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1-(3'-Chlorophenyl)-3-Methyl-5-Pyrazolone

    • Product Name 1-(3'-Chlorophenyl)-3-Methyl-5-Pyrazolone
    • Alias 3'-Chlorophenyl Mepyrazolone
    • Einecs 262-151-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    680340

    Chemical Name 1-(3'-Chlorophenyl)-3-Methyl-5-Pyrazolone
    Cas Number 89-00-9
    Molecular Formula C10H9ClN2O
    Molecular Weight 208.65
    Appearance White to off-white crystalline powder
    Melting Point 208-212°C
    Solubility In Water Slightly soluble
    Purity Typically ≥98%
    Iupac Name 3-methyl-1-(3-chlorophenyl)-1H-pyrazol-5(4H)-one
    Synonyms 3-Methyl-1-(3-chlorophenyl)-5-pyrazolone
    Storage Conditions Store in a cool, dry place
    Safety Precautions Avoid inhalation, skin and eye contact

    As an accredited 1-(3'-Chlorophenyl)-3-Methyl-5-Pyrazolone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White HDPE bottle with a tamper-evident cap, labeled “1-(3'-Chlorophenyl)-3-Methyl-5-Pyrazolone, 25g,” with hazard and handling instructions.
    Shipping 1-(3'-Chlorophenyl)-3-Methyl-5-Pyrazolone is shipped in tightly sealed containers, protected from light and moisture. It must be labeled according to hazardous chemical regulations and transported under cool, dry conditions. Standard shipping methods apply unless otherwise specified by safety data guidelines or regulatory requirements for potentially hazardous organic compounds.
    Storage Store **1-(3'-Chlorophenyl)-3-Methyl-5-Pyrazolone** in a tightly sealed container, protected from light and moisture, in a cool, dry, and well-ventilated area. Keep away from incompatible substances such as strong oxidizers. Store at room temperature or as specified on the manufacturer's safety data sheet. Clearly label storage containers, and restrict access to trained personnel only.
    Application of 1-(3'-Chlorophenyl)-3-Methyl-5-Pyrazolone

    Applications of 1-(3'-Chlorophenyl)-3-Methyl-5-Pyrazolone in Industrial Manufacturing

    As an experienced manufacturer specializing in advanced pyrazolone derivatives, we supply 1-(3'-Chlorophenyl)-3-Methyl-5-Pyrazolone to global industrial partners requiring consistent quality and fully traceable origin. Below, we detail major downstream use cases where this intermediate delivers value across process chemistry, with full transparency regarding compliance benchmarks, exact formulation range, integration stage, and product types.

    1. Synthesis of High-Performance Disperse Dyes for Polyester Fibers

    Large-scale textile dyeing and finishing operations utilize this pyrazolone derivative as a key coupling component in the azo dye synthesis for disperse dyes targeting polyester substrates. Its electron-withdrawing chlorine ring enhancement increases lightfastness and color stability during high-temperature batch dyeing processes. Manufacturers calibrate batch input based on required dye shade depth, dispersion efficiency, and regulatory colorant purity for apparel and technical textiles.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (class I-IV limits for aromatic amines, heavy metals)
    • REACH Annex XVII (substance restriction for azo colorants)
    • ZDHC Manufacturing Restricted Substances List (MRSL)
    • GB/T 17592–2006 (Chinese azo dye banned substance standard)

    Typical usage ratio

    • Formulators add 1-(3'-Chlorophenyl)-3-Methyl-5-Pyrazolone at 5–15% by weight relative to the concurrently charged diazo component, with adjustment for molecular extinction requirements, shade intensity, and specific color index targets.

    Downstream process integration

    • Chemists introduce the component as the coupling agent following diazotization of the primary amine in aqueous or solvent-based reactions under controlled pH and temperature (typically 0–10°C). After synthesis, the dye undergoes filtration, purification, concentration, and spray drying before application.

    Final product types

    • Disperse dyes for polyester filament and staple fiber, product lines for sportswear, automotive textiles, technical fabrics, and digital inkjet disperse formulations.

    2. Pharmaceutical Intermediate for Antipyretic and Analgesic Bulk APIs

    The compound serves as an advanced intermediate in the multi-step chemical synthesis of certain pyrazolone-structure APIs widely applied in generic analgesic and antipyretic drugs. Its high purity supports reproducible reaction yields, and traceability aligns with serialization and audits for good manufacturing practices in the pharmaceutical sector.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • United States Pharmacopeia (USP, applicable monographs for relevant APIs)
    • European Pharmacopoeia (Ph. Eur.) general requirements on starting materials
    • Chinese Pharmacopoeia (ChP) applicable purity and identity criteria

    Typical usage ratio

    • Introduced at fixed molar equivalence determined by API process chemistry, typically 0.95–1.05 molar ratio to the targeted next-step reactant. Small excess is sometimes used to maximize conversion and minimize process impurities.

    Downstream process integration

    • Operators charge the intermediate as the key building block in batch-reaction synthesis following initial condensation steps, often through catalytic or acid/base-controlled coupling. Filtration and crystallization purify the downstream API before formulating solid dose or suspensions.

    Final product types

    • Bulk APIs for antipyretic and analgesic use (e.g., metamizole sodium and related drugs), pain-relief formulations, fever-reducing oral and injectable medications.

    3. Raw Material for Agrochemical Azo Dye Tracers and Markers

    Agrochemical formulators use this pyrazolone derivative to produce coloring agents that serve as visual tracer dyes in hydrophobic pesticide and herbicide blends. High weather resistance, chemical inertness, and compatibility with emulsion and suspension concentrate carriers are key advantages supporting label compliance and application safety in field conditions.

    Industry compliance standards

    • US EPA 40 CFR Part 180 (inert ingredients in pesticides)
    • EU Regulation 1107/2009 on plant protection product safety
    • FAO/WHO Specifications for Agricultural Pesticides
    • China GB 2763-2021 Maximum Residue Limits standard for agrochemical colorants

    Typical usage ratio

    • Included at 0.2–2.0% by mass of total formulated product, allowing visibility at legal minimum level and adjusted according to tank-mix concentration, field dilution rates, and specific application method.

    Downstream process integration

    • The compound enters the dye synthesis during diazo coupling for azo pigment production. Final pigment is then dispersed or milled into water-based or solvent-based suspension/agrochemical concentrate according to product needs.

    Final product types

    • Non-toxic colorant additives for crop spray agents, weed and pest control marking solutions, granulated fertilizer color code systems.

    4. Intermediate for Specialty Printing Ink Colorants

    Producers of high-performance colorants for solvent- and water-based printing inks integrate this compound for the manufacture of stable azo pigments exhibiting strong chemical resistance and color brilliance. Its 3’-chlorophenyl substitution improves pigment fastness under exposure to sunlight and solvents, supporting advanced ink formulations for packaging and graphic arts.

    Industry compliance standards

    • EN 71-3 (Safety of toys – migration of certain elements for printed packaging)
    • ISO 2846-1 (Pigments and extenders for color reproduction–inks for four-color process printing)
    • Swiss Ordinance SR 817.023.21 (Printing inks on food packaging)
    • EuPIA GMP for Printing Inks (Good Manufacturing Practice Guidance Note)

    Typical usage ratio

    • Utilized at 3–8% of the total pigment mill batch weight during colorant synthesis, tailored to target color index reference and opacity specification for the final printing ink product.

    Downstream process integration

    • Chemists introduce the raw material during the coupling step of pigment manufacture, followed by filtration, washing, and drying of the pigment slurry. The finished pigment is compounded with resins, solvents, and additives in ink manufacturing lines.

    Final product types

    • Azo yellow and orange primary pigments for flexographic, rotogravure, and digital printing inks used in flexible packaging, decorative laminates, and specialty graphics.

    5. Intermediate for Laboratory Reagents and Analytical Dyes

    Academic, diagnostic, and quality control laboratories require high-purity pyrazolone derivatives in the controlled synthesis of analytical dyes for spectrophotometric assays and colorimetric titrations. The compound’s defined reactivity enhances development of precise color-change indicators and metal-complexation reagents for scientific use.

    Industry compliance standards

    • ISO 17034 (General requirements for the competence of reference material producers)
    • ISO/IEC 17025 (General testing and calibration laboratory competence)
    • Reagent-grade specifications for analytical chemicals (ACS, ISO, DIN)
    • RoHS Directive for heavy metal content

    Typical usage ratio

    • Weighouts for laboratory syntheses typically range from 0.1–1.5 mmol scale, with calculated adjustment based on stoichiometry for precise molarity of the target indicator dye or calibrator compound.

    Downstream process integration

    • Operators introduce the pyrazolone intermediate at the coupling step with selected diazo or phenol derivatives under controlled pH and temperature to synthesize the desired analytical dye, followed by purification via crystallization or column chromatography as required for reagent-grade standards.

    Final product types

    • Analytical dyes for qualitative and quantitative assays, water and food quality test indicators, trace metal detection kits, and research reagents for chemical analysis.
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    Certification & Compliance
    More Introduction

    1-(3'-Chlorophenyl)-3-Methyl-5-Pyrazolone: Reliability from Direct Chemical Manufacturing

    Our Experience with 1-(3'-Chlorophenyl)-3-Methyl-5-Pyrazolone

    At our production facility, we have worked with 1-(3'-Chlorophenyl)-3-Methyl-5-Pyrazolone for years. Seeing its journey from raw material to finished chemical has given us a unique perspective on both its practical value and the demands of the industries depending on it. This compound, often favored in fine synthesis and pigment intermediates, stands out for its clear reactivity and stable properties.

    The Manufacturing Process and Its Impact on Quality

    Quality in specialty chemicals begins with the way we source and handle the incoming precursors. For 1-(3'-Chlorophenyl)-3-Methyl-5-Pyrazolone, we select every batch of 3-chlorobenzoyl chloride and dimethylformamide with attention to purity. Control over the condensation and cyclization steps plays a direct role in the consistency of each output batch.

    Our process engineers monitor pH, temperature, and solvent removal closely, not only because these parameters drive yield, but also because slight variations can introduce color or stability differences that become problems further downstream. Through all the digital automation in the plant, experienced technicians still trust their senses—the odor during the reaction, the density during filtration, the way the solution runs through separation. There is a reality in chemical manufacturing that can’t be substituted by automated systems alone.

    By keeping production in-house rather than relying on toll manufacturers or contract partners, we remain in control of every step. This hands-on approach – following a product from raw input to isolated pyrazolone – lets us ensure customers receive every batch with trustworthy documentation, traceability, and clear lineage.

    Model and Specifications

    Our primary production model for 1-(3'-Chlorophenyl)-3-Methyl-5-Pyrazolone targets a purity of at least 99%, typically verified by HPLC, and water content below 0.3% as determined by Karl Fischer titration. The physical appearance shows as an off-white to faint yellow crystalline powder, characteristic of this molecule’s stable ring structure. In our experience, paying attention to color and free-flowing nature during finishing and packaging proves as important as analytical purity, since end uses often require consistent handling in automated dispensing systems.

    Detailed analytical controls, including IR spectra and NMR, let us catch potential impurities such as regioisomers or residual reactants, ensuring downstream reactions proceed smoothly for customers engaged in synthesis.

    Usage in Industrial Applications

    Users frequently demand 1-(3'-Chlorophenyl)-3-Methyl-5-Pyrazolone as a central intermediate in synthetic dye and pigment manufacture, as well as in certain active pharmaceutical ingredient syntheses. In pigment production, the pyrazolone ring imparts both stability and vivid color hues, especially for yellow and orange tones that resist photobleaching.

    In our plant’s history, we have seen growing demand from developers of high-performance dyes for technical textiles, plastics, and coating resins. These applications require clean, consistent batches with low byproducts, since downstream formulation often tolerates little deviation. Our facility structure, designed for multi-purpose batch reactors, allows us to flexibly schedule runs and avoid contamination from neighboring lines.

    Beyond colorants, medicinal chemistry labs rely on this compound as a scaffold for further derivatization, capitalizing on its reactivity at both the pyrazolone nitrogen and the aromatic ring. We often receive direct feedback from research customers seeking enhanced solubility or purity beyond generic grades, which has driven us to refine processes in favor of lower residual solvents and improved sieve drying to avoid moisture effects.

    Product Differentiation and Customer Expectations

    Being the original manufacturer gives us a toolkit for differentiation that trading companies lack. Our clients do not just come for the molecule—they come for the reassurance that what arrives at their facility matches what was promised, with no hidden batch variability. Characteristics such as the absence of certain by-products, tight melt point, and a specific crystal habit can affect downstream equipment or analytical methods, so we maintain logs of even minor deviations and adjust process tuning as needed.

    Customers occasionally inquire about alternative grades: technical for bulk dye production, and high-purity for pharmaceutical research. We supply both, but our experience shows that even the largest buyers often prefer tighter controls, because mistakes in downstream synthesis can cascade into wasted time and unusable product. Many confide in us about difficulties with material sourced from fragmented supply chains—off-spec batches that wreak havoc on process yields or require yet another purification step. The consistent supply, uninterrupted by shifting intermediaries, builds trust.

    Pricing sometimes leads to hard conversations. We have seen market entrants offer surface-low prices by cutting corners—mixing in non-conforming material, failing to dry batches properly, or inflating packing list weights. This creates headaches for users, from unanticipated cleaning cycles to outright production stoppages. Our commitment stays fixed: deliver verified, QA-tested material with open documentation, even in volatile cost environments.

    Addressing Industry Challenges and User Needs

    Across the sector, one persistent challenge involves residual solvents and micro-impurities. Even trace levels can interact undesirably in some dye formulations or pharmaceutical syntheses. To tackle this, our team spends significant effort optimizing solvent switches and performing staged crystallizations to reduce occluded impurities. These process improvements are not merely incremental—they directly impact customers’ ability to obtain reliable results in production.

    Batch-to-batch reactivity variation poses another concern. Our on-site QC lab checks for parameters that matter in downstream reactions, such as melting point variation and residual moisture. In pigment syntheses, even minor impurity levels can cause hue drift or loss of lightfastness—a problem that only scrutiny at the manufacturing stage can head off. Customers depending on scale-up production lines need assurance that the properties of every ton remain the same as the previous order. By maintaining archives of production data, we help customers trace any irregularity to its root, supporting them through troubleshooting and formulation optimization.

    Waste management and regulatory compliance cannot be overlooked. We designed our reactors and effluent treatment to minimize environmental impact, keeping waste streams separated for easier post-processing. Changing global regulations, especially for products ending up in textiles or drug precursors, demand constant attention to new purity and documentation standards. Investments in closed-loop processing and on-site analytics keep us ready for evolving requirements, ensuring our product never faces downstream compliance issues or causes disruption for end users.

    Building Long-Term Partnerships through Technical Support

    Many clients come to us not just for shipments, but for a relationship where technical problems in the field can be discussed openly. Over the years, we have supported projects involving new pigment shades, alternative synthetic routes, and scaled batch trials. Occasionally, customers uncover an unexpected interaction or need assistance scaling up a lab recipe. Our in-house R&D staff work with them, sharing samples, discussing minor process tweaks, or advising on purification strategies for their follow-on chemistry.

    We recognize the reality of modern manufacturing: time lost to an off-spec batch can never be recovered. For customers trialing new product lines or dealing with strict regulatory reviews, having the direct manufacturer as a troubleshooting partner becomes a significant advantage. Open channels support both sides. Our teams offer insight into process adaptations, while their plant technicians give real-time feedback on performance outcomes.

    Occasionally, the real world forces last-minute changes—urgent needs for extra stock, sudden specification shifts, or the discovery that a formulation reacts differently than lab data predicted. Our flexible production planning allows us to prioritize these needs, adjust purification protocols, or expedite sampling, all supported by on-site analytics to avoid relying on remote laboratories. In each of these situations, our role as both manufacturer and advisor gives us a stake in our customers’ outcomes.

    Continuous Improvement and Industry Expectations

    In our chemical manufacturing plant, continuous improvement stems as much from customer conversations as from internal research. New technology—whether more efficient solvent recovery, advanced filtration, or tighter process control—enters the facility because customer demand persists for better and more reliable results. We track feedback from every market served, running pilot tests and updating cleaning protocols or analytical metrics as needs shift.

    Sometimes, an industry trend triggers a shift in specification. Tightened regulations on residual halides, reduced tolerance for fine particulates, or the push for greener solvents have all caused us to examine batch records, rework pipeline connections, or bring in new testing routines. Every improvement, whether responding to global trends or direct customer feedback, raises the baseline for everyone in the sector. Competitive pressures exist, but improvements born of cooperation with users give enduring gains.

    Years of working hands-on with 1-(3'-Chlorophenyl)-3-Methyl-5-Pyrazolone have shown us that chemical production does not stand still. Even seemingly settled processes can yield better results through material and workflow upgrades. In one instance, a new crystallization technique, learned through industry exchange, trimmed process time and improved bulk product shelf life for our customers. Enthusiasm for technical progress defines those willing to invest in manufacturing, rather than treat chemicals like undifferentiated commodity cargo.

    Looking Ahead: Building Value Beyond the Molecule

    For buyers and researchers, direct access to a manufacturer who controls synthesis and understands downstream impact provides more than just a source of material. It provides insurance against unexpected process failures and a sounding board for technical planning. As the world’s demand for specialized chemicals such as 1-(3'-Chlorophenyl)-3-Methyl-5-Pyrazolone grows, companies and researchers linking up with the direct manufacturer gain not just from product access, but also from collaborative technical insight.

    Our experience underscores a simple reality: a stable, high-quality supply of critical intermediates forms the backbone of successful production lines and research pipelines. While trading companies and brokers inject price competition into the market, only the manufacturer stands ready to tweak processes, answer technical questions with real process knowledge, and respond when the unexpected happens.

    The difference in product consistency and technical support grows clear with time. Customers who have wrestled with irregular supplies, out-of-spec material, or untraceable batches know the disruption it can introduce. By focusing on direct production, open communication, and process refinement, we deliver not just a chemical, but the reassurance and partnership that allow end users to focus on what they do best: driving innovation and bringing products to market.

    Across industries, 1-(3'-Chlorophenyl)-3-Methyl-5-Pyrazolone demonstrates the value of careful manufacturing, honest technical exchange, and sustained investment in process quality. Our aim stays fixed—not as a speculative intermediary, but as a reliable manufacturing partner committed to the needs and standards of those who depend on this essential compound.