Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

1,3-Bis(Chloromethyl)Tetramethyldisilazane

    • Product Name 1,3-Bis(Chloromethyl)Tetramethyldisilazane
    • Alias BCMTMS
    • Einecs 629-144-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    179816

    Productname 1,3-Bis(Chloromethyl)Tetramethyldisilazane
    Casnumber 54143-65-6
    Molecularformula C6H18Cl2N2Si2
    Molecularweight 261.31 g/mol
    Appearance Colorless to pale yellow liquid
    Boilingpoint 88-90°C (at 3 mmHg)
    Density 1.09 g/mL at 25°C
    Refractiveindex 1.463 (20°C)
    Purity Typically ≥97%
    Solubility Decomposes in water
    Storagetemperature 2-8°C
    Synonyms Tetramethyl-1,3-disilazane dichloromethyl
    Smiles CN(C)Si(CH2Cl)(N(C)C)Si(CH2Cl)(C)C
    Inchikey KXQJNBVXWBZHLY-UHFFFAOYSA-N

    As an accredited 1,3-Bis(Chloromethyl)Tetramethyldisilazane factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The chemical is supplied in a 100g amber glass bottle, securely sealed, and labeled with hazard warnings and handling instructions.
    Shipping 1,3-Bis(Chloromethyl)Tetramethyldisilazane should be shipped in tightly sealed, chemical-resistant containers under cool, dry conditions. It must be clearly labeled as a hazardous material and protected from moisture, heat, and direct sunlight. Follow all relevant regulations for shipping dangerous chemicals, including appropriate documentation and emergency protocols. Handle with proper personal protective equipment (PPE).
    Storage **1,3-Bis(Chloromethyl)Tetramethyldisilazane** should be stored in a tightly sealed container under inert atmosphere, such as nitrogen or argon, to prevent moisture and air exposure. Store in a cool, dry, well-ventilated area away from heat, ignition sources, acids, and oxidizing agents. Clearly label the container and follow appropriate safety and chemical hygiene protocols to prevent accidental release or contact.
    Application of 1,3-Bis(Chloromethyl)Tetramethyldisilazane

    Applications of 1,3-Bis(Chloromethyl)Tetramethyldisilazane in Industrial Manufacturing

    As a specialized producer of 1,3-Bis(Chloromethyl)Tetramethyldisilazane, we support a select group of advanced industrial sectors where this silazane derivative delivers functional silanization and crosslinking reactivity. The following application scenarios highlight actual downstream uses, specifying regulatory standards, typical dosage ranges, integration stages in production, and the types of finished goods formulated by our partners.

    1. Synthesis of Organosilicon Pharmaceutical Intermediates

    Pharmaceutical ingredient manufacturers use our silazane derivative as a precise silylating agent to protect amine and hydroxyl functionalities during multi-step organic synthesis. These protection-deprotection strategies support production of complex organosilicon molecules serving as intermediates for APIs, especially in nervous system and oncological active pharmaceutical compound synthesis. Each batch must meet narrow purity and trace contaminant limits to satisfy downstream cGMP and pharmacopoeial requirements for later stages of API manufacturing.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.), monographs for relevant silicon-based intermediates
    • United States Pharmacopeia (USP) guidelines for residual solvents and elemental impurities
    • FDA 21 CFR Part 211 for process validation and traceability

    Typical usage ratio

    • 0.5–2.0 molar equivalents based on target functional group; adjusted per substrate reactivity and scale-up batch requirements

    Downstream process integration

    • Charged in situ as a protection reagent during the intermediate synthesis stage; removed via aqueous or acidic quenching steps prior to API finalization

    Final product types

    • Protected organosilicon intermediates (e.g., silazanyl-functionalized amines and alcohols)
    • Precursor chemicals for active pharmaceutical ingredient (API) synthesis

    2. Silicone Resin Crosslinker for Electronic Encapsulation Compounds

    Electronics materials producers incorporate the silazane as a crosslinking monomer in silicone resins used for device encapsulation, potting, and protective coatings. This enhances mechanical integrity and environmental resistance of semiconductor and LED modules. Formulators require close control of blending ratios and process temperatures to ensure uniform network structure and certified reliability under thermal cycling and humidity stress.

    Industry compliance standards

    • IPC-4101B for laminate and prepreg manufacture
    • UL 94 for flammability testing of plastics
    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances)
    • IEC 61249-2-21 for base materials for printed boards

    Typical usage ratio

    • 0.1–1.0 phr (parts per hundred resin) depending on resin system viscosity and desired crosslink density for thermal shock resistance

    Downstream process integration

    • Added during resin compounding in mixing reactors prior to vacuum degassing and mold casting of encapsulation materials

    Final product types

    • Silicone potting compounds for power semiconductor modules
    • Encapsulant gels for LED packaging
    • Protective conformal coatings for high-performance printed circuit boards (PCBs)

    3. Surface Modification Agent for Functional Silica Fillers

    Advanced materials processors use this silazane to functionalize silica and other mineral fillers, grafting hydrophobic and reactive organosilicon groups onto particle surfaces. This surface modification enhances compatibility with polymer matrices, improves filler dispersion, and optimizes the dielectric or rheological profile of composite materials. Controlled wet or dry surface treatment processes require continuous monitoring of reaction parameters for batch uniformity and product stability.

    Industry compliance standards

    • ISO 9001 Quality Management Systems for industrial fillers
    • REACH (EC 1907/2006) registration for surface treated minerals
    • ASTM D5630 for loss-on-ignition of inorganic fillers after surface treatment

    Typical usage ratio

    • 0.5–4.0% by weight based on filler loading; optimized for targeted surface energy and final compound application

    Downstream process integration

    • Applied during dry blending or through spray-on wet chemical treatment in agitated reactors before drying and blending into thermoplastic or thermoset polymer matrices

    Final product types

    • Functionalized silica fillers for advanced rubber compounding
    • High-dielectric composites for cable insulation
    • Improved reinforcement additives for tire and automotive components

    4. Intermediate for Silsesquioxane-Based Coating Binder Synthesis

    Coating manufacturers employ the silazane as a building-block intermediate in the hydrolytic condensation reaction for synthetizing silsesquioxane binders. These high-performance binders impart excellent thermal stability and barrier properties to specialty glass, metal, and ceramic coatings. Tightly controlled water content and pH management during condensation ensures predictable polymer architecture and consistent film-forming characteristics meeting applicable performance specifications.

    Industry compliance standards

    • ISO 12944 for corrosion protection of steel structures by protective paint systems
    • EN 13523 for coil coating product quality evaluation
    • ASTM D522 for flexibility of organic coatings

    Typical usage ratio

    • 1.0–5.0 wt% of total siloxane precursor loading; dosage adjusted for target molecular weight and crosslinking degree of final silsesquioxane binder

    Downstream process integration

    • Reacted during pre-polymer hydrolysis-condensation prior to pigment dispersion and final paint mill-base preparation

    Final product types

    • Siloxane-organic hybrid coatings for architectural glass
    • Corrosion-resistant paints for marine and chemical processing equipment
    • Thermal barrier coatings for high-temperature metal and ceramic substrates

    5. Precursor in Speciality Silicone Elastomer Vulcanization Aids

    Speciality elastomer compounders select our silazane derivative as a co-crosslinking agent supporting tailored vulcanization profiles in high-consistency and liquid silicone rubber (HCR/LSR) systems. This enables fine-tuning of network morphology and physical performance for demanding gasket, O-ring, and medical-grade elastomer applications. All batches must demonstrate predictable reactivity in platinum- or peroxide-catalyzed curing cycles to ensure consistent product performance and regulatory conformity.

    Industry compliance standards

    • ISO 10993 for biocompatibility of medical silicone
    • FDA 21 CFR 177.2600 for rubber articles intended for repeated use
    • USP Class VI for medical device elastomers
    • ISO 9001 for production process control and traceability

    Typical usage ratio

    • 0.2–1.2 phr depending on cure system, elastomer molecular weight, and application performance criteria

    Downstream process integration

    • Blended into elastomer compounding stages before catalyst addition and molding; reactivity profile monitored by rheometric analysis prior to extrusion or injection processing

    Final product types

    • Medical device silicone gaskets and seals
    • Automotive O-rings and connector boots
    • Food-contact silicone tubing and stoppers

    6. Silanization Reagent for Analytical Reference Material Preparation

    Analytical chemical manufacturers deploy this silazane as a silanization reagent to derivatize reference standards for laboratory use, particularly in silicon-based GC and LC sample preparation. The highly-controlled reaction ensures formation of uniform silyl derivatives suitable for calibration and trace impurity analysis in regulated testing laboratories. Batch reproducibility and ultra-low impurity profiles are critical for customer compliance with method validation protocols.

    Industry compliance standards

    • ISO/IEC 17025 for laboratory reference material production
    • USP Chapter <1225> on validation of compendial procedures
    • EPA Method 8270D for semivolatile organic analysis (where silylation is used for analytics)

    Typical usage ratio

    • 1.0–3.0 molar equivalents per target functional group, optimized by analytical chemist according to sample load and derivatization efficiency

    Downstream process integration

    • Utilized in controlled derivatization reactions during analytical reference material preparation prior to solvent evaporation, packaging, and certified standard distribution

    Final product types

    • Certified silylated analytical standards for chromatography
    • Derivatized calibration samples for quality control laboratories
    Free Quote

    Competitive 1,3-Bis(Chloromethyl)Tetramethyldisilazane prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    1,3-Bis(Chloromethyl)Tetramethyldisilazane: Specialty Chemical for Advanced Synthesis

    Understanding the Product

    Our work with 1,3-Bis(Chloromethyl)Tetramethyldisilazane traces back to a dedication to precision and control. As a chemical manufacturer, years of handling silazane derivatives have brought to light the versatile profile that this molecule delivers. Its structure, featuring two chloromethyl groups attached to a tetramethyldisilazane core, provides reliability in targeting specific syntheses that mainstream silazanes often cannot match. In production, each batch demands close observation, starting from the raw silicon supplies down to the accurate addition of chlorination agents. Deviations, even slight, can alter reactivity or introduce impurities. Our operation places quality front and center by designing reaction conditions suited to the desired end-use market, including the pharmaceutical, agrochemical, and advanced materials fields.

    Key Specifications and Characteristics

    1,3-Bis(Chloromethyl)Tetramethyldisilazane appears as a clear to slightly yellow liquid, a feature that hints at its purity and low impurity load. Boiling point analysis and GC-mass confirmation ensure that the product aligns with the standards required for sensitive synthesis. Moisture remains the chief threat during both storage and transport; we've engineered our filling and packaging to minimize water exposure, using nitrogen purging before final capping. Chloromethyl substitution at both ends of the molecule gives it greater chemical leverage compared to mono-chlorinated analogs.

    Weight and volume tolerances reflect choices built into our process control. Regular reactor size calibrations and packing density checks limit batch-to-batch inconsistency. Each liter of the product offers similar reactivity thanks to the batch continuity achieved by synchronizing temperature ramps and stirring speeds across lines. We keep an eye on the possibility of rearrangement side products, knowing that downstream customers demand reproducibility. Since the product must fit directly into multi-step syntheses, these details can mean the difference between reliable performance and production hiccups.

    Applications and Real-World Utility

    Our customers put 1,3-Bis(Chloromethyl)Tetramethyldisilazane to work as a crosslinking agent and as an intermediate in the construction of silicone-based and nitrogen-containing polymers. We’ve observed the compound act as a coupling element, often performing in places where monofunctional silazanes lose efficiency or give incomplete reactions. It delivers consistent results in crafting silazane-functionalized resins, coatings, and network structures, standing up to moisture and hydrolysis much better than many related compounds. Where standard trimethylsilyl reagents plateau, this molecule pushes reaction schemes further, making higher molecular weight or branched frameworks achievable.

    Research groups and industrial teams alike rely on its predictable behavior in nucleophilic substitution reactions, especially where chloromethyl groups drive selective transformations. In our own pilot plant, efforts to make advanced silicone pastes for electronics highlighted the importance of this compound’s purity. A single percentage point of impurity can wreak havoc on electronic performance due to unplanned side reactions. We’ve also worked side by side with teams in agricultural innovation who use this silazane backbone for controlled-release agents, as it enables more fine-tuned hydrolysis rates.

    The molecule does not simply offer synthetic versatility – it grants reaction planners a new level of freedom to design more robust molecular scaffolds. For instance, coupling with phenolic or amine groups in resin production provides a level of crosslinking density that enhances both mechanical properties and durability. The product’s dual chloromethyl groups open the door to bis-functional or polymeric customizations not feasible with simpler silazanes. This means formulators can aim for higher performance standards, whether in adhesives, encapsulants, or surface treatments engineered to resist breakdown.

    Why Select This Molecule Over Others?

    Choices matter in chemical synthesis, especially at scale. Most competitors or alternative products in this space come as monofunctional silazanes or as less tightly defined chlorinated silicon derivatives. Our experience shows that single-point chlorination patterns often struggle when uniform crosslinking or symmetrical functionalization is a goal. Mono-chloromethyl versions restrict what the molecule can do, forcing chemists to introduce extra steps or additional reagents to achieve similar outcomes.

    Structural symmetry in 1,3-Bis(Chloromethyl)Tetramethyldisilazane translates to cleaner downstream chemistry. This adds value not just in reaction yield, but also in ease of purification – a detail that becomes crucial when batches are measured in hundreds or thousands of kilograms. In our own processes, we’ve found that double-ended chloromethyl functionalization cuts down waste streams and avoids the introduction of extraneous protecting groups. The resulting process not only eases the load on environmental controls, but also reduces costs tied to solvents and byproduct handling.

    Other silazane derivatives often bring additional methyl or phenyl groups into the backbone for steric bulk or electronic tuning, but these can compromise stability toward strong acids or bases and invite unwanted rearrangement. 1,3-Bis(Chloromethyl)Tetramethyldisilazane, on the other hand, maintains a balance between reactivity and operational stability. It won’t hydrolyze as quickly as some more polar or heavily substituted alternatives, so users can operate with more confidence under a wider range of pH or ambient humidity levels.

    Manufacturing Perspective: What Sets Our Product Apart

    Years spent tracking the entire life cycle of this molecule have demonstrated that true difference-making starts at the input materials. From silicon metal to methylchlorosilane, sourcing decisions on our end influence not just the cost but the impurity profile right through to the end user. We employ acid-stable, corrosion-resistant reactor materials since even trace iron or copper can provoke side reactions with silazane chemistry. Each production cycle involves rigorous cleaning and inerting procedures, since exposure to oxygen or water can cause premature hydrolysis or oxidation, leading to chloromethyl loss or siloxane ring formation.

    Adjustments to catalyst levels and addition speeds matter. Over time, we’ve refined our catalyst charge techniques by monitoring real-time reaction progress via NMR sampling and in-line FTIR. Faster addition rates in colder weather, slower in hot spells – these in-plant realities ensure the product meets specification regardless of season or geography. Regular calibration of dosing pumps and reaction kettles further insulates downstream users from any surprises linked to batch variability.

    We maintain detailed batch records, with spot tests for residual chlorides and nitrogen content alongside the main purity checks. We share these findings with key partners, supporting process troubleshooting in their facilities when needs arise. Transparency pays off; clients tackling scale-up projects often share feedback about our documentation quality and our willingness to adapt packaging or shipping practices to meet specialized handling needs. As the original manufacturer, we commit resources to these steps to help guarantee successful outcomes for every end user.

    Addressing Industry Challenges

    Silazane chemistry evolves as both applications and regulations shift. Strict controls on halogenated intermediates add complexity to both manufacturing and permitting processes. We stay ahead by investing in closed-loop recovery for chlorinated byproducts and by optimizing scrubber efficiency for gaseous emissions. This both cuts environmental burden and offers savings that we can cycle back into new technology or quality improvements.

    Supply chains for advanced chemical inputs like this molecule remain exposed to occasional shocks, whether from logistics disruptions or regulatory reviews on precursor chemicals. Our direct production approach means we can secure a more stable flow of inputs and set up multiple points of redundancy. By keeping critical steps like distillation, chlorination, and packaging in-house and under our jurisdiction, we shield both ourselves and our customers from interruptions seen with outsourced or transshipped supply.

    Customers in electronics, healthcare, and advanced coatings want confidence that each liter performs identically to the last. Consistency leads to new product approvals and fewer surprises in quality audits. To support this need, we embed routine stability testing into our schedule, simulating months’ worth of exposure to both arid and humid environments. The data we gather sharpens process controls and uncovers early warning signs that can be fixed before they propagate to downstream users.

    Disposal of old or unused stock remains a recurring challenge, exacerbated by the presence of both chlorine and silicon in the molecule. We advise returning any expired or out-of-spec materials to our facility for high-temperature destruction, following protocols that neutralize hazardous byproducts and reclaim useful inorganic residues. Partnering with downstream consumers to develop take-back and recycling options not only secures environmental compliance but helps us learn more about the full lifecycle of the product and its byproducts.

    Continuous Improvement in Production and Support

    Our ethos in making silazanes isn’t static. Feedback from long-term customers shapes our priorities in the plant – complaints about minor handling difficulties have led us to redesign drum and tote closures for easier dosing and lower risk of external contamination. Increased demand for higher-purity versions prompted us to expand our fractional distillation unit, moving the product’s assay past the 98% threshold by eliminating more trace volatiles.

    Commitment to transparent quality underpins our manufacturing philosophy. On-site laboratories test incoming and outgoing lots, while data analytics support troubleshooting and trend analysis on production batches. Operators remain trained to spot subtle changes in viscosity, color, or odor – often the first signal that a deviation has crept into the process. These real-world process controls don’t appear on a spec sheet but can make all the difference to researchers or plant managers relying on uninterrupted progress.

    We periodically benchmark our process against new regulatory frameworks, rolling out upgrades when emission or safety standards tighten. For instance, anti-siphon valves and double-walled tanks let us further reduce fugitive emissions during loadout. Safety, both for plant personnel and end users, matters to us; the corrosive and flammable nature of the product means all staff receive up-to-date chemical handling training and that shipment meets all relevant international standards for hazardous materials.

    Over the years, partnerships with leading industrial labs and academic research groups have deepened our understanding of this molecule’s properties. We welcome project-specific inquiries that test the potential of 1,3-Bis(Chloromethyl)Tetramethyldisilazane in emerging applications, such as semiconductor wafer surface treatments or hybrid organic-inorganic scaffolds for medical devices. Our technical team gladly collaborates on feasibility studies or custom blends when users push beyond standard boundaries.

    Meeting the Demands of Advanced Chemistry

    Modern chemistry rarely stands still, and the push for greater precision, environmental stewardship, and process safety means expectations grow yearly. As a manufacturer, our role doesn’t end at shipment. Customer needs for troubleshooting, supply security, and regulatory assurance inspire us to keep improving. Every inquiry shapes our approach to batch management, packaging redesign, and data availability. The unique combination of reactivity, safety, and supply control embodied by 1,3-Bis(Chloromethyl)Tetramethyldisilazane positions it not as a commodity, but as a key building block for those pushing boundaries across multiple sectors.

    Each year of production sharpens our appreciation for the rigor required at every stage—from raw silicon procurement, through catalyst selection, to finished product validation and specialty packaging. The result of this diligence is a compound that meets the high expectations of users demanding reproducible and robust building blocks for their syntheses, all informed by the practical experience of a manufacturer solving the same challenges faced by our clients.

    We strive to turn every lesson learned in production and application into stronger partnerships and better service, ensuring that both large-scale professionals and innovative development teams discover not just a material, but a manufacturing ally invested in their progress and success.