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1,2-Naphthoquinone-4-Sulfonic Acid Sodium Salt

    • Product Name 1,2-Naphthoquinone-4-Sulfonic Acid Sodium Salt
    • Alias Folin's Reagent
    • Einecs 222-155-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    619635

    Chemical Name 1,2-Naphthoquinone-4-Sulfonic Acid Sodium Salt
    Cas Number COSMIC: 63451-99-6; Common: 1519-76-8
    Molecular Formula C10H5NaO5S
    Molar Mass 260.20 g/mol
    Appearance Yellow to orange-brown powder
    Solubility Soluble in water
    Melting Point Decomposes on melting
    Storage Conditions Store at room temperature, tightly closed, protected from light
    Synonyms Folin's reagent, Sodium salt of 1,2-naphthoquinone-4-sulfonic acid
    Uses Analytical reagent for amino acids and amines
    Pubchem Cid 23418
    Inchi Key APIPJEXFFQEJKQ-UHFFFAOYSA-M
    Odor Odorless
    Stability Stable under recommended storage conditions
    Hazard Class Irritant

    As an accredited 1,2-Naphthoquinone-4-Sulfonic Acid Sodium Salt factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The chemical is packaged in a 25g amber glass bottle with a secure screw cap, labeled with product details and safety information.
    Shipping 1,2-Naphthoquinone-4-Sulfonic Acid Sodium Salt is shipped in tightly sealed containers to protect from moisture and light. It is classified as non-hazardous, but should be handled with standard chemical safety precautions. Store and transport at room temperature. Ensure proper labeling and documentation during shipment to comply with safety and regulatory requirements.
    Storage 1,2-Naphthoquinone-4-Sulfonic Acid Sodium Salt should be stored in a tightly closed container, protected from light and moisture. Keep it in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizing or reducing agents. Ensure the storage area is clearly labeled and complies with all applicable chemical safety regulations. Avoid contact with skin and eyes.
    Application of 1,2-Naphthoquinone-4-Sulfonic Acid Sodium Salt

    Applications of 1,2-Naphthoquinone-4-Sulfonic Acid Sodium Salt in Industrial Manufacturing

    As a direct manufacturer with years of process experience, we supply 1,2-Naphthoquinone-4-Sulfonic Acid Sodium Salt (NQS) to a focused set of industries where its chemical specificity and performance support modern, compliant production. Below, we detail the primary industrial sectors integrating this compound, outlining technical practices and regulatory context for each use.

    1. Analytical Reagents for Amino Acid Quantification

    Laboratory and industrial diagnostics incorporate NQS as a colorimetric reagent for the determination of primary and secondary amines, particularly in amino acid analysis in food, pharmaceuticals, and life sciences. Labs rely on its rapid and sensitive chromophore-forming ability within standardized analysis protocols, which underpin batch quality releases and regulatory submissions.

    Industry compliance standards

    • ISO/IEC 17025 (Testing Laboratories Accreditation)
    • Pharmacopoeia references: USP, EP reagent listings — specified for amino acid derivatization procedures
    • Good Laboratory Practice (GLP) requirements for analytical reagent traceability
    • Food safety method validations per FDA 21 CFR Part 58 (analytical chemistry in regulated environments)

    Typical usage ratio

    • 0.2 – 1.0 mg NQS per sample, with concentration adjusted based on sample matrix, sensitivity required, and detection equipment calibration

    Downstream process integration

    • Introduced in post-extraction derivatization step after amino acid or amine extraction from sample matrices; undergoes direct reaction forming colored products detected via spectrophotometry or HPLC with UV detection

    Final product types

    • Analytical reagent kits for quantitative amino acid analysis
    • Commercial laboratory protocols for reference and proficiency testing
    • In-house QC validation kits for pharmaceutical batch release
    • Food ingredient compliance verification kits

    2. Pharmaceutical Intermediates Synthesis

    NQS is selectively used in the synthesis of sulfonated naphthoquinone derivatives as intermediates for various APIs, particularly in antihypertensive, anti-inflammatory, and antimicrobial drug production. The compound provides a high-yield, aqueous-compatible introduction of sulfonate functionality to complex molecular scaffolds, ensuring compliance with drug master file documentation and trace-level impurity controls.

    Industry compliance standards

    • Good Manufacturing Practice (GMP) per ICH Q7
    • Pharmaceutical quality standards: EP/USP compendial guidelines for intermediates
    • ICH Q3A/B (Impurities in New Drug Substances/Product)
    • FDA DMF-supporting documentation for intermediate registration

    Typical usage ratio

    • Stoichiometric quantities: 1.0–1.2 molar equivalents based on key side-chain or ring modification steps; variation depends on batch scale and purification yield requirements

    Downstream process integration

    • Charged during initial sulfonation of naphthoquinone moieties or as a post-condensation modifier in multi-step API syntheses, followed by precise chromatographic purification steps and stringent impurity profiling

    Final product types

    • Sulfonated naphthoquinone API intermediates
    • Antihypertensive and anti-inflammatory pre-drug intermediates
    • Active pharmaceutical ingredients using NQS-derivative building blocks
    • Process validation reference standards

    3. Dye Manufacturing for Textile Applications

    Textile dye manufacturers use NQS as a key intermediate in the synthesis of anthraquinonoid and related sulfonic acid-based dyes for cellulosic and protein fibers, driven by demands for high color fastness and specific spectral properties. Its controlled sulfonation profile aligns with safety and eco-label certifications for final dyed fabrics in regulated export markets.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (tested for harmful substances in textiles)
    • REACH (EU Regulation on Registration, Evaluation, Authorisation and Restriction of Chemicals)
    • ZDHC MRSL v3.1 (Zero Discharge of Hazardous Chemicals)
    • ISO 105 (Textile color fastness testing methods)

    Typical usage ratio

    • 5 – 15% of total dye intermediate mass; process chemists adjust loadings to optimize hue intensity and exhaust rates for targeted dye shades within batch synthesis

    Downstream process integration

    • Dosed into the sulfonation or diazotization reaction stage for preparation of vinyl sulfone or azo dye intermediates, then combined in condensation and finishing steps in dyehouse production lines

    Final product types

    • Reactive dyes for cotton and viscose
    • Direct dyes for wool and silk fibers
    • Anthraquinone-derived pigments for technical textiles
    • Color concentrates for printing pastes and textile inkjet formulations

    4. Specialty Paper Colorant Formulation

    Pulp and specialty paper producers employ NQS-based derivatives for controlled coloration in security paper, high-grade writing paper, and banknote production. The compound provides precise color development and acid-fastness, conforming with international paper and printing standards as well as migration safety for document security features.

    Industry compliance standards

    • ISO 12471 (Security printing inks — Resistance to chemical and physical influence)
    • EN 646 (Color fastness of paper and board)
    • FSC Chain of Custody (for papers with responsible supply claims)
    • OECD guidelines for chemical safety in consumer goods

    Typical usage ratio

    • 0.1 – 0.5% (w/w) based on dry pulp mass; proportion selected according to targeted color depth and stability against light and acids for finished paper stocks

    Downstream process integration

    • Metering into the wet-end of paper manufacturing during the slurrying of cellulose fibers prior to sheet formation; subsequently stabilized during calendaring and surface sizing steps before final drying

    Final product types

    • Security and watermark paper
    • Anti-counterfeit document substrates
    • Premium offset and writing papers with specialty hues
    • Ledger and archival paper resistant to color migration

    5. Water Treatment Colorimetric Analysis

    Industrial water testing facilities and municipal laboratories use NQS in rapid detection tests for trace-level primary and secondary amines, which are indicators of contamination or incomplete treatment. The compound enables end-users to perform on-site quality assurance, particularly within incoming raw water and post-treatment effluent streams in regulated environments.

    Industry compliance standards

    • Standard Methods for the Examination of Water and Wastewater (APHA/AWWA/WEF)
    • ISO 8466-1 (Water quality — Calibration and evaluation of analytical methods)
    • EPA Method 8316 (Amines by HPLC in water samples)
    • Local environmental quality monitoring regulations

    Typical usage ratio

    • Typically 0.05 – 0.5 mg per 10 mL sample aliquot, adjusted in line with detection range requirements and calibration standards for amine quantification

    Downstream process integration

    • Added directly to water sample aliquots following filtration or extraction steps; reacts in situ to form colored complexes, measured spectrophotometrically for compliance monitoring and operational decision-making

    Final product types

    • Colorimetric rapid water test kits
    • Laboratory sample analysis reagents
    • Routine process control QA panels for municipal and industrial waterworks
    • Environmental compliance monitoring consumables
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    Competitive 1,2-Naphthoquinone-4-Sulfonic Acid Sodium Salt prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing 1,2-Naphthoquinone-4-Sulfonic Acid Sodium Salt: Insights from the Manufacturing Floor

    Walking through the Process

    Every batch of 1,2-naphthoquinone-4-sulfonic acid sodium salt we produce reflects careful planning, tested processes, and the years we’ve worked in quinone chemistry. Our synthesis teams learned to respect this molecule early on, recognizing both its versatility and the need for precision during sulfonation and neutralization steps. While others focus on high throughput, we focus on repeatable, reliable quality; that approach comes from generations of hard-earned lessons on the shop floor. Small deviations can lead to byproducts or unwanted coloring. Maintaining consistent granule texture and color isn’t just pride—it’s the signal that every stage met our internal controls. Routine validation distinguishes a dedicated manufacturer’s product from batches sold piecemeal through trading channels.

    Model and Specifications That Matter

    Models and specifications start as customer feedback, not just numbers on a page. In our day-to-day work, we measure purity using HPLC regularly, seeking a white to light yellow powder with a minimum purity of 98%. This purity standard is stricter than many published values and comes from direct feedback among end users in analytical labs. Moisture, always a challenge, stays below 1.0%, as we found long ago that higher water content leads to clumping and handling complaints. Particle size isn’t decorative info—aggregates confuse solubility expectations during titrations and endpoint determinations. Uniform granularity emerged as a priority through repeated conversations between our technical teams and chemists using our product for diazotization and organic synthesis.

    Truth About Usage: Beyond Simple Labeling

    Using this sodium salt in colorimetric or titrimetric analysis means trusting its reactivity and consistency from lot to lot. Out in the real world, analytical chemists rely on exact dosages, and if the quinone group gets compromised or if the sulfonate sodium drifts from specs, endpoint accuracy collapses. We’ve run side-by-side tests with “third-party” samples and watched as stability dropped during storage or open-air handling. Confidence in our product means seeing no drop in chromogenic reactivity across shelf life, no surprises a year after production. That owes much to our raw material choices and the environmental controls in each batch. We watch oxygen and humidity like hawks because we already know what those variables do to shelf stability.

    Different From the Crowd: Facts from the Line

    Walking through the warehouse, it’s easy to spot which barrels did not originate from our line. Differences show up in color uniformity and dust content. Some producers skip final sieving, sending out product that cakes or shows visible clumps after just a few weeks on the shelf. Consistency goes all the way back to how thoroughly the starting naphthoquinone gets refined. Years ago, we tested blends that seemed similar—then watched staining persist on glassware, a clear sign of trace impurities in rivals’ material.

    Some lab managers switch between sodium and potassium salts, often based on price, not performance. We only manufacture the sodium salt for good reason: batch tests proved better solubility in neutral to slightly alkaline environments, and far fewer storage issues. This sodium derivative dissolves quickly in deionized water and displays a sharp endpoint in amine detection—direct feedback from food additive screening and pharma QA labs backs that up. Potassium variants, meanwhile, often show slower dissolution and more noticeably degrade under suboptimal storage. These hands-on observations pushed us to keep refining our drying system, targeting those last few tenths of a percent of water, and they remain our internal benchmarks.

    Responsibility Through Quality: Why Standards Matter

    Chemistry isn’t a commodity business for us, despite the trend to see fine chemicals this way. Poorly controlled production introduces batch variability that can cost end users both time and reputation. Some stories from customers stick with us, such as the time a large lab’s screening process stalled due to colored impurities altering test outcomes—an issue that traced back to an offshore batch. The significance of a clean reaction, free from residual aromatic sulfonates or oxidized fragments, isn’t abstract: it shows up in data sheets, regulatory compliance audits, and, critically, in customer trust.

    We employ redundant lot testing and maintain back-samples of every run, a habit developed in response to regulatory tightening in pharmaceutical excipients. Each lot receives a unique identifier that lets us trace supply chains from starting naphthalene to final storage. We’ve documented improvements over time, not just in revised specs but in the tools we’ve built on the production line—closed-system dryers, oxygen-absorbing packaging, and rigorous sieve management. Our teams know that missing any of these steps brings headaches for downstream users, so every improvement gets field-tested with regular customers before rollout.

    Supporting Research and Industry Developments

    Our collaboration with university teams and industry consortia keeps us tuned into the latest needs for diazotization, aldehyde and amine analysis, and dye intermediate research. One recent research group pointed out that even tiny shifts in moisture or pH change detection limits in spectrophotometric analyses. Batch traceability is not just an exercise in compliance—it allows feedback-driven improvements to be rapidly incorporated into process control. Over the years, we have adjusted our purification steps based on published best practices and peer-reviewed methods, and we keep technical staff in close dialogue with R&D users who drive innovation. The iterative improvements on our line are informed by actual customer workflows and validated with independent analytical comparisons.

    We don’t rest on current certifications or published literature. The real value comes from pushing the product’s reliability with every iteration, picking up on subtle customer feedback points, and acting on them. In the past, food safety labs voiced concern over trace nitrosamines, which led us to further tighten control over potential by-products. The focus moved beyond just hitting a purity threshold to confirming what isn’t in the end product, and this changed the way we run gas-phase analysis on every output. Each quality report now documents an expanded profile, not because a regulator required it, but because our own confidence—and our customers’—demanded it.

    Taking Chemistry From Batch to Bench

    We never lose sight of the scientists who depend on our product. Organic synthesis depends on batch-to-batch regularity, not promises on paper. Analytical protocols for detecting primary and secondary amines lean on reaction speed and color development. The moment chromogenic response diverges, trust gets lost; a lifetime of manufacturing experience tells us that fixing these issues after-the-fact costs far more than refining our in-line checks. That’s why we instrument more checkpoints than is strictly required—not to win points for documentation, but to make sure users never worry about surprises mid-analysis.

    We learn from those actually pipetting their samples at the lab bench. Everyone selling “spec-compliant” material sounds convincing until the real-world testing shows what paperwork can conceal: slight off-hues, sticky residue, or inconsistent color development all lead back to overlooked aspects in the production line. Our own teams have swapped out storage drums, changed over suppliers, and run down every variable simply because a trusted QC chemist flagged something odd. Many disruptions got traced to supply side changes at the trading or distribution level, reinforcing why direct manufacturer access matters for anyone with critical timelines.

    Dealing With Ever-Tightening Regulations

    The regulatory environment only gets tighter, especially for chemicals used in pharmaceutical, diagnostic, and food testing labs. Over the years, we’ve adjusted process documentation, added more frequent in-process controls, and built out traceability not because it’s interesting to talk about, but because each new regulation adds teeth to enforcement. We have sat across from auditors, justified deviation logs, and looked at repeat requests for deeper contaminant profiling. Every audit completed teaches us as much as it satisfies the regulators; sometimes that learning leads to yet another improvement step back in synthesis, purification, or packaging.

    Trace residuals, modern analytical concerns like elemental impurities, and demand for ever-lower detection thresholds keep us moving. The old approach of “nominal purity” isn’t enough in this climate, not if we want our customers to remain in good standing with their own internal or external auditors. Analytical consistency starts with honest labeling, continues in real-time control charts, and needs faith in every technician that touches a batch. From the blending tanks to the filling room, oversight and team continuity count for more than broad claims about being a “qualified supplier.”

    Feedback Drives Evolution

    Every year, end users point to new challenges. Recently, one customer flagged issues dissolving another supplier’s lot in high-throughput screening equipment—a lesson in how subtle process changes echo downstream. We incorporated freeze-thaw and long-haul shipping stability into our internal testing because we heard those stories and know how ambient exposure on a dock can undo weeks of careful handling. Through direct engagement, we’ve spotted market-wide trends early and kept pace with both chemistry and logistics changes that come with globalization.

    That’s not a one-off process, either. Some improvements mean tweaking our drying temperatures, others call for changing a filter medium to lower trace metal content. Our operators, engineers, and QC staff handle the entire production cycle, and everyone from synthesis to packing has a say in incremental adjustments. This culture of openness means standards get higher but so does customer loyalty. We already know that the real test of a batch comes in someone else’s lab—so we act on issues before they become complaints.

    Quality in Packaging and Logistics

    Proper packaging isn’t an afterthought, especially when product fate depends on shipping climates far from our plant. Over time, we developed packaging that resists humidity, includes oxygen barriers, and allows easy sampling for QC checks at customer sites. Technicians voiced frustrations over spills and caking with traditional containers—each improvement launched from those details. Consistent labeling, clear lot numbers, and batch support documentation enable easier tracking during audits or problem-solving. No detail is too small; proactive customer service keeps supply chains running and reassures buyers facing ever-shrinking inventory margins.

    Distinctive Reliability: A Result, Not a Feature

    After years in this business, one fact stays constant: true reliability surfaces during unexpected events. We’ve had logistics delays in typhoon season, supplier snafus upstream, equipment failures that tested every part of our process chain. Through all that, repeat customers come back because the quality never wavers. Instead of “good enough” lots, we chase the practices that prevent problems. That means routine backup planning, real-time system monitoring, and ongoing training for every plant worker involved. Differences between our product and the generic versions aren’t features—they’re evidence of a process that’s lived, revised, and geared for longevity.

    Why Direct Manufacturing Experience Counts

    People working in technical procurement often ask what separates a direct manufacturer’s output from a reseller’s. In our experience, it comes down to the kind of accountability that only grows from hands-on stewardship of every kilo, every drum, every outbound shipment. We walk the entire facility daily, knowing that any shortcut might not reveal itself until months later—in short shelf life, poor endpoint reproduction, or lab work disrupted by invisible contaminants. Trading houses and brokers move boxes; we build each lot from raw materials up, making decisions that reflect both industry feedback and our in-house priorities.

    Every product reflects a chain of choices. Ours mirrors ongoing relationships with employees, with returning customers, with university scientists running control experiments, and with field technicians troubleshooting machinery. Price pressures push toward simplification, but reliability comes from attention to the details few notice until something goes wrong. For specialty reagents like 1,2-naphthoquinone-4-sulfonic acid sodium salt, those details become the difference between a product that works and one that gets returned.

    Looking Ahead: Meeting the Needs of Next-Generation Labs

    As demand grows for higher-throughput analysis, multiplexed assay platforms, and tighter quality controls in both research and regulated sectors, we continue investing in making not just a compliant product, but one that anticipates users' future needs. We test new formulations, stay abreast of global standards, and embrace change as part of ongoing improvement. No batch leaves our production floor without a sense of responsibility; what starts as naphthalene in our plant ends up shaping outcomes in critical lab processes worldwide. That perspective shapes each decision we make and keeps our focus on earning trust with every shipment.