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HS Code |
619635 |
| Chemical Name | 1,2-Naphthoquinone-4-Sulfonic Acid Sodium Salt |
| Cas Number | COSMIC: 63451-99-6; Common: 1519-76-8 |
| Molecular Formula | C10H5NaO5S |
| Molar Mass | 260.20 g/mol |
| Appearance | Yellow to orange-brown powder |
| Solubility | Soluble in water |
| Melting Point | Decomposes on melting |
| Storage Conditions | Store at room temperature, tightly closed, protected from light |
| Synonyms | Folin's reagent, Sodium salt of 1,2-naphthoquinone-4-sulfonic acid |
| Uses | Analytical reagent for amino acids and amines |
| Pubchem Cid | 23418 |
| Inchi Key | APIPJEXFFQEJKQ-UHFFFAOYSA-M |
| Odor | Odorless |
| Stability | Stable under recommended storage conditions |
| Hazard Class | Irritant |
As an accredited 1,2-Naphthoquinone-4-Sulfonic Acid Sodium Salt factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The chemical is packaged in a 25g amber glass bottle with a secure screw cap, labeled with product details and safety information. |
| Shipping | 1,2-Naphthoquinone-4-Sulfonic Acid Sodium Salt is shipped in tightly sealed containers to protect from moisture and light. It is classified as non-hazardous, but should be handled with standard chemical safety precautions. Store and transport at room temperature. Ensure proper labeling and documentation during shipment to comply with safety and regulatory requirements. |
| Storage | 1,2-Naphthoquinone-4-Sulfonic Acid Sodium Salt should be stored in a tightly closed container, protected from light and moisture. Keep it in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizing or reducing agents. Ensure the storage area is clearly labeled and complies with all applicable chemical safety regulations. Avoid contact with skin and eyes. |
Applications of 1,2-Naphthoquinone-4-Sulfonic Acid Sodium Salt in Industrial ManufacturingAs a direct manufacturer with years of process experience, we supply 1,2-Naphthoquinone-4-Sulfonic Acid Sodium Salt (NQS) to a focused set of industries where its chemical specificity and performance support modern, compliant production. Below, we detail the primary industrial sectors integrating this compound, outlining technical practices and regulatory context for each use. 1. Analytical Reagents for Amino Acid QuantificationLaboratory and industrial diagnostics incorporate NQS as a colorimetric reagent for the determination of primary and secondary amines, particularly in amino acid analysis in food, pharmaceuticals, and life sciences. Labs rely on its rapid and sensitive chromophore-forming ability within standardized analysis protocols, which underpin batch quality releases and regulatory submissions. Industry compliance standards
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2. Pharmaceutical Intermediates SynthesisNQS is selectively used in the synthesis of sulfonated naphthoquinone derivatives as intermediates for various APIs, particularly in antihypertensive, anti-inflammatory, and antimicrobial drug production. The compound provides a high-yield, aqueous-compatible introduction of sulfonate functionality to complex molecular scaffolds, ensuring compliance with drug master file documentation and trace-level impurity controls. Industry compliance standards
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3. Dye Manufacturing for Textile ApplicationsTextile dye manufacturers use NQS as a key intermediate in the synthesis of anthraquinonoid and related sulfonic acid-based dyes for cellulosic and protein fibers, driven by demands for high color fastness and specific spectral properties. Its controlled sulfonation profile aligns with safety and eco-label certifications for final dyed fabrics in regulated export markets. Industry compliance standards
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4. Specialty Paper Colorant FormulationPulp and specialty paper producers employ NQS-based derivatives for controlled coloration in security paper, high-grade writing paper, and banknote production. The compound provides precise color development and acid-fastness, conforming with international paper and printing standards as well as migration safety for document security features. Industry compliance standards
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5. Water Treatment Colorimetric AnalysisIndustrial water testing facilities and municipal laboratories use NQS in rapid detection tests for trace-level primary and secondary amines, which are indicators of contamination or incomplete treatment. The compound enables end-users to perform on-site quality assurance, particularly within incoming raw water and post-treatment effluent streams in regulated environments. Industry compliance standards
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Competitive 1,2-Naphthoquinone-4-Sulfonic Acid Sodium Salt prices that fit your budget—flexible terms and customized quotes for every order.
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Every batch of 1,2-naphthoquinone-4-sulfonic acid sodium salt we produce reflects careful planning, tested processes, and the years we’ve worked in quinone chemistry. Our synthesis teams learned to respect this molecule early on, recognizing both its versatility and the need for precision during sulfonation and neutralization steps. While others focus on high throughput, we focus on repeatable, reliable quality; that approach comes from generations of hard-earned lessons on the shop floor. Small deviations can lead to byproducts or unwanted coloring. Maintaining consistent granule texture and color isn’t just pride—it’s the signal that every stage met our internal controls. Routine validation distinguishes a dedicated manufacturer’s product from batches sold piecemeal through trading channels.
Models and specifications start as customer feedback, not just numbers on a page. In our day-to-day work, we measure purity using HPLC regularly, seeking a white to light yellow powder with a minimum purity of 98%. This purity standard is stricter than many published values and comes from direct feedback among end users in analytical labs. Moisture, always a challenge, stays below 1.0%, as we found long ago that higher water content leads to clumping and handling complaints. Particle size isn’t decorative info—aggregates confuse solubility expectations during titrations and endpoint determinations. Uniform granularity emerged as a priority through repeated conversations between our technical teams and chemists using our product for diazotization and organic synthesis.
Using this sodium salt in colorimetric or titrimetric analysis means trusting its reactivity and consistency from lot to lot. Out in the real world, analytical chemists rely on exact dosages, and if the quinone group gets compromised or if the sulfonate sodium drifts from specs, endpoint accuracy collapses. We’ve run side-by-side tests with “third-party” samples and watched as stability dropped during storage or open-air handling. Confidence in our product means seeing no drop in chromogenic reactivity across shelf life, no surprises a year after production. That owes much to our raw material choices and the environmental controls in each batch. We watch oxygen and humidity like hawks because we already know what those variables do to shelf stability.
Walking through the warehouse, it’s easy to spot which barrels did not originate from our line. Differences show up in color uniformity and dust content. Some producers skip final sieving, sending out product that cakes or shows visible clumps after just a few weeks on the shelf. Consistency goes all the way back to how thoroughly the starting naphthoquinone gets refined. Years ago, we tested blends that seemed similar—then watched staining persist on glassware, a clear sign of trace impurities in rivals’ material.
Some lab managers switch between sodium and potassium salts, often based on price, not performance. We only manufacture the sodium salt for good reason: batch tests proved better solubility in neutral to slightly alkaline environments, and far fewer storage issues. This sodium derivative dissolves quickly in deionized water and displays a sharp endpoint in amine detection—direct feedback from food additive screening and pharma QA labs backs that up. Potassium variants, meanwhile, often show slower dissolution and more noticeably degrade under suboptimal storage. These hands-on observations pushed us to keep refining our drying system, targeting those last few tenths of a percent of water, and they remain our internal benchmarks.
Chemistry isn’t a commodity business for us, despite the trend to see fine chemicals this way. Poorly controlled production introduces batch variability that can cost end users both time and reputation. Some stories from customers stick with us, such as the time a large lab’s screening process stalled due to colored impurities altering test outcomes—an issue that traced back to an offshore batch. The significance of a clean reaction, free from residual aromatic sulfonates or oxidized fragments, isn’t abstract: it shows up in data sheets, regulatory compliance audits, and, critically, in customer trust.
We employ redundant lot testing and maintain back-samples of every run, a habit developed in response to regulatory tightening in pharmaceutical excipients. Each lot receives a unique identifier that lets us trace supply chains from starting naphthalene to final storage. We’ve documented improvements over time, not just in revised specs but in the tools we’ve built on the production line—closed-system dryers, oxygen-absorbing packaging, and rigorous sieve management. Our teams know that missing any of these steps brings headaches for downstream users, so every improvement gets field-tested with regular customers before rollout.
Our collaboration with university teams and industry consortia keeps us tuned into the latest needs for diazotization, aldehyde and amine analysis, and dye intermediate research. One recent research group pointed out that even tiny shifts in moisture or pH change detection limits in spectrophotometric analyses. Batch traceability is not just an exercise in compliance—it allows feedback-driven improvements to be rapidly incorporated into process control. Over the years, we have adjusted our purification steps based on published best practices and peer-reviewed methods, and we keep technical staff in close dialogue with R&D users who drive innovation. The iterative improvements on our line are informed by actual customer workflows and validated with independent analytical comparisons.
We don’t rest on current certifications or published literature. The real value comes from pushing the product’s reliability with every iteration, picking up on subtle customer feedback points, and acting on them. In the past, food safety labs voiced concern over trace nitrosamines, which led us to further tighten control over potential by-products. The focus moved beyond just hitting a purity threshold to confirming what isn’t in the end product, and this changed the way we run gas-phase analysis on every output. Each quality report now documents an expanded profile, not because a regulator required it, but because our own confidence—and our customers’—demanded it.
We never lose sight of the scientists who depend on our product. Organic synthesis depends on batch-to-batch regularity, not promises on paper. Analytical protocols for detecting primary and secondary amines lean on reaction speed and color development. The moment chromogenic response diverges, trust gets lost; a lifetime of manufacturing experience tells us that fixing these issues after-the-fact costs far more than refining our in-line checks. That’s why we instrument more checkpoints than is strictly required—not to win points for documentation, but to make sure users never worry about surprises mid-analysis.
We learn from those actually pipetting their samples at the lab bench. Everyone selling “spec-compliant” material sounds convincing until the real-world testing shows what paperwork can conceal: slight off-hues, sticky residue, or inconsistent color development all lead back to overlooked aspects in the production line. Our own teams have swapped out storage drums, changed over suppliers, and run down every variable simply because a trusted QC chemist flagged something odd. Many disruptions got traced to supply side changes at the trading or distribution level, reinforcing why direct manufacturer access matters for anyone with critical timelines.
The regulatory environment only gets tighter, especially for chemicals used in pharmaceutical, diagnostic, and food testing labs. Over the years, we’ve adjusted process documentation, added more frequent in-process controls, and built out traceability not because it’s interesting to talk about, but because each new regulation adds teeth to enforcement. We have sat across from auditors, justified deviation logs, and looked at repeat requests for deeper contaminant profiling. Every audit completed teaches us as much as it satisfies the regulators; sometimes that learning leads to yet another improvement step back in synthesis, purification, or packaging.
Trace residuals, modern analytical concerns like elemental impurities, and demand for ever-lower detection thresholds keep us moving. The old approach of “nominal purity” isn’t enough in this climate, not if we want our customers to remain in good standing with their own internal or external auditors. Analytical consistency starts with honest labeling, continues in real-time control charts, and needs faith in every technician that touches a batch. From the blending tanks to the filling room, oversight and team continuity count for more than broad claims about being a “qualified supplier.”
Every year, end users point to new challenges. Recently, one customer flagged issues dissolving another supplier’s lot in high-throughput screening equipment—a lesson in how subtle process changes echo downstream. We incorporated freeze-thaw and long-haul shipping stability into our internal testing because we heard those stories and know how ambient exposure on a dock can undo weeks of careful handling. Through direct engagement, we’ve spotted market-wide trends early and kept pace with both chemistry and logistics changes that come with globalization.
That’s not a one-off process, either. Some improvements mean tweaking our drying temperatures, others call for changing a filter medium to lower trace metal content. Our operators, engineers, and QC staff handle the entire production cycle, and everyone from synthesis to packing has a say in incremental adjustments. This culture of openness means standards get higher but so does customer loyalty. We already know that the real test of a batch comes in someone else’s lab—so we act on issues before they become complaints.
Proper packaging isn’t an afterthought, especially when product fate depends on shipping climates far from our plant. Over time, we developed packaging that resists humidity, includes oxygen barriers, and allows easy sampling for QC checks at customer sites. Technicians voiced frustrations over spills and caking with traditional containers—each improvement launched from those details. Consistent labeling, clear lot numbers, and batch support documentation enable easier tracking during audits or problem-solving. No detail is too small; proactive customer service keeps supply chains running and reassures buyers facing ever-shrinking inventory margins.
After years in this business, one fact stays constant: true reliability surfaces during unexpected events. We’ve had logistics delays in typhoon season, supplier snafus upstream, equipment failures that tested every part of our process chain. Through all that, repeat customers come back because the quality never wavers. Instead of “good enough” lots, we chase the practices that prevent problems. That means routine backup planning, real-time system monitoring, and ongoing training for every plant worker involved. Differences between our product and the generic versions aren’t features—they’re evidence of a process that’s lived, revised, and geared for longevity.
People working in technical procurement often ask what separates a direct manufacturer’s output from a reseller’s. In our experience, it comes down to the kind of accountability that only grows from hands-on stewardship of every kilo, every drum, every outbound shipment. We walk the entire facility daily, knowing that any shortcut might not reveal itself until months later—in short shelf life, poor endpoint reproduction, or lab work disrupted by invisible contaminants. Trading houses and brokers move boxes; we build each lot from raw materials up, making decisions that reflect both industry feedback and our in-house priorities.
Every product reflects a chain of choices. Ours mirrors ongoing relationships with employees, with returning customers, with university scientists running control experiments, and with field technicians troubleshooting machinery. Price pressures push toward simplification, but reliability comes from attention to the details few notice until something goes wrong. For specialty reagents like 1,2-naphthoquinone-4-sulfonic acid sodium salt, those details become the difference between a product that works and one that gets returned.
As demand grows for higher-throughput analysis, multiplexed assay platforms, and tighter quality controls in both research and regulated sectors, we continue investing in making not just a compliant product, but one that anticipates users' future needs. We test new formulations, stay abreast of global standards, and embrace change as part of ongoing improvement. No batch leaves our production floor without a sense of responsibility; what starts as naphthalene in our plant ends up shaping outcomes in critical lab processes worldwide. That perspective shapes each decision we make and keeps our focus on earning trust with every shipment.