Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

1,3-Benzodioxole

    • Product Name 1,3-Benzodioxole
    • Alias Methylenedioxybenzene
    • Einecs 204-549-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    745778

    Cas Number 274-09-9
    Molecular Formula C7H6O2
    Molecular Weight 122.12 g/mol
    Iupac Name 1,3-benzodioxole
    Synonyms Methylenedioxybenzene
    Appearance Colorless liquid
    Boiling Point 172-173 °C
    Melting Point -11 °C
    Density 1.094 g/cm3
    Solubility In Water Slightly soluble
    Flash Point 59 °C
    Refractive Index 1.537
    Smiles c1ccc2c(c1)OCO2
    Pubchem Cid 8462
    Odor Pleasant, aromatic

    As an accredited 1,3-Benzodioxole factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 1,3-Benzodioxole is packaged in a sealed amber glass bottle, 500 mL, with hazard labels, batch details, and safety data sheet.
    Shipping 1,3-Benzodioxole should be shipped in tightly sealed, properly labeled containers, protected from physical damage. It must be transported in accordance with local, national, and international regulations for hazardous chemicals. Ensure compatibility with other materials and avoid sources of ignition, as 1,3-Benzodioxole is flammable. Appropriate shipping documentation and safety data sheets are required.
    Storage **1,3-Benzodioxole** should be stored in a cool, dry, well-ventilated area, away from direct sunlight and sources of ignition. Keep the container tightly closed and store separately from strong oxidizing agents and acids. Use appropriate safety containers to prevent leaks or spills. Ensure that storage conditions minimize vapor accumulation and comply with local regulations regarding hazardous chemicals.
    Application of 1,3-Benzodioxole

    Applications of 1,3-Benzodioxole in Industrial Manufacturing

    1,3-Benzodioxole, also known as methylenedioxybenzene, supports industrial production as a core aromatic intermediate. The material’s stable ring structure and reactivity enable downstream synthesis in multiple specialty sectors. We manufacture and supply 1,3-benzodioxole for direct use in compliant, validated manufacturing chains.

    1. Pharmaceutical Intermediate Synthesis

    Manufacturers in the pharmaceutical sector utilize 1,3-benzodioxole as a building block for the synthesis of various APIs, including antiprotozoal, antiparasitic, and antifungal compounds. The material’s aromatic structure allows for selective electrophilic substitution reactions and functional group modifications. Pharmaceutical synthesis typically requires precise reagent quality, and we control trace impurities in line with cGMP guidelines. Our product integrates into the first-stage coupling or protection steps during multi-step organic synthesis, enabling consistent results in downstream formulation and purification of target intermediates.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice Guidance for Active Pharmaceutical Ingredients
    • European Pharmacopoeia and USP guidelines on pharmaceutical intermediates
    • FDA 21 CFR Part 211 (cGMP for Finished Pharmaceuticals)
    • REACH (EC No 1907/2006) chemical safety dossier (for EU use)

    Typical usage ratio

    • Varies by target molecule; generally 0.2–1.0 molar equivalent per synthesis stage
    • Adjusted according to stoichiometry and purity specification of the API route

    Downstream process integration

    • Introduced in batch reactors at coupling or ring-modification steps
    • Dosed via automated metering for reproducibility and minimized operator exposure
    • Processed under nitrogen or inert atmosphere to control unwanted side reactions

    Final product types

    • Antiprotozoal pharmaceuticals (e.g., certain metronidazole derivatives)
    • Antifungal actives for topical and systemic medications
    • Intermediates for antimalarial compounds

    2. Agrochemical Synthesis

    1,3-Benzodioxole functions as a core scaffold in the crop protection industry, supporting large-scale synthesis of insecticides and fungicides such as pyrethroid analogues and synergistic ingredients. Agrochemical companies rely on its chemical stability and reactivity for multi-step processes, especially in industrial halogenation and esterification reactions. Compliance with food safety and environmental residue standards is critical, and we maintain analytical documentation to support agricultural registration dossiers.

    Industry compliance standards

    • FAO/WHO Codex Alimentarius MRL (Maximum Residue Limit) requirements for pesticide actives
    • ISO 9001:2015 Quality Management System
    • Globally Harmonized System (GHS) chemical labeling
    • EU Regulation (EC) No 1107/2009 for plant protection products

    Typical usage ratio

    • 0.5–2.5 mole per mole of active ingredient backbone structure in synthesis
    • Adjusted depending on final product’s required activity and purity

    Downstream process integration

    • Charged into jacketed synthesis vessels during aromatic substitution or etherification steps
    • Quality-monitored input for continuous or semi-batch production lines

    Final product types

    • Insecticide actives, including piperonyl butoxide precursors
    • Fungicide actives for seed treatment formulations
    • Intermediate compounds for agricultural synergists

    3. Fragrance and Flavor Ingredient Manufacturing

    1,3-Benzodioxole is processed in the fragrance and flavor industry to manufacture aroma chemicals such as piperonal (heliotropin) and related benzaldehyde derivatives. Producers value the clean aromatic core for developing complex notes in fine fragrances, soaps, and food flavorings. Downstream users require conformity with food additive and cosmetic ingredient standards, including low-odor grades and batch traceability. Integration typically begins with oxidation, condensation, or acetalization reactions under controlled thermal and pH conditions, determining yield and sensory profile.

    Industry compliance standards

    • IFRA (International Fragrance Association) guidelines
    • EU Regulation (EC) No 1334/2008 for flavorings and food ingredients
    • US 21 CFR 172.515 for synthetic flavoring substances and adjuvants
    • ISO 9001 and HACCP food safety protocols

    Typical usage ratio

    • 0.8–1.2 mole per mole of desired aldehyde/ketone target
    • Optimized based on selective oxidation yield and impurity minimization

    Downstream process integration

    • Introduced at the initial oxidation or formylation stage in stirred and vessel reactors
    • Closely monitored for peroxide and color index during processing
    • Separated and recovered via vacuum distillation or crystallization

    Final product types

    • Piperonal (heliotropin) for fine fragrance bases
    • Benzaldehyde derivatives for flavor compositions
    • Soap and detergent perfume ingredients

    4. Polymer and Specialty Monomer Production

    Chemicals manufacturers use 1,3-benzodioxole as a precursor during the production of specialty monomers and performance polymers. Its aromatic dioxole unit helps introduce rigidity and electronic properties to advanced polymer chains, supporting niche electronics, coatings, and film applications. Manufacturers manage monomer conversion through careful catalyst selection and controlled thermal processing. Documentation supports conformance with materials safety and hazardous reaction management in regulated industrial facilities.

    Industry compliance standards

    • RoHS EU Directive 2011/65/EU for hazardous substance content in electronics
    • ISO 14001 Environmental Management Standard
    • REACH Annex XIV restrictions for monomer precursors
    • ASTM D883 terminology for polymer classification

    Typical usage ratio

    • 0.05–0.3 mole per mole of polymer backbone depending on targeted material properties
    • Adjusted for chain length, thermal stability, and dielectric properties

    Downstream process integration

    • Dosed into multi-stage bulk polymerization or copolymerization reactors
    • Blended with co-monomers and crosslinkers as required by formulation
    • Monitored for conversion rate and residual monomer content

    Final product types

    • High-performance polyarylene polymers for electronic applications
    • Films and coatings with modified dielectric and UV-resistant properties
    • Niche thermoplastics for specialty engineering uses

    5. Fine Chemical and Analytical Reagent Production

    Producers in the fine chemical sector use 1,3-benzodioxole as a critical precursor for synthesizing analytical standards, research intermediates, and specialty ligands. Compounds derived from this core structure are essential for laboratory analysis and calibration, requiring ultra-high purity and documented analytical profiles (NMR, HPLC). Our manufacturing ensures consistent low-level impurity thresholds for downstream blending or derivatization under controlled conditions, supplied with full batch traceability and regulatory documentation.

    Industry compliance standards

    • ISO 17034 General requirements for the competence of reference material producers
    • OECD Good Laboratory Practice (GLP) principles
    • USP and EP requirements for analytical standards
    • REACH chemical registration for non-pharmaceutical analytical use

    Typical usage ratio

    • 0.01–0.1 mole per mole of finished standard or reference compound
    • Dosed based on required calibration concentration and final yield

    Downstream process integration

    • Charged into glassware synthesis setups for analytical or high-purity grades
    • Controlled addition in semi-preparative chromatography workflows
    • Integrated into derivatization or protective-group chemistry protocols

    Final product types

    • Certified analytical reference standards for chemical analysis
    • Research intermediates for academic and industrial labs
    • Specialty ligands for laboratory catalysis or binding studies
    Free Quote

    Competitive 1,3-Benzodioxole prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    1,3-Benzodioxole: A Core Building Block for Modern Chemistry

    Our Commitment to Quality Production

    As a dedicated manufacturer, we blend a combination of chemistry know-how, operational discipline, and years of hands-on plant experience in every batch of 1,3-Benzodioxole. Our teams run multipurpose trickle-bed reactors at scale, maintaining precise temperature and pressure to ensure proven batch-to-batch reliability. Familiar issues like purity drift, residual moisture, and persistent color bodies led us to invest in extra purification columns and a custom distillation sequence that consistently holds purity above 99.5%. Because teams handling bulk orders—whether for intermediates, research, or crop protection—count on real consistency, we resist shortcuts and keep sharp control at every stage.

    What Makes Our 1,3-Benzodioxole Distinct

    This molecule, also recognized in the trade by its ring structure or “methylenedioxybenzene,” is prized by formulators for its chemical stability and its predictable performance under reaction conditions. Aromatic ring systems like this appear across natural product synthesis, performance polymers, perfumery bases, dyes, and crop chemistry. Our process avoids the usual phenolic byproducts—the sort that add color or lingering odor—since we refine away trace impurities that can trouble downstream steps. We run regular HPLC assays and GC testing as part of our plant routine to double-check, not just for organic contamination, but also for trace halogens, as these can trigger off-smells or hazardous reactions if left unchecked.

    Specifications Shaped by Real-World Demands

    Many clients approach us not looking for an off-the-shelf solvent grade, but for a reliable input that stands up to daily use in research or production. Our 1,3-Benzodioxole is liquid at room temperature, colorless or nearly so, and holds a boiling range consistent with published values (around 172°C at atmospheric pressure). Viscosity tends to be low, so it dispenses readily through standard pumps or by hand. Because downstream chemistry often demands clean conversions, we test for residual solvents and non-volatile metals. That also means we never rework batches based on theoretical specs—actual plant data tells us when a batch matches our standard.

    Where 1,3-Benzodioxole Makes a Measurable Difference

    We supply 1,3-Benzodioxole to buyers along three major segments: specialty chemical formulators, agrochemical synthesis, and the fine fragrance industry. Its aromatic stability brings value in the hands of chemical manufacturers building complex ring systems, and it remains a go-to choice for anyone scaling up derivatives like piperonyl compounds or related heterocycles. In our own labs, verified samples have shown reliable yields in both electrophilic aromatic substitution and as a protected scaffold for multi-step synthesis. Its performance stands out where ring integrity and low side reactivity count most—field trials in insecticide intermediate synthesis have shown over 93% conversion yield, compared with typical grades that fall to 87% due to trace water contamination or higher peroxide content.

    Insights Learned from Decades of Work

    We run a chemical operation that supplies not just finished goods but also years of knowledge that help our clients get results. Unlike distributors, we field questions about reaction incompatibilities, mixing order, and storage—so we weave these lessons straight into our plant management. For example, some batches destined for dye precursor applications struggled with color issues. Our team traced this to a small batch of feedstock that arrived oxidized. Since then, we’ve developed a closed-loop nitrogen purge right through reception and decanting, cutting oxygen exposure and stabilizing color far beyond common storage methods.

    Moisture matters as much as purity. We used to hear from fine fragrance mixers that off-notes appeared after a few weeks’ storage. Careful Karl Fischer titration and direct field visits pointed us toward microcrystalline water picking up in drums exposed during humid months. Since building our dedicated packaging line, fitted with climate-stabilizing controls, recurrence dropped off and shelf-life for tightly sealed containers stretched months longer.

    Key Differentiators from Other Benzodioxoles and Related Aromatics

    There’s a persistent market confusion about 1,3-Benzodioxole, especially in comparison to isomeric or substituted relatives like 1,2-benzodioxole, 1,4-benzodioxane, or substituted methylenedioxybenzenes. Direct experience tells us that 1,3-Benzodioxole’s position of the oxygen atoms, and its methylene bridge, delivers a unique chemical pattern. In processes that call for clean cyclization or that feed into oxidative cleavage, its predictability outpaces related structures.

    End-users testing multiple aromatics for downstream coupling quickly remark on process fouling when switching away from pure 1,3-Benzodioxole. We’ve observed that even switching to a high-purity 1,2-isomer increases byproduct trapping and drop-in color stability. These performance gaps do not appear in the lab alone; plant-scale blending or formulation amplifies them. Because of that, we issue real-world batch compliance data drawn from our production floor, not just third-party certificates.

    Building this molecule in-house, we control the full route starting from phenol, handling methylation and ring closure stages in a way that sidesteps side reactions that yield other ring isomers. That’s a core advantage for buyers running regulated syntheses requiring narrow isomer ranges, or for operations where lot recalls could disrupt the entire chain. For those wanting even tighter specs, we can tailor purification protocols, but our standard plant grade already matches what high-throughput manufacturers and regulatory-driven customers expect.

    Real-World Usage: From Concept to Large-Scale Outcomes

    Formulators in the flavor and fragrance space see direct results when using this grade for perfumery core construction. One client, making a ton-scale batch of piperonyl alcohol, noted a 12% improvement in catalytic yield over the market’s standard due to our continuous-feed purity checks. In agrochemical applications, regulatory filings demand consistent analytical profiles from every drum. That accountability makes transparency more than a sales slogan—it’s integrated into batch records and delivery logs, reviewed before any large shipout leaves our gate.

    Custom testing for compounds where subtle odor or trace pigment makes or breaks a product shows the practical upside of precise, well-controlled 1,3-Benzodioxole production. Fragrance firms running stability tests have traced reduced base discoloration to our practice of adding a final neutralization and pressure-filtration step—preventing long-term oxidative drift in blends. The difference between good-enough and long-haul stability comes back, again and again, to choices made during actual plant operation, not just to chemical purity as read by an instrument.

    Practical Production Challenges and How We Solve Them

    Anyone running commercial chemistry knows that real-world production seldom follows textbook diagrams. We’ve run into line blockages during low-temperature crystallization—common with multi-tonne batches, though rarely mentioned outside production circles. We adapted our heat tracing and flow sequencing to sidestep these cold spots, maintaining homogenous transfer during winter cycles with no reduction in throughput. Our distillation stack, critical for strict boiling range and flashpoint, takes more time than single-stage cuts, but earns its keep each year in reduced rework and customer claims.

    Trace residuals in our source materials have sometimes threatened to taint larger lots. We dealt with a spate of trace chlorinated solvent carryover in phenol years ago. By knocking out suspect suppliers and setting up a double-column pre-purification, our remedial protocol raised production cost slightly but delivered a major jump in long-term customer satisfaction. These moves add to our running costs, but we’ve learned that a small hit now beats the cost and reputation damage of bulk returns.

    Container compatibility, too, adds unseen value. We used to run bulk packouts in standard drums, but repeated analytics pointed to cross-contamination risks from liner failure on extended shipments. We switched to high-density polyethylene drums with UV-blockers, verified leaching rates under heat and humidity loads, and moved to batch-sealed composite closures. That step, tested against field complaints, cleaned up a lot of “mystery” out-of-spec complaints we’d seen before.

    Continued Investment in Safety and Transparency

    Commitment to safety and traceability drives many of our investments. Direct manufacturer responsibility runs deeper than simple compliance. We track every lot with scan-based batch records from plant chemistry through to final dispatch, which our customers benefit from with clear, auditable supply chains. For products destined for regulated end-use—like crop chemistry or regulated fragrances—we draw on our in-house analytical team to generate supporting data sets. Investment in safer reactor design, secondary containment, and digitized record-keeping supports both practical safety and accountability with our customers and their auditors.

    Our in-house logistics team handles documentation for each batch, from real chemical analysis printouts to regulatory compliance summaries. This comes from fielding customs or transport hazard queries directly, ensuring client partners receive valid and up-to-date safety and logistics information. We meet applicable regulatory standards and hold certificates for export, but more importantly, our teams are accessible and respond quickly to specific batch questions, shipment concerns, or extra analytical requests.

    Why Direct Manufacturing Experience Counts

    Trader warehouses or distribution operations seldom see the realities behind a well-made specialty compound. Our approach—from plant investment to ongoing staff training—focuses on what it takes to build the molecule repeatedly and correctly, year after year. Our technical team and plant operators draw on collective decades of making, troubleshooting, and optimizing 1,3-Benzodioxole. They see not only the molecular structure on paper, but also the technical “feel” of a good batch: the color in the drum, the flow during packing, and the lack of harsh odor at final inspection.

    We do not push commodity-grade, high-impurity lots just to lower costs. Instead, we recognize that our clients’ quality—and our own long-term relationships—rests on not just short-term yield, but ongoing supply trust. Direct manufacturing oversight means every bottle, drum, and tank arrives backed by the people who actually made it. This hands-on control cannot be duplicated by buyers who only see the box, not the process.

    The Importance of Listening to Our Customers

    Over years of working directly with formulation chemists, regulatory teams, and production managers, we’ve learned that successful 1,3-Benzodioxole supply doesn’t end at the shipping dock. We set up routine feedback loops and site visits, asking users about odd odors, unexpected color, or yield anomalies—even when results land within official specifications. By translating field reports straight back into our plant protocols, we close quality gaps invisible to outsiders or sales-focused intermediaries.

    Much of our product improvement came from honest feedback: agricultural labs tracing lower catalyst fouling to our cleaner, drier product; fragrance teams finding shelf-life extensions after our packaging upgrades; technical buyers appreciating the direct, jargon-free support offered by people who actually control the chemistry. Real manufacturer-user dialog, kept free of sales fluff and technical smoke-screens, drives us to raise the bar—without inflating costs beyond what practical budgets can support.

    Looking Ahead: Sustaining Value in a Changing Market

    Markets fluctuate, feedstock cycles shift, and global supply chain hiccups continue to challenge the specialty chemical sector. Rather than chasing the cheapest feed or cutting corners, we keep additional raw material stock and backup plant capacity to buffer against short-term spikes. We invest in ongoing training for our staff in both process safety and analytical troubleshooting, because experience on the plant floor pays off during tight or unpredictable supply periods.

    Emerging applications—such as advanced materials, personal care, or green chemistry—have started pulling on new specifications and tighter tolerances. We respond by working with customers early, offering direct plant tours, technical data, and flexible scheduling, so new requirements integrate smoothly into our production flow. For those facing regulatory upgrades or compliance reviews, our technical and regulatory staff help to audit process records, provide full documentation, and deliver lot-specific transparency.

    As chemical manufacturers, we recognize that the continued utility of 1,3-Benzodioxole depends on both chemical quality and trusted, reliable business practices. While the market will see more digitalization and automation, hands-on manufacturing skill—combined with transparent, experience-based communication—remains a strong advantage for everyone involved in the supply chain.

    Summary

    1,3-Benzodioxole remains a mainstay in our catalog because of its real-world utility and its role as a bridge molecule for countless industries. Through a rigorous approach to quality, responsiveness to partner feedback, and a clear record of technical improvement, we’ve built a product and a support network our clients trust. Our years of direct manufacturing experience underpin every drum, shipment, and technical answer—not as a routine slogan, but as a proven track record. We always welcome dialog with users and prospective partners who share our values of safety, transparency, and chemistry done right.