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HS Code |
258320 |
| Product Name | 1-(2-Methoxyphenyl)piperazine Hydrochloride |
| Cas Number | 119532-26-2 |
| Molecular Formula | C11H16ClN2O |
| Molecular Weight | 226.71 g/mol |
| Appearance | White to off-white crystalline powder |
| Melting Point | 194-196°C |
| Solubility | Soluble in water, methanol, and ethanol |
| Purity | Typically >98% |
| Storage Conditions | Store at 2-8°C, tightly closed, protected from light |
| Synonyms | 2-MeO-PP.HCl; o-Methoxyphenylpiperazine hydrochloride |
| Smiles | COC1=CC=CC=C1N2CCNCC2.Cl |
As an accredited 1-(2-Methoxyphenyl)Piperazine Hydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle containing 10 grams of 1-(2-Methoxyphenyl)piperazine hydrochloride, labeled with hazard, storage, and identification information. |
| Shipping | **Shipping Description:** 1-(2-Methoxyphenyl)piperazine hydrochloride is securely packaged in airtight, moisture-resistant containers to preserve stability during transit. Labeled with appropriate hazard information, it ships in compliance with international and domestic regulations for chemical transport. Standard delivery uses courier services with tracking, ensuring safe and timely arrival for laboratory or research use only. |
| Storage | 1-(2-Methoxyphenyl)piperazine hydrochloride should be stored in a tightly sealed container, protected from moisture and light. Keep it in a cool, dry, and well-ventilated area, ideally at room temperature (15–25°C). Avoid exposure to incompatible materials such as strong oxidizers. Proper chemical labeling and secure storage, away from direct heat or ignition sources, are essential for safety. |
Applications of 1-(2-Methoxyphenyl)Piperazine Hydrochloride in Industrial ManufacturingAs a direct manufacturer, we supply 1-(2-Methoxyphenyl)Piperazine Hydrochloride with stringent quality control for integration into precise downstream applications. Below, we outline specialized sectors where this intermediate plays an essential and differentiated role in compliant industrial production, with key technical parameters and standards noted for each segment. 1. Active Pharmaceutical Ingredient (API) Synthesis for CNS Therapeutics1-(2-Methoxyphenyl)Piperazine Hydrochloride serves as a controlled building block in the synthesis of select central nervous system (CNS) drug APIs, notably within the pharmaceuticals targeting serotonin receptor modulation. Our clients integrate this intermediate at early to mid-stage synthesis steps, where the specific substitution pattern is critical for desired pharmacological profiles of finished APIs. Strict adherence to regulatory guidelines assures product safety from intermediates through to batch release. Industry compliance standards
Typical usage ratio
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2. Reference Standard and Intermediate for Analytical Bioassay Reagent ManufacturersDownstream analytical reagent producers use our material as a calibration or synthetic reference during the manufacture of bioassay test kits targeting piperazine derivatives. The compound’s structural specificity ensures accurate lot-to-lot assay validation, and traceability requirements mandate endpoint verification in production. Strict audit trails and batch-level documentation control cross-contamination and analytical errors throughout the entire handling process. Industry compliance standards
Typical usage ratio
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3. Chemical Intermediate for Custom Organic Synthesis (CDMO / CMO Services)Contract development and manufacturing organizations (CDMOs and CMOs) source 1-(2-Methoxyphenyl)Piperazine Hydrochloride for custom production of fine chemicals with piperazine frameworks. Its regulated use allows controlled introduction of methoxy-substituted phenyl moieties in advanced intermediates for ongoing drug discovery or agricultural chemical research. Purity profile management and traceability of input chemicals form key quality parameters for customized contract synthesis orders. Industry compliance standards
Typical usage ratio
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4. Synthesis of Experimental Neuroactive and Psychopharmacological CompoundsInnovative neuroscience R&D labs utilize this compound for synthesizing structural analogs and molecular probes designed to map neurotransmitter pathways or profile receptor-ligand interactions. Its unique methoxylated phenyl-piperazine structure underpins SAR (structure-activity relationship) research, where traceability, batch homogeneity, and compliance with laboratory safety protocols remain critical throughout experimental compound preparation. Industry compliance standards
Typical usage ratio
Downstream process integration
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In our line of work, 1-(2-Methoxyphenyl)Piperazine Hydrochloride stands out for more than just its chemical formula. Years at the reactor and the bottling line have shown our team that every batch takes skill, clear protocols, and a deep respect for detail. Our senior process chemists watch the raw materials like hawks—knowing pure, validated inputs breed reliable results. We pay careful attention to each distillation cut and filtration checkpoint, learning from every lot. That way, we consistently deliver clear, solid hydrochloride salt with dependable assay values and well-contained trace impurities.
This compound, sometimes referred to in research circles as a valuable piperazine derivative, plays a unique role in chemical development, screening, and synthesis work among pharmaceutical and agrochemical labs. Quality never happens by shortcut. Our batch records keep every stage honest, and our spectroscopic checks spot trace issues early. We find that this level of discipline supports our partners’ drug discovery and scale-up work by reducing unpredictability. Our goal is always a product you can count on, not just for one project but time and again.
Our frontline teams understand the ‘why’ behind every quality checkpoint. For our 1-(2-Methoxyphenyl)Piperazine Hydrochloride, we track every input—aromatic amines, piperazine, methylation agents, and the quality of HCl used in final crystallization. Overseen by our most seasoned shift runners, the closed-system syntheses rely on controlled temperatures and slow addition schedules. We find that this approach curbs unwanted side products and yields more consistent product.
Solid phase washes, multi-stage filtration, and measured drying help us hit the safety standards and assure bulk buyers of a stable salt—fine, white, and free-flowing, avoiding the cake-prone trouble seen elsewhere. We hold confidence in our process because we back it up with documented yields, retention samples, and analysis archives going back over a decade. Our warehouse keeps stocks managed by batch so traceability is never lost.
Quality, in our daily job, comes down to practical checks, not just paperwork promises. We routinely confirm content (typically >99% by HPLC), water (less than 0.5% KF), and limit heavy metals by using the same validated protocols as our own internal R&D. Each bag or drum ships with documentation based on actual samples, not theoretical specs. You want to know if your new method gives consistent results from drum to drum; we put that proof in your hands.
Particle uniformity, ease of handling, and reactivity all depend on how we finish and pack the product. We’ve learned from experience that some research customers need smaller, convenient units, while production-scale users value 25 kg drums for throughput. Our team coordinates each run’s packing lot to avoid cross-contamination. In the rare event a quality concern is flagged, we hold back the affected batch and investigate root cause—tracking back through operator logs and equipment cleaning records, responding with corrective action. We treat your applications as we do our own.
Labs working with 1-(2-Methoxyphenyl)Piperazine Hydrochloride often use it as a key building block for synthesizing more complex molecular frameworks. Our product fits best in research workflows that demand consistent reactivity—either for preparing advanced pharmaceutical intermediates or for use in combinatorial library construction. Those in medicinal chemistry value the piperazine core and the ortho-methoxy group for unlocking unique molecular shapes and electron distribution patterns. Some research groups are exploring this material in central nervous system agent design, always within controlled lab settings.
We support scale-up projects by not only providing kilograms as needed, but by freely sharing years of operator insights. Our process data, scale transfer tips, and training materials are all on tap for collaborative projects. We’ve worked closely with pilot line engineers to ensure smooth solvent recovery and minimal yield losses, a difference you feel most when budgets and timelines are tight. Seeing tough runs turn into smooth campaigns makes every late shift worthwhile.
Research users have told us our attention to particle size and salt form keeps their chromatographic results sharp and reproducible. No oily residues, minimal clumping—the choices we make on drying cycles and filtration impact your yields.
Having spent years troubleshooting batch issues and tracking customer feedback, we recognize that not all 1-(2-Methoxyphenyl)Piperazine Hydrochloride on the market performs the same way. Some products hold excess solvent, may introduce higher levels of metallic residues, or exhibit inconsistent color and flow. These deviations often show up during scale-up, stalling project progress or lowering final yields. Our production floors favor stepwise solvent exchanges and avoid high-shear drying to maintain integrity of our crystalline hydrochloride salt.
Through larger and more frequent in-process checks, we’ve seen a marked decrease in out-of-spec material—dropping rework rates compared to years past. Buyers who once worked with mixed-source batches now rely on our traceable lots and see less need for their own pre-treatment. Open channels between our plant labs and customers’ technical teams have solved more than a few problems before they ever grew into shipment delays or wasted labor hours.
We’ve focused on controlling not only product quality, but how we handle logistics. Our product stays protected with food-grade inner liners and tamper-evident closure. Each outbound lot comes with its own full quality dossier, which bridges the confidence gap for pilot and registration batches. At the end of the day, that focus on transparency and hands-on technical backup supports your results.
Across our workbench, we see the real differences between 1-(2-Methoxyphenyl)Piperazine Hydrochloride and other piperazines—whether simple unsubstituted rings or other phenyl-substituted versions with chloride, methyl, or ethoxy functional groups. Material behavior changes with each molecular tweak: reaction rates, stability, and patterns in chromatography. The ortho-methoxy ring plays a special role in shifting electronic behavior and altering reactivity, and we’ve seen proper control over hydrochloride content enables more reliable downstream coupling reactions.
We manufacture related products as well, including 1-(4-Methoxyphenyl)Piperazine and its hydrochloride. Our plant teams recognize how different substitution points control melting range, solubility, and color—buffing the workflow or introducing technical headaches based on subtle structural changes. Years in the trenches have taught us not to take a “one piperazine fits all” approach. Specific research and synthesis demands favor certain derivatives, so we tune our purification, crystallization, and packing for each. There is no shortcut to selective quality.
Colleagues in process chemistry emphasize how the hydrochloride salt often offers the cleanest, safest handling profile for trial scale-ups, limiting airborne dust and hygroscopicity compared to free base forms. We ensure our product doesn’t bridge or harden in well-sealed containers so that bench technicians face fewer logistical snags.
Safety around 1-(2-Methoxyphenyl)Piperazine Hydrochloride, as with many fine chemicals, comes down to practical procedures. We prioritize clear labeling, secondary containment for storage, and regular training refreshers for our warehouse and plant staff. By documenting every shipment with updated safety data, we support customer workplace compliance and safe transport under international guidelines.
There are no high-sounding shortcuts—just gloves, goggles, and clean working zones, repeated by every shift team. Spills and accidental exposure never get ignored, and we share every near-miss internally as a teaching case to strengthen plant-wide controls. Customers who’ve trained their own teams tend to spot fewer incidents with our product thanks to packaging and consistent documentation.
Regulators do not just ask for compliance—they require a trail of evidence for every lot. We maintain these records as central part of our QA culture. You build trust one shipment at a time, and we keep that promise with every drum we send out the door.
Over the past year, we’ve received feedback on particle size, dryness, and even drum closures—not every suggestion comes in as praise. We’ve used this input to improve not only product but also packaging configuration, right down to liner thickness and anti-caking additives. This willingness to adjust keeps researchers confident, since we work with their preferences, not in spite of them.
Some clients have outlined their exact workflow—opening a drum, weighing out powder under vacuum, resealing, and storage for weeks or months at a time. By walking through these routines together, we’ve selected closure systems that stop moisture creep and cut down on repacking. These concrete improvements stem directly from our plant meetings—where QA, logistics, and production teams dissect each tweak until every bottle does its job.
Partnerships grow stronger when we open our floors to audits and site visits, welcoming questions on plant conditions, raw material identity checks, and storage practices. This open environment invites trust—something that resin seals and batch logs alone do not guarantee.
1-(2-Methoxyphenyl)Piperazine Hydrochloride is not just a repetition of yesterday’s products. Our R&D group keeps pushing for new routes to cleaner, more efficient manufacturing—aiming to reduce solvent use and recycling waste streams back to raw materials. Where process safety or environmental load can be improved, we invest alongside customers requesting larger runs. By testing greener solvents and lower energy crystallization steps, we look for ways to keep cost and waste in line with tight regulatory standards.
Researchers advance novel targets every year—so we aim to match their pace, prepping pilot runs and trial batches ahead of new demands. This advance work, done shoulder-to-shoulder with process teams, means we arrive ready to deliver not just raw material, but technical insight. Having the right partner for on-the-fly troubleshooting keeps project timelines alive.
Some of our most exciting feedback comes from startups, academic groups, and R&D teams at multinational labs discovering new uses for our established material. These early efforts do not always lead to the next blockbuster, but they highlight how well-supported, rigorously controlled raw materials play a role in scientific progress. We revise our handling guidelines and expand technical documentation to keep pace.
Our job does not get easier as demand rises. Scaling up means confronting more than just liters and kilograms—it brings new challenges of process efficiency, impurity control, and facility maintenance. Investments in better automation and inline monitoring have paid off: reaction end-points now tie directly to real-time readings, shortening time-to-clear and reducing resource waste. Shifting to higher-purity starting materials, though costly, lowers rework rates downstream.
We also battle against moisture creep and airborne dust, especially during local periods of high humidity. Installing closed transfer systems and air-lock manways limits exposure, protects worker health, and preserves product stability. Our lessons from years of site audits and regulatory queries encourage us to pre-empt trouble with robust documentation, not just for authorities but for our own learning.
Every new market adds a layer: language support for safety data, adapting to regional handling permits, and providing swift documentation for customer imports. Our compliance team navigates each requirement by offering detailed, localized support. The learning curve stays steep, but we climb together, knowing transparency aids everyone.
We view every container of 1-(2-Methoxyphenyl)Piperazine Hydrochloride as more than a chemical—each one carries our name, our plant’s reputation, and layers of teamwork. The trust built depends on how we keep improving: tighter process controls, clearer documentation, and a willingness to support every customer challenge. Our manufacturing team stands behind each drum with real process experience and technical knowledge grown from years in the fine chemical trenches.
By focusing on quality, clear accountability, and technical partnership, we aim to help every chemist, engineer, and researcher move their project forward. We bring 1-(2-Methoxyphenyl)Piperazine Hydrochloride to the bench, pilot plant, and enterprise scale with the confidence that comes from hands-on manufacturing. We stand ready for the questions, challenges, and innovations ahead, committed to being the steady, responsive partner our customers deserve.