment to comply with shipping requirements.
    Storage 1,3-Dichloro-4-iodobenzene should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers. The storage area should be clearly labeled, protected from light and moisture, and in compliance with all relevant chemical safety regulations. Avoid heat, open flames, and sources of ignition to ensure stability.
    Application of 1,3-Dichloro-4-Iodobenzene

    Applications of 1,3-Dichloro-4-Iodobenzene in Industrial Manufacturing

    1,3-Dichloro-4-Iodobenzene serves as a core intermediate in advanced industrial synthesis. As a direct manufacturer, we support global customers in sectors where this compound drives selective halogenation, coupling, and functionalization steps. Below, we detail actual industrial application tracks, real downstream integration schemes, and production parameters.

    1. Pharmaceutical Active Ingredient Synthesis

    This compound plays a significant part in multi-step synthesis of specialty pharmaceutical intermediates, especially for heterocyclic APIs and advanced halogenated benzenes. Customers use it in Suzuki, Buchwald-Hartwig, or Ullmann reactions for controlled aromatic functionalization. It ensures precise halogen placement, improving yield in synthetic routes targeting antihypertensives, anti-inflammatory drugs, and emerging small-molecule oncology APIs.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for API
    • USP/NF and EP monographs for intermediates
    • FDA cGMP 21 CFR Part 211 Compliance
    • REACH Registration for chemical intermediates (EU)

    Typical usage ratio

    • 0.5–1.6 mole equivalents, determined by stepwise halogen/phenyl coupling requirements and side reaction suppression needs

    Downstream process integration

    • Enter at the aromatic ring halogenation or cross-coupling step, often after bromination or amidation
    • Applied in the formation of biaryl or diaryl motifs via palladium or copper catalysis
    • Used in optimized solvent systems to maximize regioselectivity

    Final product types

    • API intermediates for Atorvastatin analogs
    • Pyridine-based antihypertensive drug intermediates
    • Benzamide class anti-inflammatory precursors
    • Investigational oncology API precursors for clinical pipelines

    2. Agrochemical Intermediate Production

    Producers of advanced agricultural chemicals adopt this raw material for constructing halogenated phenyl cores required in new-generation herbicides and fungicides. By providing iodine and chlorine functionalities in one molecule, downstream manufacturers achieve targeted substitution in triazole and other active scaffolds, while meeting environmental and toxicology threshold requirements for regulated crop protection agents.

    Industry compliance standards

    • FAO/WHO Good Laboratory Practice (GLP)
    • ISO 9001 Process Quality Management
    • EU Regulation (EC) No 1107/2009 on Plant Protection Products
    • China Pesticide Registration Requirements (ICAMA)

    Typical usage ratio

    • 5–12% weight/weight relative to the main agrochemical backbone, modified by process batch scale and catalyst loading in halophenyl introduction steps

    Downstream process integration

    • Serves as a phenyl halide source in Grignard or lithiation reactions for aryl triazole coupling
    • Added before or concurrent with chlorination in synthesis of active pesticidal moieties
    • Allows streamlined isolation by direct crystallization of the intermediate

    Final product types

    • Selective triazole herbicidal intermediates
    • Fungicide precursors with halogenated aromatic cores
    • Custom synthetic building blocks for developmental insecticides
    • Halogenated biocide intermediates for seed treatment formulations

    3. Electronic and OLED Material Synthesis

    Manufacturers of specialty electronic chemicals require halogenated aromatic intermediates for semiconducting dyes and liquid crystal materials. 1,3-Dichloro-4-Iodobenzene offers key halogen selectivities, leading to improved charge mobility and color purity in OLED emitters and alignment layers. Stringent process control ensures minimal ionic contamination, meeting the high-purity demands of electronics fabrication environments.

    Industry compliance standards

    • IEC 62474 Standard for Material Declaration
    • RoHS 2 Directive (2011/65/EU) for hazardous substances
    • ISO 14001 Environmental Management for chemical plants
    • SEMI S2 Safety Guideline for semiconductor materials

    Typical usage ratio

    • 3–8 mol% in relation to total aromatic content, adjusted by target electronic bandgap and end-product structure

    Downstream process integration

    • Used in the halogenation and coupling phases of blue and green OLED emitter synthesis
    • Introduced during high-purity solvent extraction and purification after initial coupling
    • Supports formation of clean aryl halide layers for high-contrast displays

    Final product types

    • OLED emission layer intermediates
    • Substituted polythiophene conductive polymers
    • Liquid crystal precursors for display manufacturing
    • Specialty dyes for semiconductor photoresists

    4. Advanced Dye and Pigment Manufacturing

    Producers of high-value dyes and pigments integrate this intermediate into processes for synthesizing selective halogenated benzene derivatives. The dual halogen pattern supports downstream coupling in azo, quinoline, and phthalocyanine dye systems, where precise positioning influences solubility, color fastness, and spectral profile required in textile, ink, and plastics industries.

    Industry compliance standards

    • Oeko-Tex Standard 100 for textile colorants
    • EN 71-3:2019 for migration of hazardous elements in toys
    • REACH Annex XVII, Restricted Substances List
    • ISO 9001 for dye manufacturing QA/QC

    Typical usage ratio

    • 0.3–2.5 mass equivalents per target chromophore, tuned for pigment shade, solubility, and dispersibility requirement

    Downstream process integration

    • Charged at the aromatic substitution or azo coupling stage of dye synthesis
    • Used in preparative batch and continuous flow processes for pigment intermediates
    • Supports late-stage halogenation for color intensity adjustments

    Final product types

    • Bright yellow and orange azo dye intermediates
    • Halogenated phthalocyanine pigments
    • Solvent-stable dyes for high-performance plastics
    • Quinoline-derived fluorescent dyes for safety textiles

    5. Specialty Polymer Synthesis

    Manufacturers synthesize engineered polymers for demanding applications using this halogenated benzene to introduce tailored functionality, flame resistance, and morphological control. In high-performance resins and specialty copolymers, controlled incorporation of halogenated aromatic rings through polycondensation or cross-linking steps improves high-temperature performance and chemical durability.

    Industry compliance standards

    • ASTM D5201 for Polymer Additives and Modifiers
    • UL 94 Flammability Standard for plastic components
    • ISO 11357 Differential Scanning Calorimetry in polymers
    • REACH Regulation (EC) No 1907/2006 for polymer producers

    Typical usage ratio

    • 1–7 mol% based on target molecular weight and flame retardancy class, with adjustment for end-use mechanical properties

    Downstream process integration

    • Added during aromatic monomer synthesis for step-growth polymerization
    • Fed into melt or solution-polymerization reactors for specialty copolymer formation
    • Aids cross-link density enhancement in thermoset resin manufacturing

    Final product types

    • Flame retardant copolymer resins
    • High-performance thermosetting composites
    • Specialty engineering plastic masterbatches
    • Wire and cable insulation polymers with tailored halogen profiles
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    Certification & Compliance
    More Introduction

    Introducing 1,3-Dichloro-4-Iodobenzene: Reliable Chemistry from the Source

    Every Batch, Every Detail: Our Commitment to Consistency

    In our facility, each batch of 1,3-dichloro-4-iodobenzene comes off the line under the watchful eyes of seasoned chemists and a team of hands-on production staff who’ve measured and mixed thousands of kilograms of fine aromatic compounds over decades. Our process doesn’t hide behind buzzwords or promises; we rely on a grounded routine—careful handling, regular testing, direct accountability—to ensure every kilogram of this compound meets expectations for purity, moisture content, and physical presentation. The result, batch after batch, is a crystalline solid with a molecular formula of C6H3Cl2I that holds up to inspection, whether analyzed by a bench technician, a QC chemist, or an end user in a downstream synthesizing lab.

    Specification and Handling: Details That Matter at Scale

    From raw material selection to post-synthesis storage, diligence shapes each stage of making 1,3-dichloro-4-iodobenzene. We run GC and NMR analyses in-house, pulling frequent spot-check samples from large lots. The melting point—a direct indicator of purity for this compound—lands typically between 98-102°C, and the iodine content sits tightly within the expected range by weight. We deliver predominantly in fiber drums with double liners, sealed against the creeping ingress of moisture.

    Through years of direct feedback from process chemists, we’ve learned that glassiness, caking, or odd particle size distribution only add time and headaches to multi-step organometallic reactions. We invest time in sieving and conditioning, and our QC staff will never ship pale, yellowed, or sticky product. We refuse to cut corners on crystal habit or presentation, because poor handling at the factory means wasted time and cost downstream.

    Where It Fits: Real-World Uses and Upstream Value

    1,3-dichloro-4-iodobenzene doesn’t just sit on a catalog page; it sees heavy use as an intermediate for agrochemical, pharmaceutical, and material science projects. We’ve watched research groups and pilot plants pull it into such varied applications as selective Suzuki coupling routes, specialized arylation reactions, and as a controlled halogen source for more elaborate aromatic scaffolds. Over the years we have tailored our process to match the needs of these groups, learning firsthand how sensitive downstream yields become when major impurities sneak into starting material.

    From what lab and production teams report, the most immediate challenges arise not only from outright impurities but subtle differences in residual solvents, dust content, or unintended halogen exchange. We keep our process closed and limit all unnecessary exposure. We regularly consult with synthesis chemists when they tell us a trace halogen mix-up causes exothermic surprises in their runs. Anyone who has scaled an aryl coupling from flask to kilo knows the risk—one inconsistent batch can introduce hard-to-track byproducts, clog filtration, or degrade sensitive ligands. These are headaches we strive to prevent, not just patch up.

    Key Differences: Manufacturing Mindset Over Distribution

    Nothing in this compound’s marketplace substitutes for factory-level control. Some resellers dilute the chain of accountability. We manufacture from raw inputs, not pre-bought intermediates. Our technicians make their livelihoods off the predictability of small details—like washing protocols, temperature ramps, and agitation rates—not off trading desk margins. The spec sheet doesn’t tell the full story. Early-career chemists often overlook the less quantifiable: how a dense cake forms in the wrong filter, how an off-color indicator signals microcontaminants, or why particle shape makes a difference in continuous flow.

    By running production ourselves, we hold the data, from batch logbooks to environmental chamber readings. Some companies send every few batches out to contract labs for occasional checks. We check daily. If a sample’s color or IR spectrum diverges, it gets flagged and reprocessed or disposed. Our clients, often experienced synthetic chemists or project leads, have little patience for inconsistency, and neither do we.

    Addressing Challenges in Halogenated Intermediates

    Anyone who has spent a career in halobenzene chemistry knows the headaches: managing corrosive vapors, cleaning stubborn residues from plant equipment, safely storing and transporting iodinated solids without cross-contamination. Routine shortcuts accumulate into headaches for end users. We streamline our workflows not to speed up production, but to reduce avoidable mishaps before they leave our site. Every kilo crosses a pathway of antistatic controls, sealed loading, and final visual inspection under daylight lamps.

    We’ve seen instances where lesser-quality 1,3-dichloro-4-iodobenzene arrives to a customer with excessive fines, dust, or unexplained coloring. These appearance changes often trace back to rushed drying steps or unmonitored cooling and are rarely fixed with a quick screening. Instead of relying entirely on paperwork, we’ve put our energy into training staff to catch these flaws early. Our team works to standardize conditions, always checking off critical parameters—weight loss on drying, trace solvent residue, absence of cake or clump formation—before the product leaves the packaging line.

    Why Manufacturing Experience Yields Better Results for Innovation

    Firsthand experience running reactors, maintaining environmental controls, and monitoring quality batch after batch shapes our approach more than any sales promise or data sheet. Process engineers, operators, and chemists encounter the reality: operational variations quickly multiply across tonnage-scale production. Consistency only comes from routine hands-on process control and accountability. Over time, we’ve learned to invest in staff experience and detailed records rather than chasing fleeting margin savings through unchecked outsourcing or speculative bulk buying.

    We’ve worked with teams scaling up arylation processes or specialty material syntheses, and we have witnessed how material quality impacts total project cost, often in ways invisible at the purchase order stage. When high-purity, consistent intermediate is on hand, reaction workup and purification become more straightforward. Less time spent chasing untracked impurities or troubleshooting unexplained byproducts allows chemists to focus energy on process optimization.

    Direct Support for Technical Teams: Real-Time Answers, Real Solutions

    Some of our longest-standing relationships grew from early technical conversations. Lab chemists calling direct to ask about potential side products or finer points in our drying and washing protocols. Feedback became central to our work: an off-color shipment prompted an immediate review, not a customer service runaround. Our technical staff, many with bench or pilot plant experience, stay ready for detailed discussions rather than relying on templated responses.

    Complex synthesis programs often require minor adjustments in input purity, solvent residuals, or supply format. We listen and offer specific feedback, including adjustments in crystalline size or specialized packaging. Our on-site chemists have supported technology transfer into multi-ton runs through continuous direct dialogue—tracking not only chemical parameters but how they interact with downstream assets and workflows.

    Insights on Market and Regulatory Shifts

    As regulatory standards tighten—especially in agrochemical and pharmaceutical applications—we’ve taken proactive steps to align our process documentation and batch record-keeping with current guidelines. Internal audits review chain-of-custody documentation. All outgoing product carries an analytical report including GC, IR, and water content testing. We check for regulated impurities using the latest detection techniques; response time for issues is quick because corrective action happens in-house.

    Recent volatility in halogen source costs and increasing global scrutiny have made direct relationships ever more important. Customers who run their own regulatory checks appreciate faster answers and deeper traceability when they source from a manufacturer directly accountable for every step of production. As a result, our team allocates significant resources to compliance and transparency, believing these standards aren’t a marketing feature, but a necessity.

    Continuous Improvement Driven by Direct Feedback

    Small process tweaks, suggested by hands-on users, often lead to meaningful production changes. We maintain a communication loop: synthesis teams share results from unusual coupling reactions, and our plant managers use these reports to review upstream processing. Discovering a trace impurity linked back to a storage temperature deviation taught us the hard way to never treat any production step as trivial. Each incident leads to written process changes, additional staff training, and periodic reviews on the shop floor.

    Quality audits, whether internal or by visiting customer teams, are welcomed rather than deflected. Many tough questions about process reproducibility or storage stability stem from real-world headaches in bench or pilot settings; we share details that help users make their own judgments about fit for purpose. Open process and documentation reviews keep the material up to evolving demands, whether for ever-tighter impurity limits in active pharmaceutical intermediates or changing process specs in advanced chemical manufacturing.

    Handling and Safety from a Manufacturer’s Viewpoint

    1,3-dichloro-4-iodobenzene deserves respect in the plant and laboratory. Chlorinated and iodinated intermediates carry risks—fume exposure, skin contact, or unexpected reactivity if mixed carelessly. Factory staff receive hands-on training around transfer and containment. Technical datasheets help guide but never substitute for familiarity built through years of practical handling. All packaging lines include both emission control and sample monitoring to guard against fugitive dust exposure.

    Shipping teams coordinate with downstream users to select drum or bag sizes that fit not just inventory but safe handling practices on receipt. We offer guidance drawn from practice: for storage, this solid prefers a dry, cool, ventilated area free from direct sunlight or high humidity. Each drum is filled under nitrogen, sealed, and lot-labeled by shift supervisors—a level of traceability learned through responding to serious customer incidents caused by breakdowns in chain of custody elsewhere.

    What Sets Our 1,3-Dichloro-4-Iodobenzene Apart

    Direct manufacturing means direct ownership of every production challenge. Our focus extends to both consistency in chemical content and predictability in particle size, moisture resistance, and stability through transit. We’ve discovered that small differences—from a slightly higher residual dichlorobenzene content to unexpected formation of mixed halides—result in hours or even days lost by project teams working downstream. For this reason, we don’t see our responsibility ending with a shipped package. The regular exchange of analytical data, rapid technical response, and flexibility in specification are our answers to practical market needs, not just regulatory checking.

    In contrast, trading houses and brokers often lose sight of these practical details. They focus on availability or short-term cost, and problems left unresolved risk being recycled through the supply chain. Manufacturing accountability, in our experience, is the sole reliable source of predictable outcomes—especially in a diverse and fast-changing sector where adaptability and problem-solving set suppliers apart as true partners.

    Investing in the Future of Chemical Intermediates Manufacturing

    We treat each batch of 1,3-dichloro-4-iodobenzene as a link in a broader chain of innovation. Leading research and process teams depend on stable, high-quality intermediates to fuel new chemistry and production-scale runs alike. Through hands-on monitoring, honest feedback, and an ongoing commitment to technical transparency, we continually refine our manufacturing approach. It’s a strategy shaped by practical, long-term relationships rather than fleeting transactions.

    By remaining open to direct discussion, on-site audits, new analytical techniques, or shifts in packaging and handling, we raise the bar for ourselves—and, by extension, for the users who trust us to supply their critical intermediates. Genuine chemical manufacturing rests on experience, openness, and a shared goal: chemistry that works the way it’s supposed to, every time, from bench to full-scale production.